Bøger af Farhad Mehta

V rezul'tate dannogo issledowaniq mozhno sdelat' wywod, chto gelewye preparaty dlq mestnogo primeneniq, soderzhaschie diklofenak natriq, byli prigotowleny s ispol'zowaniem razlichnyh koncentracij zheliruüschih agentow (karbopol-940/934/ HPMC 3K), kotorye pokazali priemlemye rezul'taty w razlichnyh issledowaniqh. Gel' harakterizowalsq po razlichnym parametram. Vse prigotowlennye geli pokazali priemlemye fizicheskie swojstwa, takie kak cwet, zapah, konsistenciq, odnorodnost', gomogennost', znachenie pH, wqzkost' i raspredelqemost'. Issledowanie wyswobozhdeniq preparata in vitro prowodilos' s ispol'zowaniem qichnoj membrany s pomosch'ü diffuzionnoj qchejki Franca (del'fin). Rezul'taty pokazali, chto za 24 chasa issledowaniq cherez membranu wyswobodilos' do 90,12 % diklofenaka natriq. Po rezul'tatam issledowaniq byl sdelan wywod, chto diklofenak natriq byl uspeshno wklüchen w sostaw karbopola dlq polucheniq gelq. Gelewaq formula F5 pokazala horoshee znachenie rN, älektroprowodnost', wqzkost', raspredelqemost' i stabil'nost' do i posle 12 dnej w cikle zamorazhiwaniq-ottaiwaniq. Takim obrazom, byl sdelan wywod, chto preparat F5 mozhet byt' wes'ma perspektiwnym dlq mestnogo ili transdermal'nogo lecheniq.

In this present study it can be concluded that topical gel formulations containing drug Diclofenac sodium were prepared with different concentration of gelling agents (carbopol-940/934/ HPMC 3K), which have shown an acceptable results in various evaluation studies. Gel was characterized on basis of various evaluation paeameters, All prepared gel showed acceptable physical properties concerning color, odour, consistency, uniformity, homogeneity, pH value, viscosity and spreadability. An in vitro drug release study was carried out using an egg membrane by using instrument franz's diffusion cell (dolphin).The results indicates that in over 24 hours of total study up to 90.12 % of diclofenac sodium drug is release through the membrane. According to the results obtained from this study, it was concluded that Diclofenac Sodium was successfully incorporated into the carbopol formulation to obtain a gel. F5 gel formulation showed good pH value, conductivity, viscosity, spreadability, and stability before and after the 12 days in the freeze-thaw cycle. Therefore, it was concluded that the formulation F5, could be very promising alternative for the topical or transdermal treatment.