Medicinsk forskning

STANDARDVÆRK I FARMAKOLOGIDenne 7. udgave af Basal og klinisk farmakologi markerer 30 års jubilæum af den populære lærebog, der for længst er blevet en klassiker inden for det farmakologiske speciale. Bogen er opdateret og revideret på flere punkter, men samme velkendte struktur og generelle opbygning er bevaret fra de tidligere udgaver.Bogen består af tre dele. Del I giver en indføring i den basale farmakologi med en grundig omtale af lægemidlers farmakodynamik, farmakokinetik og receptorsystemer mv.. Del II er orienteret mod farmakoterapi og præsenterer den organrelaterede specielle farmakologi. Del III omhandler den kliniske farmakologi.Basal og klinisk farmakologi kan med fordel anskaffes tidligt og benyttes under hele medicinstudiet. 7. udgavens indhold er tilstræbt pensumdækkende ved landets fire uddannelser i medicin. Målgruppen omfatter også studerende inden for human biologi, odontologi, farmaci, biomedicin, biomekanik, farmaceutisk kemi og lægemiddelvidenskab – for blot at nævne nogle. Desuden kan den benyttes af læger, farmaceuter og ansatte i industrien samt ved postgraduate kurser.FagredaktørerUlf Simonsen, professor, dr.med., Aarhus Universitet, Institut for BiomedicinKim Peder Dalhoff, professor, overlæge, dr.med., Bispebjerg og Frederiksberg Hospital, Klinisk Farmakologisk AfdelingTroels K. Bergman, professor, overlæge, ph.d., Odense Universitetshospital, Syddansk Universitetshospital, Esbjerg, FarmakologiMette Rosenkilde, professor, ph.d., dr.med., Københavns Universitet, Biomedicinsk Institut

CASES I SANSEFAGOFTALMOLOGI | OTORHINOLARYNGOLOGI | DERMATOLOGIMed CASES I SANSEFAG kan du træne dine kliniske evner med udgangspunkt i specialerne, der beskæftiger sig med øjensygdomme, øre-næse-hals-sygdomme og hudsygdomme. Bogen tager det vigtigste og hyppigste fra fagområderne og tilføjer en ny læringsdimension: Den kliniske, casebaserede tankegang som brobygning til virkelighedens diagnostiske landskab.At træffe den rette lægefaglige beslutning kræver teoretisk viden og klinisk erfaring. Den gode case kombinerer og formidler begge dele i systematiseret form, som er afgørende for øvelse og læring af mønstergenkendelse, en analytisk tilgang og kritisk refleksion – fra patientmodtagelse, over udredning til behandling og plan for det videre forløb.CASES I SANSEFAG er tilpasset medicinstuderende, som læser på landets medicinske fakulteter i København, Odense, Århus og Aalborg, og postgraduate yngre læger under KBU-, intro- og HU-uddannelse. Bogen er skrevet af speciallæger indenfor deres respektive fagområder.

The main objective of translational health science is to concentrate on discovering healthcare products for all people where care gaps exist. This book examines the applications of translational research, identifies its difficulties, outlines its essential characteristics, considers healthcare management strategies, and examines the public's perspectives today. This book assists aspiring implementation scientists in researching this area because the discipline is still relatively young for the wide range of researchers tackling the challenge of clinical and translational science, a field dedicated to examining human health and disease, interventions, and outcomes to develop new treatment approaches, devices, and modalities to improve health. This book Edition is the most authoritative and timely resource that introduces new physiological and therapeutic processes to engage the fastest-growing scientific outcomes from academic and industrial research. The chapters in this book give insights into perspectives on the field of clinical and translational science and discuss artificial intelligence in drug development and conventional and novel clinical trial designs. There is a lot of hope that using artificial intelligence (AI) will significantly advance all facets of healthcare, from diagnosis to therapy. AI is prepared to assist medical staff with various duties, including administrative workflow, clinical documentation, patient outreach, and specialist support like image analysis, medical device automation, and patient monitoring. Some of the most important uses of AI in healthcare will be covered in this book by eminent Scientists, Academicians, and Industrial persons from both clinical and non-clinical fields.

