Biofysik

This book gathers selected, extended and revised contributions to the 17th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering and the 5th Conference on Imaging and Visualization (CMBBE 2021), held online on September 7-9, 2021, from Bonn, Germany. It reports on cutting-edge models, algorithms and imaging techniques for studying cells, tissues and organs in normal and pathological conditions. It covers numerical and machine learning methods, finite element modeling and virtual reality techniques, applied to understand biomechanics of movement, fluid and soft tissue biomechanics. It also reports on related advances in rehabilitation, surgery and diagnosis. All in all, this book offers a timely snapshot of the latest research and current challenges at the interface between biomedical engineering, computational biomechanics and biological imaging. Thus, it is expected to provide a source of inspiration for future research and cross-disciplinary collaborations.

Quantitative ultrasound (QUS) continues to mature as a research field and is primed to make a swift transition to routine preclinical and clinical applications. This book will serve two main purposes:Advanced education in QUS by providing a complete and thorough review of all theoretical, physical, and engineering aspects of QUS.Review of recent development of QUS by lead contributors in the research field.This 2nd edition will focus on 6 modern research topics related to quantitative ultrasound of soft tissues:Spectral-based methods for tissue characterization, tissue typing, cancer detection, etc.Attenuation estimation for tissue characterization and improving spectral based methodsEnvelope statistics analysis as a means of quantifying and imaging tissue properties.Ultrasound computed tomography for preclinical and clinical imaging.Scanning acoustic microscopy for formingimages of mechanical properties of soft tissues with micron resolution.Phantoms for quantitative ultrasound.

This book develops and describes surgical rationales in the field of reconstructive surgery for upper limb function, both in children and adults suffering from various diseases or trauma leading to a variety of motor and sensory impairments, sometimes associated with growth-related deformities. Every surgical career is a unique living story of learning, performing, questioning, trial and error, and finally success. Every surgeon has to integrate a wealth of information regarding ongoing clinical and research work in a range of disciplines; and with time and experience, a surgical rationale is developed that serves as a baseline and support for their day-to-day work.Following a structure starting with the patient¿s needs, the surgeon and the training, the different tissues are addressed and their pathophysiology discussed in detail, including basic research and surgical expertise. The book is not a surgical compendium, but instead focuses on the detailed baseline behind day-to-day clinical examinations, functional evaluations and surgical work. Readers will learn how the tissues interact, how pathologies change them and interfere with their functions, and how to reverse the pathophysiological sequence by surgical-technical means to improve function.Although the book presents the author¿s personal views, all aspects are explained and debated on the basis of past and current clinical findings, ongoing basic research and input from other disciplines: readers may disagree with certain points, but choose to implement some of the rationales and priorities, incorporate findings from fields they¿d never previously explored, or investigate them further.This book offers an extensive framework of argumentation and is intended to inspire and support readers in terms of decision-making and understanding current or uncommon procedures. Practitioners in the fields of peripheral nerve surgery, reconstructive plastic surgery, upper limb orthopedics, neuropediactrics, biomechanics, physiotherapy and ergotherapy will find the book a valuable asset, and a trusted companion in the daily quest to improve patient care!

This book provides comprehensive information on starch modification using physical approaches ¿ a field that has attracted increasing interest in recent years due to the fact that it is no longer desirable to label starch a modified. The required functionalities can be conveniently achieved by physical methods that are less expensive and more environmentally friendly. In the second edition, chapters are updated according to the recent research progress. Three new chapters are added including pulsed electric fields, dry heating and physical treatments that produce chemical changes. Chapter one is rewrote into three individual chapters including Molecular Structure of Starch, Granular Structure of Starch and Physicochemical Properties of Starch, aiming to help the readers better understand the structure of starch.This book summarizes recent developments in the areas of starch physical modifications and reviews the structure, function and potential industrial applications of modified starch. It provides valuable information for researchers and product developers to work on starch.

This book summarizes the recent advancements for biomechanics of injury and prevention in mechanism, application and developing frontiers. Biomechanics plays an important role in achieving safety, health, comfort, and a high quality of life by revealing injury mechanism and providing prevention methods. The book covers injury and prevention to the entire human body, from head to toe, including injury and prevention in sports, traffic, accident, clinic and so on. In addition, bionics prevention method inspired by woodpecker is also introduced. The book provides the reader with not only the mechanism of injury but also the advanced injury diagnosis, treatment, and prevention devices based on biomechanics.

