Cellebiologi (cytologi)

Revealing Unchartered Biology with Single Intact Cells: Case Studies explores the path to research success, key projects, the role of techniques, the selection process, other alternatives considered, what other paths have led to dead ends, detailed protocols followed, and how the analysis of generated data allowed researchers to visualize unchartered biology. Focusing on the research journey that led to the publication of each article, the book's editors interviewed the researchers on the use of the Multiplex Single Cell technique and how it helped hone in on the biological quest. These methods can be expanded to a wide variety of research objectives. In conclusion to each chapter, the authors critically review their process and provide suggestions of improvement or alternate techniques that could be employed. This book is the ideal reference for researchers new to the world of single-cell multiplex techniques. The discussion on failures encountered along the research path provides insights on how to avoid repeating the same errors.

The book Heat Shock Proteins in Inflammatory Diseases provides the most comprehensive highlight and insight of the expression, function and therapeutic activity of Heat Shock Proteins in inflammatory diseases including sepsis, psoriasis, neurodegenerative diseases, cancers, viral infection and autoimmune rheumatic diseases. Using an integrative approach, the contributors provide a synopsis of the most current updates on the state of HSP in inflammatory diseases.Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Cancer Biology, Oncology, Translational Medicine, Clinical Research, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

Cell Physiology Source Book, Fifth Edition covers a broad range of topics in cell physiology. The book discusses research areas that have become active since the last edition (e.g., aquaporins, apicoplast and other organelles) and broadens its scope to include chronobiology, expansion of receptor/sensory physiology, endocrinology, and other topics such as quorum sensing and taxis. As methods or approaches on performing experiments appear to be very valuable parts of books to which readers tend to frequently refer, expansion of these types of chapters and/or appendices are included in this edition. Applicable to scientists, researchers, postdocs and graduate students across physiological, biochemical, biological and biomedical backgrounds, cell physiology is important for understanding larger organisms and potential advances in biomedicine.

This volume explores the latest techniques used to study the field of tissue engineered vascular grafts (TEVGs). The chapters in this book cover a wide array of topics such as deriving vascular cells from monocytes and induced pluripotent stem cells; engineering vascular grafts using various biomaterials and stem cells, stem cell-derived, or primary vascular cells; biomaterial modification by anticoagulation molecules; vascular bioengineering technologies such as 3D bioprinting; and fabrication of TEVGs with different geometry and multiphase structures. This book also features protocols for grafting and evaluation of vascular grafts in animal models, vascular imaging in animals, and the quantification of blood vessel permeability. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tipson troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Vascular Tissue Engineering: Methods and Protocols is a valuable resource for biomedical engineers, cell biologists, vascular surgeons, doctors, and nurses.

"An exploration of the transformative ways in which nature has inspired the technological advancement of humankind. Biomimetics literally means emulating biology and in a broader sense the term covers technological advances where the original inspiration came from nature"--

'David Christian's approach to understanding history can help all of us learn to prepare for the future' - Bill GatesA user's guide to the future: from the algorithms in DNA to why time is like a cocktail glass, interstellar migrations, transhumanism, the fate of the galaxy, and the last black hole...Every second of our lives - whether we're looking both ways before crossing the street, celebrating the birth of a baby, or moving to a new city - we must cope with an unknowable future by telling stories about what will happen next. Where is the future, the place where we set those stories? Can we trust our future stories? And what sort of futures do they show us?David Christian, historian and bestselling author of Origin Story, is renowned for pioneering the emerging discipline of Big History, which surveys the whole of the past. But with Future Stories, he casts his sharp analytical eye forward, offering an introduction to the strange world of the future, and a guide to what we think we know about it at all scales, from the predictive mechanisms of single-celled organisms and tomato plants to the merging of colossal galaxies billions of years from now.Drawing together science, history and philosophy from a huge range of places and times, Christian explores how we prepare for uncertain futures, including the future of human evolution, artificial intelligence, interstellar travel, and more. By linking the study of the past much more closely to the study of the future, we can begin to imagine what the world will look like in the next hundred years and consider solutions to the biggest challenges facing us all.

This book establishes a bridge between exercise-mediated functional status of autophagy and non-communicable chronic diseases for elucidating and clarifying the corresponding signal pathways and underlying mechanisms. The book consists of 13 chapters focusing on the in-depth discussion on signal pathways for regulating the functional status of autophagy for the prevention, treatment and rehabilitation of chronic diseases, the optimization of exercise intervention strategies for common and frequently-occurring chronic diseases, and the development of exercise mimetic pills for the persons with disability for exercise performance, or the persons without willing to exercise. This book is interesting and will be useful to a wide readership in the various fields of exercise science, exercise fitness, sports medicine, preventive medicine, and functional foods.

