Bøger i Experientia Supplementum serien

2nd Workshop, Bayreuth 1983

Following an opening chapter by the late Susumu Ohno on paralogues of sex-determining genes, the five best-studied genes essential for early mammalian gonadal development are portrayed in detail: SF-1 and WT1 and their roles in early events in gonadal development, SRY and SOX9 in testis determination, and the anti-testis gene DAX-1.

Among the various theories proposed to account for the process of aging, the free radical theory is of practical interest since it includes the possibility of retarding this process by administrating natural or synthetic antioxidants and free radical scavengers.

The 39 chapters in this volume consider subjects ranging from genetics, markers, and molecular biology of alcoholism, to clinical observations and treatment. The aim is to integrate pertinent information from the fields of molecular and cell biology with view to establishing a molecular basis of alcohol use and abuse.

It can be argued that nonselective cation channels were the first sort of ion channel to be described, though the word channel was not used at the time.

Although DNA fingerprinting is a very young branch of molecular genetics, being barely six years old, its recent impact on science, law and politics has been dramatic.

receptors containing an integral ionic channel), 2) metabotropic receptors (receptors coupled to G proteins) and 3) voltage-dependent ionic channels (Na+, K + and Ca2+ channels) were already well differentiated when vertebrates separated from invertebrate species.

If it is true that science proceeds from a romantic through a scientific to a technological stage, then research on bird orientation is certainly on its move from its first to its second grade, and recent developments in radiotelemetry and satellite tracking of migrating birds might already indicate the advent of the third stage.

Clinical Toxicology is the second volume of a three-volume set on molecular, clinical and environmental toxicology that offers a comprehensive and in-depth response to the increasing importance and abundance of chemicals of daily life.

As a consequence, researchers and project managers in the pharmaceutical industry should have a solid knowledge of the more important methods available to drug discovery, because it is the rapidly and intelligently combined use of these which will determine the success or failure of preclinical projects.

The most specific immune response to chemicals and drugs that cause allergic contact dermatitis, respiratory disease and adverse drug reactions is the highly antigen-specific T lymphocyte response.

Galanin is a neuropeptide found both in the central and peripheral nervous system. The studies reviewed in this volume give a fairly complete overview of the spectrum of the biological actions and functions of galanin and its receptors and on possible therapeutic applications in a number of pathological conditions.

Galanin is a neuropeptide found both in the central and peripheral nervous system. The studies reviewed in this volume give a fairly complete overview of the spectrum of the biological actions and functions of galanin and its receptors and on possible therapeutic applications in a number of pathological conditions.

Matrix metalloproteinases (MMPs) are proteolytic enzymes that are involved in many physiological and pathological processes. The present book discusses the design and development of different classes of inhibitors of important classes of MMPs, such as gelatinases and collagenases.

It is no longer time-consuming analysis of unknown products, but rather selective identifications of individual forms, modifications and processings, and overall analysis of global protein outputs from cells and tissues in health and disease.

The present book is the ideal complement to the practitioner's manual Techniques in Molecular Systematics and Evolution, recently published by the same editors in the Birkhauser MTBM book series.The first part of this book deals with important applications of evolutionary and systematic analysis at different taxonomic levels.

receptors containing an integral ionic channel), 2) metabotropic receptors (receptors coupled to G- proteins) and 3) voltage-dependent ionic channels (Na+, K + and Ca2+ channels) were already well differentiated when vertebrates separated from invertebrate species.

Environmental Toxicology is the third volume of a three-volume set on molecular, clinical and environmental toxicology that offers a comprehensive and in-depth response to the increasing importance and abundance of chemicals of daily life.

This collection of abstractions contains, in condensed form, research results in the field of nicotine research presented at the satellite symposium of the 12th International Congress of Pharmacology held in Montreal in July 1994.

DNA fingerprinting had a well-defined birthday. In the next year (October, 1986) DNA fingerprinting made a dramatic entree in criminal investigations with the Enderby murder case, whose story eventually was turned into a best-selling book ("The Blooding" by Joseph Wambaugh).

Are demographic and environmental stochas ticity by far more important for the fate of a population or species than genetic stochasticity (genetic drift and inbreeding)?

In this volume outstanding specialists review the state of the art in nervous system research for all main invertebrate groups. Novel techniques in molecular and developmental biology are creating new perspectives that point toward a theoretical foundation for a modern organismic biology.