Bøger i Subcellular Biochemistry serien

In this hypothesis, these rare genetic events represent rate-limiting 'bottlenecks' in the clonal evolution of a cancer, and pre-cancerous cells can evolve into neoplastic cells through the acquisition of somatic mutations.This book is written by international leading scientists in the field of genome stability.

Established researchers and postgraduate students in the fields of protein chemistry, biochemistry and structural biophysics will find Fibrous Proteins: Structures and Mechanisms to be an invaluable collection of topical reviews that describe the basic advances made in the field of fibrous proteins over the past decade.

Co-chaperones are important mediators of the outcome of chaperone assisted protein homeostasis, which is a dynamic balance between the integrated processes of protein folding, degradation and translocation.

In this hypothesis, these rare genetic events represent rate-limiting 'bottlenecks' in the clonal evolution of a cancer, and pre-cancerous cells can evolve into neoplastic cells through the acquisition of somatic mutations.This book is written by international leading scientists in the field of genome stability.

This volume summarizes the new developments that made subcellular proteomics a rapidly expanding area. In addition, the book includes coverage of systems biology that deals with the integration of the data derived from these different levels to produce a synthetic description of the cell as a system.

This volume summarizes the new developments that made subcellular proteomics a rapidly expanding area. In addition, the book includes coverage of systems biology that deals with the integration of the data derived from these different levels to produce a synthetic description of the cell as a system.

Eminent researchers provide broad coverage of plant molecular biology and genetic engineering, detailing technological advances in plant cell transformation and responses.

Here, researchers review the latest breakthroughs in protein research. Articles examine the possibility of a Boltzman-like distribution in protein substructures, the new technique of Raman spectroscopy, and compact intermediate states of protein folding.

The mycoplasmas, a trivial name used to denote organisms included in the class Mollicutes, are a group of prokaryotic organisms comprising more than 120 species distinguished from ordinary bacteria by their small size and the total lack of cell walls.

Scientific reviews are now of two complementary types: short, very up-to-date articles, as are found in the Trends series, and the more traditional longer re views, which are more comprehensive but take longer to publish.

This book is about the importance of water in determining the structure, stability and responsive behavior of biological membranes. Water confers to lipid membranes unique features in terms of surface and mechanical properties. The analysis of the hydration forces, plasticiser effects, controlled hydration, formation of microdomains of confined water suggests that water is an active constituent in a water-lipid system.The chapters describe water organization at the lipid membrane¿water interphase, the water penetration, the long range water structure in the presence of lipid membranes by means of X-ray and neutron scattering, general polarization, fluorescent probes, ATR-FTIR and near infrared spectroscopies, piezo electric methods, computer simulation and surface thermodynamics.Permeation, percolation, osmotic stress, polarization, protrusion, sorption, hydrophobicity, density fluctuations are treated in detail in self-assembled bilayers. Studies in lipid monolayers show the correlation of surface pressure with water activity and its role in peptide and enzyme interactions. The book concludes with a discussion on anhydrobiosis and the effect of water replacement in microdomains and its consequence for cell function. New definitions of lipid/water interphases consider water not only as a structural-making solvent but as a mediator in signalling metabolic activity, modulating protein insertion and enzymatic activity, triggering oscillatory reactions and functioning of membrane bound receptors. Since these effects occur at the molecular level, membrane hydration appears fundamental to understand the behavior of nano systems and confined environments mimicking biological systems.These insights in structural, thermodynamical and mechanical water properties give a base for new paradigms in membrane structure and function for those interested in biophysics, physical chemistry, biology, bio and nano medicine, biochemistry,biotechnology and nano sciences searching for biotechnological inputs in human health, food industry, plant growing and energy conversion.

Here, researchers review the latest breakthroughs in protein research. Articles examine the possibility of a Boltzman-like distribution in protein substructures, the new technique of Raman spectroscopy, and compact intermediate states of protein folding.

This latest volume in the "Subcellular Biochemistry" series is an attempt to give an in-depth overview of the field of bacterial cell invasion. Late-20th century knowledge about all well-studied bacteria with the ability to invade eukaryotic cells is brought together.

The way fatty acid metabolism is regulated in the liver and how fatty acids are desaturated are subjects considered in the first part of this volume.

Provides review of research covering different modes of interaction between microbes and plants. It examines the symbiotic association of Rhizobium, Azorhizobium and Frankia with different plant systems disease resistance strategies for plants the role of the agrobacterium system in the formation of tumors, and oligosaccharides.

This book focuses on respiratory proteins, the broad hemoglobin family, as well as the molluscan and arachnid hemocyanins (and their multifunctional roles). Featuring 20 chapters addressing invertebrate and vertebrate respiratory proteins, lipoproteins and other body fluid proteins, and drawing on the editorsΓÇÖ extensive research in the field, it is a valuable addition to the Subcellular Biochemistry book series.The book covers a wide range of topics, including lipoprotein structure and lipid transport; diverse annelid, crustacean and insect defense proteins; and insect and vertebrate immune complexes. It also discusses a number of other proteins, such as the hemerythrins; serum albumin; serum amyloid A; von Willebrand factor and its interaction with factor VIII; and C-reactive protein. Given its scope, the book appeals to biologists, biomedical scientists and clinicians, as well as advanced undergraduates and postgraduates in these disciplines. Available as a printed book and also as an e-book and e-chapters, the fascinating material included is easily accessible.

This text looks at subcellular chemistry, particularly at intermediate filaments. Topics include fish intermediate filament proteins in structure, evolution, and function, and lessons from keratin transgenic and knockout mice.

We proudly present the first book to integrate all aspects of purinergic signaling in the respiratory system.

Del Rio's research group focuses on the metabolism of reactive oxygen species (ROS), reactive nitrogen species (RNS) and antioxidants in plant peroxisomes, and the ROS- and RNS-dependent role of peroxisomes in plant cell signalling.

Although urea represents roughly 40% of all urinary solutes in normal human urine, the handling of urea in the tissues has been largely neglected in the past and few clinical or experimental studies now report data on urea.

Knowledge of cholesterol and its interaction with protein molecules is of fundamental importance. This books examines the structural and functional aspects of the families of cholesterol-binding and cholesterol transport proteins.

Written from a genome-based perspective, this volume provides an objective overview of transcription factor biochemistry. Topics include known transcription factor classes, origins and evolution of transcription factor types, and mechanisms of interaction with chromatin.

This new volume in the Subcellular Biochemistry series will focus on the biochemistry and cellular biology of aging processes in human cells. Main topics for discussion are mitochondrial aging, protein homeostasis and aging and the genetic processes that are involved in aging.