Immunologi

Few recipes are as beloved and revered as chicken soup in the world of comfort food. Touted as a cure-all for both physical and mental ills, it is a culinary tradition that has been passed down through the years, whispered from grandmothers to grandchildren. Whether relished as a comforting dinner on a frigid winter evening or as a treatment for the common cold, chicken soup has gone beyond simple feeding to become a symbol of warmth, healing, and nourishment.Chicken soup is more than just a warm bowl of broth with some vegetables and chicken; it's a nutritional powerhouse of vitamins, minerals, and other bioactive components hidden beneath the seemingly straightforward exterior. These substances not only satisfy the palate but also have a number of positive health effects. We will learn the truths behind this liquid gold's lore as a healing potion as we delve into its depths. We'll examine the vitamins and minerals that make it a nutrient-rich treasure trove, analyze how its components affect our immune system, and find out how it may not only calm our souls but as well as our symptoms.Welcome to the nutritional world of chicken soup!

This second edition explores standard laboratory protocols and methodology commonly used in basic and translational studies in the field of rheumatoid arthritis (RA) treatment. Chapters detail including basic RA models, evaluation of disease activity and immunological status, systemic drug delivery, and new research tools. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Rheumatoid Arthritis: Methods and Protocols, Second Edition aims to be a basic manual for clinical researchers who are just getting started in the field of intervention study.

In the dynamic world of cellular biology, the intricate dance of life and death plays out through the lens of cytotoxicity. Delve deep into cellular responses¿ mysteries, where threats and defenses wage a microscopic war, influencing the broader landscape of health and disease. This authoritative volume on cytotoxicity encapsulates the breadth and depth of current knowledge, illuminating pathways that have been meticulously charted and those yet to be discovered. Each chapter, penned by experts in the field, unveils the molecular intricacies, external triggers, and translational potential of understanding cellular damage. Key Highlights: ¿Comprehensive explorations of molecular mechanisms ¿Cutting-edge methodologies in cytotoxic research ¿Insight into the profound implications for drug development and disease therapeutics Whether you are a seasoned researcher, an aspiring scientist, or an avid learner, this book promises to challenge, enlighten, and inspire. As the boundary between known territories and uncharted frontiers blurs, Cytotoxicity - Understanding Cellular Damage and Response is your definitive guide to a world where cellular responses hold the keys to groundbreaking discoveries. This book is an indispensable resource for anyone eager to navigate the complexities of cell damage and defense. Join us on a journey into the cellular realm, where every page turns a new chapter in understanding, innovation, and hope.

Nutrition is an important environmental factor for the maturation of the human immune system and essential for maintaining immunological homeostasis. Based on this, a variety of food applications with medical claims are being generated by food manufacturers worldwide in order to expand the market potential of products creating interesting linkages with other market segments, such as cosmetics and pharmaceuticals. However, in addition to the health benefits, active principles of such components often remain unexplored.This book focusses on the specific interactions between food ingredients and the immune system along the entire immune defense response. Starting from the immune barrier, through the innate and adaptive immune response, to active limitation and termination, all major mechanisms of the immune response are addressed and different biochemical, cellular and genetic interactions of components of our diet are discussed. The book presents a wealth of disease patterns for which nutritional factors are relevant and thereby provides indications for potential intervention strategies. In addition, associated food-technological aspects are discussed.  Being the first of its kind, this book provides an overview of the variety of functional food components and their influence on immunological responses. Written in an accessible style, it addresses researchers, health professionals and students with different scientific backgrounds.

This book presents paraproteinemia and the highly complex scientific information behind it to clinicians in a way they can understand and, ultimately, apply to their diagnostic and treatment practices. Paraproteinemia or dysproteinemia is characterized by the overproduction of an immunoglobulin by clonal expansion of cells from the B cells lineage which includes the plasma cells. The resultant monoclonal protein can be composed of the entire immunoglobulin or of its components. The identification and categorization of the different representatives of this group of disorders have traveled a long distance, but despite its high prevalence there is surprisingly limited evidence, in some areas, to guide the best clinical practice both at the time of diagnosis and during follow up. This book seeks to fill that gap.  The book is divided into three sections, introductory chapters, disease entities and experimental therapies. The text guides clinicians through these diseases and disorders. The group of renal diseases attributed to deposition of monoclonal immunoglobulins or their components are arranged as one disease category in order to simplify the understanding of these complicated diseases in plasma cell dysplasia. In emulation of this practical approach, at a larger scale, the volume editors and chapter authors attempt to encompass the whole spectrum of the paraproteinemias in this text. This will have the dual benefit of offering the audience a panoramic view of this group of disorders and simultaneously keeping them focused on its individual representatives. There have been many recent advances in diagnosis, risk stratifications, and management of many members of this group of diseases and they are explored in depth here.  This is an ideal guide for rheumatologists, hematologists, nephrologists, immunologists, oncologists, and relevant trainees caring for patients with paraproteinemia and related disorders.

