Bøger i Developments in Nephrology serien

Biota of the St. Marys River: habitat evaluation and environmental assessment.- Polycyclic aromatic hydrocarbons in surficial sediments and caged mussels of the St. Marys River, 1985.- Effects of pollution on benthic invertebrate communities of the St. Marys River, 1985.- Use of a geographic information system data base to measure and evaluate wetland changes in the St. Marys River, Michigan.- Limnological aspects of the St. Clair River.- Distribution and abundance of young fish in the St. Clair River and associated waters, Ontario.- Distribution and abundance of young fish in Chenal Ecarte and Chematogen Channel in the St. Clair River delta, Ontario.- Environmental quality assessment of the St. Clair River as reflected by the distribution of benthic macroinvertebrates in 1985.- Growth and overwinter survival of the Asiatic clam, Corbicula fluminea, in the St. Clair River, Michigan.- Deformities in larval Procladius spp. and dominant Chironomini from the St. Clair River.- Biota of Lake St. Clair: habitat evaluation and environmental assessment.- The plankton ecology of Lake St. Clair, 1984.- Plankton community structure in Lake St. Clair, 1984.- Phosphorus cycling by mussels (Unionidae: Bivalvia) in Lake St. Clair.- Biology of the exotic zebra mussel, Dreissena polymorpha, in relation to native bivalves and its potential impact in Lake St. Clair.- The Detroit River: effects of contaminants and human activities on aquatic plants and animals and their habitats.- Response of bacteria and phytoplankton to contaminated sediments from Trenton Channel, Detroit River.- Tumors in fish from the Detroit River.- Heavy metal contamination of sediments in the Upper Connecting Channels of the Great Lakes.- Application of a microcomputer-based algal fluorescence technique for assessing toxicity: Lake St. Clair and St. Clair River examples.- A method for evaluating the impact of navigationally induced suspended sediments from the Upper Great Lakes Connecting Channels on the primary productivity.- Heavy metals in aquatic macrophytes drifting in a large river.- Distribution of Hexagenia nymphs and visible oil in sediments of the Upper Great Lakes Connecting Channels.- Production of Hexagenia limbata nymphs in contaminated sediments in the Upper Great Lakes Connecting Channels.

Ethical Problems in Dialysis and Transplantation presents an overview of issues with which nephrologists and decision makers are confronted in their daily practice. The search for a universal system of ethics and theories of justice are addressed. Furthermore the work provides a normative ethical discussion of ways of distributing resources with a view to selection and commercialization. Others chapters discuss a philosophical and religious analysis of stopping treatment and the clinical and ethical aspects of stopping treatment in dialysis. Different views from different countries on the subject of dialysis and transplantation are covered including the views expressed by contributors from India, Africa, Japan, Great Britain and China. The work presents the clinician with a guide to the ethical considerations underlying the treatment of dialysis and renal transplantation patients.

The Proceedings of the Fifth International Pediatric Nephrology Symposia are dedicated to those who make the writing possible: the delegates; those who wanted to attend, but could not, and to our colleagues, families and friends who helped organize the meeting. with the advent of certification of pediatric nephrologists in the USA and the increasing numbers of pediatric nephrologists contributing to and practic­ ing this specialty throughout the world, it is appropriate that we begin to record our international symposia in order to periodically document the State of the Art of pediatric nephrology and to share new information in a timely fashion with colleagues who care for children. Four previous international pediatric nephrology symposia have been spon­ sored by the International Pediatric Nephrology Association. These meetings were held in Guadalajara, Mexico, 1968, Paris, France, 1971, Washington, DC, USA, 1974 and Helsinki, Finalnd, 1977. This is the first time that it has been possible to organize the publication of the proceedings of a symposium. The enclosed manuscripts represent more than seventy percent of the symposia presentations delivered at the Fifth International Pediatric Symposia (October 6-10, 1980, Phila., PAl which was - hosted by St. Christopher's Hospital for Children and The Children's Hospital of Philadelphia representing the Departments of Pediatrics of Temple University School of Medicine and The University of Pennsylvania School of Medicine.

