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In order to enrich and expand this topic information whit an update searches, new studies and allows widely benefits international. Hence this work was written in Italian and English languages. The recent study was verified the statistical hypotesis of prevalence and distribution of covid-19 related some Relevant division of high way in italy (especially north regions). The geomorphological characteristic of PIANURA PADANA , an area located in Italia which is also Named PO valley (a low area land between hills and mountains). This area is surrounded from the north by a close connection with a serial range ALPI mountains and from south by APPENINI MOUNTAINS have created since ancient time particular climate condition. If we observe diffusion of covid -19 in italy at today date is possible to verify a sort of different velocity in diffusion between north region vs the other. There are obvious relationship between this ¿closed environment¿ and diffusion of some relevant virus? Pianura padana is famous for its kind of climate with lots of fog in some season, but also for air pollution as reported by EPHA and other organization.
NERVOUS SYSTEM FUNCTIONS, EVOLUTIVE PATTERN , AND RELATIONSHIP WITH SOME NEURODEGENERATIVE CONDITION: The nervous system directs and coordinates our movements. It receives stimuli from the environment around us and from all our internal organs. It interprets these stimuli and elaborates responses, which are transmitted to muscles or glands.To compare the nervous systems of invertebrates to vertebrates and between the various vertebrates Can be an useful instrument in field fo neuroscience, molecular biology, forensic science, and pharmacology, regenerative medicine. Why in example some neuronal circuits in superior vertebrates cross themselves like decussatio pyramid or in optical chiasm?And why in brain vs spinal cord grey matter and white matter are inverse (opposite)? And this fact make possible to verify relationship between degenerative pathology of cortex vs spinal cord under an evolutive approach. And this cam be related also to the ¿brain and spinal cord wasting system¿ functionality? Is universally knowed that different neurodegenerative disease involved different CNS parts: cortex( DA), PD(basal nuclei), ALS spinal cord preferentially.
Aim of this work is to verify some relevant relationship between MULTIPLE SCLEROSYS and a detoxicant strategy in order to fight this severe disease.It is also verified the oxygen role played in this condition. In this work some metabolic- vascular and MS relationship are reported In order to search new pharmacological ¿ toxicological strategy for MS it is interesting to verify the efficacy of a Detoxicant procedure .The umbalances of immune system with activation of immune cells , related free radicals production Demyelination and mitochondrial injury can be considered as and endogen toxicological movens.If considered this aspect relevant can be a detoxicant strategy but not only using a local blockers system of free radical but also a medical devices that can produce the same effect whit a physical way.Scavengers or chelants or other physical strategy :but it must be efficacy and of persistence effect and in the local microenvironment without tissue neuronal toxicity .The key factor is a local action , long time of exposition but with great attention to preserve neurons life.
Related some last reference (1) it is showed the IN VITRO profile of action of some m-Rna covid vaccine not only to Produce translate for the production of the Spike protein but also the INTRACELLULAR reverse trascription in some human cells.In this study it was verified effect on different times: at 6- 24- 48 hours and the results are clear.Related this aspects it is needed to be verified during the time 3-6- 12 -24 and more time month what happen.This can be useful to complete the profile of security for spike protein molecules production inducers related also this aspect.
LEFT AND RIGTH Colon cancer can be considered a really interesting model to better understand what happen in a single apparatus and the related cancer phenomena Environmental risk factors, hereditary syndromes and ¿sporadic¿ form added to 2 final different kind of pathology ( LEFT and right CANCER ) contribute to a real complex epidemiological situation. Aim of this work is to set 2 different kinds of ¿TOXIC-PATHOLOGIC ¿ factors that make possible whit their GRADIENT the development of this 2 different kind of cancer in the same part of an apparatus.
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