This book deals with the advantages of using artificial intelligence (AI) in the fight against the COVID-19 and against future pandemics that could threat humanity and our environment. This book is a practical, scientific and clinically relevant example of how medicine and mathematics will fuse in the 2020s, out of external pandemic pressure and out of scientific evolutionary necessity. This book contains a unique blend of the world's leading researchers, both in medicine, mathematics, computer science, clinical and preclinical medicine, and presents the research front of the usage of AI against pandemics.Equipped with this book the reader will learn about the latest AI advances against COVID-19, and how mathematics and algorithms can aid in preventing its spreading course, treatments, diagnostics, vaccines, clinical management and future evolution.

This book focuses on nanomaterials with antibacterial properties. Antibacterial resistance is a growing concern that poses a serious threat to public health worldwide. This book looks at the fabrication, material's properties, and characterization of a range of metallic, bimetallic, and metal-oxide-based nanomaterials that can be exploited for their antimicrobial properties. A key focus of this book is its emphasis on 'green' synthesis of nanomaterials, as many conventional routes of nanomaterial fabrication do not fulfill key sustainability criteria in terms of their toxicity and lack of eco-friendliness. Additionally, this book introduces the application of nanoparticles to veterinary medicine. Given the ever-increasing global livestock population coupled with the emergence of drug-resistant pathogens of animal origin (bacterial, parasitic, and hemoprotozoa), the use of nanoparticles as antibacterial agents represents a paradigm shift in every aspect of veterinary care. Authored by scholars with combined expertise in nanomaterials and veterinary medicine, this book provides valuable information for researchers working on sustainable nanomaterials with antibacterial properties.

This detailed volume provides methods to guide assay development, procedures designed to investigate the chemokine and glycosaminoglycan (GAG) networks, as well as their interactions, in a wide range of organs and tissues in disease and in health. The initial chapters in this book present in vivo models used to examine the roles of chemokines and GAGs in normal physiology and in the pathophysiology of disease. The book then explores present cell- and tissue-based in vitro assays to examine chemokine:GAG interactions. Finally, analytic approaches are presented that provide assays for measuring GAGs, chemokines, and cellular responses. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Chemokine-Glycosaminoglycan Interactions: Methods and Protocols serves as an ideal guide for researchers seeking to analyze chemokine and GAG functions, interactions, and molecular mechanisms in vivo and in vitro.

This second edition volume provides new and updated chapters detailing simple and accessible experiment protocols to explore thymus biology. Chapters are divided into three parts presenting short reviews, analysis strategies, protocols for cell preparation, flow cytometry analyses, Innate Lymphoid Cells (ILC), mouse T-cell development, antigen receptor-less cousins of T cells, bone marrow chimeras, thymic stroma, and multiple aspects of thymocyte biology. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, T-Cell Development: Methods and Protocols, Second Edition aims to be a useful practical guide to help readers overcome obstacles associated with experimental approaches of T-cell development.

"Comprehensive up-to-date guide to clinical and diagnostic virology. Individual chapters cover viruses from A-Z, which are then grouped under syndromes. Liberal use of tables and algorithms enable quick access to key information. An ideal introduction for interested trainees and a practical reference for more experienced hospital clinicians and GPs"--

This edited volume provides insights about the molecular virology, pathoenesis of infection and host responses to varicella-zoster virus, which is a medically important human herpesvirus.  The chapters not only discuss genetics and molecular evolution of the virus, but also new structure-based knowledge on the functions of viral glycoproteins. Further, the authors illustrate how mechanisms from the virus are used to take over and remodel host cells during pathogeneis. These mechanisms also enable viral modulation of host cells and evasion of the host immune response. Part of these evasion and survival strategies, is the reaction to triggered host cell responses like autophagy, the stress response, modulation of apoptosis and other cell death pathways. This hands-on knowledge is crucial for students and clinicians in Virology, Immunology, and Infectious Diseases.Chapter "e;Common features between stroke following varicella in children and stroke following herpes zoster in adults"e; is available open access under a Creative Commons Attribution 4.0 International License via Springerlink.com.

