Bøger udgivet af Springer New York

In the last few years, there has been extensive research activity in the emerging area of Intermittently Connected Mobile Ad Hoc Networks (ICMANs). By considering the nature of intermittent connectivity in most real word mobile environments without any restrictions placedon users' behavior, ICMANs are eventually formed without any assumption with regard to the existence of a end-to-end path between two nodes wishing to communicate. It is different from the conventional Mobile Ad Hoc Networks (MANETs), which have been implicitly viewed as aconnected graph with established complete paths between every pair of nodes. For the conventional MANETs, mobility of nodes is considered as a challenge and needs to be handled properly to enable seamless communication between nodes. However, to overcome intermittentconnectivity in the ICMANs context, mobility is recognized as a critical component for data communications between the nodes that may never be part of the same connected portion of the network. This comes at the cost of addition considerable delay in data forwarding, since data areoften stored and carried by the intermediate nodes waiting for the mobility to generate the next forwarding opportunity that can probably bring it close to the destination. Such incurred large delays primarily limit ICMANs to the applications, which must tolerate delays beyond traditionalforwarding delays. ICMANs belong to the family of delay tolerant networks (DTNs). However, the unique characteristics (e.g., self-organizing, random mobility and ad hoc based connection) derived from MANETs distinguish ICMANs from other typical DTNs such as interplanetarynetwork (IPN) with infrastructure-based architecture.By allowing mobile nodes to connect and disconnect based on their behaviors and wills, ICMANs enable a number of novel applications to become possible in the field of MANETs. For example, there is a growing demand for efficient architectures for deploying opportunistic contentdistribution systems over ICMANs. This is because a large number of smart handheld devices with powerful functions enable mobile users to utilize low cost wireless connectivities such as Bluetooth and IEEE 802.11 for sharing and exchanging the multimedia contents anytime anywhere. Note that such phenomenal growth of content-rich services has promoted a new kind of networking where the content is delivered from its source (referred to as publisher) towards interested users (referred to as subscribers) rather than towards the pre-specified destinations.Compared to the extensive research activities relating to the routing and forwarding issues in ICMANs and even DTNs, opportunistic content distribution is just in its early stage and has not been widely addressed.With all these in mind, this book provides an in-depth discussion on the latest research efforts for opportunistic content distribution over ICMANs.

This volume presents the MD Anderson experience in providing care and services to the rapidly growing population of cancer survivors, which is currently estimated to be 12 million in the United States and more than 25 million worldwide. As cancer survival rates have increased, it has slowly become clear that the challenges faced by people with cancer do not end with treatment but simply change. This book aims to assist community oncologists, physicians, and their staff, who care for the vast majority of cancer survivors, by disseminating models of surveillance for disease recurrence, screening for second primary cancers, education regarding potential late effects of treatment, and psychosocial counseling. These models have proven valuable to cancer survivors who receive care at MD Anderson.

Climate change, urban sprawl, abandonment of agriculture, intensification of forestry and agriculture, changes in energy generation and use, expansion of infrastructure networks, habitat destruction and degradation, and other drivers of change occur at increasing rates. They affect patterns and processes in forest landscapes, and modify ecosystem services derived from those ecosystems. Consequently, rapidly changing landscapes present many new challenges to scientists and managers. While it is not uncommon to encounter the terms "global change" and "landscape" together in the ecological literature, a global analyses of drivers of change in forest landscapes, and their ecological consequences have not been addressed adequately. That is the goal of this volume: an exploration of the state of knowledge of global changes in forested landscapes with emphasis on causes and effects, and challenges faced by researchers and land managers. Initial chapters identify and describe major agents of landscape change: climate, fire, and human activities. The next series of chapters address implications of changes on ecosystem services, biodiversity conservation and carbon flux. A chapter that describes methodologies of detecting and monitoring landscape changes is presented followed by chapter that highlights the many challenges forest landscape managers face amidst of global change. Finally, we present a summary and a synthesis of the main points presented in the book. Each chapter will contain the individual research experiences of chapter authors, augmented by review and synthesis of global scientific literature on relevant topics, as well as critical input from multiple peer reviewers.

