Bøger i Georgia Genetics Review serien

Once considered merely `selfish' or `parasitic' DNA, transposable elements are today recognized as being of major biological significance. The topics of presentations ranged from how the elements themselves have evolved to the impact transposable elements have had on the evolution of their host genomes.

Focuses on articles relevant to mouse chemical mutagenesis. This book provides an overview of the history of the Human Genome Project and use of the mouse as the primary organism for the functional annotation of the mammalian genome. It analyzes data on DNA damage after chemical treatment; summarizes the power of allelic series; and more.

Once considered merely `selfish' or `parasitic' DNA, transposable elements are today recognized as being of major biological significance. The topics of presentations ranged from how the elements themselves have evolved to the impact transposable elements have had on the evolution of their host genomes.

An enduring controversy in evolutionary biology is the genetic basis of adaptation. Darwin emphasized "e;many slight differences"e; as the ultimate source of variation to be acted upon by natural selection. In the early 1900's, this view was opposed by "e;Mendelian geneticists"e;, who emphasized the importance of "e;macromutations"e; in evolution. The Modern Synthesis resolved this controversy, concluding that mutations in genes of very small effect were responsible for adaptive evolution. A decade ago, Allen Orr and Jerry Coyne reexamined the evidence for this neo-Darwinian view and found that both the theoretical and empirical basis for it were weak. Orr and Coyne encouraged evolutionary biologists to reexamine this neglected question: what is the genetic basis of adaptive evolution?In this volume, a new generation of biologists have taken up this challenge. Using advances in both molecular genetic and statistical techniques, evolutionary geneticists have made considerable progress in this emerging field. In this volume, a diversity of examples from plant and animal studies provides valuable information for those interested in the genetics and evolution of complex traits.