This book reports on new trends, challenges and solutions, in the multidisciplinary fields of biomedical engineering and medical physics. Contributions spans from biomechanics, to robotic rehabilitation, radiation oncology, and image and signal processing, among many other topics. They cover advanced devices for diagnosis or patient monitoring, as well as for therapy (non-invasive surgery, rehabilitation and more). Gathering the proceedings of the 19th Nordic-Baltic Conference on Biomedical Engineering and Medical Physics, NBC 2023, held on June 12¿14, 2023, in Liepaja, Latvia, this book is expected to inform a wide audience of researchers, engineers and other professionals working in the broad field of biomedical engineering, and to offer a timely snapshot of research and projects that have been carried out within Nordic and Baltic countries, in particular, but not limited to them.

Sweet Biochemistry: Remembering Structures, Cycles, and Pathways by Mnemonics, Second Edition makes biochemistry lively, interesting and memorable by connecting objects, images and stories to biochemistry concepts. Here, Dr. Asha Kumari has converted cycles and difficult pathways into very simple formula and short stories and images to help readers see things in complicated cycles and better visualize biochemistry. As biochemistry is evolving steadily, with new and impactful topics, this new edition has been fully updated to include mnemonics on timely topics in biochemistry such as DNA replication, RNA, transcription, translation, and CRISPR technology, as well as fundamentals of immunity.

The concept of free will has long been accepted in society as the controlling force behind human behavior, and it is regarded as a fundamental truth within the Christian faith and other religious dogmas. But what if free will is a myth? When biophysicist Bruce Lehnert started to question the notion along with the legitimacy of his prior faith-based religious teachings, he discovered the scientific reality he sought. In The Irresponsible Human, Lehnert turns the assumption of free will on its head. He does so by providing scientific evidence in support of the book's deterministically premised Central Thesis. That is, humans have no conscious or unconscious control over their thoughts, intentions, and physical actions. Lehnert adheres to the deterministic laws of cause and effect, which he summarily calls the "Law of Must", without deviation in his analyses. The results lay bare the fallacy that humans possess the capability to consciously regulate their mental and physical behaviors. Instead, all evidence indicates we are controlled by our unconscious minds over which we also lack regulatory dominion.¿Accordingly, humans are not responsible for their mental and physical behaviors, thereby providing us all with an excuse as need be for all prior errant judgements and actions. Further, the validity of the Central Thesis puts an end to free will as a fundamental foundation upon which Christianity and other religious dogmas are based. Instead, our hope resides in our choice selections, which both prescribe and are our individual destinies.

This book includes high-quality papers presented at the Second International Symposium on Computer Vision and Machine Intelligence in Medical Image Analysis (ISCMM 2021), organized by Computer Applications Department, SMIT in collaboration with Department of Pathology, SMIMS, Sikkim, India, and funded by Indian Council of Medical Research, during 11 - 12 November 2021. It discusses common research problems and challenges in medical image analysis, such as deep learning methods. It also discusses how these theories can be applied to a broad range of application areas, including lung and chest x-ray, breast CAD, microscopy and pathology. The studies included mainly focus on the detection of events from biomedical signals.

This book provides an overview of the contemporary integrated biology approaches for solving structures and understanding mechanisms of complex biological systems.

This book covers every aspect of radiation myelopathy and considers the evidence from all species in which it has been studied. The historical and current understanding of the pathogenesis of this rare but devastating injury is first discussed. The evidence regarding the role of a variety of factors in radiation myelopathy is then reviewed. Readers will find detailed information on the impacts of total radiation dose, radiation volume, dose fractionation, hyper fractionation, age, anatomic level, comorbidities, radiation modifiers, other therapies, and retreatment of the spinal cord. Given the similarity of the pathogenesis of radiation myelopathy in humans and experimental animals, the potential for cross-species modelling of dose response is explored, with attention to relevant species differences. Treatment of the condition is also fully considered. New theories are presented regarding retreatment, small volume response, and the final step in white matter necrosis. The final chapter addresses the medicolegal issues elicited by radiation myelopathy, which is often the result of treatment error. Radiation Myelopathy will be of high value for radiation oncologists, radiation physicists, dosimetrists, biologists, neurologists, medical oncologists, and attorneys.

