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This volume provides a collection of protocols from researchers in the statistical genomics field. Chapters focus on integrating genomics with other ¿omics¿ data, such as transcriptomics, epigenomics, proteomics, metabolomics, and metagenomics. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and thorough, Statistical Genomics hopes that by covering these diverse and timely topics researchers are provided insights into future directions and priorities of pan-omics and the precision medicine era.
This detailed volume provides methods that can be used to study dendritic cell (DC) ontogeny, isolation, migration, and functions. After an introduction to murine and human DC subsets and their unique transcriptional, phenotypic, and functional properties, the book continues with sections covering in vivo studies, in vitro differentiation, enrichment, functional characterization, as well as Omics approaches to study dendritic cells. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Dendritic Cells: Methods and Protocols is an ideal guide to familiarize readers with the current state of the art techniques to investigate these vital cells.
This fully updated volume explores notable developments in the field of mammalian cell-based recombinant protein production. Beginning with methods for transient recombinant protein production, the book continues with methods for stable cell pool generation, protein production using stable clonal cell lines, as well as high-throughput screening technologies for characterizing transient cell surface protein ectodomain expression and for identifying host genes involved in protein production. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Recombinant Protein Expression in Mammalian Cells: Methods and Protocols, Second Edition serves as an ideal guide for researchers investigatingprotein structure and function and accelerating the discovery of new therapeutic proteins.
"This graduate textbook covers the basic formalism of supergravity, as well as a wide range of its modern applications, suitable for a focused first course. Assuming a working knowledge of quantum field theory, it gives Ph.D. students the tools they need to do research that uses supergravity"--
Waste-derived Nanoparticles: Synthesis, Applications, and Sustainability embarks on an illuminating exploration at the intersection of waste management and nanotechnology. Delving deep into the realm of nanoparticle synthesis, this comprehensive volume meticulously examines various waste sources, ranging from industrial residues to electronic waste, uncovering their potential for sustainable innovation. Through detailed discussions on synthesis methodologies and characterization techniques, each chapter offers insights into the intricate processes involved in transforming waste materials into functional nanoparticles. Beyond synthesis, the book ventures into the diverse applications of waste-derived nanoparticles, offering transformative solutions to pressing environmental challenges. From revolutionizing wastewater treatment to combating air pollution and advancing energy technologies, these applications hold promise for a greener future. With a forward-looking perspective, this book envisions a shift toward a circular economy, where waste materials are not only repurposed but also contribute to a more sustainable and environmentally conscious world. This book serves as a beacon, guiding us toward a future where waste becomes a valuable resource in our quest for a cleaner and healthier planet.
Trustworthy AI in Medical Imaging brings together scientific researchers, medical experts, and industry partners working in the field of trustworthiness, bridging the gap between AI research and concrete medical applications and making it a learning resource for undergraduates, masters students, and researchers in AI for medical imaging applications. The book will help readers acquire the basic notions of AI trustworthiness and understand its concrete application in medical imaging, identify pain points and solutions to enhance trustworthiness in medical imaging applications, understand current limitations and perspectives of trustworthy AI in medical imaging, and identify novel research directions. Although the problem of trustworthiness in AI is actively researched in different disciplines, the adoption and implementation of trustworthy AI principles in real-world scenarios is still at its infancy. This is particularly true in medical imaging where guidelines and standards for trustworthiness are critical for the successful deployment in clinical practice. After setting out the technical and clinical challenges of AI trustworthiness, the book gives a concise overview of the basic concepts before presenting state-of-the-art methods for solving these challenges.
Water Pollution Calculations: Quantifying Pollutant Formation, Transport, Transformation, Fate and Risks provides a comprehensive collection of relevant, real-world water pollution calculations. The book's author explains, in detail, how to measure and assess risks to human populations and ecosystems exposed to water pollutants. The text covers water pollution from a multivariate, systems approach, bringing in hydrogeological, climatological, meteorological processes, health and ecological impacts, and water and wastewater treatment and prevention.After first reviewing the physics, chemistry, and biology of water pollution, the author explores both groundwater and surface waters. This is followed by an in-depth look at water quality indicators, measurements, models, and water engineering. Groundwater remediation, risk assessment, and green engineering round out the text with forward-thinking ideas towards sustainability. This invaluable reference offers a practical tool for those needing a precise and applicable understanding of different types of water pollution calculations.
