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X-ray crystallography is the prime method for the elucidation ofthree-dimensional molecular structures. The determination of novelstructures is hampered by the crystallographic phase problem. Forbiological macromolecules experimental phasing is one technique tosolve this phase problem; it usually requires the incorporation ofheavy atoms in the protein crystal.In this thesis a new class of compounds was developed that combinesheavy atoms for experimental phasing with functional groups for interactionwith biological macromolecules. Three functional groupsinteract with protein residues and make the compounds sticky. Threehalogen atoms provide a strong anomalous signal and may be usedfor experimental phasing. The halogen atoms form an equilateraltriangle, which is easily recognised in the heavy-atom substructure. So farseveral novel protein structures have been solved with the iodinetriangle compound. The sticky compounds of the current work arereadily available and easy to use.
Develop Better Communication Techniques for Successful RelationshipsInsightful, funny at times, and creative, this book is a must-read for anyone who wants to live their best life...Scott Miller,Wall Street Journalbestselling author and former Chief Marketing Officer at FranklinCoveyWe are all connected with more people than ever before. Without guidance, it can be easy to get burdened by a bad relationship. In the follow-up to his international best seller Unbox Your Life, German speaker and consultant Tobias Beck returns with advice on successful relationships through improved communication techniques.Inside secrets to successful relationships.The relationship advice offered in this book is the first step toward growing successful relationships. By developing a relationship with yourself, you learn how to forgive the past, find joy, and live in happiness. Becoming a good communicator helps you understand how to attract love, friendships, and bring the right relationships into your life.Amusing stories, personality types, and relationship advice.Tackling everything from couples communication to friendship feuds, Becks model of the four human-animal types is the second step to fostering deeper connections. Designed to help you find out how the people around you are feeling, you will recognize your partner, family, friends, colleagues, and yourself on every page.Inside, youll find:How a positive mindset can affect your relationshipsWhy communication techniques are important in relationshipsHow to become a better communicatorIf youre looking for self-help books or self-empowerment giftsor enjoyed books likeTogether, Here to Make Friends, orThe Friendship Formulathen youll loveUnbox Your Relationships.
Grow and succeed: keep energy vampires out of your life with Tobias Beck's Liberated (R) philosophy
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