Patologi

"Learn anatomy, physiology, and pathology of the human body with this fun and student-focused learning and coloring workbook-includes study tips and 100+ images"--

A pacy, real-life page-turner by Reuters journalist on the global 100-days mission to identify and catch the next virus outbreak, codenamed DISEASE X, before it spreads worldwide.

This volume explores in detail the molecular biology, genetics and immunology of the bacterium Helicobacter pylori that causes serious gastric diseases such as gastric cancer. The book provides in-depth insights into the mechanisms of H. pylori-induced pathogenicity, gives an overview of how the bacterium colonizes the human gut, how it manages to persist in the body and which factors play a role in the development of H. pylori-induced gastric cancer. Furthermore, the interaction between the Gram-negative bacterium and the human gut microbiome is explored, and clinical management and treatment strategies to combat gastric cancer are discussed.Helicobacter pylori is an extremely successful pathogen that persistently colonizes the gut of about 50% of the world¿s population. H. pylori and its human host share a long co-evolutionary relationship that dates back for at least last 100,000 years and possibly longer. Infection by thisbacterium is a high-risk factor for the development of gastric diseases, including gastric cancer. Gastric cancer is associated with high morbidity and mortality and represents the 5th most common malignant tumour and the 4th leading cause of cancer-related death worldwide. H. pylori is the first bacterium that has been classified as a type-I carcinogen by the International Agency for Research on Cancer (IARC). Recent research progress identified crucial bacterial, host and environmental factors which control H. pylori-induced gastric malignancy. New studies also suggest that specific human germline mutations and other genetic aberrations have an important impact on H. pylori-induced pathology. In this volume, all these recently discovered mechanisms are reviewed in the light of gastric cancer development, and H. pylori epidemiology, virulence factors, immune evasion, pathophysiology, cancer signalling and novel therapeutic protocols are presented. This volume is aimed at researchers in the fields of immunology, genetics, microbiology and medicine who are interested in the detailed mechanisms of the pathogenicity of this carcinogenic stomach bacterium.

Neglected Zoonoses and Antimicrobial Resistance: Impact on One Health and Sustainable Development Goals provides a thorough examination of how neglected zoonoses and antimicrobial resistance together hinder the achievement of sustainable development goals declared by the United Nations in the pursuit of a disease-free world. Neglected zoonotic diseases, as defined by the World Health Organization, are diseases likely to impact the livelihoods of livestock keepers and those living in periurban communities in developing countries. This book examines how such zoonoses affect the health of vulnerable farming populations and reduce the production capacity of their livestock. Written by internationally recognized experts in the field of livestock and poultry zoonoses, this book provides the reader with a comprehensive description of modern sustainable development goals and defines neglected zoonotic diseases and their impacts on human physical, mental, social, and economic health. Subsequent chapters systematically describe the epidemiology, hosts and transmission, disease process, economic significance, and prevention and treatment protocols of key neglected zoonotic diseases, including echinococcosis, leishmaniasis, zoonotic tuberculosis, anthrax, brucellosis, leptospirosis, borreliosis, rickettsioses, and rabies. The book concludes with an assessment of the obstacles to achieving Sustainable Development Goals and possible mitigation strategies for veterinary researchers and policymakers alike.

This volume in the Diagnostic Pathology series is an ideal point-of-care resource for practitioners at all levels of experience and training. Covering the full range of solid organ transplantation (SOT) of the kidney, liver, heart, lung, pancreas, intestine, and more, it provides a current understanding of transplant immunology and pathology to help ensure accurate diagnosis for optimal clinical management. Richly illustrated and easy to use, Diagnostic Pathology: Transplant Pathology, third edition, is a visually stunning, one-stop reference for practicing pathologists, transplant practitioners, and students of organ transplantation.Covers all areas of transplant pathology, incorporating the collective knowledge and experience from a team of transplant pathology experts with the latest updates from the 2022 Banff classificationGroups content by specific organ transplant, including kidney, liver, heart, lung, intestine, pancreas, and vascularized composite allotransplantationFeatures sweeping updates throughout, including new chapters on transplant immunology that cover chronic viral infections and the immune response, immune manipulation and accommodation, and graft-vs.-host diseaseContains a new chapter on islet cell transplantation and new, detailed information on xenotransplantation-specifically kidney xenograftCovers advances in vascularized composite allografts (hands, face, uterus, phallus) transplantationFeatures more than 1,500 superb images, including histology, gross pathology, full-color illustrations, and radiologic imagesEmploys consistently templated chapters, bulleted content, key facts, annotated images, and an extensive index for quick, expert reference at the point of careIncludes an eBook version that enables you to access all text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. Any additional digital ancillary content may publish up to 6 weeks following the publication date

