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Polyphenols are compounds that are derived from plant sources and are beneficial for the human body. These compounds have one aromatic ring along with attached hydroxyl (-OH) functional groups. They are divided into two types, namely, flavonoids and non-flavonoids. Lignans, phenolic acids and their derivatives, flavonoids, and stilbenes are among antioxidants that fall under the category of polyphenols. They inhibit carcinogenesis during the initiation of cell defense systems, including antioxidant and detoxifying enzyme systems, and inhibit anti-cellular and anti-inflammatory growth signaling pathways in cellular death. A diet rich in vegetables and fruits containing natural polyphenols can lower the risk of certain cancers. Dietary polyphenols have been demonstrated to influence the overall process of carcinogenesis through a variety of mechanisms. The effects of consuming dietary polyphenols might vary depending on tissue or cell type, and can also vary based on the quantity consumed. Polyphenols may also be recommended for cancer prevention and improving the existing cancer treatments. This book provides comprehensive insights into the role of polyphenols in treating cancer. It will provide comprehensive knowledge to the readers.
Polyphenols refers to a broad family of naturally occurring organic compounds that are distinguished by the presence of several phenol units. They are abundantly found in plants and are structurally diverse. Polyphenols can be found in a variety of plant-based foods and beverages including nuts, fruits, wine, soy, vegetables, tea and spices. A diet high in vegetables and fruits may reduce the chance of developing certain types of cancer. Natural polyphenols are known to decrease the risk of cancer through their anti-cancer mechanisms such as anti-inflammation, modulation of cell cycle signaling, removal of anticancer agents, and activity of antioxidant enzymes. They also regulate numerous molecular events implicated in carcinogenesis such as apoptosis and arrest of the cell cycle. This book aims to understand the therapeutic effects of polyphenols in treating cancer. From theories to research to practical applications, case studies related to all contemporary topics of relevance to this area of study have been included herein. The book will help new researchers by foregrounding their knowledge on this topic.
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