Patologi

This book covers the wide set of well-regulated virulence factors and defense mechanisms of Pseudomonas aeruginosa focusing on stress responses and the evolution of this opportunistic human pathogen.Pseudomonas aeruginosa is responsible for one out of ten hospital infections.  Additionally, this Gram-negative bacterium is accountable for persistent infections in immunocompromised individuals and the leading cause of chronic lung infections in cystic fibrosis patients. This book provides insight on the metabolic versatility of Pseudomonas aeruginosa and its mechanisms for biofilm formation that make this organism highly efficient  in causing infections.  The book invites the readers to learn more about the intrinsic ability of Pseudomonas aeruginosa to resist a wide variety of antimicrobial agents due to the concerted action of multidrug efflux pumps, antibiotic-degrading enzymes, and the low permeability of bacterial cellular envelopes. Particular focus is put on the evolutionary role of different types of protein-secretion systems in pathogenesis, flagella and their role in chemotaxis and surface sensing, and host-pathogen interactions.This book is a useful introduction to the field for junior scientists interested in the biology and pathogenesis of Pseudomonas aeruginosa. It is also an interesting read for advanced scientists and medical specialists working within this field, providing a broader view of the topic beyond their specific area of specialization.

Das Therapiemanual stellt 7 Module zur prozessbasierten Behandlung der körperdysmorphen Störung (KDS) im Einzelsetting vor ¿ Adressaten sind psychologische und ärztliche Psychotherapeuten, Psychiater, psychosomatisch tätige Ärzte, Dermatologen, ästhetisch-plastische Chirurgen. Teil I des Buches gibt eine fundierte Einführung in Störungsbild, Ätiologie, Diagnostik, psychotherapeutische und medikamentöse Behandlung. Im Teil II wird praxisnah Schritt für Schritt die prozessbasierte Behandlung der KDS anhand evidenzbasierter Interventionen vorgestellt. Das Manual liefert wertvolle Anregungen, die die Behandlung der körperdysmorphen Störung individuell und sehr effektiv machen. Arbeitsblätter stehen im Buch und zum Download zur Verfügung. Aus dem Inhalt: Detaillierte Veranschaulichung prozessbasierter Interventionen ¿ Veränderung von Aufmerksamkeits- und Wahrnehmungsprozessen, Vorstellungsbildern, autobiografischen Erinnerungen, Kognitionen, Grundüberzeugungen, frühen maladaptiven Schemata bei KDS ¿ Zusatzmodule zu spezifischen Problembereichen (Wunsch nach ästhetisch-plastischer Chirurgie, Muskeldysmorphie, Skin Picking, Depression). Über das Autorenteam: PD Dr. Viktoria Ritter, wissenschaftliche Mitarbeiterin/Assistentin Goethe-Universität Frankfurt. Psychologische Psychotherapeutin, Verhaltenstherapie. Dozentin und Supervisorin in Aus- und Weiterbildung. Prof. Dr. Ulrich Stangier, Psychologischer Psychotherapeut. Lehrstuhlinhaber Klinische Psychologie und Psychotherapie Goethe-Universität Frankfurt. Leiter des Zentrums für Psychotherapie und des Ausbildungsprogramms für Psychologische Psychotherapie.

This book covers topical subjects within the field of death investigation, where changes in practice have recently occurred. The topics embrace the multi-disciplinary approach required for death investigation, and address advances in the fields of forensic fractography in relation to road traffic death investigations, pathology, MicroCt and 3D printing as applied to forensics. Chapters are written in a uniform easy-to-follow format to ensure they are accessible to both specialists and non-specialists in the field. Essentials of Autopsy Practice - Updates and Reviews to Aid Practice is a practical focused resource covering the latest advances in autopsy practice, making it an ideal resource for trainees, consultants, generalists and specialists, along with multi-disciplinary teams working in this field.

This new and updated edition provides an extensive overview of the antibodies employed in diagnostic tumor histopathology, and it presents concise summaries of the immunoprofiles of most tumors. Additionally, it offers practical diagnostic algorithms and invaluable tips to facilitate the interpretation of results.The work includes the newest available antibodies and the most recent 5th edition of the WHO classification of tumors. Furthermore, a chapter on biomarkers for theranostic applications has been added to enhance the book's utility. Designed as a practical and user-friendly bench reference for diagnostic tumor histopathology, this book is recommended to histopathologists of all levels, from aspiring residents to seasoned specialists seeking a reliable and comprehensive resource for tumor diagnostics. Moreover, it is highly recommended for oncologists, hematologists, and researchers involved in these fields.

