Bøger udgivet af Springer New York

This book provides a broad survey of the field of biochips, including fundamentals of microelectronics and biomaterials interaction with various, living tissues, as well as numerous, diverse applications. Although a wide variety of biochips will be described, there will be a focus on those at the brain-machine interface. Analysis is included of the relationship between different categories of biochips and their interactions with the body and coverage includes wireless remote control of biochips and arrays of microelectrodes, based on new biomaterials.

There is increasing interest in the scientific literature on immigrant health and its impact on disease transmission, disease prevention, health promotion, well-being on an individual and population level, health policy, and the cost of managing all these issues on an individual, institutional, national, and global level. The need for accurate and up-to-date information is particularly acute due to the increasing numbers of immigrants and refugees worldwide as the result of natural disasters, political turmoil, the growing numbers of immigrants to magnet countries, and the increasing costs of associated health care that are being felt by governments around the world.Format and Scope: The first portion of the encyclopedia contains chapters that are approximately 25 to 40 manuscript pages in length. Each overview chapter includes a list of references and suggested readings for cross referencing within the encyclopedia. The opening chapters are: Immigration in the Global Context, Immigration Processes and Health in the U.S.: A Brief History, Alternative and Complementary Medicine, Culture-Specific Diagnoses, Health Determinants, Occupational and Environmental Health, Methodological Issues in Immigrant Health Research, Ethical Issues in Research with Immigrants and Refugees, Ethical Issues in the Clinical Context.The second portion of the book consists of alphabetical entries that relate to the health of immigrants. Entries are interdisciplinary and are drawn from the following fields of study: anthropology, demographics, history, law, linguistics, medicine, population studies, psychology, religion, and sociology. Each entry is followed by a listing of suggested readings and suggested resources, and also links to related terms within the whole book. Outstanding FeaturesThe book adopts a biopsychosocial-historical approach to the topics covered in the chapters and the entries. Each entry includes suggested readings and suggested resources. The chapters and entries are written graduate level that is accessible to all academics, researchers, and professionals from diverse backgrounds. We consider the audience for the entries to be well educated, but a non expert in this area. The primary focus of the book is on the immigrant populations in and immigration to magnet countries. References are made to worldwide trends and issues arising globally.In addition to the comprehensive subject coverage the text also offers diverse perspectives. The editors themselves reflect the multidisciplinary nature of the topics, with expertise in psychiatry, law, epidemiology, anthropology, and social work. Authors similarly reflect diverse disciplines.

The annual Computational Neuroscience Meeting (CNS) began in 1990 as a small workshop called Analysis and Modeling of Neural Systems. The goal of the workshop was to explore the boundary between neuroscience and computation. Riding on the success of several seminal papers, physicists had made "e;Neural Networks"e; fashionable, and soon the quantitative methods used in these abstract model networks started permeating the methods and ideas of experimental neuroscientists. Although experimental neurophysiological approaches provided many advances, it became increasingly evident that mathematical and computational techniques would be required to achieve a comprehensive and quantitative understanding of neural system function. "e;Computational Neuroscience"e; emerged to complement experimental neurophysiology. The Encyclopedia of Computational Neuroscience, published in conjunction with the Organization for Computational Neuroscience, will be an extensive reference work consultable by both researchers and graduate level students. It will be a dynamic, living reference, updatable and containing linkouts and multimedia content whenever relevant.

A comprehensive overview on the advances in the field, this volume presents the science underpinning the probiotic and prebiotic effects, the latest in vivo studies, the technological issues in the development and manufacture of these types of products, and the regulatory issues involved. It will be a useful reference for both scientists and technologists working in academic and governmental institutes, and the industry.