This volume provides a brief résumé of the history of testosterone research, from the early pioneers through to the most recent advances in the field. We discover how steroid hormones were first identified and how testosterone was shown to be essential for male development. Moving forward we explore how and where testosterone is produced, and how the body controls testosterone production. We then investigate the impact testosterone has on different body systems both during their development and function, and how perturbation of testosterone action is associated with disease. We complete our story with an exploration of the emerging roles of testosterone in clinical therapy, and the future potential for manipulation of the testosterone signaling system for human health benefit.

Cloud storage is an important service of cloud computing, which offers service for data owners to host their data in the cloud. This new paradigm of data hosting and data access services introduces two major security concerns. The first is the protection of data integrity. Data owners may not fully trust the cloud server and worry that data stored in the cloud could be corrupted or even removed. The second is data access control. Data owners may worry that some dishonest servers provide data access to users that are not permitted for profit gain and thus they can no longer rely on the servers for access control. To protect the data integrity in the cloud, an efficient and secure dynamic auditing protocol is introduced, which can support dynamic auditing and batch auditing. To ensure the data security in the cloud, two efficient and secure data access control schemes are introduced in this brief: ABAC for Single-authority Systems and DAC-MACS for Multi-authority Systems. While Ciphertext-Policy Attribute-based Encryption (CP-ABE) is a promising technique for access control of encrypted data, the existing schemes cannot be directly applied to data access control for cloud storage systems because of the attribute revocation problem. To solve the attribute revocation problem, new Revocable CP-ABE methods are proposed in both ABAC and DAC-MACS.

Low- and middle-income countries have seen a dramatic rise in the incidence of breast and gynecological cancers in the past decade. Organized cancer screening programs are not widely available in developing countries, leading to disproportionately higher mortality rates compared to those in the developed world. This book addresses cost-effective strategies for implementing programs aimed at screening for the early detection of breast, cervical, endometrial, and ovarian cancers. A well woman clinic concept providing such services as part of women's health examinations is proposed, aiming to ensure patient compliance by limiting clinic visits required for initial testing and diagnosis of screen positive cases.

Management of the Patient at High Risk for Breast Cancer provides a state-of-the art review of patients who are at high risk for breast cancer, how to identify them, the tools available for risk assessment and quantification and indications for genetic counseling and testing. The book summarizes the high risk breast imaging options, including newest techniques and schedules. Pathologic evaluation of high risk lesions are featured as well as the management issues surrounding these lesions. The volume also covers the management of concomitant cancer risk and screening strategies.A concise, yet comprehensive overview of the current status of the topic, Management of the Patient at High Risk for Breast Cancer serves as a useful resource for physicians and researchers dealing with and interested in patients at high risk for breast cancer.

Advances in technological and analytical methods have fostered rapid growth of systems biology and synthetic biology.  There continues to be rapid changes and discoveries in both fields with a small number of recent peer-reviewed reviews indicating some of the relationships between systems biology and synthetic biology.  This proposed SpringerBrief will cover core concepts of systems biology and synthetic biology and illustrate the implementation of associated research methodologies for an integrated approach to specifically address engineering microorganisms for biofuel production.¿

Polynomial optimization have been a hot research topic for the past few years and its applications range from Operations Research, biomedical engineering, investment science, to quantum mechanics, linear algebra, and signal processing, among many others. In this brief the authors discuss some important subclasses of polynomial optimization models arising from various applications, with a focus on approximations algorithms with guaranteed worst case performance analysis. The brief presents a clear view of the basic ideas underlying the design of such algorithms and the benefits are highlighted by illustrative examples showing the possible applications. This timely treatise will appeal to researchers and graduate students in the fields of optimization, computational mathematics, Operations Research, industrial engineering, and computer science.

