Bøger af Imen Touihri Barakati

Allium roseum, is a spontaneous species of the genus Allium and belonging to the family Alliaceae, and are among the species of the Tunisian flora. We proposed in this work to evaluate the antioxidant and antimicrobial activities of the volatile fractions and polar fractions of the different organs (leaves, flowers and bulbs) of Allium roseum var. grandiflorum Briq and to characterize the extracts with interesting activities in order to correlate the chemical composition to the antioxidant and antimicrobial potential and to valorize the bioactive substances offered by the Tunisian biodiversity. The evaluation of the antioxidant power shows that the ethyl acetate fraction of the leaves has an interesting strong antioxidant activity. The analysis by LC-MS showed the richness of this fraction in flavonol. A strong antimicrobial activity was attributed to the volatile fraction, which is even higher than that of Ampicillin. The presence of a major sulphur compound: dimethylthiosulfinate (48.28%), endowed with antibacterial and antifungal activity was demonstrated on the selected strains.

Human glioblastoma is the most common and aggressive brain tumor. This disease involves several complex physiological processes that involve membrane adhesion receptors, notably integrins. Plants have been at the origin of many active molecules that have shown their effectiveness in the treatment of various cancers. In this work, we proposed to study the anticancer effects of a spontaneous plant: Ecballium elaterium. The interest was given to the anti-adhesive, anti-migratory, anti-proliferative and anti-angiogenic activities. The characterization of the extracts and compounds responsible for these activities was also carried out. The work showed for the first time that the seed oil of Ecballium elaterium and the cucurbitacin B purified from its leaves are endowed with an important anti-tumor activity. These substances act via ¿v¿3, ¿5¿1, and ¿6¿4 integrins in U87 cells and thus represent novel natural agents that target integrins in high-grade gliomas.