The book covers 75 autopsy-based cases (about 75) of common and uncommon presentations of various cardiovascular diseases (CVDs). It emphasizes the importance of the autopsies, which have played a pivotal role in the understanding of the pathology and hence the clinical manifestations of several CVDs. The book attempts to present the material from the perspective of the autopsy table. It uses the clinical data as the initial framework and the autopsy findings to develop a true understanding of the disease and the associated pathophysiology of the condition with final clinico-pathological correlation. Each case covers a complete journey of the deceased patient concisely under the following headings-title, clinical history, autopsy findings and discussion, which includes a brief review of the literature. The text is accompanied by relevant high-quality macroscopic and microscopic images. The book is relevant for specialists in pathology, cardiology, cardiac surgery, internal medicine, critical care and pediatrics

'Will change your life' Chris Evans'Completely fascinating' Heston Blumenthal'Important and devastating' The TimesFrom a world-leading microbiome scientist and surgeon comes Dark Matter, a pioneering guide to hacking your microbiome for a healthier life.Our microbiome - the complex ecosystem of bacteria, viruses and other microbes inside us - is vital for our health and wellbeing. An invisible powerhouse whose potential we're only just beginning to understand, it influences our mood and appetite, determines how fast we run and even who we choose as a partner.In this ground-breaking book, microbiome expert Dr James Kinross takes us on a guided tour of our extraordinary inner universe and highlights the damage we inflict when we don't protect it. Showing through cutting-edge research and years of clinical experience, the practical steps we can all take to optimise the microbiome to live better, healthier lives.Now with a new, eye-opening afterword on the rise of home microbiome tests, IBS and FMTs. 'Addictive and illuminating' Dr Saliha Mahmood Ahmed, bestselling author of The Kitchen Prescription

Bacteria and fungi are able to aggregate together or on surfaces in densely packed microcolonies, facilitated by extracellular polymeric substances for cell protection and stability. These biofilms have proven to be extremely hard to eradicate and remove once established. In chronic infections, this condition can result in a high degree of morbidity and mortality as regular antibiotic treatments are ineffective against biofilms. In industrial facilities, the formation of biofilms can ruin production and result in enormous financial losses.In this book, the current state of antibiofilm research is presented by experts from around the world. Novel, cutting-edge techniques and new optimized strategies based on established methods are discussed in chapters focused on biofilm prevention, treatment and control for the application in clinical, industrial and veterinary settings.Antibiofilm strategies, such as chemical and enzymatic treatments, surface modification and coatings, quorum sensing inhibition and dispersal induction, phage therapy, cold plasma treatment, hyperbaric oxygen treatment, and metal-based nanomedicine are covered, among many others.This book contributes to the UN's Sustainable Development Goal 3: Good Health and Well-Being and is a valuable resource for healthcare professionals, microbiologists, academics and for educators to inform curricula of universities and colleges.

This fully updated volume serves as multidisciplinary compendium of approaches and techniques employed to analyze the role of different molecules, processes, or strategies used by different guests to survive and proliferate in their associations with eukaryotic hosts. Beginning with animal-pathogen interactions, the book then continues with chapters exploring virus-host interactions, plant-microbe interactions, as well as different molecular techniques that were initially applied to non-pathogenic interactions but can be adapted to study other host-pathogen associations. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips for troubleshooting and avoiding known pitfalls.Authoritative and up-to-date, Host-Pathogen Interactions: Methods and Protocols, Second Edition contributes to the study of host-pathogen interactions with numerous techniques that can be used in a variety of bacteria.

Advances in Antiparasitic Therapies and Drug Delivery systematically discusses the fundamentals, principles, and methods of molecular mixing and reaction process intensification. The book demonstrates, in detail, the implementation approach, process, and effectiveness of Higee chemical reaction engineering through novel industrial case studies that help industrial technicians to select reaction intensification technology route more scientifically. Sections cover the innovation and development process of Higee chemical reaction engineering, hydrodynamics behavior in Higee reactors, equipment design principles and methods, multiphase reaction of liquid-liquid, gas-liquid, gas-solid, gas-liquid-solid and reactive crystallization process intensification principles and effectiveness. The book is a systematic summary of several national award and key projects, such as the State Technological Innovation Award, State Science and Technology Advancement Award, National Natural Science Foundation of China, National key R&D Program of China, National ''863'' Program of China, National ''973'' Program of China and also some international cooperation.