Anxiety disorders have long been a research subject for scientists in different areas of inquiry, and the particular role of serotonin ¿ the neurotransmitter which has probably most captured the imagination of laymen and academics alike ¿ is as elusive as the clinical aspects of serotonergic medications. Why are drugs acting at certain serotonin receptors efficacious against generalized anxiety disorder, but not panic disorder? Why is the inverse true for monoamine oxidase inhibitors? These clinically relevant issues are clarified by the neurochemical, anatomical and physiological organization of the serotonergic system.In this book, the author summarizes the latest findings regarding the role of serotonin in modulating the activity of brain regions which organize behavioral patterns associated with fear, anxiety and stress. The emergent picture is one of far greater complexity than previously thought: while the serotonergic innervation of those brain regions arises from the same structure ¿ the dorsal raphe nucleus ¿ that structure is not homogeneous from anatomical, physiological and neurochemical points of view, nor are its projections to the cerebral aversive and behavioral inhibition systems.The diverse findings which compose this picture of complexity ¿ whether they arise from developmental neurobiology, electrophysiology, neurochemistry, neuroendocrinology, neuropsychopharmacology or behavioral neuroscience ¿ are integrated in this book. Advanced undergraduate, graduate students, and researchers will benefit from the information. The result sheds light on many important questions regarding the neuroanatomical, pharmacological and functional aspects of the role of serotonin in anxiety disorders, and points to future avenues of research.

This book provides insights into how to be a productive clinical researcher via real-life case examples of successful clinical research -- and also clinical research gone awry. Through these examples of success and failure, the book develops a blueprint for building a career in clinical research. Future medical practice depends on the quality of the clinical trials to which drugs, devices, and treatment procedures are subjected today. However, clinical trials are not easy to do, and many physicians and health care providers who attempt clinical research struggle in this endeavor, primarily because of lack of instruction. Clinical Research aims to fill the gap between training and research through case studies of a long-time clinical researcher's rich and varied experiences.

This book presents a range of cloud computing platforms for data-intensive scientific applications. It covers systems that deliver infrastructure as a service, including: HPC as a service; virtual networks as a service; scalable and reliable storage; algorithms that manage vast cloud resources and applications runtime; and programming models that enable pragmatic programming and implementation toolkits for eScience applications. Many scientific applications in clouds are also introduced, such as bioinformatics, biology, weather forecasting and social networks. Most chapters include case studies.Cloud Computing for Data-Intensive Applications targets advanced-level students and researchers studying computer science and electrical engineering. Professionals working in cloud computing, networks, databases and more will also find this book useful as a reference.

This is the second volume in a 2-volume compendium that is the go-to source for both research- and practice-oriented information on the importance of branched chain amino acids in maintaining the nutritional status and overall health of individuals, especially those with certain disease conditions.  Over 150 well recognized and respected contributors have come together to compile these up-to-date and well-referenced works. The volumes will serve the reader as the benchmarks in this complex area of interrelationships between dietary protein intakes and individual amino acid supplementation, the unique role of the branched chain amino acids in the synthesis of brain neurotransmitters, collagen formation, insulin and glucose modulation and the functioning of all organ systems that are involved in the maintenance of the body's metabolic integrity.  Moreover, the physiological, genetic and pathological interactions between plasma levels of branched chain amino acids and aromatic amino acids are clearly delineated so that students as well as practitioners can better understand the complexities of these interactions.Branched Chain Amino Acids in Clinical Nutrition: Volume 2 covers the role of branched chain amino acids in healthy individuals, and branched chain amino acid status in disease states, liver diseases, and supplementation studies in certain patient populations.

Using rodent models, this volume explores the basic neurobiology of the relationship among chronic pain, opioid pharmacology, and addiction.

This collection of papers offers a broad synopsis of state-of-the-art mathematical methods used in modeling the interaction between tumors and the immune system. These papers were presented at the four-day workshop on Mathematical Models of Tumor-Immune System Dynamics held in Sydney, Australia from January 7th to January 10th, 2013. The workshop brought together applied mathematicians, biologists, and clinicians actively working in the field of cancer immunology to share their current research and to increase awareness of the innovative mathematical tools that are applicable to the growing field of cancer immunology.Recent progress in cancer immunology and advances in immunotherapy suggest that the immune system plays a fundamental role in host defense against tumors and could be utilized to prevent or cure cancer. Although theoretical and experimental studies of tumor-immune system dynamics have a long history, there are still many unanswered questions about the mechanisms that govern the interaction between the immune system and a growing tumor. The multidimensional nature of these complex interactions requires a cross-disciplinary approach to capture more realistic dynamics of the essential biology. The papers presented in this volume explore these issues and the results will be of interest to graduate students and researchers in a variety of fields within mathematical and biological sciences.