Die therapeutische Freiheit bezieht sich auf das Recht und die Verantwortung von Therapeut:innen, die beste Behandlungsmethode für Patient:innen auszuwählen. Es ist möglich, dass der Einsatz von KI-Algorithmen in der Psychotherapie diese Freiheit bedroht, wenn er z.B. die therapeutischen Entscheidungen dominiert oder ersetzt. Jedoch kann der Einsatz von KI-Algorithmen auch positive Auswirkungen haben, etwa im Bereich der Qualitätssicherung. Möglicherweise können Algorithmen-basierte Tools uns darin unterstützen, typische menschliche Verzerrungen und Unzulänglichkeiten bei komplexen Vorhersagen zu reduzieren. Sollten sich dann also Psychotherapeut:innen nicht die Freiheit nehmen, technische Hilfsmittel (incl. zukünftiger KI-Algorithmen) zur Unterstützung heranzuziehen¿?Die wichtigste Freiheits-Bedrohung scheint darin zu liegen, dass Psychotherapeut:innen sich selbst beschränken könnten oder sich durch KI das Denken abnehmen lassen. Dieses essential gibt einenEinblick und stellt weiterführende Fragen.

Pattern analysis is a powerful method that changed dermatopathology, nowadays an indispensable tool in the diagnostic workup of inflammatory and neoplastic lesions. The diagnosis of melanocytic lesions can also be mastered by pattern analysis, which is the link between pathology, dermatoscopy, and clinical dermatology and supports the integration of all views. The histopathologic diagnosis of melanocytic lesions can be challenging for novices and experts alike. While classifications of melanocytic lesions come and go, pattern analysis is timeless; it can be assigned to any classification, current or future, and provides a framework that allows to address complex and uncertain cases in a repeatable manner. While uncertainty cannot be totally eliminated, pattern analysis helps to express this uncertainty in a meaningful way. Written by expert dermatopathologists with experience in dermatoscopy, this book is dedicated to young colleagues and to those who have not yet settled on one of the competing schools of thought; it is intended as a practical guide to help making correct observations, to describe them with a well-defined terminology, and to yield critical decisions in the face of incomplete or conflicting information. The illustrations contained in the volume are all original pictures in high-quality and full-color: reproductions of histopatological cuts in low and high magnification will assist pathologists, dermatologists, and dermatopathologists in interpreting histological slides of melanocytic skin lesions.

Diagnosis and Management of Poultry Coccidiosis provides a comprehensive overview of current trends in the control of Eimeria and coccidiosis. Chicken coccidiosis cost the global economy $12.58 billion in 2016, including lost productivity and expenditures associated with prevention and treatment. As a result, chicken producers have developed several management approaches to combat coccidiosis. With consumer and regulatory pressure, nutritional interventions, and the need to identify anticoccidial alternatives that do not impair growth performance, this book contemplates the antibiotic-free future of the chicken industry. Initial chapters in this book introduce readers to chicken coccidiosis and the identification and diagnosis of the Eimeria parasite. Subsequent chapters describe innate and adaptive immune responses of poultry to Eimeria and delve into the purification of Eimeria lifecycle stages and in vitro culture systems for the study of Eimeria. The latter half of the book examines a variety of modern immunization measures, dietary interventions, and anticoccidial medications designed to combat coccidiosis.