Discover everything you need to know about biology, with the simplest most visual guide to the science of life.How do vaccines work? What is special about stem cells? How did we evolve from bacteria? The science of life can be dauntingly complex, and it can be hard to separate "good" science from "bad", fundamental truths from the much-hyped breakthroughs reported in the media.With clear, easy-to-understand graphics and packed with fascinating facts, How Biology Works demystifies both the core biology that may have eluded us at school, and the cutting-edge life science that makes the news, answering the questions that spark our curiosity.With power to every page, this striking science book:Is illustrated entirely by specially commissioned, boldly coloured, distinctive, flat, vector graphics that explain each topic clearly and engagingly.Supports the curriculum up to GCSE, but also includes some higher-level topics and cutting-edge biology that makes the news.Uses clear, distinctive, eye-catching graphics to make even complex biology easy to understand.Offers a practical, no-nonsense approach to each subject.Building from life's fundamental ingredients, such as carbon and water, the book explains chemical processes in living cells, controlled by the ultimate biochemical, DNA. It shows how DNA is made of units called genes, which are shuffled in each generation of offspring, leading to variation and evolution. It covers topics from school biology, such as how plants work and how animals, including humans, work, and goes on to ecology and biotechnology.Beyond school science, however, it covers the background to the latest medical technology and biotechnology: how gene therapy works, what stem-cell research is achieving, and how our immune systems, boosted by vaccines, are in an arms race with ever-mutating viruses and other pathogens.At DK, we believe in the power of discovery.So why stop there?How Biology Works is part of DK's widely successful How Stuff Works series. Discover the inner workings of the mind with How the Brain Works, succeed in all things science with How Science Works and discover the cosmos like you've never known before with How Space Works. Whatever topic sparks your interests, there's a plethora of knowledge to discover!

Phenotypic plasticity - the ability of an individual organism to alter its features in direct response to a change in its environment - is ubiquitous. This book brings together researchers who approach plasticity from diverse perspectives to explore new ideas and recent findings about the causes and consequences of plasticity.

This new volume, a part of the Proteomics, Metabolomics, Interactomics and Systems Biology series, will explain how proteomic studies of post-translational modifications (PTMs) can be applied to neurodegenerative diseases and relevant studies. The goal of the book is to increase awareness among researchers about how PTMs may be helpful in understanding mechanisms in various neurodegenerative diseases through proteomic studies. This book will serve as a tool for those who want to begin work in the proteomics field and explore how to implement PTMs studies into their work. Chapter authors will describe different PTMs enrichment methods developed by experts in the field so that researchers may learn to apply these methods and techniques to new studies. Divided into three sections, chapters will cover sample preparation, data quality, enrichment techniques, guidelines on how to analyze PTMs, and explain the role of PTMs and different brain diseases. Among those topics includes will be brain cancer, SLA disease, Parkinsons disease, muscular dystrophies, and schizophrenia. This volume will be useful for researchers and students studying brain and neurodegenerative diseases who are interested in delving into work with proteomic studies and PTMs. 

Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions.This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature's longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the thirteenth volume of a continuing series.

This book explores the importance of Single Nucleotide Polymorphisms (SNPs) in biomedical research. As SNP technologies have evolved from labor intensive, expensive, time-consuming processes to relatively inexpensive methods, SNP discovery has exploded. In terms of human biology, this research, particularly since the completion of the Human Genome Project, has provided a detailed understanding of evolutionary forces that have generated SNPs. It also has shown how SNPs shape human variation. The ability to inexpensively generate and analyze vast amounts of genetic data is poised to transform our understanding of human evolution and biology. "e;Single Nucleotide Polymorphisms"e; covers a broad  survey of SNPs and their classification into synonymous and non-synonymous; the role of SNPs in human disease; case studies providing specific examples of synonymous and non-synonymous SNPs associated with human diseases or affecting therapeutic interventions; mechanisms by which synonymous mutations affect protein levels or protein folding which affect human physiology and response to therapy; and the role of SNPs in personalized medicine. Understanding what SNPs are, how they have been shaped is necessary for an increasingly expanding audience. This research will revolutionize the future of medicine. Chapter 4 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com. SNPs Ability to Influence Disease Risk: Breaking the Silence on Synonymous Mutations in Cancer"e; is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Leading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.

Principles of Genomics and Proteomics is the perfect reference for graduate students and researchers in these areas to understand its principles and execute precise and reproducible experiments. Following an introductory chapter, the book dives into proper research, including genome mapping. Experiments covered in the book span from Sangers Sequencing, Shotgun sequencing, SAGE analysis, DNA footprinting, Gel retardation, ChIP, and protein resolution methods, including PAGE, 2D gel electrophoresis and isoelectric focusing. Biophysical techniques are also described in detail, including ultraviolet and visible light spectroscopy, fluorescence spectroscopy, NMR and X-ray diffraction. A final proteome analysis is dedicated to functional analysis. Other chapters cover applications of omics technologies broadly. This book is the perfect reference for genetics labs around the world. Graduate students will benefit from the structured and detailed coverage of methods and established researchers will benefit from the book for staff training in research and may find it particularly helpful in enhancing reproducibility of experiments.