Tracing the life of a giant in inorganic chemistry and key trends in his science, Boranes and Beyond follows Hawthorne from his mid-American origins to the halls of Harvard and UCLA and back again. It naturally details the accomplishments in his lab. This book is a fascinating mixture of science and autobiography. Prof. Hawthorne won the Priestley Medal, the highest award of the American Chemical Society, for his pioneering work in elucidating the chemistry of boron. He has chronicled in this book the developments in his lab which ultimately led to this achievement.Not content to rest on his laurels, after retiring from UCLA Prof. Hawthorne explored the use of boron in biomedicine and directed the International Institute of Nano & Molecular Medicine at the University of Missouri-Columbia.

This book serves as an introduction to the continuum mechanics and mathematical modeling of complex fluids in living systems. The form and function of living systems are intimately tied to the nature of surrounding fluid environments, which commonly exhibit nonlinear and history dependent responses to forces and displacements. With ever-increasing capabilities in the visualization and manipulation of biological systems, research on the fundamental phenomena, models, measurements, and analysis of complex fluids has taken a number of exciting directions. In this book, many of the world's foremost experts explore key topics such as:Macro- and micro-rheological techniques for measuring the material properties of complex biofluids and the subtleties of data interpretationExperimental observations and rheology of complex biological materials, including mucus, cell membranes, the cytoskeleton, and bloodThe motility of microorganisms in complex fluids and the dynamics of active suspensionsChallenges and solutions in the numerical simulation of biologically relevant complex fluid flowsThis volume will be accessible to advanced undergraduate and beginning graduate students in engineering, mathematics, biology, and the physical sciences, but will appeal to anyone interested in the intricate and beautiful nature of complex fluids in the context of living systems.

This book is about object-oriented programming and how it is implemented in Microsoft Visual Basic. Accordingly, the book has two separate, but inter- twined, goals. The first is to describe the general concepts of object orientation and the second is to describe how to do object-oriented programming in Visual Basic. I intend this to be a short, no-nonsense book that can be read through once and then easily referred to at later times. (Long stories about a mythical company and its programming problems are seldom interesting the first time through, let alone the second, third or fourth times!) To read this book, you need only a minimal acquaintance with Visual Basic. In particular, I assume you can construct a simple Visual Basic program and have some rudimentary knowledge of fundamental programming tech- niques. This book does not teach Visual Basic - it teaches you how to pro- gram Visual Basic in an object-oriented way. The issue here is not how much Visual Basic you already know - it is that you want to learn about object- oriented programming techniques. With regard to the first goal of the book, it is my feeling that a discussion of the underlying concepts of object orientation Oust what is an object, a class, encapsulation, abstraction, and so on) is essential in order to take full advan- tage of any object-oriented language. Simply put, it will help you understand what you are doing if you know why you are doing it.

Medical Therapy of Ulcerative Colitis will serve as an invaluable resource for individual physicians use who treat patients with ulcerative colitis. The text presents a comprehensive overview of medical therapy for management of specific clinical scenarios and also a focus on the individual medications used to treat patients with ulcerative colitis. The book will be evidence based and focus on simplifying the current treatment to make it easy to understand. The chapters are written by experts in their fields and provide the most up to date information. This book will target gastroenterologists who focus on IBD, general gastroenterologists, fellows, and surgeons such as colorectal surgeons or GI surgeons who may treat patients with ulcerative colitis.

This monograph offers a thorough and updated guide to the theory and methods of progressive censoring, an area that has experienced tremendous growth in recent years. Progressive censoring, originally proposed in the 1950s, is an efficient method of handling samples from industrial experiments involving lifetimes of units that have either failed or censored in a progressive fashion during the life test, with many practical applications to reliability and quality.Key topics and features:Data sets from the literature as well as newly simulated data sets are used to illustrate concepts throughout the textEmphasis on real-life applications to life testing, reliability, and quality controlDiscussion of parametric and nonparametric inferenceCoverage of experimental design with optimal progressive censoringThe Art of Progressive Censoring is a valuable reference for graduate students, researchers, and practitioners inapplied statistics, quality control, life testing, and reliability. With its accessible style and concrete examples, the work may also be used as a textbook in advanced undergraduate or beginning graduate courses on censoring or progressive censoring, as well as a supplementary textbook for a course on ordered data.