RICHARD J. GLASSOCK Introducing a scientific symposium is an uncertain and difficult task. The remarks must not be too specific lest the participant's later contributions be intruded upon, yet an overview of the goals and objectives of the conference should be presented in an inquisitive and stimulating fashion. Perhaps a compromise position would be to make a few general statements and pose a limited number of questions which hopefully would then be addressed dur­ ing the formal or informal portions of the meeting. A conclusion incorpo­ of the relevance of the specific topic to the more rating some perspectives global issues of disease and its consequences might be appropriate. The goals and objectives of this conference, as set forth by its organizers, Professors Ponti celli, D'Amico and Minetti, are rather simple and straight­ forward; namely, to review and elucidate the immunopathophysiology of cryoimmunoglobulins and auto-antibodies to immunoglobulins (lg) and, secondarily, to explore the possible participation of these disordered states in glomerular injury. As such, this conference is principally devoted to an analysis of two properties of certain species of the globulin fraction of serum proteins, specifically the ability to self associate on the basis of immune interactions and to form insoluble aggregates when exposed to reduced ambient temperature. As we shall see, these two properties are often dis­ tinctly related.

Twenty-seven papers present state-of-the-art analysis of the subject dealing with four major areas: the plasma cell dyscrasias; light chain nephrotoxicity; the kidney involvement in plasma cell dyscrasias; and the therapeutic approach. Annotation copyright Book News, Inc. Portland, Or.

The mechanisms by which animals regulate the volume and composition of their body fluids has long had a particular fascination for students of biology. As a consequence, the subject can lay claim to an impressive record of ground­ breaking scientific achievements as well as a provocative body of philosophical speculation concerning the role of the system in the origin and evolution of life. Indeed, the entire concept of homeostasis on which so much of o~r current biologic thinking is based, derives from Claude Bernard's pioneering exploration of the forces that determine the composition of this 'internal sea'. Other seminal achievements credited to this area of inquiry include the first description of a genetically transmitted human disease (familial neurogenic diabetes insipidus); the first isolation sequencing and synthesis of a peptide hormone (vasopressin and oxytocin); the first demonstration of peptide hormone synthesis by way of a larger protein precursor; the first description of resistance to the biologic actions of a hormone (nephrogenic diabetes insipidus); and the conceptual realization of the unique counter-current mechanism that permits concentration of the urine. This record of far reaching and fundamental advances has been distinguished by many fruitful inter­ actions between clinical and basic science.

The Final Report of the USA CAPO Registry summarizes eight years of observation and analysis that reflects the experiences of 485 clinical centers and over 25,000 CAPO patients. As such, it offers a wealth of information, available here for the first time to interested parties around the world. Because the National Institutes of Health was quick to see the potential of CAPO as a promising therapy for patients with end stage renal disease, the Registry project was begun soon after its introduction into clinical practice in the USA. Accordingly, the Registry offered the nephrology community in the United States a special opportunity to study this emerging new therapy in some detail, an opportunity not previously available for any other form of dialysis. As will be seen in this report, the result of this early and intensive research effort has been the development of a vast amount of clinically important information regarding the utilization, safety, and efficacy of this important dialytic therapy.

The thrust here is for those who want to know more than the answer to an exam question - an approach to disease diagnosis and treatment which emphasizes thoughtful consideration of alternatives, finding ones way through uncertainties and lack of knowledge. The annual seminar on which this volume is based has evolved into a forum for open discussion of puzzling questions - actually old questions in the light of new data. To me, the adventure of life is in recognizing the openendedness of all things. So you thought that a certain disease was a settled question? In medicine a "e;settled"e; question is a transient conclusion. Even the solutions to the so-called simplest problems have another side. Our aim this year was to air out concepts and conclusions about hypertension, fluid-electrolytes, and tubulopathies. The stars were Drs. Juan Rodriguez-Soriano, Alan Gruskin, and Donald Potter, along with Drs. Gustavo Gordillo, Ronald Kallen, and Antonia Novello as guest faculty. Local stars included Drs. Mary Jane Jesse, Jacques Bourgoignie, and Carlos Vaamonde. Their contributions added to those of the other faculty and registrants, coalesced into vibrant exchanges which are reproduced here for the reader's perusal.

