Bøger i Contemporary Endocrinology serien

As the diabetes epidemic continues to burden the healthcare system, and with the literature supporting enhanced patient outcomes with improved glycemic control, the need for expertise in the clinical management of inpatient diabetes is an increasingly important and timely matter. While some books have been published on inpatient diabetes, this guide serves as a comprehensive but clinically relevant review of the available literature and recommended management for the key areas surrounding hospital diabetes management. This book is designed to provide practical guidance on diabetes management for hospitalized patients. The number of topics covered is meant to be comprehensive and include discussion on many potential scenarios encountered on the inpatient service, but in a concise and user-friendly manner. This book is intended to be a valuable resource for fellows, residents, students, and existing providers looking to improve their knowledge and skills in evidence-based inpatient diabetes management. The enclosed chapters were written by many globally renowned physicians, researchers, and clinicians. Diabetes Management in Hospitalized Patients: A Comprehensive Clinical Guide is a valuable resource for endocrinologists, hospitalists, pharmacists, PAs and NPs, and all staff responsible for clinical care of these patients.

Reviewing the most current literature, this text is a guide to medical decision-making regarding the diagnosis and treatment of patients with acromegaly. The scope of the book is comprehensive, covering all relevant facets of acromegaly, beginning with a history of the disorder and a review of the somatotrophic axis. Etiology is then discussed, including growth hormone secreting pituitary adenomas and other neuroendocrine tumors. Subsequent chapters present imaging modalities and diagnosis via radiology and clinical findings, as well as comorbid symptoms such as sleep apnea, musculoskeletal considerations, cardiovascular disorders, cancer and diabetes. Both medical and surgical management chapters describe each in detail, including radiotherapy, transsphenoidal surgery, somatostatin analogues and dopamine agonists. Concluding chapters present long-term follow-up as well as an extended selected patient story detailing life with the disease.Bringing together the latest in endocrinologic and neurosurgical evidence and practice, Acromegaly will be the go-to resource for this challenging condition for years to come. 

Managing COVID-19 alone can be a difficult in many cases, but for persons with pre-existing conditions such as diabetes the challenge can be all the greater, and specific considerations need to be taken when prescribing treatment to manage them. This book is a culmination of scientific work driven by personal conviction to enhance the care provided to the vulnerable populations COVID-19 patients with diabetes. It spans topics from the epidemiology and predictors of complications and increased mortality in COVID-19, to in-depth discussion of the pathophysiology of the disease. Pathophysiology of COVID-19 is addressed comprehensively as common soil pathogenetic pathways, and by organ system such as the lung, the kidney and most pertinently for diabetes, the diabetic foot ulcers and diabetes co-morbidities. A multi-disciplinary approach was needed to manage these complex patients; thus, the authors represent a variety of disciplines including pharmacology, endocrinology, nephrology,infectious diseases, podiatry, vascular surgery, pulmonary/critical care, and general medicine.Written by experts in the field, Diabetes and COVID-19: Considerations and Clinical Management is a blueprint for treatment of patients with both conditions.

Incidentally discovered thyroid nodules and palpable neck masses present a common clinical problem. Further evaluation with neck ultrasound helps to characterize these lesions and stratify the risk of malignancy. Based on ultrasound characteristics, these lesions can be better defined using pathologic and other clinical data in order to determine the best management. This practical handbook is a case compendium based on thyroid and neck ultrasonography patterns that are commonly encountered in clinical practice. A chapter will be designated for each of the major types of thyroid nodule ultrasound features, and additional chapters will be designated for other non-thyroid neck lesions. Beginning with imaging (photographic) examples of each of the ultrasound findings, clinical cases will be used to subdivide each feature and illustrate the differential diagnoses of the various types of thyroid and neck lesions. Associated cytology and histopathology images will beshown and described, as well as clinical data, including relevant history, physical exam, molecular marker results and clinical course. Chapters will include bulleted key points for quick reference as well as suggested readings for further investigation.While several handbooks exist to educate readers about neck and thyroid ultrasonography and about cytopathology, this is a unique work that combines ultrasound and pathology data into a case-based, easy-to-read and concise format that fits in your pocket, adapting common terminology that is emerging for ultrasound, which will allow readers to employ a "standardized" approach to evaluating nodules, depending on the risk scoring system used.

While there are some books that include discussions of individual causes of hypercalcemia, there are none that provide basic guidance on the approach, diagnosis and treatment of hypercalcemia, while also offering an in-depth, detailed, state-of-the-art review of the individual causes by world-renowned experts in the field. Topics discussed include pathophysiology, differing diagnostic strategies for both the pediatric and adult patient, the various forms and causes of hypercalcemia as well as current treatment regimens and algorithms. Selected chapters are enhanced with illustrative cases, thereby complementing theoretical matter with real-world applications to the practice of medicine, and tables and figures allow the reader to solidify concepts in an easily digestible format. By integrating an evidence- and guideline-based framework along with an up-to-date, research-based summary of each cause, Hypercalcemia is relevant for expert clinicians and up-and-coming medical students alike. 