This book describes the basic concepts and recent advances in new discoveries and technologies related to microbial omics and their role in environmental research and human health. The term "omics" refers to a blend of high-throughput analysis and traditional methods including genomics, transcriptomics, proteomics, lipidomics and metabolomics for a variety of applications in the field of life sciences, biomedical sciences, environmental sciences, and related industries. The book aims to fill the existing gap in terms of a comprehensive approach that incorporates recent advances in this dynamic field and provides an answer to why this field requires an interdisciplinary research approach.The focus of this book is on the applications of genomics, epigenomics, metagenomics, integrative omics, machine learning and microbiome research in environmental health, disease, wastewater epidemiology, antibiotic resistance, drug discovery, cancer, production of secondary metabolites of microbial origin, oxidative stress alleviating mechanisms, etc. The overall construction of this book emphasizes three major perspectives, namely, elaborate knowledge from fundamentals to recent advances in technologies about omics in general and its application in microbiology, environment, and health in particular; illustrative figures capable of easy visualization of complex pathways; and serving as a platform for highly demanded bioinformatics strategies including relevant codes, programming scripts, machine learning and use of artificial intelligence strategies needed to streamline the research outcomes. With global contributions from authors from internationally renowned organizations who excel in relevant research, this book will benefit bibliophiles and prospective audiences from the research fraternity, academia, professionals, and experts in the field of life sciences, biomedical as well as industries related to the development of drug design and novel advances in biotechnological applications.

Fluorescence is the most popular technique in chemical and biological sensing and this book provides systematic knowledge of basic principles in the design of fluorescence sensing and imaging techniques together with critical analysis of recent developments. Its ultimate sensitivity, high temporal and spatial resolution and versatility enables high resolution imaging within living cells. It develops rapidly in the directions of constructing new molecular recognition units, new fluorescence reporters and in improving sensitivity of response, up to the detection of single molecules. Its application areas range from the control of industrial processes to environmental monitoring and clinical diagnostics. Being a guide for students and young researchers, it also addresses professionals involved in basic and applied research. Making a strong link between education, research and product development, this book discusses prospects for future progress.

Ny grundbog om den almene praksis.Den praktiserende læge har en afgørende rolle og et stort ansvar i det danske sundhedsvæsen. Hvert eneste år uddannes mange praktiserende læger til at varetage opgaverne i primærsektoren, og 85 % af danskerne er i kontakt med deres praktiserende læge i løbet af et år. Derfor er det også en høj prioritet, at de medicinstuderende i hele landet uddannes grundigt i opbygningen af den primære sundhedssektor, oplever dagligdagen og de mange former for konsultationer i almen praksis, og lærer hvordan en dygtig og grundig praktiserende læge arbejder. ”Almen medicin” fra FADL’s Forlag er målrettet danske medicinstuderende samt læger i klinisk basisuddannelse (KBU), og dækker organisationen af den danske primære sundhedssektor samt konsultation og diagnostik i almen praksis. Derudover har bogen et kapitel i kommunikation og bogen har lagt vægt på, at de kommunikative færdigheder og trygge relationer er altafgørende i mødet mellem den praktiserende læge og sine patienter. Alle forfattere tilknyttet bogen er eksperter i deres felt og har mange års ekspertise. Bogen er redigeret af Lærke Smidt Gasbjerg og Maja Worm Frandsen.

This second edition provides new and updated methods for establishing reliable and reproducible experimental models of cardiovascular diseases. Chapters detail practical protocols from expert laboratories focusing on cardiovascular research, that would be critical in exploring novel discoveries in cardiac biology, and the development of effective therapeutic approaches. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Experimental Models of Cardiovascular Diseases: Methods and Protocols, Second Edition aims to provide detailed and practical protocols that will be valuable tools for researchers in cardiology to conduct their research.