This new volume in the series Emerging Infectious Diseases of the 21st Century is a novel book on the role of microbes in the pathogenesis of common and disabling non-infectious diseases. New insights have emerged over the past several years suggesting that our commensal microflora of the gut is extremely important in regulating physiological and immune functions of the body. Covered are the perturbations of the normal composition of our endogenous microbiota, influenced by diet and genetic predispositions, as well as the mechanisms to produce common disorders such as obesity, diabetes, irritable bowel syndrome, colon cancer and atherosclerotic vascular diseases. Also explored is the evidence suggesting that predisposition to increasingly common afflictions such as asthma and multiple sclerosis is influenced, in combination with our genetic composition, by early life exposure to environmental microbes and the time of onset of common viral infections. Chapters provide the most recent information on these disorders with regards to epidemiology, current concepts on pathogenesis and mechanisms of their biology, recent research and data on the role of microbes, analysis of their validity and conclusive remarks and areas for future research.The Role of Microbes in Common Non-Infectious Diseases is an excellent resource for both physicians and investigators from a broad range of disciplines that will help to stimulate new concepts of disease pathogenesis and lead to the unraveling of their mechanisms of diseases and to novel treatments.

Every mathematician agrees that every mathematician must know some set theory; the disagreement begins in trying to decide how much is some. This book contains my answer to that question. The purpose of the book is to tell the beginning student of advanced mathematics the basic set- theoretic facts of life, and to do so with the minimum of philosophical discourse and logical formalism. The point of view throughout is that of a prospective mathematician anxious to study groups, or integrals, or manifolds. From this point of view the concepts and methods of this book are merely some of the standard mathematical tools; the expert specialist will find nothing new here. Scholarly bibliographical credits and references are out of place in a purely expository book such as this one. The student who gets interested in set theory for its own sake should know, however, that there is much more to the subject than there is in this book. One of the most beautiful sources of set-theoretic wisdom is still Hausdorff's Set theory. A recent and highly readable addition to the literature, with an extensive and up-to-date bibliography, is Axiomatic set theory by Suppes.

Obesity is a risk factor for breast cancer in older women. A number of adipose-derived and obesity-related factors have been shown to affect tumour cell growth. These include adipokines, insulin, IGF-1 and oestrogens. The majority of obesity-related postmenopausal breast cancers are oestrogen-dependent. Since the ovaries no longer produce oestrogens after menopause, and that circulating levels are negligible, it is evident that it is the oestrogens produced locally within the breast adipose that are responsible for the increased growth of breast cancer cells. Aromatase is the enzyme that converts androgens into oestrogens and its regulation is dependent on the activity of a number of tissue-specific promoters. Targeting oestrogen biosynthesis in obesity may be useful for the prevention of breast cancer. Aromatase inhibitors are efficacious at treating postmenopausal breast cancer and recent studies suggest that they may also be useful in the prevention setting. However, these compounds inhibit the catalytic activity of aromatase and as a consequence lead to a number of undesirable side-effects, including arthralgia and possible cognitive defects due to inhibition of aromatase in the bone and brain, respectively. Novel therapies, such as those employed to treat obesity-associated disease, including anti-diabetics, may prove successful at inhibiting aromatase specifically within the breast. This SpringerBrief will explore all of these issues in depth and the authors are in a unique position to write about this topic, having extensive experience in the field of aromatase research.

Aimed at mathematicians and computer scientists who will only be exposed to one course in this area, Computability: A Mathematical Sketchbook provides a brief but rigorous introduction to the abstract theory of computation, sometimes also referred to as recursion theory. It develops major themes in computability theory, such as Rice's theorem and the recursion theorem, and provides a systematic account of Blum's complexity theory as well as an introduction to the theory of computable real numbers and functions. The book is intended as a university text, but it may also be used for self-study; appropriate exercises and solutions are included.