Kardiologi

Because stroke is essentially a disease of the vessels and blood flow, the most fundamental aspects of ischemic blood flow in the brain are under investigation by researchers. Their work was the focus of the sixth in the series of Keio University International Symposia for Life Sciences and Medicine, held in Tokyo in 1999. Selected here are 55 papers from the symposium, covering the buffy coat (glycocalyx) of endothelial cells, the blood-brain barrier and permeability, gene expression, vascular reactivity, dysregulation, inflammatory deterioration, cortical spreading depression, edema, microvascular derangement, and pathology, in ten major sections. The book includes the thought-provoking discussions that followed the presentations, thus providing an invaluable source of up-to-date information not only for researchers investigating microcirculation but also for clinicians implementing the most effective treatment for stroke patients.

Dieses Buch dient der Standortbestimmung der verschiedenen Verfahren, die durch ausgewiesene Experten der verschiedenen Fachgebiete aktuell und in übersichtlicher Form dargestellt werden. Dabei folgt einem Kapitel der interventionellen Kardiologie jeweils ein entsprechendes Kapitel der interventionellen Angiologie bzw. Radiologie, wodurch die enge Verwandtschaft, aber auch die Unterschiede leicht erkennbar werden.Ziel der Herausgeber ist es, zum einen die interdisziplinäre Diskussion anzuregen und zum anderen die Kenntnisse außerhalb des eigenen Bereiches bei gleicher Indikation zu vertiefen. Entsprechend wendet sich das Buch gleichermaßen an die interventionell tätigen Kollegen der unterschiedlichen Fachrichtungen wie auch an den Allgemeinmediziner oder Internisten, der die Weichen für eine erfolgreiche Weiterbehandlung seines Patienten stellen muss.

Arterial disease and inflammation are fundamental causes of many medical conditions. Recently, there have been several major advances in our understanding of the causes of diseases affecting the heart, lungs, kidneys, skin and blood vessels. The role of endothelium derived growth factors, nitric oxide and other messengers in vascular disease has been more clearly defined. New treatments targeting these molecular disorders are being used with beneficial effects. Further progress depends on a combined approach embracing basic and clinical research so that treatments of common, important diseases can be designed intelligently and logically. "e;Vascular Complications in Human Disease"e; presents our understanding of vascular disease, in reviews of the main strands of basic and clinical research written by leading international experts. It also identifies routes for further fruitful research and development. This concise and carefully edited book, avoiding repetition, includes the full spectrum of basic research which is not covered in other textbooks.

Cardiac Ischemia: From Injury to Protection has been divided into six parts. The first part describes the differences between hypoxia and ischemia, animal models, the effects of ischemia on myocardial function and metabolism, and the electrophysiological consequences of ischemia. The second part deals with the mechanisms of cardiomyocyte death in ischemia, structural aspects of irreversible ischemic injury, necrosis and apoptosis of cardiac cells, the role of calcium, and the concept of calcium antagonism. The third chapter is a brief description of reperfusion injury, its clinical relevance, and possible prevention. The fourth part summarizes changes in myocardial vasculature during ischemia and reperfusion. The fifth part is the survey of two main possibilities for increasing cardiac resistance to ischemia and hypoxia, i.e. long-lasting adaptation to chronic hypoxia and short-lasting preconditioning. The last part of the book deals with comparative and ontogenetic aspects of cardiac sensitivity to oxygen deprivation; this chapter also summarizes the ontogenetic differences and limitations in endogenous and exogenous protection of the ischemic/hypoxic heart.

