Molekylærbiologi

This book deliberates recent developments in microbial science in combating infectious diseases and explores advances in antimicrobial constituents and their applications in the fight against bacteria.

This book aims to introduce the reader to the fascinating mechanisms by which the immune system keeps at bay the microorganisms that menace us every day and threaten to make us sick. The first part of the book is structured as a story in which a bacterium attacks the organism. To defend itself, it sets in motion different cellular actors and molecular mechanisms, which we introduce in a simple way, but emphasizing the most important details as the story unfolds. In particular, the way in which the immune system distinguishes between self and foreign is explained in a narrative style and with great simplicity. The mechanisms of action of vaccines and the different types of vaccines that are known, including the novel RNA vaccines against coronavirus, are also addressed, as well as some of the fascinating reasons why microorganisms can evade immune system action and vaccines can be ineffective.The knowledge gained from reading the first seven chapters is applied in the following seven to delve deeper into the action of the immune system while addressing the problems that its malfunction can cause. Allergies, immunodeficiency diseases, autoimmune diseases, and transplant rejection, among other interesting aspects, are explained. Finally, how the immune system can be pharmacologically manipulated for the benefit of our health it discussed. Reading this book will help to understand some of the reasons for pandemics and infectious diseases, and the reasons why some overcome them, and others do not.

Rapidly growing interest in the role of organic cation transporters (OCTs) and plasma membrane monoamine transporter (PMAT) in central monoamine homeostasis makes this book especially timely, given its thematic alignment with the role of OCTs and PMAT in CNS. This book discusses latest insights into the field laying an emphasis on health, disease and therapeutics. The chapter, "e;General Overview of Organic Cation Transporters in Brain"e;, of this book is available open access under a CC BY 4.0 license at link.springer.com

The Chemical Biology of Carbon examines chemical biology open to carbon-containing natural metabolites that allow both retrospective and predictive behaviours of both biosynthetic and degradative metabolism in primary and secondary pathways ideal for medicinal chemists, chemical biologists and postgraduate students.

In recent decades, time-dependent density functional theory has been developed for computing excited-state properties of large-scale systems to high accuracy in biomolecules and nanomaterials, especially for ab initio nonadiabatic molecular dynamic simulations. It is therefore regarded as a most unique efficient method to do accurate simulation for large complex systems.This book compiles and details cutting-edge research in quantum chemistry and chemical physics from interdisciplinary groups from Japan, China, South Korea, the United States, Hong Kong, and Taiwan. These groups are developing excited-state dynamics methods involving conical intersections and intersystem crossings for large complex systems. Edited by Chaoyuan Zhu, a prominent chemical physics researcher, this book will appeal to anyone involved in molecular dynamics and spectroscopy, photochemistry, biochemistry, and materials chemistry research.

The prime focus of the book is to determine the mechanism, extent, and efficiency of biodegradation processes, as it is necessary to know the composition of the original crude oil or crude oil product. The technology of bioremediation and the concerns of whether or not bioremediation technologies can accelerate this natural process enough to be considered practical, and, if so, whether they might find a niche as replacements for, or adjuncts to, other crude oil-spill response technologies. This book also introduces the reader to the science of the composition of crude oil and crude oil products is at the core of understanding the chemistry of biodegradation and bioremediation processes.

This book discusses the utilization of nano-based formulations for control of viral agents. Antiviral potential of green synthesized silver, chitosan nanoparticles encapsulating curcumin, photoinduced antiviral carbon nanohorns, and role of carbon-based materials like fullerenes &carbon nanotubes in repression of viral antigens are explained.

This book is a valuable reference that discusses green technologies, like enzyme technologies, to meet the ever-growing demand of nutraceuticals and functional foods. Microorganisms like bacteria (lactic acid bacteria, Bacillus species), yeasts, and filamentous fungi have been exploited for food preparations globally. Microbial Enzymes in Production of Functional Foods and Nutraceuticals discusses how to use them commercially. Chapters include enzyme sources, processing, and the health benefits of microbial enzymes. Other interesting Chapters include the application of metagenomics and the molecular engineering of enzymes. This book is useful for students, academicians, and industry experts in food science and applied microbiology.

