Bøger udgivet af Springer Verlag GmbH

This volume provides an overview of the fluid aspects of the climate system, focusing on basic aspects as well as recent research developments.

The topics treated include animal models, pathophysiology of cerebral hemorrhage, experimental treatment for cerebral hemorrhage, cerebral hemorrhage clinical manifestations, prognosis of cerebral hemorrhage, and clinical management.

This book provides a broad overview on the relationship between structure and mechanical properties of carbon nanomaterials from world-leading scientists in the field.

Also many of the different constitutive damage models that have recently appeared in the literature and the different approaches to this topic are presented, making them easily accessible to researchers and graduate students in civil engineering, mechanical engineering, engineering mechanics, aerospace engineering, and material science.

"Outer Space in society, politics and law" is an inter-disciplinary approach to the understanding of modern space law. Technical, cultural and historical aspects lay the foundation for a sound comprehension why space law norms have been established and what they mean in practice.

The main topics treated are: ischemia & hemorrhage, trauma (experimental and clinical), cerebral hemorrhage, tumor, hydrocephlaus & intracranial pressure (ICP), neuromonitoring & neuroimaging, treatments, blood brain barrier, and miscellaneous.

Sphingolipids are lipid components of the plasma membrane of eukaryotic cells with an important function in signaling mechanisms in the cell. The function of Sphingolipids in cell signaling with regard to infectious and lung diseases, cancer, cardiovascular diseases and neuropsychiatric disorders are described and treated in distinct parts.

The classical problem of free material design is shown to be reducible to a locking material problem, even in the multiload case.

Sphingolipids are lipid components of the plasma membrane in eukaryotic cells. This book on sphingolipids provides insights into the basics of sphingolipid biology and drug development, with a particular emphasis on the sphingolipid derivative ceramide.

The articles in this volume cover the various options of the optimal management of brain tumors, vascular lesions, and functional disorders. They provide a good balance between microneurosurgery and radiosurgery, presenting also alternative surgical and radiosurgical treatment options with discussions on their advantages and disadvantages.

This book follows the concept of perceiving the entire aorta as one functional organ assuming that all individual pathologies and local interventional procedures affect the up- and downstream segments with consequences for complications and disease progression.

Many pathogens and aberrant malignant cells express unique carbohydrates on their surface representing attractive targets for vaccine design. Considerable progress has recently been made in the identification of novel carbohydrate based vaccines and a large number has reached clinical phase studies. The success of several licensed carbohydrate based vaccines against bacterial pathogens such as Haemophilus influenzae type b, Neisseria meningitidis or Streptococcus pneumoniae demonstrates their great potential. However, the study of anti-carbohydrate antibodies is technically challenging and partly because of low affinities and promiscuous specificity they have not been medically exploited to full potential. The study of antibody specificities and identification of protective carbohydrate epitopes lies at the heart of successful vaccine design. In addition to therapy, antibodies in general serve as diagnostic tools in medical and scientific laboratories. In this setting high affinity and exquisite specificity are important factors for their successful use. ¿Anticarbohydrate Antibodies ¿ from molecular basis to clinical application¿ compiles current knowledge on the immunological recognition of carbohydrates by the adaptive immune system from a molecular perspective providing fundamental insight needed for advancing clinically relevant diagnostics and therapeutic applications. Based on significant progress in the fields of glycoimmunology and structural biology in recent years, the book comprehensively reviews the state-of-the-art in defining the key elements of carbohydrate recognition by antibodies, the molecular mimicry of carbohydrate epitopes as well as the molecular features leading to specific and relaxed binding modes. Backed-up by a combination of modern technologies to elucidate structural details of carbohydrate-antibody interactions, biomedically important carbohydrate antigens from viral, bacterial, parasite, insect and tumor cells have beenanalyzed in in-depth reviews written by well-known experts in the field. Fundamental knowledge of these molecular mechanisms eventually provides a rational basis to improve efficacy of carbohydrate-based vaccines and to further refine diagnostic tools in detection of pathogens and malignant cells.

This book provides an essential overview of the science of polysaccharides. Owing to the multidisciplinary character of the European Polysaccharide Network of Excellence (EPNOE), the book describes all main aspects of polysaccharide science and technology (biology, enzymology, physics, chemistry, materials science and processing).

The topics presented cover a broad spectrum ranging from energy transformation and transduction processes in animal sensing systems to the fabrication and application of bio-inspired synthetic sensor arrays.

Femoral neck fractures occur primarily in the elderly population, and nowadays arthroplasty is chosen most frequently as a treatment solution.

The largely taxon-based chapters are supplemented by essays on topical aspects relevant to modern-day EvoDevo research such as regeneration, embryos in the fossil record, homology in the age of genomics and the role of EvoDevo in the context of reconstructing evolutionary and phylogenetic scenarios.

Evolutionary Developmental Biology of Invertebrates is a must-have for any scientist, teacher or student interested in developmental and evolutionary biology as well as in general invertebrate zoology.This second volume on ecdysozoans covers all animals commonly known as crustaceans.

This volume collects about 20 contributions on the topic of robotic construction methods. Contributions will explore the current status quo in industry, science and practitioners. This book is to be the first of the series, comprising the current status of robotics in architecture, art and design.

This volume starts off with three chapters that set the stage for the entire work by covering general aspects of EvoDevo research, including its relevance for animal phylogeny, homology issues in the age of developmental genomics, and embryological data in the fossil record.

This multi-author, six-volume work summarizes our current knowledge on the developmental biology of all major invertebrate animal phyla. Evolutionary Developmental Biology of Invertebrates is a must-have for any scientist, teacher or student interested in developmental and evolutionary biology as well as in general invertebrate zoology.

Experts in climate and water sciences from Canada, the United States, Brazil, Denmark, Germany, Belgium, France, Serbia, and other European countries and the UNESCO gathered at the Serbian Academy of Sciences and Arts on the occasion of the 130th birthday anniversary of the geophysicist Milutin Milankovitch.

The main focus of computational medicine lies in the development of data analysis methods and mathematical modeling as well as computational simulation techniques specifically addressing medical problems.

This manual, to be published in two volumes, provides a condensed overview of the analytical investigation of 80 Chinese Herbal Drugs which are most frequently in use.

Giardia is a relatively simple eukaryotic microbe, causing acute and chronic diarrhea which has been used as a model to understand complex biological processes occurring in eukaryotic cells.

New high-resolution crystal structures of functional ribosome complexes and cryo-EM structures of translating ribosomes are presented, while partial reactions of translation are examined in structural and mechanistic detail, featuring translocation as a most dynamic process.

The induction of antigen-specific immune responses after in vivo transfection with expression plasmids has triggered a revolution of vaccine research.

This book brings together experts from different fields, who used a broad spectrum of methods to investigate the physiological and cellular adaptation of alpine plants from the tree line to the upper limits.