The Afrotropical Streams and Rivers: Structure, Ecological Processes and Management is a comprehensive guide that provides assessment of major rivers and tributaries in Africa. Unlike other books available, the editors present a thorough study of geomorphological, hydrological, biological, and ecological processes incorporating a range of plant and animal communities, while considering implications of human communities that depend upon them. This book, edited by a diverse cohort of researchers and/or scholars, is intended as an educational and practical guide for graduate students, researchers and scientists who focus on the biodiversity, conservation and management/policy issues of the African river systems.
Systems Biology and In-Depth Applications for Unlocking Diseases provides the essence of systems biology approaches in a practical manner illustrating the basic principles essential to develop and model in real life science applications. Methodologies covered show how to interrogate biological data, with the purpose of obtaining insight about disease diagnosis, prognosis, and treatment. Systematically written in 4 parts, this book first provides an introduction and history of systems biology; second, it provides the tools and resources needed for the structure and function of biological systems; next, it provides the evidence of systems biology in action to better understand disease connections; and finally, it provides the extensions of systems biology in various scientific fields including pharmacology, immunology, vaccinology, neuroscience, virology, and medicine. Examples include big data techniques, scale networks, mathematical model development, and much more. This is the perfect reference to provide the fundamental base of knowledge needed for systems biologists, professionals in systems medicine, computational biologists, and bioinformaticians, whether needed for immediate application or for building a comprehensive understanding of the field.
Artificial Intelligence for a More Sustainable Oil and Gas Industry and the Energy Transition: Case Studies and Code Examples presents a package for academic researchers and industries working on water resources and carbon capture and storage. This book contains fundamental knowledge on artificial intelligence related to oil and gas sustainability and the industry’s pivot to support the energy transition and provides practical applications through case studies and coding flowcharts, addressing gaps and questions raised by academic and industrial partners, including energy engineers, geologists, and environmental scientists. This timely publication provides fundamental and extensive information on advanced AI applications geared to support sustainability and the energy transition for the oil and gas industry.
Green Chemistry: A Path to Sustainable Development provides updated information and knowledge on green chemistry, analyzes greener solutions for environmental sustainability, and includes principles and practices, metrics, green chemical technologies, and real-world applications. Chapters explore interdisciplinary approaches to green chemistry, as well as value added through by-products, conversion of waste to value added products, remodeling from a conventional approach to a greener approach, and the challenges, opportunities, and future scope of green chemistry. Finally, this book discusses green methodologies, processes, and new chemical development.
Decision-making is a key factor to achieve success in any discipline, especially in a field like civil engineering, which is based on calculations and requires large amounts of information being taken into account. Most processes and procedures are a compendium of many different tasks and requirements specific to each project under development, and making decisions in such environments can often be an arduous endeavor. That is why the need for analytical criteria capable of assisting with untangling complex scenarios has arisen preponderantly. As an all-encompassing resource, Multicriteria Decision-Making Analysis for Civil Engineering Applications facilitates civil engineers by outlining state-of-the-art techniques for quantitative decision-making to optimally select the appropriate approach when faced with operational issues or to prioritize among multiple options. Authored by recognized experts in the field, this book proves to be a balanced reference volume that is essential not just for civil engineers, but also for a wide variety of audiences in interconnected disciplines.