Peripheral and Cerebrovascular Intervention draws upon experts from diverse fields to provide readers with a comprehensive foundation for understanding and performing endovascular procedures-from the basic steps to the most current and advanced techniques. Individual chapters focus on primary intervention sites, including lower extremity, renal/mesenteric, subclavian/upper extremity, carotid/vertebral, intracranial and venous interventions. Additionally, chapters covering critical limb ischemia and abdominal and thoracic aortic aneurysms are included. By incorporating valuable clinical information, such as indications, contraindications, complications and discussions of surgical techniques and procedures, this book is a valuable resource for the busy practitioner and will be of interest to all interventional and general cardiologists, radiologists and neurologists; vascular surgeons; internists and residents and fellows.

Over the past decade, significant advances in research methodology have stimulated dramatic progress in the field of child psychiatry in general, and in pediatric anxiety disorders, more specifically. Pediatric Anxiety Disorders: A Clinical Guide is a comprehensive and vital addition to the literature at an exciting time in the field of psychiatry. This state-of-the-art reference aims to bridge the most up-to-date research findings with relevant clinical perspectives, making it a unique and essential resource for established clinicians and researchers, as well as for students and trainees. The book is organized into four sections, each of which includes chapters on a specific area of interest. The first section reviews the current research regarding etiological mechanisms of pediatric anxiety. The second section provides in-depth descriptions of the anxiety disorders that affect children and adolescents. The third section summarizes the literature on empirically supported assessment tools and evidence based cognitive-behavioral and pharmacological interventions. Of special practical note, the authors of these chapters have included comprehensive summary tables that can serve as quick reference tools. The final section of the text is dedicated to understanding how anxiety manifests in two special populations, children with chronic medical illnesses and those with autism spectrum disorders. Pediatric Anxiety Disorders: A Clinical Guide is an authoritative new volume developed by a renowned collection of clinicians and researchers in the field of childhood anxiety disorders.

This proceedings volume is based on papers presented at the Workshops on Combinatorial and Additive Number Theory (CANT), which were held at the Graduate Center of the City University of New York in 2011 and 2012. The goal of the workshops is to survey recent progress in combinatorial number theory and related parts of mathematics. The workshop attracts researchers and students who discuss the state-of-the-art, open problems and future challenges in number theory.

This volume is composed of peer-reviewed papers that have developed from the First Conference of the International Society for Non Parametric Statistics (ISNPS). This inaugural conference took place in Chalkidiki, Greece, June 15-19, 2012. It was organized with the co-sponsorship of the IMS, the ISI and other organizations. M.G. Akritas, S.N. Lahiri and D.N. Politis are the first executive committee members of ISNPS and the editors of this volume. ISNPS has a distinguished Advisory Committee that includes Professors R.Beran, P.Bickel, R. Carroll, D. Cook, P. Hall, R. Johnson, B. Lindsay, E. Parzen, P. Robinson, M. Rosenblatt, G. Roussas, T. SubbaRao and G. Wahba. The Charting Committee of ISNPS consists of more than 50 prominent researchers from all over the world.The chapters in this volume bring forth recent advances and trends in several areas of nonparametric statistics. In this way, the volume facilitates the exchange of research ideas, promotes collaboration among researchers from all over the world and contributes to the further development of the field. The conference program included over 250 talks, including special invited talks, plenary talks and contributed talks on all areas of nonparametric statistics. Out of these talks, some of the most pertinent ones have been refereed and developed into chapters that share both research and developments in the field.

This volume describes the design of relay-based circuit systems from device fabrication to circuit micro-architectures. This book is ideal for both device engineers as well as circuit system designers, and highlights the importance of co-design across design hierarchies when trying to optimize system performance (in this case, energy-efficiency). The book will also appeal to researchers and engineers focused on semiconductor, integrated circuits, and energy efficient electronics.