It provides a comprehensive view of recent advents of hybrid treatment technologies in wastewater treatment, addresses the current limitations and challenges of applying these tools in wastewater treatment systems.

Few, if any, genes have had the same level of impact on the field of evolutionary-developmental biology (evo-devo) as the Hox genes. These genes are renowned for their roles in patterning the body plans and development of the animal kingdom.

Perishable products such as fruits and vegetables account for the largest proportion of food loss due to their short shelf life, especially in the absence of proper storage facilities, which requires sustainable, universal and convenient preservation technology.

This reference book provides advanced knowledge on sustainable biogenic waste management. It covers innovative waste processing technologies to produce biofuels, energy products, and biochemicals. To create a circular bioeconomy, it is imperative to develop processes where the waste generated through one process acts as a feedstock for the other. This book discusses the latest developments in biochemical and thermochemical methods of conversion and covers the potential of different kinds of biomass in more decentralized biorefineries. It describes sustainable solutions for a greener supplement to fossil resources. The book is meant for microbiologists, chemists, and biotechnologists.

This book explores the answers to fundamental questions about the human mind and human behaviour with the help of two ancient texts. The first is Oedipus Rex (Oedipus Tyrannus) by Sophocles, written in the 5th century BCE. The second is human DNA, with its origins around 4 billion years ago, and continuously revised by chance and evolution. With Sophocles as a guide, the authors take a journey into the Genomic era, an age marked by ever-expanding insights into the human genome. Over the course of this journey, the book explores themes of free will, fate, and chance; prediction, misinterpretation, and the burden that comes with knowledge of the future; self-fulfilling and self-defeating prophecies; the forces that contribute to similarities and differences among people; roots and lineage; and the judgement of oneself and others.Using Oedipus Rex as its lens, this novel work provides an engaging overview of behavioural genetics that demonstrates its relevance across the humanities and the social and life sciences. It will appeal in particular to students and scholars of genetics, education, psychology, sociology, and law.

A fresh look at electricity and its powerful role in life on EarthWhen we think of electricity, we likely imagine the energy humming inside our home appliances or lighting up our electronic devices-or perhaps we envision the lightning-streaked clouds of a stormy sky. But electricity is more than an external source of power, heat, or illumination. Life at its essence is nothing if not electrical.The story of how we came to understand electricity's essential role in all life is rooted in our observations of its influences on the body-influences governed by the body's central nervous system. Spark explains the science of electricity from this fresh, biological perspective. Through vivid tales of scientists and individuals-from Benjamin Franklin to Elon Musk-Timothy Jorgensen shows how our views of electricity and the nervous system evolved in tandem, and how progress in one area enabled advancements in the other. He explains how these developments have allowed us to understand-and replicate-the ways electricity enables the body's essential functions of sight, hearing, touch, and movement itself.Throughout, Jorgensen examines our fascination with electricity and how it can help or harm us. He explores a broad range of topics and events, including the Nobel Prize-winning discoveries of the electron and neuron, the history of experimentation involving electricity's effects on the body, and recent breakthroughs in the use of electricity to treat disease.Filled with gripping adventures in scientific exploration, Spark offers an indispensable look at electricity, how it works, and how it animates our lives from within and without.

Glycoside Hydrolases provides a detailed overview of the biochemical, biophysical, and protein engineering properties of glycoside hydrolases, a class of enzymes in growing use across various applications. Here, more than a dozen global experts discuss the structural and catalytic mechanisms of specific glycoside hydrolases, followed by their implications in biotechnological applications of different industrial sectors such as the food and feed industry, paper and pulp industry, the bioenergy sector and the pharmaceutical industry. Authors consider how the application of glycoside hydrolases may boost industrial production of valued products, and the broader environmental and sustainability goals of converting agrowaste into valued products. This book helps researchers and students across industry and academia gain deep knowledge of glycoside hydrolases, to advance new experimental research and applications from biofuel to drug discovery.