Microgrid Technology and Microgrid Cluster Development is a comprehensive guide to microgrid systems fundamentals, optimization, control, protection, and energy management. The book explains microgrid architectures that might be combined to create a cluster of microgrids. This is a valuable resource for all those looking to gain a complete understanding of current microgrid and cluster technology, including students, researchers, faculty, R&D professionals, engineers, and other industry personnel with an interest in grid integration, power systems, and renewable energy. The microgrid is first defined as a standalone entity with potential interconnections with external grids. Then, the layout, line technology, and interface technology of potential microgrid cluster topologies are designed, with comparison and analysis of the various microgrid and cluster designs in terms of price, scalability, security, dependability, stability, communications, and business models. Key aspects are covered in detail, including optimization algorithms and the role of machine learning and artificial neural networks, control and protection techniques, and energy management and storage.
Nanoferrites for Emerging Environmental Applications discusses the synthesis and structure of nanoferrites, as well as their electrical, optical, and magnetic properties. This book also provides a detailed discussion of the use of nanoferrites for various environmental applications, such as for water and air pollution detection and remediation. This book covers almost every aspect of nanoferrites for environmental applications and will be of great use to researchers working in multidisciplinary areas. Nanoferrites’ superior electronic, optical, and magnetic properties make them promising agents in a wide spectrum of applications. After looking at the fundamentals of nanoferrites, this book proceeds to analyze their application in a comprehensive range of environmental applications. Topics covered include wastewater treatment, the removal of heavy metal ions, remediation of organic and inorganic pollutants, and their use in the detection and remediation of both air and solid pollution. Future opportunities for research are also addressed.
Microplastics: Origins, Risks, and Mitigation discusses the sources, origin, and health risk assessment of microplastics in the environment. The various contamination indices, like contamination factor, atmospheric behavior, enrichment factor, and marine pollution are also included to provide further context on the state of microplastics in the environment and environmental impacts. The book present reviews on microplastics toxicology research, health hazards, and green remedial solutions for pollution control in terrestrial and aquatic environments, aiming to provide scientists and researchers with the knowledge to combat microplastic pollutants through sustainable means. Covering a variety of approaches, techniques, and scenarios, this book is a key resource for environmental scientists working to address microplastic environmental pollutants. It presents reviews on microplastics toxicology research, health hazards, and green remedial solutions for pollution control in terrestrial and aquatic environments.
Industrial Decarbonization and the Energy Transition: Innovative Solutions for a Carbon-Free, Sustainable, and Clean Environment provides detailed information on a range of cutting-edge solutions, supporting decarbonization, clean energy production, and energy transition. Sectors covered include chemical and photochemical, cement and concrete, class, pulp and paper, steel and iron-making, fertilizer, clay, methanol, refineries, sugar, and thermal power plants. Technology, regulations, climate impact, and finance are considered for each sector, and throughout the book, emphasis is placed on the industry perspective and expertise, with thorough techno-economic analysis and in-depth discussion of other key considerations such as scale-up, cost reductions, waste, and future possibilities. This book is of interest to engineers, R&D, and other professionals involved in energy transition and decarbonization of industrial processes and plants across a range of industrial sectors, as well as academic researchers, scientists, and advanced students in energy transition, renewable energy, engineering, decarbonization, and sustainability.
Genetics and Epigenetics of Genitourinary Diseases aims to provide a comprehensive collection of data on genetics and epigenetics in almost all genitourinary diseases for researchers, clinicians, and graduate students. This book discusses several genetic and epigenetic changes like DNA methylation, mutations, single nucleotide polymorphisms, DNA rearrangements, chromosomal remodeling, microsatellite instability, and chromosomal instability (CIN) in genitourinary cancers. This book is split into 18 chapters, beginning with the importance of genetics and epigenetics in genitourinary diseases. It then goes on to cover the genetics and epigenetics of various diseases and tumors. Certain chapters present novel techniques of next-generation sequencing (NGS). Furthermore, RNA-Seq is discussed as a sequencing technique that uses NGS to reveal the presence and quantity of RNA in a biological sample. This book is a valuable resource for researchers, practitioners, and students in genetics and epigenetics who want to broaden their understanding of the field.