Cushing's syndrome is a relatively rare clinical disorder that is associated with many co-morbidities such as systemic hypertension, diabetes, osteoporosis, impaired immune function and growth impairment in children, all of which severely reduce quality of life and life expectancy. Cushing's Syndrome: Pathophysiology, Diagnosis and Treatment reviews the difficulties in distinguishing Cushing's syndrome from these and other common conditions, such as central obesity, menstrual irregularity and depression. It also provides state-of-the-art information on various strategies to establish the diagnosis of Cushing's syndrome and the differential diagnosis among its diverse etiologies, as well as therapeutic approaches. Additionally, a range of conditions that represent challenges for the diagnosis and treatment--such as renal failure, pediatric age, cyclic hypercortisolism, and pregnancy--are covered in detail. A valuable resource not only for endocrinologists but also internal medicine physicians, gynecologists, pediatricians, , pituitary surgeons and urologists, Cushing's Syndrome: Pathophysiology, Diagnosis and Treatment provides insights by experts that will help all physicians dealing with Cushing's syndrome to expand their knowledge about the condition and provide targeted, comprehensive care.

The hypothalamus is an anatomically small but functionally important part of the brain. In functional and pathophysiological terms, the hypothalamus represents the intersection of several areas of clinical and medical expertise. The human hypothalamus can be astutely referred to as the crossroad of endocrinology, psychiatry, neurology and neurosurgery. Because of its involvement in myriad physiologic functions and the varied ways disorders involving it can manifest, hypothalamic disease can initially come to medical attention in widely disparate settings and with widely different clinicians. Therefore, the detection and proper care of hypothalamic dysfunction and disease often requires carefully coordinated multidisciplinary care.This volume fills a significant void in the medical professional community, comprehensively presenting the scope of hypothalamic structure, function, dysfunction and disease to cater to the various clinical, teaching and researchprofessionals that have a stake in this part of the human brain. This text captures in one place all the information that practicing clinicians, clinician scientists, and researchers need to be adequately informed about various aspects of the hypothalamus in all its complexity. It is comprehensive and broad in scope so that it provides relevant reference information for the wide range of professionals involved in the pre- and post-mortem detection, diagnosis, characterization, care and management of various hypothalamic disorders and diseases in addition to providing a sound anatomic and physiologic foundation of the normal human hypothalamus. The Human Hypothalamus can be used to differing degrees by medical professionals and students alike, finding utility for interested general clinicians, medical school and allied health professional teaching faculty as well as subspecialists in domains as wide as neurosurgery, neuroendocrinology, clinical psychiatry and neuro-oncology.

Medical emergencies due to disorders of the endocrine system represent a unique category of clinical care. Hypotension, fever, palpitations, confusion, and electrolyte abnormalities are all signs of disparate endocrine emergencies that require immediate diagnoses and treatment. Recognition of endocrine emergencies will frequently lead to rapid improvement and stabilization of the patient.Now in a revised and expanded second edition including the latest clinical guidelines and protocols, Endocrine Emergencies serves as a handy single reference for any endocrinologist, internist, hospitalist, and emergency medicine physician to rapidly identify and initiate treatment. Topics covered include acute adrenal insufficiency, diabetic ketoacidosis, thyroid storm, hyponatremia, and myxedema coma, among many others. Each chapter opens with a precis that provides, in a single page, a presentation of symptoms, workup, and therapy. This serves as a rapid, ¿off the shelf¿ cue to immediately begin a differential diagnoses and therapy plan. The remainder of each chapter is an in-depth review of the pathophysiology, diagnoses, and management of the disease process. Book chapters are written by experts in the field and reflect the consensus and standard of care for specific endocrine emergencies.Updated with the latest clinical evidence and treatment options, Endocrine Emergencies remains a valuable resource for practitioners in endocrinology and internal medicine, as well as emergency room physicians, hospital support staff, fellows and residents.

Medical emergencies due to disorders of the endocrine system represent a unique category of clinical care. Hypotension, fever, palpitations, confusion, and electrolyte abnormalities are all signs of disparate endocrine emergencies that require immediate diagnoses and treatment. Recognition of endocrine emergencies will frequently lead to rapid improvement and stabilization of the patient.Now in a revised and expanded second edition including the latest clinical guidelines and protocols, Endocrine Emergencies serves as a handy single reference for any endocrinologist, internist, hospitalist, and emergency medicine physician to rapidly identify and initiate treatment. Topics covered include acute adrenal insufficiency, diabetic ketoacidosis, thyroid storm, hyponatremia, and myxedema coma, among many others. Each chapter opens with a precis that provides, in a single page, a presentation of symptoms, workup, and therapy. This serves as a rapid, ΓÇ£off the shelfΓÇ¥ cue to immediately begin a differential diagnoses and therapy plan. The remainder of each chapter is an in-depth review of the pathophysiology, diagnoses, and management of the disease process. Book chapters are written by experts in the field and reflect the consensus and standard of care for specific endocrine emergencies.Updated with the latest clinical evidence and treatment options, Endocrine Emergencies remains a valuable resource for practitioners in endocrinology and internal medicine, as well as emergency room physicians, hospital support staff, fellows and residents. 