This book offers the first comprehensive coverage of microwave medical imaging, with a special focus on the development of novel devices and methods for different applications in both the diagnosis and treatment of various diseases. Upon introducing the fundamentals of electromagnetic imaging, it guides the readers to their use in practice by providing extensive information on the corresponding measurement and testing techniques. In turn, it discusses current challenges in data processing and analysis, presenting effective, novel solutions, developed by different research groups. It also describes state-of-the-art medical devices, which were designed for specific applications, such as brain stroke monitoring, lymph node diagnosis, image-guided hyperthermia, and chemotherapy response monitoring. The chapters, which report on the results of the EU-funded project EMERALD (ElectroMagnetic imaging for a novel genERation of medicAL Devices) are written by leading European engineering groups in electromagnetic medical imaging, whose coordinated action is expected to accelerate the translation of this technology ¿from research bench to patient bedside¿. All in all, this book offers an authoritative guide to microwave imaging, with a special focus on medical imaging, for electrical and biomedical engineers, and applied physicists and mathematicians. It is also intended to inform medical doctors and imaging technicians on the state-of-the-art in non-invasive imaging technologies, at the purpose of inspiring and fostering the translation of research into clinical prototypes, by promoting a stronger collaboration between academic institutions, industrial partners, hospitals, and university medical centers.

... Le problème de l'évolution de l'univers a toujours excité l'intérêt du monde pensant. Il conservera, sans nul doute, la première place parmi toutes les préoccupations intellectuelles qui n'ont pas une portée pratique immédiate. Les solutions qui, de loin en loin, ont été formulées à ce problème favori donnent une image fidèle de l'état de la pensée concernant les sciences naturelles, et de leur développement. J'ai le vif espoir que l'exposé contenu dans les pages de ce volume, correspondra au magnifique développement que nous ont présenté les sciences physiques et chimiques à la fin du siècle dernier...

This book describes the shape formation of living organisms using mathematical models. Genes are deeply related to the shape of living organisms, and elucidation of a pathway of shape formation from genes is one of the fundamental problems in biology. Mathematical cell models are indispensable tools to elucidate this problem.  The book introduces two mathematical cell models, the cell center model and the vertex model, with their applications. The cell center model is applied to elucidate the formation of neat cell arrangements in epidermis, cell patterns consisting of heterogeneous-sized cells, capillary networks, and the branching patterns of blood vessels. The vertex model is applied to elucidate the wound healing mechanisms of the epithelium and ordered pattern formation involving apoptosis. Pattern formation with differential cell adhesion is also described. The vertex model is then extended from a two-dimensional (2D) to a three-dimensional (3D) model. A cell aggregate involving a large cavity is described to explain the development of the mammalian blastocyst or the formation of an epithelial vesicle. Epithelial tissues and the polarity formation process of the epithelium are also explained. The vertex model also recapitulates active remodeling of tissues and describes the twisting of tissue that contributes to understanding the cardiac loop formation of the embryonic tube. The book showcases that mathematical cell models are indispensable tools to understand the shape formation of living organisms. Successful contribution of the mathematical cell models means that the remodeling of collective cells is self-construction. Examining the successive iterations of self-constructions leads to understanding the remarkable and mysterious morphogenesis that occurs during the development of living organisms.  The intended readers of this book are not only theoretical or mathematical biologists, but also experimental and general biologists, including undergraduate and postgraduate students who are interested in the relationship between genes and morphogenesis. 

Total Knee Arthroplasty: Medical and Biomedical Engineering and Science Concepts provides an extensive overview of the most recent advancements in total knee arthroplasty (TKA) through a thorough review of the literature in medicine, engineering, and technology. Coverage includes the most recent engineering and computing techniques, such as robotics, biomechanics, artificial intelligence (AI), deep learning (DL), machine learning (ML), and optimization, as well as the medical and surgical aspects of pre-existing conditions, surgical procedure types, surgical complications, patient care, and psychological factors. This book will be a valuable introduction to TKA concepts and advances for academics, students, and researchers.

This book describes the application of signal and image processing technologies, artificial intelligence, and machine learning techniques to support Covid-19 diagnosis and treatment. The book focuses on two main applications: critical diagnosis requiring high precision and speed, and treatment of symptoms, including those affecting the cardiovascular and neurological systems.The areas discussed in this book range from signal processing, time series analysis, and image segmentation to detection and classification. Technical approaches include deep learning, transfer learning, transformers, AutoML, and other machine learning techniques that can be considered not only for Covid-19 issues but also for different medical applications, with slight adjustments to the problem under study.The Covid-19 pandemic has impacted the entire world and changed how societies and individuals interact. Due to the high infection and mortality rates, and the multiple consequences of the virus infection in the human body, the challenges were vast and enormous. These necessitated the integration of different disciplines to address the problems. As a global response, researchers across academia and industry made several developments to provide computational solutions to support epidemiologic, managerial, and health/medical decisions. To that end, this book provides state-of-the-art information on the most advanced solutions.

