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Rheumatoid arthritis (RA) refers to an autoimmune disorder that affects the joints. It usually causes painful, swollen and warm joints. The joints of knees, hands and wrists are affected by RA. In addition to damaging the joint tissues, RA can also affect other organs, including the eyes, heart and lungs as well as other tissues all over the body. There are various signs and symptoms of RA, which includes fever, stiffness in several joints, weight loss, tiredness or fatigue. Smoking, aging, obesity and genetics are its major risk factors. The diagnosis of this disorder is done through assessing symptoms, physical examination and by performing lab tests and X-rays. The objectives of treatment are to reduce inflammation, alleviate pain and enhance overall functioning. Self-management techniques as well as medications can effectively manage and treat RA. This book unravels the recent studies on rheumatoid arthritis. It elucidates the diagnosis, pathophysiology and treatment of this disease. The readers would gain knowledge that would broaden their perspective in this area.
Rheumatoid arthritis (RA) is an autoimmune disorder which affects the joints, and causes pain and stiffness. These symptoms typically worsen after rest. Generally, the joints of the cervical spine, hands and feet are affected. However, larger joints may also be involved. Over time, polyarthritis sets in, and as the disease progresses, the inflammatory activity of the body causes tendon erosion and tethering, and leads to the destruction of the joint surface. This leads to deformity and limits the range of movement. RA can also cause inflammation around the lungs and the heart, and low red blood cell count. People with RA are susceptible to atherosclerosis, myocardial infarction, stroke and lung fibrosis. The diagnosis is made on the basis of the presenting signs and symptoms, laboratory testing and X-ray results. There is no known strategy to prevent the disease from occurring or treat the condition when it has set in. Treatments are designed to slow disease progression and control symptoms, such as pain and swelling. This book aims to shed light on some of the unexplored aspects of rheumatoid arthritis and the recent researches in this condition. It provides comprehensive insights into the study of rheumatoid arthritis. This book, with its detailed analyses and data, will prove immensely beneficial to professionals and students involved in this area at various levels.
Rheumatic arthritis (RA) is the condition in which the body's immune system attacks the joints. This causes the tissue lining of the synovium to thicken, leading to swelling and pain around the joints. If the inflammation is not controlled, it can damage the bone and cartilage. Over time, joints become loose, painful and unstable, and lose their mobility. RA most commonly affects women between the ages of 30 and 60, while in men it occurs later in life. The development of RA is subject to an interplay between genetic and environmental factors. Close to a hundred different genes have been implicated with RA. The early diagnosis and aggressive treatment of rheumatoid arthritis is necessary before extensive damage of the joints sets in as the condition is irreversible. With the aid of medical imaging techniques, such as MRI, ultrasound and X-rays, a diagnosis of RA can be established. Generally, anti-inflammatory and analgesic agents, disease-modifying drugs and certain lifestyle modifications are recommended for the management of RA. This book includes some of the vital pieces of work being conducted across the world, on various topics related to rheumatoid arthritis. It provides significant information of this condition to help develop a good understanding of the management of rheumatoid arthritis. Through this book, we attempt to further enlighten the readers about the new concepts in orthopedics.
Rheumatoid arthritis (RA) is an autoimmune condition which affects the joints of the wrists, hands, elbows, feet, ankles and knees. It primarily causes the joints to swell. It may also affect other parts of the body. Symptoms tend to appear gradually over a period of weeks to months, as the disease progresses. The development of RA occurs with the activation of autoimmunity in joints and organs where it manifests. The disease starts with a phase of initiation due to non-specific inflammation, followed by a phase of amplification owing to T cell activation, and finally it enters a chronic inflammatory phase in which tissue injury starts to occur. The goal of treatment in RA is the reduction of pain and inflammation, and improvement in the overall functioning of the individual. Steroids, pain medications and NSAIDs are prescribed for the management of symptoms. This book contains some path-breaking studies in the pathophysiology and management of rheumatoid arthritis. It consists of contributions made by international experts. This book is an essential guide for both academicians and those who wish to pursue orthopedics further.
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