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The commonness and complexity of COPD necessitate rapid communication of significant new knowledge of the disease. This book provides a platform for sharing new notions in scientific research as well as contemporary clinical best practices. It combines noetic theoretical concepts with the ontic practical management of COPD. Epistemological concepts explored in this book include contextualization in the evaluation and treatment of COPD, as well as the latest in the basic science of airway inflammation, "omics" research, and delivery therapeutics. Practical topics addressed include early detection and alleviation of COPD exacerbation, pulmonary rehabilitation, and identifying phenotypes or treatable traits to optimize inhaled therapy.
In order to perform its function in gas exchange, the lungs and all components of the respiratory system are constantly exposed to pathogens, toxins, pollutants, irritants, and allergens in the environment. Lung inflammation involves an array of mechanisms to defend the lung against these extrinsic agents and to repair injured tissue. Additionally, the lungs are a frequent target at risk to conditions associated with systemic inflammation that cause multi-organ damage. The inflammatory reaction in the lung is a complex and dynamic process, and our understanding in this field is rapidly progressing. Further elucidation of the complexity of inflammation will likely improve the clinicians approach to as well as the treatment of a myriad of lung disorders. The chapters in this book are selected topics of current interest in lung inflammation.
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