Cutaneous adverse drug reactions are common and range from the benign to those which are life-threatening. The clinical presentation of these dermatoses is varied and many may mimic common skin conditions. Consequently, diagnosis in drug-induced skin disease is challenging and the treatment considerations are complex.     This book aims to bridge the divide between dermatology and allergy by providing a comprehensive review on the pathomechanisms and clinical features of cutaneous adverse drug reactions. Broken up into three distinct sections: General Considerations, Reaction Patterns, and Special Drug Categories, these chapters cover the common and rare adverse skin reactions and provide information on recent advances - particularly immunopathology and pharmacogenetics - as well as highlighting new adverse drug signals and novel therapies. Drug Eruptions is a must-have resource for dermatologists, allergists, internal physicians and general practitioners.

This volume details state-of-the- art methods on computer-aided antibody design. Chapters guide readers through information on antibody sequences and structures,  modeling antibody structures and dynamics, prediction and optimization of biological and biophysical properties of antibodies, prediction of antibody-antigen interactions, and computer-aided antibody affinity maturation and beyond. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols.Authoritative and cutting-edge, Computer-Aided Antibody Design aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge. Chapter 2 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

In this issue of Otolaryngologic Clinics, guest editors Drs. Sarah K. Wise and Daniel M. Beswick bring their considerable expertise to the topic of Allergy and Asthma in Otolaryngology. Top experts in the field provide a comprehensive review of up-to-date management strategies for allergic rhinitis and asthma in otolaryngologic settings, including diagnosis, treatment, anticipated future therapies, and associated comorbidities.Contains 15 relevant, practice-oriented topics including the burden of asthma and allergic rhinitis: epidemiology and health care costs; management of asthma for the otolaryngologist: current and future therapies; promising new diagnostic and treatment modalities for allergic rhinitis; update on the role of fungus in allergy, asthma, and the unified airway; air quality, allergic rhinitis, and asthma; allergic rhinitis and its effect on sleep; and more.Provides in-depth clinical reviews on allergy and asthma in otolaryngology, offering actionable insights for clinical practice.Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

This autobiography chronicles the life and career of Haralampos M. Moutsopoulos, an internationally renowned professor of medicine and prolific researcher on Sjogren's syndrome and autoimmune rheumatic diseases. In language that is simple and direct, he takes us on a fascinating journey from the days of his first scientific awakenings at a hospital in his native town of Ioannina, Greece, through his university years in Athens and training in the U.S., to his eventual return to his homeland. In Greece, he developed two centers of excellence in his field, first at the newly founded University of Ioannina Medical School Department of Internal Medicine and, second, at the Athens University Medical School, Department of Pathophysiology, where he taught until his retirement in 2011. Along the way, he introduces us to his teachers and mentors, and to the colleagues and students he mentored in turn, many of whom went on to assume high-ranking positions in Greece and abroad. A major theme throughout the book is his impassioned struggle for excellence, meritocracy, and transparency in universities and in the National Health System in Greece. Peppered with both amusing and unsettling incidents from this lifelong crusade to raise professional standards and against misconduct, the book is a must-read for anyone interested in learning about or entering the medical profession.

This book provides an essential overview of the role of phosphoinositide-3-phosphate kinase (PI3K) isoforms in modulating the function of immune system cells and their involvement in disease.PI3K is a family of kinases involved in basic cellular processes such as proliferation, migration and cell death. Recent work has highlighted the multiple roles of PI3K classes and subunits and their involvement in the immune response to the body's own and foreign antigens and diseases such as cancer and autoimmunity.  This book offers a detailed introduction to the biology of the three PI3K classes, followed by an extensive discussion of the diverse roles of AKT and PI3K isoforms in immune cells. Based on this knowledge, it subsequently explains in more detail how specific isoforms are connected to immune-mediated diseases. The book concludes by highlighting the latest advances in the production of isoform-specific inhibitors and their use in various human diseases. This book is intended as a reference guide for students and researchers interested in the multifaceted aspects of PI3K biology.