This book is written in a quick reference style to help clinical and basic researchers, as well as graduate students, in the understanding of hemodynamics. Recent dev- opments in genetics and molecular biology on the one hand, and new noninvasive measurement techniques on the other hand, make it possible to measure and und- stand the hemodynamics of heart and vessels better than ever before. Hemodynamics makes it possible to characterize, in a quantitative way, and even with noninvasive techniques the function of the heart and the arterial system, separately and in c- bination, thereby producing information about what genetic and molecular processes are of importance for cardiovascular function. We have made the layout of the book such that it gives a succinct overview of individual topics in short chapters Therefore every chapter starts with a "e;box"e; c- taining a figure and caption, describing the main aspects of the subject. It is often sufficient to study the contents of this box alone to obtain this basic information, and therefore it is not necessary to read the book from cover to cover.

Wie lassen sich potentielle kardiotoxische Schäden in der onkologischen Behandlung vermeiden? Die verbesserte Diagnostik und Therapie onkologischer Erkrankungen führt auch zu neuen Herausforderungen in der Herz- und Kreislaufmedizin. Hierbei sind nicht nur die kurz- oder langfristigen Folgen onkologischer Therapieverfahren, z.B. die Entwicklung einer Herzinsuffizienz, gemeint, sondern auch kardiovaskuläre Folgen der onkologischen Grunderkrankung selbst wie Thrombosen oder Lungenembolien. Gemeinsame Risikofaktoren mit kardiovaskulären Erkrankungen können die Krebsbehandlung zunehmend erschweren. Umgekehrt können auch kardiologische Standardtherapieverfahren wie die Antikoagulation bei onkologischen Patienten verheerende Nebenwirkungen haben. Ein tumorfreies Überleben ist dementsprechend als alleiniges Therapieziel nicht ausreichend. Insbesondere verbesserte onkologische Therapien mit einem verlängerten Überleben von Risikopatienten sowie die rasche Einführung hochwirksamer onkologischer Therapieverfahren mit unklarem kardiovaskulärem Nebenwirkungsprofil erfordern profunde Kenntnisse auf dem neuen Gebiet der Kardio-Onkologie.

Was verbirgt sich hinter IAP, IVP, AH, HV und LAVA? Durch welche Stimulationsmanöver lässt sich eine SVT differenzieren? Wie gelingt das Mapping komplexer Arrhythmien? Die Techniken der invasiven Elektrophysiologie entwickeln sich rasant und werden immer anspruchsvoller. Das Buch erklärt verständlich formuliert, reich bebildert und mit vielen Tipps für die Praxis die wesentlichen Grundlagen des Faches. Dargestellt werden die technischen, apparativen und logistischen Voraussetzungen elektrophysiologischer Eingriffe, ebenso wie die anatomischen Grundlagen, die Diagnostik und Therapie der einzelnen Herzrhythmusstörungen. Besonderes Highlight sind Filmbeiträge zu einzelnen Arrhythmien, Mappingtechniken und diagnostischen Manövern. Das Buch wendet sich explizit an Einsteiger, die einen Überblick zu allen Aspekten der invasiven Elektrophysiologie suchen und Zusammenhänge verstehen möchten.

This new title is ideal for clinicians working in out-of-hospital settings who need to interpret electrocardiography safely and understand when to consult a cardiologist. The book presents a new method, ECG10+, for assessing ECGs without missing relevant pathology. The method enables readers systematically and safely to read ECGs by addressing 10 ECG findings and linking them to the clinical presentation. The book covers indications and quality of assessment, how to undertake ECGs, explanations of equipment and assessment of the various types of ECG waves. Assessing and Understanding ECGs is ideal for GPs, nurses and other healthcare workers who may need to make or interpret ECGs, as well as residents and clinicians working in hospital settings both in and outside cardiology. Logical and easy to follow - written in plain language for non-cardiology clinicians Bespoke images specially created to support understanding Unique and visually uniform translation from the heart function to the ECG-view enables the reader to thoroughly understand the ECG Full explanation of the electrophysiological function of the heart and related PQRST-waves as seen on the 12-lead ECG ('from pump to paper') Introduction and explanation of ECG10+ - a safe and systematic method to assess ECGs quickly and thoroughly Simple checklist to facilitate ECG interpretation in daily practice 61 case studies describe highly relevant clinical ECG-related problems in out-of-hospital situations, for practising theory and the ECG10+ method Summaries and reference chapter provide a concise overview