Learn all the microbiology and basic immunology concepts you need to know for your courses and exams. Now fully revised and updated, Mims' clinically relevant, systems-based approach and abundant colour illustrations make this complex subject easy to understand and remember. Learn about infections in the context of major body systems and understand why these are environments in which microbes can establish themselves, flourish, and give rise to pathologic changes. This systems-based approach to microbiology employs integrated and case-based teaching that places the 'bug parade' into a clinical context. Effectively review for problem-based courses with the help of chapter introductions and 'Lessons in Microbiology' text boxes that highlight the clinical relevance of the material, offer easy access to key concepts, and provide valuable review tools. Approach microbiology by body system or by pathogen through the accompanying electronic 'Pathogen Parade' - a quickly searchable, cross-referenced glossary of viruses, bacteria and fungi A new electronic 'Vaccine Parade' offers quick-reference coverage of the most commonly used vaccines in current clinical practice Deepen your understanding of epidemiology and the important role it plays in providing evidence-based identification of key risk factors for disease and targets for preventative medicine. Grasp and retain vital concepts easily, with a user-friendly colour coded format, succinct text, key concept boxes, and dynamic illustrations. New and enhanced information reflects the growing importance of the human microbiota and latest molecular approaches Access the complete contents on the go via the accompanying interactive eBook, with a range of bonus materials to enhance learning and retention - includes self-assessment materials and clinical cases to check your understanding and aid exam preparation.

Intelligent Packaging: Current Technologies and Applications, Volume Six in the Developments in Food Quality and Safety series is the most up-to-date resource on topics such as Advances in the analysis of toxic compounds and control of food poisoning; Food fraud, traceability and authenticity; Revalorization of agrifood industry; Natural antimicrobial compounds and application to improve the preservation of food; Non-thermal processing technologies in the food industry; Nanotechnology in food production; and Intelligent packaging and sensors. This updated volume covers intelligent packaging by discussing the aspects of emerging technologies and strategies to obtain such packaging relevant to the development of traceable food products. Topics such as indicators, sensors, tracing devices, and intelligent packaging used in various food products, such as dairy, meat, fruits and vegetables are also explored. The series is edited by Dr. José Manuel Lorenzo and authored by a team of global experts in the fields of Food Quality and Safety, providing comprehensive knowledge to food industry personals and scientists.

Dieses Fachbuch für Psychotherapeuten und Gruppentherapeuten regt den Leser, die Leserin entlang des eigenen Lebenslaufs an, eigene Gruppenerfahrungen neu zu reflektieren ¿ und diese Einsichten in Beziehung zu Therapieprozessen zu setzen. Psychisches Leben und persönliche Entwicklung entsteht immer in Netzwerken. Analytische Gruppentherapie nutzt dies und macht psychische Vorgänge sichtbar, die in Einzelbehandlungen zu oft unklar bleiben. Unser Bild der psychischen Entwicklung des Menschen wandelt sich angesichts neurowissenschaftlicher Erkenntnisse und vor dem Hintergrund komplexer gesellschaftlicher Herausforderungen unserer Zeit in ein Bild des Menschen als Social Animal. Wir sehen einen Aufschwung für die Gruppentherapie und eine Öffnung gegenüber Theorien, die unsere gegenseitige Abhängigkeit in einem positiven Sinn betonen. Zusammengehörigkeit und Solidarität können so gemeinschaftlich eingeübt werden und transformatorische Kraft für Veränderung beim Einzelnen, aber auch für dieGesellschaft entfalten. Viele lebensnahe Beispiele vor allem aus therapeutischen Gruppen illustrieren dies. Geschrieben für:Psychotherapeut*innen, Gruppenpsychotherapeut*innen, Gruppenleiter*innen im medizinischen und sozialen Bereich.Über den Autor: Dipl. Psych. Volker Münch, Psychologischer Psychotherapeut in eigener Praxis in München. Lehranalytiker, Supervisor und Dozent an der MAP, München. Veröffentlichungen zu den Themen Therapeutische Haltung, Digitalisierung, Krise in der Lebensmitte.