Proceedings of the 4th Bari Seminar in Nephrology, April 25-28, 1990

The initial observations of dialytic support were brought from the laboratory and confined to patients with reversible acute renal failure. The thought at that time was one of short term maintenance. It was theorized that removal of waste products from the blood, albeit incomplete and inefficient, might allow these patients time to regenerate damaged tubules and regain renal function. After a dis- appointing earlier experience in survival, greater sophisti- cation and broader practice refined the dialysis skills and reduced mortality. It also became apparent that long periods of support were possible and successful attempts were then made in utilizing this technology in patients with chronic renal failure. These early young patients were a very select group who possessed only renal dysfunction and no other systemic involvement. Nonetheless, they demonstrated a one year survival of only 55-64%. There are presently over 80,000 patients on dialytic support in the United States and over 250,000 patients worldwide dependent on artificial replace- ment. Mortality statistics vary but despite a 20-30% systemic disease involvement and a fifth decade average age in the North American experience, the one year survival has risen to apparently 90%.

The purpose of this volume and Pediatric Nephrology Seminar IX from which it was created is to provide easy access to current concepts in the diagnosis and management of kidney diseases in the newborn. Complimentary to this purpose is the opportunity the Seminar structure gives me to invite those particularly interested in the subject chosen to come together, share experiences and ideas in an unhurried, unpressured atmosphere for four con­ tinuous days - an oasis for me and, I am told, also for the faculty and registrants. This year's subject choice is an expression of my perennial interest in the kidney of the newborn. A step back to view the steps forward reveals unwittingly intertwined associations and actions which now fall into focus. When I was just beginning my pediatric nephrology training with Sol Kaplan at Downstate in Brooklyn, we discussed Bob Usher's pioneering thought that there was something wrong with the kidneys of babies with RDS. Without really knowing what needed to be done, I started looking at the kidneys of those babies. Subsequently, Dick Day who was Chairman of the Department of Pedia­ trics there, stopped me in the hall, and asked me to come into his office. Glowing in quiet introspection, he extolled the joy of working with one's hands, then hurried away to his laboratory. He had been the Director of the Newborn Nursery at Babies Hospital before coming to Downstate, and (as I later found out) was trying to do something with oxygen electrodes.

This Pediatric Nephrology series is a focus on salient points which at the time of each annual seminar are of importance to the practicing pediatrician and nephrologist, the clinical researcher, and basic researcher interested in clinical problems. Hence the format of selected papers and panel discussions to capture the tenor of the times. More thorough coverage of many of the subjects can be found in current journals and textbooks listed in the authors' references. Those searching for the conventional should look there rather than here since our aim is not to cover each subject in its entirety but to secure attention to the controversial aspects of the subjects, dispel the notion that there is one answer to a question, and raise the level of inclination toward dynamic problem solving. The basic subject chosen this year reflects dominant concerns this year and the participants chosen--speakers and discussants--represent certain views relevant to the subject at this time. To reflect the tempo and flavor produced by this unique blend, the discussions are included almost verbatim. For some this means readability; for others, excess verbiage. The careful reader will notice that I have been the chairman of all sessions and have moderated all discussions. This is in keeping with our aim to ferret out interrelated basic questions and varying answers to the subjects--seen as related in problems and solutions. In the discussions, all names have been deleted.

Collected Papers from the Seventh International Symposium on Biochemical Aspects of Kidney Function, Bratislava, 9-12 April 1984

This is a book about renal cysts and cystic kidneys. Experimental analogs of human disease offer increasing opportunities to basic researchers to examine, in sequence and under controlled circumstances, those events that favor nephron dilation, cyst growth and ultimate renal failure.

Indeed, because of continuous ambulatory peritoneal dialysis (CAPD), long-term per itoneal dialysis after a two-decade incubation period is finally becoming an equal option to hemodialysis and transplantation in the management of chronic renal failure.

Second Milano Meeting of Nephrology, September 30-October 1, 1985

The Final Report of the USA CAPO Registry summarizes eight years of observation and analysis that reflects the experiences of 485 clinical centers and over 25,000 CAPO patients.

This is a book about renal cysts and cystic kidneys. Experimental analogs of human disease offer increasing opportunities to basic researchers to examine, in sequence and under controlled circumstances, those events that favor nephron dilation, cyst growth and ultimate renal failure.

The mechanisms by which animals regulate the volume and composition of their body fluids has long had a particular fascination for students of biology.