Medicinal Biotechnology: Methods and Applications covers a wide range of topics from traditional herbal medicine to recent plant and animal biotechnology approaches used for the production of vaccines, hormones, enzymes, edible medicinal products, herbal therapeutics, and other secondary metabolites. The book opens with a historical perspective of medicinal biotechnology which includes a discussion of successive development in the field of medicine, starting from early civilization up to current and advanced approaches and strategies. The book also provides a wide range of topics that include: a discussion engineering approaches in medicinal biotechnology, metabolomics, extraction of metabolites, personalization approaches, and strategies for the effective use of medicinal product and drugs; explanation of engineering approaches in medicinal biotechnology, metabolomics, extraction of metabolites, personalization approaches, and strategies for the effective use of medicinal product and drug; and coverage of specific knowledge on the production and use in vaccines, antibodies, and hormones.
Rehabilitation Robotics and Healthcare Devices presents cutting-edge topics in rehabilitation robotics and healthcare devices, covering basic concepts and providing readers with enough information to solve various practical problems. The book proves to be an excellent source to study the different emerging paradigms in rehabilitation robotics and healthcare areas, including related technologies such as sensors, wearable devices, internet of medical things, big data, machine learning for eHealth, edible sensors, robots in medicine, and exoskeleton robots for rehabilitation.
Antibiofouling Membranes for Water and Wastewater Treatment: Principles and Applications covers most recent advances, challenges, and industrial applications of antibiofouling membranes to help in reducing cost and increasing sustainability of long term-filtration performance of membranes in water and wastewater treatment. This book will provide a compact source of relevant and timely information on antibiofouling membranes and will be of great interest to scientists, engineers, industry R&D personnel, and graduate students engaged in the development, engineering scale-up, and applications of antibiofouling membranes, as well as other readers who are interested in microfiltration, membrane bioreactor, ultrafiltration, nanofiltration, reverse osmosis, and related topics.
Water Resources Monitoring, Management, and Sustainability: Application of Geostatistics and Geospatial Modeling, Volume 16, a new volume in the Developments in Environmental Science series, introduces a variety of advanced modeling techniques like changing climate and land use/land cover, hydrological models, and machine learning approaches. These techniques are applied to address water resources and environmental monitoring, as well as planning and sustainable management of water resources. Further, the book discusses how to manage water resources at various local, regional, and international levels while incorporating environmental considerations. Finally, it delves into cutting-edge techniques based on open-source software and R statistical programming, Google Earth Engine, and modeling in modern artificial intelligence techniques, with a particular emphasis on recent trends in datamining techniques and robust modeling in water resource crisis-related hazards.
Subsurface Hydrogen Energy Storage: Current status, Prospects, and Challenges presents a comprehensive explanation of the technical challenges and solutions associated with subsurface hydrogen energy storage, including system design, safety measures, and operational efficiency. Supported by real-world case studies, the book analyses the economic and environmental benefits and drawbacks of subsurface hydrogen energy storage, including a comparative analysis of different forms of energy storage. The book brings together the latest research and knowledge on subsurface hydrogen energy storage, including the geological and hydrogeological aspects of hydrogen storage, hydrogen production, storage technologies, and safety and regulatory issues. It discusses the potential applications of subsurface hydrogen storage in various sectors, such as power generation, transportation, and industry. The book also features case studies and current applications, as well as a detailed examination of the technical challenges and solutions associated with subsurface hydrogen energy storage. Addressing all the scientific and technical challenges that must be overcome for subsurface hydrogen storage to be deployed at scale, Subsurface Hydrogen Energy Storage: Current status, Prospects, and Challenges is an invaluable reference for researchers, engineers, and industry professionals involved in hydrogen and energy storage, the hydrogen economy, and reservoir engineering.
Combustion Synthesis: Processing and Materials provides a comprehensive introduction to combustion synthesis, from fundamentals to applications. The book offers an up¿tödate reference for both researchers who have already been working on combustion synthesis and those entering this field. Focusing specifically on the materials science and engineering dimensions of combustion synthesis, the book thoroughly explores the most important processes and materials under investigation today. It offers a comprehensive overview of the field to beginners, while experienced readers will find detailed explanations and up¿tödate descriptions of the state of the art of combustion synthesis, focused on a range of vital processes and materials.