Biological sex and gender have a tremendous impact on the efficacy and safety of pharmacological interventions in virtually every disease state. This book presents a comprehensive and up-to-date overview on how sex-specific information is guiding the diagnosis and treatment of diseases affecting men and women, as well as of disease states that disproportionally affects women. Experts in various fields discuss both preclinical and clinical research that is contributing to a better understanding of the impact of sex in the presentation, etiology, treatment, and disease outcomes. Also discussed are the challenges encountered in implementing this growing body of knowledge into practice, as well as possible avenues to recognize and reduce health disparities between men and women so that therapeutic interventions are tailored and improved.

This Handbook discusses the pathology, etiology, pathogenesis, and therapeutic interventions of different neurodegenerative diseases. The initial section of the Handbook reviews the recent advances in understanding neurodegenerative diseases and the commonalities and differences between the major pathologies. The subsequent section presents recent developments in understanding fundamental biological mechanisms that influence the onset and development of neurodegenerative diseases. It provides current biomedical studies that are aimed at identifying the underlying causes of neurodegeneration. The book also examines the recent observations from biological, cellular, and studies from the model organisms for gaining mechanistic insights into neurodegenerative disorders. It also presents the epidemiological and genetics studies relevant to clinical aspects of neurodegenerative diseases. The book's subsequent chapters offer new and more effective therapeutic strategies to combat these devastating diseases. Towards the end, the Handbook presents recent advances in molecular diagnostics for neurodegenerative disorders and a perspective on the future directions to provide a framework for further developments and refinements of molecular diagnostics to combat neurodegenerative diseases.

This book provides a systematic review of the development, function, and patho-physiologic role of plasmacytoid dendritic cells (pDCs) in humans. The chapters of the book discuss the origin and discovery, hematopoietic development as well as molecular regulation of pDCs in the context of immune activation as well as immune tolerance. It also discusses the role of pDCs in human diseases, including infections, autoimmune/inflammatory diseases, cancers and metabolic disorders, and opportunities for pDCtargeting therapies in these varied clinical contexts. 

This detailed volume collects updates on the technical advances in hematopoietic stem cell research and incorporates new techniques focused on the molecular/genetic, cellular, and whole organism levels. Exploring methods that apply stress to hematopoiesis, the book also contains chapters focused on better understanding the role of hematopoietic niches and their cellular components, as well as in vivo models that test and quantitate stem cell function and are key to further development of therapeutic applications. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Hematopoietic Stem Cells: Methods and Protocols serves as a valued addition to laboratories focused on understanding hematopoietic stem cell biology and the therapeutic advances that can be derived from it.

This volume details multiple areas of new and emerging methods to develop the next generation of immunotherapy treatments. Chapters guide readers through analysis and characterisation of the interactions between tumour and immune cells, and cell engineering tools for cancer treatment, to provide a unique and compelling set of techniques instrumental to work with, and engineer, immune cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Cancer Immunotherapy: Methods and Protocols aims to ensure successful results in the further study of this vital field.

This volume provides a collection of protocols that will allow researchers to further explore the multiple, fascinating activities of Alpha-1 Antitrypsin (AAT) isoforms in innate immunity, and gene therapy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Alpha-1 Antitrypsin: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Learn all the microbiology and basic immunology concepts you need to know for your courses and exams. Now fully revised and updated, Mims' clinically relevant, systems-based approach and abundant colour illustrations make this complex subject easy to understand and remember. Learn about infections in the context of major body systems and understand why these are environments in which microbes can establish themselves, flourish, and give rise to pathologic changes. This systems-based approach to microbiology employs integrated and case-based teaching that places the 'bug parade' into a clinical context. Effectively review for problem-based courses with the help of chapter introductions and 'Lessons in Microbiology' text boxes that highlight the clinical relevance of the material, offer easy access to key concepts, and provide valuable review tools. Approach microbiology by body system or by pathogen through the accompanying electronic 'Pathogen Parade' - a quickly searchable, cross-referenced glossary of viruses, bacteria and fungi A new electronic 'Vaccine Parade' offers quick-reference coverage of the most commonly used vaccines in current clinical practice Deepen your understanding of epidemiology and the important role it plays in providing evidence-based identification of key risk factors for disease and targets for preventative medicine. Grasp and retain vital concepts easily, with a user-friendly colour coded format, succinct text, key concept boxes, and dynamic illustrations. New and enhanced information reflects the growing importance of the human microbiota and latest molecular approaches Access the complete contents on the go via the accompanying interactive eBook, with a range of bonus materials to enhance learning and retention - includes self-assessment materials and clinical cases to check your understanding and aid exam preparation.

