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Kidneys are the two bean-shaped organs and each kidney is approximately the size of a fist. They filter unnecessary water and waste from the blood and produce urine. Kidney disease refers to the impairment of kidneys where the kidneys are damaged to an extent where they are incapable of filtering blood efficiently. The cells of the kidneys can be damaged due to ischemic, immunological and toxic complaints, which cause organ dysfunction and failure in certain cases. Acute kidney injury is a prevalent occurrence that is linked to negative renal and patient outcomes. The human kidneys have a limited capacity for regeneration. The immune system plays a significant role in the regeneration capacity of the kidneys, as it first promotes inflammation and then promotes tissues healing. This book explores all the important aspects of kidney diseases in the present day scenario. It provides the readers with a thorough understanding of the diagnosis and treatment of these diseases. With state-of-the-art inputs by acclaimed experts of nephrology, this book targets students and professionals.
The kidneys are two reddish-brown bean-shaped organs found in vertebrates. They are situated on the right and left sides of the retroperitoneal space. The kidneys are essential for the body's basic physiological activities. Kidney dysfunction disrupts these physiological activities and can result in a variety of diseases. A range of immunological, toxic and ischemic insults can harm kidney cells. This results in inflammation and cell death, which in turn leads to organ damage or complete failure. The damage to renal cells and the subsequent cellular regeneration processes are both influenced by inflammation. However, chronic inflammation can lead to renal fibrosis. The kidneys have the ability to regenerate after injury and can recover completely based on the type of renal lesions. The therapeutic intervention options facilitating the regeneration process are limited to fluid management and extracorporeal kidney support. This book unravels the recent studies on kidney diseases. It attempts to understand the molecular mechanisms and clinical assessment of these diseases. This book will help new researchers by foregrounding their knowledge in this area of study.
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