In the continuous pursuit of optimizing performance, development of advanced materials with highly specific properties has consistently been a critical component of aerospace engineering’s research. Aerospace Materials: Novel Technologies and Practical Applications puts strong emphasis on updating existing knowledge of a wide range of functional and structural materials and contextualizing it for industrial practice.The volume not only comprehensively covers different classes of materials, while providing an overview of each material’s mechanical and physical properties, as well as processing and testing, but also offers state-of-the-art guidance on their commercial use in the sector. Furthermore, it looks ahead to clarify what’s still needed to adapt traditional and novel materials to ever-changing aerospace technologies and related pressing sustainability challenges.The breadth of technical expertise that this international group of researchers provides proves to be an invaluable asset for users in academia and established professionals alike.
Gait, Balance, and Mobility Analysis: Theoretical, Technical, and Clinical Applications provides a comprehensive overview of gait and movement analysis techniques, from traditional motion capture to modern wearable technologies. The book contains both a technical element that focuses on biomechanics and engineering concepts for gait analysis and the application of gait analysis with clinical populations. Beginning with a comprehensive background on the underlying neural control of gait and mobility in humans and physiological control of balance, the book then covers analysis methods and techniques for laboratory, clinic or remote patient assessment. It then examines how gait, mobility and balance are impacted by musculoskeletal, neurological, and cardio-respiratory conditions. Lastly, it discusses future directions and provides recommendations for future studies. Combining the expertise of engineers and clinicians, this book takes a multidisciplinary approach to show how and why gait, balance and mobility can be used to tackle important clinical questions for various conditions.
Energy Transport Infrastructure for a Decarbonized Economy evaluates the transportation of fluids required in the decarbonized energy economy. The book will help researchers, design manufacturers, and those within government and academia to understand challenges and guide the design and development of systems, machinery, and infrastructure needed for a decarbonized energy economy. The book provides comprehensive insights on the implications of the energy transition for a critical aspect of commerce: the infrastructure central to energy transportation and the economy. This practical book highlights the unique systems central to the efficient transport of various forms of energy. After outlining the need for transporting energy, types of fluids used to transport energy, and various means of transportation, the book covers the importance of understanding the energy marketplace, global perspectives, and then moves into the transport of natural gas, hydrogen, and carbon dioxide. The work concludes with coverage of technology gaps, research and development, future trends, and solutions. Led by professionals with decades of experience and collecting insights from expert contributors, this book begins with the essentials of energy transport, provides detailed coverage of modes of transport, considers critical questions of energy supply and economics, and looks at long-term environmentally sensitive, sustainable options for the transport thereof. A powerful tool for the energy transition, Energy Transport Infrastructure for a Decarbonized Economy offers expert analysis on sustainable energy transport and its impact on our future.
Greening Our Economy for a Sustainable Future examines the green economy by balancing social needs, the environment, and the economy. It argues that different economic models must be developed to address the environment caused by economic expansion. The book not only looks at the opportunities of having a green economy, but also goes into areas such as greenwashing, social washing, sustainability, economics, and more. In addition, it addresses how one can improve well-being through a symbiotic relationship between economic growth and environmental stewardship.
Advancements in Nanotechnology for Food and Packaging explores current trends, advances and associated challenges of the applications of nanotechnology in the food sectors, such as the fabrication and characterization of functional food, developments and shelf-life extension. This book is organized into 16 chapters that cover the main concepts related to the use of nanotechnology in food processing, packaging and monitoring. Coverage includes food functionalization, quality management and control, food sensory, membrane filtration technology, nanotechnology-based sensors, sustainable packaging, regulatory aspects, and much more. This book an essential resource for materials and food scientists, technologists, researchers, academics and professionals working in nanotechnology and food science.
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