Providing a comprehensive review of the most up-to-date evidence, this book presents the latest biology, diagnosis and management for pheochromocytomas, paragangliomas and related disorders of the sympathoadrenal system.

Based on the most novel approaches and cutting-edge clinical and scientific information regarding radionuclide imaging and therapies for neuroendocrine tumors, this clinical guidebook represents a unique collaborative effort between endocrinologists, nuclear physicians, oncologists, surgeons, physicists, radio-pharmacists and geneticists.

While the skeletal effects of vitamin D are well-documented, the role and importance of vitamin D outside of bone health has not been well-established. This book provides an in-depth examination of these extraskeletal effects of vitamin D and the associations between vitamin D deficiency and various disease states.

Now in a revised and expanded second edition, this unique text presents topics related to insulin resistance in youth and its consequences across the lifespan. In the first section of the book examining epidemiology, the contributors review controversies over the definition of insulin resistance in children and what is known about how insulin resistance in youth differs from adults, the measurement of insulin resistance in youth in the research and clinical settings, and current knowledge regarding the epidemiology of insulin resistance in the pediatric population. The second section of the book explores pathophysiology, including current knowledge of the molecular, metabolic, and physiologic mechanisms of insulin resistance, the unique pathophysiology of pregnancy and puberty, the contributions of the prenatal and early childhood environment to the development of insulin resistance, and adipose and biochemical mediators. This section concludes with discussion of the relationship between insulin resistance and cardiovascular disease and liver disorders. A third section, new to this second edition, explores insulin resistance in unique models: intrauterine growth restriction and girls with polycystic ovary syndrome and metabolic syndrome. The final section of the book explores the concepts of treatment through medications directed at insulin sensitivity, as well as exercise, weight loss medications and consequences of bariatric surgery.Insulin Resistance: Childhood Precursors of Adult Disease, Second Edition provides up-to-date reviews of all of these areas, providing the reader with a current perspective on issues in insulin resistance in youth, an emerging risk factor for disease across the lifespan, that will spur continued interest in the topic on the part of clinicians and researchers, perhaps promoting new points of view and creative approaches to this daunting challenge.

This practical resource provides the latest evidence, management strategies and recommendations for the treatment of disorders of the adrenal glands, including related physiology, genetics and pharmacology.

Utilizing the most current evidence, this practical book is the first publication of its kind to focus exclusively on the clinical and laboratory evaluation and therapy of thyroid nodules, including advances in evaluation and controversies in management.

This second edition of Freemark's text embodies all of the strengths of the original work but is deeper and broader in scope, with new chapters on emerging themes including metabolomics, genomics, and the roles of gastrointestinal hormones, the microbiome, brown adipose tissue, and endocrine disruptors in the pathogenesis of childhood obesity.

This unique book will serve as a valuable resource for clinicians and researchers interested in prolactin physiology and pathophysiology and those who are involved in the care of patients with related disorders, including hyperprolactinemia and prolactin-secreting pituitary adenomas.

This unique book is a practical guide for the clinician faced with the challenge of diagnosing and managing neonates, infants and children with congenital hyperinsulinism (HI), within the framework of pathophysiology and molecular genetics.

Although transgender persons have been present in various societies throughout human history, it is only during the last several years that they have become widely acknowledged in our society and their right to quality medical care has been established. In the United States, endocrinologists have been providing hormonal therapy for transgender individuals for decades; however, until recently, there has been only limited literature on this subject, and non-endocrine aspects of medical care for transgender individual have not been well addressed in the endocrine literature.The goal of this volume is not only to address the latest in hormonal therapy for transgender individuals (including pediatric and geriatric age groups), but also to familiarize the reader with other aspects of transgender care, including primary and surgical care, fertility preservation, and the management of HIV infection. In addition to medical issues, psychological, social, ethical and legal issues pertinent to transgender individuals add to the complexities of successful treatment of these patients. A final chapter includes extensive additional resources for both transgender patients and providers. Thus, an endocrinologist providing care to a transgender person will be able to use this single resource to address most of the patient¿s needs. While Transgender Medicine is intended primarily for endocrinologists, this book will be also useful to primary care physicians, surgeons providing gender-confirming procedures, mental health professionals participating in the care of transgender persons, and medical residents and students.

Completely revised and updated, and utilizing the most current evidence and practice guidelines for the treatment of osteoporosis, this comprehensive third edition discusses the basic aspects of bone metabolism, the pathophysiology of osteoporosis, current diagnostic techniques and medical treatment strategies.

This unique book presents an up-to-date discussion of clinical disorders of the pituitary gland in children with specific emphasis on state-of-the-art diagnostic and treatment modalities, highlighting the newest scientific advances in genomics and molecular biology that clinician-scientists caring for children need to know.

Now in a revised second edition, this comprehensive text covers all aspects of male hypogonadism from the basic science to clinical management, comprehensively explaining and applying new insights to the treatment of hypogonadal men.

New chapters in this edition discuss the profound effects oflifestyle change on sexual function, alternative and internet drugs that affectsexual function, endovascular approaches to ED, penile length considerations,the effect of radiation on erectile function, and optimizing ED research.