Upper Tract Urothelial Carcinoma represents the first book of its kind to be dedicated solely to UTUC. It's aim is to improve understanding and eventually care of a disease that is greatly understudied and underappreciated, yet commonly dealt with by many medical and urologic oncologists. The volume features new data regarding genetic susceptibility, gene expression studies and causative factors; contemporary concepts and controversies regarding diagnosis and staging of UTUC; prediction tools and their value in treatment decisions within each disease stage and patient selection and treatment options such as endoscopic management, distal ureterectomy, radical nephroureterectomy and chemotherapy. Up-to-date information regarding boundaries of surgical resection, indication and extent of lymphadenectomy is covered as well as the role of perioperative/neoadjuvant chemotherapy in patients with high-risk UTUC.Upper Tract Urothelial Carcinoma will be of great value to all Urologists, Medical Oncologists and fellows in Urologic Oncology as well as upper level residents in training in Urology and Medical Oncology.

Regulatory Foundations for the Food Protection Professional is a comprehensive guide for the entry-level food protection professional (FPP) working in either the public or private sector. The book can also serve as a foundation for students in academic programs preparing for a career in food protection. Additionally, as the Food Safety Modernization Act (FSMA) is implemented, this book will provide valuable information for countries wishing to export foods and food ingredients to the U.S. and comply with U.S. food safety regulations.The book is based on the Entry-Level component of the National Curriculum Framework for regulators, created by the International Food Protection Training Institute (IFPTI) located in Battle Creek, Michigan. The Entry-Level component of the National Curriculum Framework contains more than twenty content areas, including Epidemiology, Microbiology, Labeling, Food Defense Awareness, Program Standards, Environmental Health and Safety, Sampling, and Allergens.Each chapter is divided into specific learning objectives aimed at equipping the entry-level FPP with the knowledge and skills necessary to successfully perform his or her job, whether in the public or private sector, and whether in food safety or food defense.Established in 2009, IFPTI is improving public health by building competency-based training and certification systems, and cultivating leadership for the food protection community worldwide. Our mission is to enhance public health by improving the protection of the world's food supply through training, certification, thought leadership, and technology. See more at www.ifpti.org.

This is the first comprehensive International Handbook on the History of Mathematics Education, covering a wide spectrum of epochs and civilizations, countries and cultures. Until now, much of the research into the rich and varied history of mathematics education has remained inaccessible to the vast majority of scholars, not least because it has been written in the language, and for readers, of an individual country. And yet a historical overview, however brief, has become an indispensable element of nearly every dissertation and scholarly article. This handbook provides, for the first time, a comprehensive and systematic aid for researchers around the world in finding the information they need about historical developments in mathematics education, not only in their own countries, but globally as well.  Although written primarily for mathematics educators, this handbook will also be of interest to researchers of the history of education in general, as well as specialists in cultural and even social history.

This SpringerBrief on Spx reviews the investigations that led to the discovery of Spx and its orthologs and ties together the results of various studies that have explored the function and control of spx in Gram-positive organisms.  Spx of Bacillus subtilis has been extensively studied, but very little has been published about it. This book incorporates a number of studies that have been conducted in other Gram positive bacteria, which examined the role of Spx orthologs in stress response, bacterial development and virulence.  The book contains an overview that will introduce the protein and its orthologous forms, its association with RNA polymerase, the species of Gram-positive bacteria in which it is found, and the conditions in which it is abundant and active. Spx is a member of a large group of proteins belonging to the ArsC/Spx protein family, so the review touches upon the bioinformatic support for the protein family composition and its meaning with regard to protein structure/function. ¿

In the treatment of chronic diseases, wireless Implantable Medical Devices (IMDs) are commonly used to communicate with an outside programmer (reader). Such communication raises serious security concerns, such as the ability for hackers to gain access to a patient's medical records. This brief provides an overview of such attacks and the new security challenges, defenses, design issues, modeling and performance evaluation in wireless IMDs.  While studying the vulnerabilities of IMDs and corresponding security defenses, the reader will also learn the methodologies and tools for designing security schemes, modeling, security analysis, and performance evaluation, thus keeping pace with quickly-evolving wireless security research.

