Bøger i Experientia Supplementum serien

Volume II focuses on the state-of-the-art technologies and applications of various types of sensors. A picture thus emerges of how applications can be expanded in the future and novel markets can be opened up.

Matrix metalloproteinases (MMPs) are proteolytic enzymes that are involved in many physiological and pathological processes. The present book discusses the design and development of different classes of inhibitors of important classes of MMPs, such as gelatinases and collagenases.

It is no longer time-consuming analysis of unknown products, but rather selective identifications of individual forms, modifications and processings, and overall analysis of global protein outputs from cells and tissues in health and disease.

Carbonic anhydrase (CA) is a seemingly ubiquitous enzyme of profound physiological importance, which plays essential roles in respiration, acid-base homeostasis, bone resorption, calcification, photosynthesis, several biosynthetic pathways and a variety of processes involving ion, gas and fluid transfer.

Aims to understand, from a evolutionary perspective, the impact of stress on biological systems. This work discusses the role of stress in evolutionary change, from stress induced mutations and selection to speciation and evolution at the geological time scale.

Molecular Toxicology is the first volume of a three-volume set Molecular, Clinical and Environmental Toxicology that offers a comprehensive and in-depth response to the increasing importance and abundance of chemicals in daily life.

This volume aims to provide a timely view of the state-of-the-art in systems biology. The editors take the opportunity to define systems biology as they and the contributing authors see it, and this will lay the groundwork for future studies. The volume is well-suited to both students and researchers interested in the methods of systems biology.

The research provides a more accurate, though complex, picture of how the brain provides cognitive function, and offers new understanding about the mechanisms of cognitive dysfunction and novel avenues for therapeutic treatment.

The recognition of the role of NPY in stimulation of food intake has already resulted in discovery of potent and selective NPY receptor Y-5 antagonists which are in clinical development for obesity while NPY Y1 receptors are targeted for cardiovascular indications.

As a consequence, researchers and project managers in the pharmaceutical industry should have a solid knowledge of the more important methods available to drug discovery, because it is the rapidly and intelligently combined use of these which will determine the success or failure of preclinical projects.

The present book is the ideal complement to the practitioner's manual Techniques in Molecular Systematics and Evolution, recently published by the same editors in the Birkhauser MTBM book series.The first part of this book deals with important applications of evolutionary and systematic analysis at different taxonomic levels.