Gute Leistung muss gut bezahlt werdenAlle relevanten Informationen für die erfolgreiche Abrechnung im Praxisalltag zu UV-GOÄ, Arbeitsunfällen und Berufskrankheiten: korrekt, verlässlich, vollständig.Aus dem InhaltZuständigkeit auf einen Blick: Tabellen/Adressen der UV-Träger, BGs - nach Branchen geordnet.Alle praxisrelevanten Kommentierungen, inklusive ausgewählten Arbeitshinweisen der UV-Träger, Beschlüssen der ständigen Gebührenkommission, aktuelle Gerichtsurteile.Abrechnung mit den Honorarerhöhungen ab 1.10.2023; kommentierte Gebührenpositionen mit den aktuellen Honoraren der allgemeinen und besonderen Heilbehandlung; Angabe der Ausschlüsse. Übersichtstabellen erleichtern bei schwierigen Abrechnungsfällen die korrekte Zuordnung zu entsprechenden Gebührenordnungspositionen.Inklusive Verletzungsartenverzeichnis; ¿Berufskrankheiten¿: Definition, Was ist zu tun? Erläuterungen zur ärztlichen Anzeige bei begründetem Verdacht einer Berufskrankheit, Liste der anerkannten Berufskrankheiten, die von den UV-Trägern vorgeschriebene Diagnostik, Checkliste zur Meldung einer Berufskrankheit, Begutachtungsempfehlungen. Gebührenverzeichnis ¿Einbindung von ärztlichen und psychologischen Psychotherapeuten in das Heilverfahren der UV-Träger¿; Gebührenverzeichnis niedergelassener Physio- und Ergotherapeuten; Änderungen der ständigen Gebührenkommission zur Höhe der Vergütung und der Leistungsbeschreibung verschiedener Gebührenpositionen.

This detailed volume provides an updated overview of current uses of peptide microarray technology, showcasing consolidated applications while highlighting some of the most intriguing novelties and emerging fields of use. The methodologies within this collection are of considerable value for both advanced users and new-comers in the peptide microarray arena, as the renowned contributors describe full coverage of the aspects related to their workflows, from microchip manufacturing to advanced analytical applications. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Peptide Microarrays: Methods and Protocols, Third Edition aims to make the use of peptide microarrays more and more accessible while stimulating further developments to sustain exciting discoveries in the biochemistry and medicine realms.

This volume provides methods and models for investigating the immunosuppressive subset of CD4+ T-cells, regulatory T-cells (Treg). Chapters guide readers through, basic protocols for analyzing Treg in mice and humans, single-cell analysis for analyzing Treg, and methods for the analysis of Treg in clinical application. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Regulatory T-Cells: Methods and Protocols aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge. 

The modern miracle of vaccines is in danger due to the rising number of anti-vaccination communities, so to tackle that problem and avoid misinformation, this book covers the real possible dangers and benefits of vaccination, as well as taking a look at the history of immunizing ourselves. Other than that, modern day data based statistics will be the backbone of all information in this book, to guarantee precision and accuracy. Here is a preview of what you'll learn...What a vaccine really isToxins that are present in vaccinesThe difference between immunization and vaccinationMethods of detoxing and cleansing the body to remove toxins from previous vaccinationsHealthy alternatives to vaccinationCommon myths and truths about vaccinesMuch, much more!This book gives a clear and concise explanation of the excipients in vaccine formulations and the important role each one plays, the book also aims to allay fears and concerns about vaccination and hopefully debunk some of the myths surrounding vaccination. The book also aims to encourage patient's to ask those key important questions from their doctors in order to give assurances that vaccines are safe for infants.