The textbook describes the complexity of the human dynamic behavior in space and its ability to produce coordinated, adaptive, dynamically stable movements under steady conditions while negotiating complex terrains and experiencing unexpected perturbations. Applying fundamental theories of biomechanics and physiology, the authors further consider the physical, perceptual, and motor aspects of the locomotor system towards the analysis of how humans can behave adaptively in space by virtue of their intelligent sensory-motor functions and to illuminate our understanding of how this complexity in behavior can provide insight into the neural control of locomotion of the musculoskeletal system. The text provides a foundation for describing the normal and abnormal human locomotor systems.¿ The Human Locomotor System: Physiological and Technological Foundations is intended as a primary text for upper-undergraduate and graduate-level courses in neuroscience, gait analysis, kinesiology, physical therapy, sports science, and biomedical and rehabilitation engineering. It is also a valuable professional reference for scientists and engineers at medical and pharmaceutical companies involved in bioengineering research and development.

This book acts as a field-guide for human cells. The book¿s unique structure first separates cells by what makes them distinctive, and then examines the essential ¿tools and parts¿ needed for both the cells¿ specialized function, and also the basic mechanisms that are shared with most other cells. The chapters highlight interactions between multiple cell types, exploring areas such as immunology and cancer to exemplify the complex coordination of cells, as well as the manipulation of normal cell interactions. This book works as a companion reference for an academic text in cell and molecular science, and will be of general interest to anyone who wants to learn more about how cells work and interact.

Carbon-Based Nanomaterials in Biosystems: Biophysical interface at Lower Dimensions provides a thoroughly comprehensive overview of all major aspects of carbon-based nanomaterials, their biophysical response, and biotechnological applications. The book articulates the underlying physics, chemistry, and the basic phenomenon of the broad-range carbon-based nanomaterials (CNMs) with biological systems, particularly the interface analysis. Organized in six sections, it discusses state-of art technological interventions of carbon-based nanomaterials and their application in biomedical sectors in healthcare, food sciences, and technology. The book also highlights the carrying capacity of different CNMs in payload efficiency mechanisms in various biomedical fields. The theranostic efficiency and the safety of various forms of CNMs is assessed. This book will be a helpful resource to those specializing in the areas of nanomedicine, bionanomaterials, and nanotechnology applications.

Cintia Perugachi Israëls received her Master in Physics in 2022 after defending her theoretical physics thesis on the movement of chloroplasts. The quality of this thesis was not just in the research and the writing, it was also beautifully produced. This makes it an inspiring example for other students.Physics master theses in The Netherlands generally are the result of one full year of research.Note, the production of the back cover is a bit tongue-in-cheek, as humor is an important element of making it to the end of all these years of hard work

Spontaneous pattern formation in nonlinear dissipative systems far from equilibrium is a paradigmatic case of emergent behaviour associated with complex systems. It is encountered in a great variety of settings, both in nature and technology, and has numerous applications ranging from nonlinear optics through solid and fluid mechanics, physical chemistry and chemical engineering to biology.This book is a first-hand account by one of the leading players in this field, which gives in-depth descriptions of analytical methods elucidating the complex evolution of nonlinear dissipative systems, and brings the reader to the forefront of current research.Since the publication of the first edition, applications of the theory of nonlinear dynamics have been substantially extended to the novel area of active systems, largely motivated by problems of biophysics and biomorphic technology. These problems typically involve media with internal orientation. This new edition incorporates a chapter discussing dynamics of liquids and soft solids with internal orientation, including special features of their instabilities and motion of topological defects, which form the background for various applications to the motion of cells, tissues, and activated soft materials. The contents of the first edition have also been substantially reworked, improving graphics, emphasizing more complex secondary instabilities, and dropping some material pertaining to dynamical systems.This book caters for graduate students and young researchers from many pertinent areas including applied mathematics, physical chemistry, chemical engineering and biophysics, as well as the seasoned scientist in search of a modern source of reference.