Cytology evaluates cellular details, and in contrast, histology relates to tissue assessment with rather preserved architecture. During daily cytology practice, we frequently encounter certain situations which are often challenging such as differentiating normal cytology components or non-neoplastic lesions from a neoplastic process, abnormality versus artifact, contaminants from lesional sampling, immunostain expression in unexpected cells, identifying/or characterizing infectious microorganisms and use of special stains. In-depth knowledge about normal tissue cytology, the pattern of immunohistochemical expression in various organs, and recognizing diagnostic pitfalls would help to overcome diagnostically challenging situations. This book presents a detailed and state-of-the-art approach to non-neoplastic cytology. High-yield content, mostly used in daily practice, is in tabular format. The book provides detailed information about cytomorphologic features of infectiousmicroorganisms and the use of special stains, the use of immunohistochemistry along with expression in normal cell types, artifacts/contaminants or incidental findings, and cytomorphologic features of non-tumor related lesions in an organ-based structure. There is a further elaboration of differential diagnosis and mimickers of cytologic material from normal parenchymal tissue, infectious/inflammatory conditions, and benign cystic lesions. The last chapter describes a quick overview of important reference material in tables, which is useful for daily anatomic pathology sign-out. Non-Neoplastic Cytology: A Comprehensive Guide provides practical information about non-neoplastic cytology in one concise format using tables and images. It aims to be a practical resource for cytotechnologists, pathologists, pathology residents, and fellows.

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all aspects of placental pathology and the critical role the placenta plays in the unique interface between mother and fetus, this volume incorporates the most up-to-date scientific and technical knowledge to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Placenta is a visually stunning, one-stop resource for every practicing pathologist, fellow, resident, or student as an ideal day-to-day reference or as a reliable training resource, and is useful to even the most experienced placental pathologist for diagnostic criteria, grading, and relevance of placental tissue samples.Covers all areas of placental pathology, with clear and concise information on gross and microscopic changes of the placenta, common diagnoses, and placental evaluation in special circumstancesProvides expert guidance on key topics such as maternal mortality, gestational trophoblastic disease, placental pathology constellations, and typical clinical correlates; pregnancy complications such as preeclampsia, intrauterine growth restriction, and multiple gestation; and the pathology of disorders of placental implantation and the postpartum hysterectomyIncludes detailed, up-to-date information on maternal COVID-19 and placental pathology, including SARS-CoV-2 placentitis, and new chapters on fetal hydrops, common placental associations with stillbirth, second trimester demise, and moreContains significantly updated information throughout, including new content, images, and references to reflect the most current diagnoses and provide ease for daily case sign-outFeatures nearly 1,700 images both in print and online, including histology and gross pathology images, full-color medical illustrations, clinical photographs, radiology images, and online video content (including quick tutorials on key pathologic diagnoses) to help practicing and in-training pathologists reach a confident diagnosisEmploys consistently templated chapters, bulleted content, key facts, annotated images, reference tables for placental evaluation, sample templates for gross and microscopic placental description, and an extensive index for quick, expert reference at the point of careIncludes an eBook version that that provides you access to all text, figures, and references with the ability to search and customize your content, have it read aloud, and make notes and highlights. Any additional digital ancillary content may publish up to 6 weeks following the publication date.

This second edition provides state-of-the-art and novel methods on antibiotic isolation and purification, identification of antimicrobial killing mechanisms, as well as methods for the analysis and detection of microbial responses and adaptation strategies. Antibiotics: Methods and Protocols,  Second Edition, guides readers through updated and entirely new chapters on production and design, mode of action, and response and resistance. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Antibiotics: Methods and Protocols, Second Edition aims to inspire scientific work in the exciting field of antibiotic research.