Progress and Prospect of Nanocarriers: Design, Concept, and Recent Advances examines the different nanocarriers that are currently being developed for specific applications in biomedical drug delivery, disease management, diagnosis and therapy. Nanosized drug delivery systems have gained tremendous amounts of clinical interest due to their effective bio-distribution and enhanced pharmacokinetic and selective targeting capability which results in high therapeutic potential, low side effects, and the generation of cost-effective drug delivery systems. Numerous effective nanocarriers have been evolving, including polymeric nanoparticles, liposomes, microspheres, dendrimers, and carbon nanotubes.This book is a helpful reference for scientists and students in the fields of drug delivery, biomaterials and nanomedicine, as well as scientists and engineers in industrial disciplines of drug delivery and drug formulation.

Former Vice President Dick Cheney and his longtime cardiologist, Dr. Jonathan Reiner, share the story of Cheney’s thirty-five-year battle with heart disease—providing insight into the incredible medical breakthroughs that have changed cardiac care over the last four decades.For as long as he has served at the highest levels of business and government, Vice President Dick Cheney has also been one of the world’s most prominent heart patients. Now, for the first time ever, Cheney, together with his longtime cardiologist, Jonathan Reiner, MD, shares the very personal story of his courageous thirty-five-year battle with heart disease, from his first heart attack in 1978 to the heart transplant he received in 2012. In 1978, when Cheney suffered his first heart attack, he received essentially the same treatment President Eisenhower had had in 1955. Since then, cardiac medicine has been revolutionized, and Cheney has benefitted from nearly every medical breakthrough. At each juncture, when Cheney faced a new health challenge, the technology was one step ahead of his disease. Cheney’s story is in many ways the story of the evolution of modern cardiac care. Heart is the riveting, singular memoir of both doctor and patient. Like no US politician has before him, Cheney opens up about his health struggles, sharing harrowing, never-before-told stories about the challenges he faced during a perilous time in our nation’s history. Dr. Reiner provides his perspective on Cheney’s case and also gives readers a fascinating glimpse into his own education as a doctor and the history of our understanding of the human heart. He masterfully chronicles the important discoveries, radical innovations, and cutting-edge science that have changed the face of medicine and saved countless lives. Powerfully braiding science with story and the personal with the political, Heart is a sweeping, inspiring, and ultimately optimistic book that will give hope to the millions of Americans affected by heart disease.

The Pocket Guide to Diagnostic Cardiac Catheterization provides general cardiology fellows, nurses, and technicians entering the cardiac catheterization laboratory a practical guide addressing key aspects of left and right heart catheterization, selective coronary angiography, and the utilization of other invasive cardiology procedures for diagnostic purposes.Written by a team of physicians from Emory University Hospital's Cardiac Catheterization Laboratories, practical pearls of wisdom about the technical aspects of cardiac catheterization and other invasive cardiology procedures are presented with step-by-step instructions and easy-to-follow illustrations in this quick reference of essential material.Also included is a chapter with video clips that highlight the role and technical versatility of the multipurpose catheter in cardiac catheterization-a technique developed, taught, and learned over many generations in the cardiac catheterization laboratories at Emory University.

This book examines the application of stem cell surgery for diabetes and heart failure.Organized into two sections, the first identifies and summarizes the current worldwide stem cell trials for heart failure. Subsequent chapters in part two analyze the current worldwide stem cell trials in patients with Diabetes Mellitus. Both sections utilize studies that include non-expanded stem cells; each study is grouped by stem cell type and geographic location.Stem Cell Surgery Trials in Diabetes and Heart Failure is a comprehensive, convenient reference for cardiologists, endocrinologists, internists, and family physicians.