ICT Development for Social and Rural Connectedness provides an introduction to the concept of 'connectedness', and explores how this socio-psychological term has evolved during the age of the Internet. The book surveys the principles of ICT for development (ICTD), and closely examines how ICT has played a pivotal role in the rural community development of various countries. To highlight the continued benefits of ICT in these regions, the book presents an in-depth case study that analyzes the connectedness within the rural internet centers of Malaysia. The book is intended primarily for researchers and practitioners as a reference guide to ICTD in rural environments.

This book covers layout design and layout migration methodologies for optimizing multi-net wire structures in advanced VLSI interconnects. Scaling-dependent models for interconnect power, interconnect delay and crosstalk noise are covered in depth, and several design optimization problems are addressed, such as minimization of interconnect power under delay constraints, or design for minimal delay in wire bundles within a given routing area. A handy reference or a guide for design methodologies and layout automation techniques, this book provides a foundation for physical design challenges of interconnect in advanced integrated circuits.

Financial identity theft is well understood with clear underlying motives. Medical identity theft is new and presents a growing problem. The solutions to both problems however, are less clear. The Economics of Financial and Medical Identity Theft discusses how the digital networked environment is critically different from the world of paper, eyeballs and pens. Many of the effective identity protections are embedded behind the eyeballs, where the presumably passive observer is actually a fairly keen student of human behavior. The emergence of medical identity theft and the implications of medical data privacy are described in the second section of this book. The Economics of Financial and Medical Identity Theft also presents an overview of the current technology for identity management. The book closes with a series of vignettes in the last chapter, looking at the risks we may see in the future and how these risks can be mitigated or avoided.

This brief surveys existing techniques to address the problem of long delays and high power consumption for web browsing on smartphones, which can be due to the local computational limitation at the smartphone (e.g., running java scripts or flash objects) level. To address this issue, an architecture called Virtual-Machine based Proxy (VMP) is introduced, shifting the computing from smartphones to the VMP which may reside in the cloud. Mobile Web Browsing Using the Cloud illustrates the feasibility of deploying the proposed VMP system in 3G networks through a prototype using Xen virtual machines (in cloud) and Android Phones with ATT UMTS network. Techniques to address scalability issues, resource management techniques to optimize the performance of the VMs on the proxy side, compression techniques to further reduce the bandwidth consumption, and adaptation techniques to address poor network conditions on the smartphone are also included.

This two volume set presents over 50 of the most groundbreaking contributions of Menahem M Schiffer. All of the reprints of Schiffer's works herein have extensive annotation and invited commentaries, giving new clarity and insight into the impact and legacy of Schiffer's work. A complete bibliography and brief biography make this a rounded and invaluable reference.

We make complex decisions every day, requiring trust in many different entities for different reasons. These decisions are not made by combining many isolated trust evaluations. Many interlocking factors play a role, each dynamically impacting the others.  In this brief, "trust context" is defined as the system level description of how the trust evaluation process unfolds.Networks today are part of almost all human activity, supporting and shaping it. Applications increasingly incorporate new interdependencies and new trust contexts. Social networks connect people and organizations throughout the globe in cooperative and competitive activities. Information is created and consumed at a global scale. Systems, devices, and sensors create and process data, manage physical systems, and participate in interactions with other entities, people and systems alike.  To study trust in such applications, we need a multi-disciplinary approach.  This book reviews the components of the trust context through a broad review of recent literature in many different fields of study. Common threads relevant to the trust context across many application domains are also illustrated.Illustrations in the text © 2013 Aaron Hertzmann. www.dgp.toronto.edu/~hertzman