This book comprehensively covers various aspects of biobased nanomaterials, including their types, fabrication methods, characterization techniques, and applications in different fields. The book starts with an introduction to biobased nanomaterials, highlighting their significance in various fields due to their unique properties. The first few chapters cover the different types of biobased nanomaterials, their properties, and how they are extracted from various natural sources. The methods of fabrication of biobased nanomaterials are discussed in detail, including the techniques for controlling their size, shape, and composition. It then delves into the characterization of biobased nanomaterials, discussing the different techniques used to determine their properties, including their morphology, size, structure, and composition. The subsequent chapters explore the various applications of biobased nanomaterials in different fields such as environmental applications, wound healing, tissue engineering, food industry, agriculture, sensing technology, biomedical applications, and energy storage devices. The advantages of biobased nanomaterials over traditional nanomaterials are highlighted, including their biodegradability and sustainability. The environmental concerns associated with biobased nanomaterials, as well as the health and safety concerns, are also discussed. The book concludes by looking at the prospects of biobased nanomaterials and how they can contribute to sustainable development. Overall, the book is an informative and comprehensive book that provides a thorough understanding of biobased nanomaterials and their various applications. It is a valuable resource for researchers, students, and professionals in various fields such as materials science, chemistry, biology, and environmental science. alike.

¿Biomedical Application of 4-Hexylresorcinol¿ is a comprehensive review of the latest research findings on the biomedical effects of 4-hexylresorcinol (4HR), a compound widely used as an antiseptic and food additive to prevent melanosis. Over the past two decades, the author has conducted extensive studies on 4HR, uncovering additional properties and applications that extend far beyond its traditional uses. This book aims to provide a thorough understanding of 4HR¿s numerous mechanisms and potential applications, with a focus on its anti-cancer, anti-inflammatory, and antioxidant effects.The book, ¿Biomedical Application of 4-Hexylresorcinol,¿ is poised to fill this critical knowledge gap. It will captivate professionals in the realms of biomedical research, medicine, and pharmacology, as well as students pursuing these disciplines. What truly sets our book apart is its unique concentration on 4HR and the wide-ranging applications in biomedical research and clinical practice. As interest in alternative therapeutic approaches continues to grow, along with the increasing acknowledgment of the value of natural compounds, this book is perfectly positioned to become an indispensable resource for researchers, clinicians, and aspiring professionals alike.

This book presents the recent developments in immunomodulatory biomaterials for cell-based therapies in various diseases, including diabetes, cancer, cardiovascular disease, and bone regeneration. The authors first cover the fundamentals of conventional immunology and immunomodulation, before focusing on the history, advantages, and challenges of cell therapies. Biological cell therapy has gained immense attention for various diseases due to unique advantages it has over chemical drugs regarding cost, ease of production, toxicity, and therapeutic efficacy. However, these cell-based therapies need an inert delivery system that can locally deliver cells and minimally elicit foreign body response. The book discusses the foreign body response to the immunomodulatory biomaterials as well as the current and future strategies for potential mitigation of considerable immune responses toward immunomodulatory biomaterials and devices.

Glæden ved at kæmpe er en selvbiografi skrevet af den kvinde, der blev den første kvindelige professor i medicin på Rigshospitalet i 1990, som havde en international forskerkarriere, og som siden bestred en række bestyrelsesposter i både offentligt og privat regi i en relativ nær fortid, hvor mænd stadig satte dagsordenen. Glæden ved at kæmpe er en stimulerende fortælling om at ville gøre en forskel på trods af modstand fra nedgroede fagtraditioner.Hvad Gunhild Lange Skovgaard har opnået baserer sig på engagement og stædighed og at insistere på at blive ved på trods af modstand. At hun er kvinde, har igennem hendes karriere fra især 1970’erne til og med 1990’erne været ensbetydende med megen nedladenhed, obstruktion og had fra modkønnets side, men det kvalte ikke hendes lyst til at kæmpe videre. Tværtimod. Gunhild Lange Skovgaard (f. 1945) er speciallæge i dermato-venerologi og blandt pionererne i AIDS-forskningen og fra 1990-2007 professor ved Københavns Universitet på Rigshospitalet. Hun har beklædt en række poster på Bispebjerg Hospital, Finseninstituttet og Rigshospitalet og er tildelt en række priser heriblandt International Award of AIDS Research, USA 1988. Hun har siddet i en række bestyrelser, bl.a. som formand i Mødrehjælpen fra 1992-1995, formand i Care Danmark 1998-2006, i DSB’s bestyrelse 1995-2010 og DSB S-tog A/S 2008-2013. Derudover er hun stadig engageret som formand i den private velgørende forening Hellebro, der hjælper unge hjemløse og udsatte mennesker mellem 18-29 år.