Breast cancer remains the leading cause of cancer in women, which makes accurate diagnoses on core needle biopsy (CNB) specimens of vital importance in staging and guiding therapy decisions for patients. The first edition of this multi-authored text written by leaders in the field from major academic medical centers provided a comprehensive guide on diagnostic breast pathology in the core biopsy setting. In addition to in-depth coverage of benign and malignant entities encountered in breast core biopsies, the book provided additional resources to improve diagnostic accuracy such as pattern-based approaches to evaluation, mimickers of breast lesions arising in extra-mammary sites, and pitfalls specific to small tissue samples. In recent years, there have been several notable developments in the field of breast pathology including revisions in AJCC breast cancer staging, updated guidelines in the testing and reporting of ER, PR, and HER2, as well as implementation of immunotherapy and companion biomarker testing. In addition, several key updates were included in the most recent edition of the WHO Classification of Breast Tumours (2020). In addition to updates specific to individual breast entities, the second edition will detail updates regarding biomarker testing in the primary and metastatic setting, and incorporate newly defined entities and updated definitions of rare tumors in alignment with the WHO Classification of Breast Tumours (2020). Furthermore, this edition will address the role of CNB in companion biomarker testing for eligibility for immunotherapy in the context of advanced triple-negative breast carcinoma. Written by leaders in the field and edited by expert breast pathologists, The Second Edition of Comprehensive Guide to Core Needle Biopsies of the Breast is the definitive reference on breast core needle biopsies for practicing pathologists, pathology trainees, oncologists and clinicians of patients with breast disease.

This book, Gut microbiome and Brain Ageing, deals with the mechanisms and phenomenon that relates gut microbiome and aging of the brain. This book will bring forth the connection between good gut and brain aging and includes some cutting edge research topics dealing with gut physiology and its importance as future therapeutic option in neurological disorders. The gut microbiome's impact on neuronal function, mediated by neurotransmitters, vitamins, and neuroactive microbial metabolites, is an exciting area of investigation that this book thoroughly explores. It also covers the pivotal role of the gut microbiome in the etiology of various neurodegenerative disorders such as Alzheimer¿s disease (AD), Parkinson¿s disease (PD), depression, or multiple sclerosis (MS). It also explores the expanding understanding of the importance of the early-life gut microbiota and its implications for long-term health consequences. This book primarily addresses researchers, clinicians, and doctoral andgraduate students working in biomedicine, neurobiology, nutrition, microbiology, and translational medicine streams.

Dieses essential widmet sich der Verbindung von Psychoanalyse und Film. Die Psychoanalyse eignet sich für eine methodisch geleitete Filmbetrachtung. Dabei kommt es nicht zu einer Anwendung der psychoanalytischen Theorie, sondern zu einer Anwendung ihrer Methode eines reflektierten In-Beziehung-Stehen zu einem Gegenüber. So können latente Bedeutungen in den Blick genommen und eine Interpretation entwickelt werden. Im vorliegenden essential werden die Möglichkeiten eines solchen Zugangs rekonstruiert und bestehende Ansätze vorgestellt. Schließlich wird der Vorschlag eines Leitfadens zur Durchführung einer filmpsychoanalytischen Interpretation gemacht. Zahlreiche Filmbeispiele dienen dabei der Veranschaulichung.

This text consists of neoplastic and non-neoplastic lung pathology. It discusses frequently encountered issues and diagnostic problems using a Q&A format and case presentations.  Emphasis is placed on differentiating one from another based on the histopathological features, ancillary tests including immunohistochemical and molecular analyses, and clinical and radiologic correlation. In particular, clinical-radiologic-pathologic correlation is emphasized in the diagnosis of interstitial lung disease (ILD).    This text addresses the issues and diagnostic criteria in segregating a reactive process from adenocarcinoma, poorly differentiated adenocarcinoma from poorly differentiated squamous cell carcinoma, small cell carcinoma from other types of neuroendocrine tumors, large cell carcinoma from large cell neuroendocrine carcinoma, spindle cell/sarcomatoid carcinoma from sarcomatoid mesothelioma, and carcinoma from epithelioid mesothelioma in small biopsy specimens. It also discusses key features useful for differentiating usual interstitial pneumonia (UIP) pattern from non-UIP patterns of ILD such as hypersensitivity pneumonitis, nonspecific interstitial pneumonia, and organizing pneumonia patterns in wedge biopsy specimens as well as highlights the differential diagnosis in the granulomatous inflammation.  As a whole, this text answers many of the difficult questions relevant to daily practice of lung pathology. Each chapter addresses a specific diagnostic question significantly related to patients' treatment options. 