Recommender systems are one of the recent inventions to deal with the ever-growing information overload in relation to the selection of goods and services in a global economy. Collaborative Filtering (CF) is one of the most popular techniques in recommender systems. The CF recommends items to a target user based on the preferences of a set of similar users known as the neighbors, generated from a database made up of the preferences of past users. In the absence of these ratings, trust between the users could be used to choose the neighbor for recommendation making. Better recommendations can be achieved using an inferred trust network which mimics the real world "friend of a friend" recommendations. To extend the boundaries of the neighbor, an effective trust inference technique is required. This book proposes a trust interference technique called Directed Series Parallel Graph (DSPG) that has empirically outperformed other popular trust inference algorithms, such as TidalTrust and MoleTrust. For times when reliable explicit trust data is not available, this book outlines a new method called SimTrust for developing trust networks based on a user's interest similarity. To identify the interest similarity, a user's personalized tagging information is used. However, particular emphasis is given in what resources the user chooses to tag, rather than the text of the tag applied. The commonalities of the resources being tagged by the users can be used to form the neighbors used in the automated recommender system. Through a series of case studies and empirical results, this book highlights the effectiveness of this tag-similarity based method over the traditional collaborative filtering approach, which typically uses rating data. Trust for Intelligent Recommendation is intended for practitioners as a reference guide for developing improved, trust-based recommender systems. Researchers in a related field will also find this book valuable.

Designing a New Class of Distributed Systems closely examines the Distributed Intelligent Managed Element (DIME) Computing Model, a new model for distributed systems, and provides a guide to implementing Distributed Managed Workflows with High Reliability, Availability, Performance and Security. The book also explores the viability of self-optimizing, self-monitoring autonomous DIME-based computing systems. Designing a New Class of Distributed Systems is designed for practitioners as a reference guide for innovative distributed systems design. Researchers working in a related field will also find this book valuable.

The authors survey a recent technique in computer vision called Interactive Co-segmentation, which is the task of simultaneously extracting common foreground objects from multiple related images. They survey several of the algorithms, present underlying common ideas, and give an overview of applications of object co-segmentation.

In the last few years, there has been extensive research activity in the emerging area of Intermittently Connected Mobile Ad Hoc Networks (ICMANs). By considering the nature of intermittent connectivity in most real word mobile environments without any restrictions placedon users' behavior, ICMANs are eventually formed without any assumption with regard to the existence of a end-to-end path between two nodes wishing to communicate. It is different from the conventional Mobile Ad Hoc Networks (MANETs), which have been implicitly viewed as aconnected graph with established complete paths between every pair of nodes. For the conventional MANETs, mobility of nodes is considered as a challenge and needs to be handled properly to enable seamless communication between nodes. However, to overcome intermittentconnectivity in the ICMANs context, mobility is recognized as a critical component for data communications between the nodes that may never be part of the same connected portion of the network. This comes at the cost of addition considerable delay in data forwarding, since data areoften stored and carried by the intermediate nodes waiting for the mobility to generate the next forwarding opportunity that can probably bring it close to the destination. Such incurred large delays primarily limit ICMANs to the applications, which must tolerate delays beyond traditionalforwarding delays. ICMANs belong to the family of delay tolerant networks (DTNs). However, the unique characteristics (e.g., self-organizing, random mobility and ad hoc based connection) derived from MANETs distinguish ICMANs from other typical DTNs such as interplanetarynetwork (IPN) with infrastructure-based architecture.By allowing mobile nodes to connect and disconnect based on their behaviors and wills, ICMANs enable a number of novel applications to become possible in the field of MANETs. For example, there is a growing demand for efficient architectures for deploying opportunistic contentdistribution systems over ICMANs. This is because a large number of smart handheld devices with powerful functions enable mobile users to utilize low cost wireless connectivities such as Bluetooth and IEEE 802.11 for sharing and exchanging the multimedia contents anytime anywhere. Note that such phenomenal growth of content-rich services has promoted a new kind of networking where the content is delivered from its source (referred to as publisher) towards interested users (referred to as subscribers) rather than towards the pre-specified destinations.Compared to the extensive research activities relating to the routing and forwarding issues in ICMANs and even DTNs, opportunistic content distribution is just in its early stage and has not been widely addressed.With all these in mind, this book provides an in-depth discussion on the latest research efforts for opportunistic content distribution over ICMANs.