This volume explores in detail the molecular biology, genetics and immunology of the bacterium Helicobacter pylori that causes serious gastric diseases such as gastric cancer. The book provides in-depth insights into the mechanisms of H. pylori-induced pathogenicity, gives an overview of how the bacterium colonizes the human gut, how it manages to persist in the body and which factors play a role in the development of H. pylori-induced gastric cancer. Furthermore, the interaction between the Gram-negative bacterium and the human gut microbiome is explored, and clinical management and treatment strategies to combat gastric cancer are discussed.Helicobacter pylori is an extremely successful pathogen that persistently colonizes the gut of about 50% of the world¿s population. H. pylori and its human host share a long co-evolutionary relationship that dates back for at least last 100,000 years and possibly longer. Infection by thisbacterium is a high-risk factor for the development of gastric diseases, including gastric cancer. Gastric cancer is associated with high morbidity and mortality and represents the 5th most common malignant tumour and the 4th leading cause of cancer-related death worldwide. H. pylori is the first bacterium that has been classified as a type-I carcinogen by the International Agency for Research on Cancer (IARC). Recent research progress identified crucial bacterial, host and environmental factors which control H. pylori-induced gastric malignancy. New studies also suggest that specific human germline mutations and other genetic aberrations have an important impact on H. pylori-induced pathology. In this volume, all these recently discovered mechanisms are reviewed in the light of gastric cancer development, and H. pylori epidemiology, virulence factors, immune evasion, pathophysiology, cancer signalling and novel therapeutic protocols are presented. This volume is aimed at researchers in the fields of immunology, genetics, microbiology and medicine who are interested in the detailed mechanisms of the pathogenicity of this carcinogenic stomach bacterium.

This fully updated volume provides an up-to-date and comprehensive overview of the current state of technologies helping to accelerate Alzheimer¿s disease drug development. Addressing the latest advances in preclinical and clinical research, including new insights into the molecular mechanisms and emerging therapeutic strategies, the book continues by exploring digital biomarkers and advanced neuroimaging analysis which will transform how clinical trials in the Alzheimer¿s disease field are performed. Written for the highly successful Methods in Molecular Biology series, chapters feature the kind of detailed implementation advice that leads to greater success in the lab or clinic. Authoritative and practical, Biomarkers for Alzheimer¿s Disease Drug Development, Second Edition seeks to inspire and inform future efforts to develop effective treatments for this devastating disease.

The book deals with the effective operation of the rules related to biomedical research and pays attention to the activities of the national legislatures of the 27 Member States in the field of scientific research. This multilevel system has an impact on biobanking activity. The book answers questions realized by operators on the main biobanks around the EU in the field of GDPR. The authors and editors used the questions born from brainstorming among members of the Association European, Middle East & Africa for Biopreservation and Biobanking (ESBB) to offer to the operators in biobanking activity and researchers quickly answer to their daily questions, but with authors highest quality. Further the book provides a comprehensive review of the rapidly expanding field of biobanking. It provides researchers and scholars working on biobanking and bio-sharing and more in general in the university hospitals and clinical trial consortiums, and companies, biomedical researchers, but also jurists and the professionals (in particular judges, lawyers, officers) an instrument rigorous but easy to use of the GDPR in the case of biobanking activities. The book identifies a methodological path to tackle the legal or ethical problem on a specific scientific-technological to verify existing solutions and give ideas for future applications. The importance of the legal solution influences the implementation of the development of the biobanking activity service itself.

This volume details critical and valuable experimental protocols to facilitate researchers in this fascinating field. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Maternal Placental Interface: Methods and Protocols aims to ensure successful results in the further study of this vital field.