The second edition of this atlas focuses on imaging methods and techniques, new diagnostic concepts and therapeutic approaches in management of pancreatic neoplasms. Although interest in pancreatic pathology is very high in the radiological and gastroenterological communities, less is known about it than about, for example, liver pathology. Diagnosis depends on the structure of the pancreatic lesion, which can be directly visualized in US, CT or MR images.The book's focus is very much on the imaging and pathological appearances, with most of the text concentrated at the beginning of the book followed by images gallery. A comprehensive overview is provided of typical and atypical presentations and diverse aspects of common and rare pancreatic tumors, including ductal adenocarcinomas with dedicated chapter to ductal adenocarcinoma downstaging, neuroendocrine neoplasms, cystic pancreatic neoplasms and intraductal papillary mucinous neoplasms. The Verona "e;Pancreas Centre,"e; the first institute of its kind in Italy and one of very few in the world, pursues an interdisciplinary approach to treating the problems of this organ, focusing on the patient, on research, and on teaching. A dedicated center that can look back on 40 years of tradition, many of its respected specialists have made essential contributions in surgery, gastroenterology, oncology, pathology, and radiology. Given its scope, this atlas will be an invaluable asset, helping radiologists understand the underlying pathology and helping pancreatic pathologists understand the imaging translation.

This textbook provides an up-to-date overview of the most important parasites in humans and their potential vectors. For each parasite, the book offers a concise summary including its distribution, epidemiology, life cycle, morphology, clinical manifestations, diagnosis, prophylaxis and therapeutic measures. Numerous tables, diagrams and over 200 colorful illustrations highlight the main aspects of parasitic infestations and present suitable control measures. 60 questions help to test readers' theoretical knowledge of the field. In short, the book is highly recommended for anyone looking to delve into the field of human parasitology. It is intended for students of biology and human medicine, medical doctors, pharmacists and laboratory staff alike. Furthermore, persons who plan to visit or live longer in endemic regions will find essential information on necessary preventive and control measurements.

"Comprehensive up-to-date guide to clinical and diagnostic virology. Individual chapters cover viruses from A-Z, which are then grouped under syndromes. Liberal use of tables and algorithms enable quick access to key information. An ideal introduction for interested trainees and a practical reference for more experienced hospital clinicians and GPs"--

This expert volume in the Diagnostic Pathology series is an excellent resource for practitioners at all levels of experience and training. Covering all aspects of hospital autopsy in the way it is practiced clinically, this volume incorporates the most up-to-date scientific and technical knowledge to provide a comprehensive overview of all key issues relevant to today’s practice, helping pathologists accurately determine the cause and mechanism of in-hospital death. Richly illustrated and easy to use, Diagnostic Pathology: Hospital Autopsy, second edition, is a visually stunning, one-stop resource for every practicing pathologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource.Features complete coverage of every aspect of autopsy practice-including clinical presentation with chart review, technical and diagnostic aspects of autopsy performance, and reportingPresents classic autopsy techniques while also emphasizing the role of molecular studies and other laboratory and ancillary tests not commonly thought of during autopsy practiceContains new chapters on emerging pathogens and medical entities (deaths from COVID-19 or vaccine complications, multisystem inflammatory disorders in children, adenoviral hepatitis in children, and more), toxicity/pathology associated with new drug therapies (CAR-T, mRNA vaccine-related immune events, etc.), and new cardiac and other medical devicesFeatures new or updated content on morgue/autopsy suite maintenance, enhanced biosafety techniques, the role of the autopsy practitioner in a pandemic setting, and moreProvides important clinical and diagnostic information through more than 1,100 clinical and gross pathology photographs, histologic images, full-color illustrations, and radiologic imagesIncludes case presentations highlighting important aspects of reporting that impact clinicians as well as next of kinFocuses on pathologists in hospital settings, but also provides value to forensic pathologists, private practice pathologists, and others involved in death investigation, such as coroners, medical examiners, law enforcement, and pathology residentsEmploys consistently templated chapters, bulleted content, key facts, a variety of tables, annotated images, pertinent references, and an extensive index for quick, expert referenceIncludes an eBook version that enables you to access all text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. Any additional digital ancillary content may publish up to 6 weeks following the publication date.