EURECA-PRO is the global educational core hub and interdisciplinary research and innovation leader in qualitative environmental and social framework development for responsible consumption and production.Through its novel approach, on the one hand, it holistically contributes to the highly topical issue of Sustainable Consumption and Production under the umbrella of Sustainable Development Goal 12, and on the other hand it effectively contributes to the development of the European Higher Education Area complimentary to Sustainable Development Goal 4.In this book readers will find the discussion results among professionals, academics and scientists on responsible consumption and production, regarding the latest advances to achieve a sustainable society. This book contents 5 chapters focused on: Smart and healthy societies, Recycling, reused and longer lasting products, fresh air, clean water, healthy soil and biodiversity, cleaner energy and cutting-edge clean technological innovation, and industry 4.0.This book also intends to show the current and future challenges, and innovative solutions considering the technological, humanistic, educational, economic, social and environmental dimensions of sustainability

The book presents emerging techniques for the development of latent fingerprint on various surfaces using nanotechnology. It explores the use of nanoparticles for the development of fingerprints. Various topics covered in this book include chemistry of nanomaterials for finger printing, quantum dots in fingerprinting, florescent nanoparticles in fingerprinting, nanocomposite and hybrid materials for fingerprints, carbon-based nanomaterial, silver and gold nanoparticles development of fingerprint, zinc oxide nanoparticles, silica nanoparticles for development of fingerprints, etc. Given the contents, the book will be highly useful for the students, researchers and professionals working in the areas of forensic science and nanotechnology.

This textbook provides a comprehensive foundation of food physics by addressing the physical properties of food, food ingredients, and their measurements. Physical properties of food play a key role in all fields where modern technological processes are applied for the generation of food raw materials and the production of food. The determination of the physical properties of food and related products is a pre-requisite for product and process development, production engineering and automation in today¿s food, pharmaceutical and cosmetics industries, as well as related quality control activities.Following the success of its first edition published in 2007, the book has been updated to reflect recent industrial applications of novel physical food processing technologies. Each chapter begins with basic principles and progresses to a comprehensive coverage of the topic. The authors enriched this second edition with several didactic elements, including definition boxes,examples, and chapter-end summaries.This textbook helps readers to build up their knowledge of the important aspects surrounding the physical properties of foods and food ingredients. It is also an essential resource for students of food science and technology to complement textbooks in food chemistry and food microbiology, as well as for food and chemical engineers, technologists, and technicians in the food industry.

This book presents the structure formation and dynamics of animate and inanimate matter on the nanometre scale. This is a new interdisciplinary field known as Meso-Bio-Nano (MBN) science that lies at the intersection of physics, chemistry, biology and material science. Special attention in the book is devoted to investigations of the structure, properties and dynamics of complex MBN systems by means of photonic, electronic, heavy particle and atomic collisions. This includes problems of fusion and fission, fragmentation, surfaces and interfaces, reactivity, nanoscale phase and morphological transitions, irradiation-driven transformations of complex molecular systems, collective electron excitations, radiation damage and biodamage, channeling phenomena and many more. Emphasis in the book is placed on the theoretical and computational physics research advances in these areas and related state-of-the-art experiments. Particular attention in the book is devoted to the utilization of advanced computational techniques and high-performance computing in studies of the dynamics of systems.

This book mathematically analyzes the basic problems of biology, decision making and psychology within the framework of the theory of open quantum systems.In recent years there has been an explosion of interest in applications of quantum theory in fields beyond physics. The main areas include psychology, decision-making, economics, finance, social science as well as genetics and molecular biology. The corresponding models are referred to as quantum-like; they don¿t concern any genuine physical processes in the human brain.Quantum-like models reflect the special features of information processing in biological, cognitive, and social systems which match well with the quantum formalism. This formalism gives rise to the quantum probability model (QP) which differs essentially from Kolmogorov's classical probability model. QP also serves as the basis for quantum information theory.Recently QP has been widely applied to the resolution of the basic paradoxes of decision making theory and to modeling experimental data stemming from cognition, psychology, economics, and finance thereby shedding light on probability fallacies and irrational behavior.In this book, the theory of quantum instruments and the quantum master equation are applied to the modeling of biological and cognitive processes, in particular, to the stability of complex biological and social systems interacting with their environment. An essential part of the book is devoted to the theory of the social laser and the Fröhlich condensate.

Transglutaminase: Fundamentals and Applications, a new volume in the Foundations and Frontiers in Enzymology series, stands as a comprehensive resource on this increasingly important class of enzymes. Following an introduction to the field, international experts discuss basic biology and structure - function relationships of transglutaminases, ongoing fundamental research, and new application areas, including food processing, material synthesis, biomedicine, disease treatment, and biotechnology. Approaches for sourcing transglutaminases from animals, plants, and microorganisms are considered, followed by chapters on applied uses in biomedicine, skin, bone biology, medicine, drug development, tissue engineering, seafood bioprocessing, dairy bioprocessing, synthesis of materials and polymers, and as an immobilization agent. Research protocols are also provided, including research rationale, design, substrates, assays, and microassay steps for studying transglutaminases.