Biotechnology of Microbial Enzymes: Production, Biocatalysis, and Industrial Applications, Second Edition provides a complete survey of the latest innovations on microbial enzymes, highlighting biotechnological advances in their production and purification along with information on successful applications as biocatalysts in several chemical and industrial processes under mild and green conditions. The application of recombinant DNA technology within industrial fermentation and the production of enzymes over the last three decades have produced a host of useful chemical and biochemical substances. The power of these technologies results in novel transformations, better enzymes, a wide variety of applications, and the unprecedented development of biocatalysts through the ongoing integration of molecular biology methodology, all of which is covered insightfully and in-depth within the book. This fully revised, second edition is updated to address the latest research developments and applications in the field, from microbial enzymes recently applied in drug discovery to penicillin biosynthetic enzymes and penicillin acylase, xylose reductase, and microbial enzymes used in antitubercular drug design. Across the chapters, the use of microbial enzymes in sustainable development and production processes is fully considered, with recent successes and ongoing challenges highlighted.

Navigating Non-coding RNA: From Biogenesis to Therapeutic Application provides a concise overview of the field of non-coding RNA (ncRNA). Chapters cover the history of discoveries that have occurred in the area of ncRNA, specific types of ncRNA, housekeeping ncRNAs such as ribosomal RNA, transfer RNA, small nuclear RNA and telomerase RNA, regulatory ncRNAs such as microRNA, small interfering RNA, long non-coding RNA and Y RNA. Biogenesis, structure, function, and regulation of each of these are also explored in addition to traditional and cutting-edge methods for the identification, functional characterization and structural characterization of ncRNA. The book also focuses on the different types of epitranscriptomic modifications and their involvement in regulating ncRNA structure, stability and intermolecular interactions in addition to the role of ncRNAs in a range of diseases and potential therapeutic applications.

Cell Physiology Source Book, Fifth Edition covers a broad range of topics in cell physiology. The book discusses research areas that have become active since the last edition (e.g., aquaporins, apicoplast and other organelles) and broadens its scope to include chronobiology, expansion of receptor/sensory physiology, endocrinology, and other topics such as quorum sensing and taxis. As methods or approaches on performing experiments appear to be very valuable parts of books to which readers tend to frequently refer, expansion of these types of chapters and/or appendices are included in this edition. Applicable to scientists, researchers, postdocs and graduate students across physiological, biochemical, biological and biomedical backgrounds, cell physiology is important for understanding larger organisms and potential advances in biomedicine.

The New Biology argues that mechanical reductionism, though helpful in answering many biological questions, cannot on its own explain complex biological systems. Promoting a more holistic approach, the authors contend that both mechanistic and organicist views are invaluable frameworks for understanding life.

Mycotoxins represent an assorted range of secondary fungal metabolites that extensively occur in numerous food and feed ingredients at any stage during pre- and post-harvest conditions. Mycotoxin contamination in food and feed cause acute and chronic mycotoxicosis, including teratogenic, carcinogenic, oestrogenic, neurotoxic, and immunosuppressive effects and several others health issues. Mycotoxins in Food and Feed presents an overview of all the major mycotoxins, sources of production, chemistry and biosynthesis, occurrence in food and feed, effect on agriculture, effect on human health, detection technique, masked mycotoxins, and management and control strategies.Key FeaturesProvides broad coverage of mycotoxins and their effects on food and feedIncludes comprehensive information of occurrence, chemistry, detections methods and management strategies for each toxinDiscusses the recent development in detection technologies for major mycotoxinsExplores agricultural practices and post-harvest management strategies for managing mycotoxin infestations