Medicinsk toksikologi

Arsenic contamination in drinking water and associated adverse outcomes is one of the major health issues in more than 50 countries worldwide. The scenario is getting even more detrimental with increasing number of affected people and newer sites reported from all over the world. Apart from drinking water, the presence of arsenic has been found in various other dietary sources. Threatening the health of millions of people due to arsenic¿s toxicity and carcinogenicity, the major routes of arsenic exposure for humans are either through drinking water or crops. This edited volume brings together a diverse group of environmental science, sustainability, and health researchers to address the challenges posed by global mass poisoning caused by arsenic water contamination. The book sheds light on this global environmental issue and proposes solutions to aquatic contamination through multi-disciplinary sustainable approaches and case studies from different parts of world. This book addresses the problem of arsenic by pursuing a holistic approach. It presents the status quo in different parts of the world and provides essential information on food-related arsenic exposure risks for humans and possible preventive and curative measures for tackling arsenic poisoning. The mechanisms of arsenic uptake, translocation, and distribution in plants and grains are also explained. In closing, the book reviews a variety of prospective sustainable solutions to the problem of arsenic accumulation in soil and water.The book comprises three sections. First section describes the routes of exposure to environmental arsenic and its transport in soil and aquatic ecosystems including its source and distribution in specific locations. Second section explains the health risks linked to arsenic exposure in food and the environment. Third section addresses sustainable arsenic contamination mitigation strategies using the potential applications of recent biotechnological techniques, bioremediation, phytoremediation, genetic engineering, nanotechnology, and in silico approaches.The book is intended for a broad audience including researchers, scientists, and readers with diverse backgrounds including agriculture, environmental science, food science, environmental management, and human health. It can also be used as an important reference guide for undergraduate and graduate students, university faculties, and environmentalists. The book may serve as a reference to environment and sustainability researchers, students, and policy makers.

Hypoxia refers to a type of condition in which the entire or a part of the body does not receive enough supply of oxygen at the tissue level. Its symptoms include difficulty in breathing, bluish skin, disorientation, a rapid heartbeat and agitation. The underlying illnesses which affect breathing and blood flow, resulting in hypoxia are asthma, emphysema, pneumothorax, sleep apnea, anemia, pulmonary edema and congestive heart failure. There are several ways to diagnose hypoxia, such as arterial blood gas test (ABG), six-minute walk test (6MWT), pulse oximetry, pulmonary function test (PFT), etc. Hypoxic condition can be treated by administering oxygen. It involves various equipments that can be used for inhaling oxygen such as non-rebreather masks, transport ventilators, nasal cannula, bag valve masks and simple oxygen facemasks. This book provides significant information to help develop a good understanding of hypoxia. It aims to understand the clinical perspectives of this medical condition. The readers would gain knowledge that would broaden their perspective in this area of study.

Medical toxicology is a branch of medicine that focuses on toxicity and treatment of poisoning and other harmful effects caused by drugs, occupational and environmental toxins, and biological agents. The drug intake may be unintentional or intentional. It may include overdoses of antidepressants, cardiac medications, addictive agents such as alcohol, and drugs of abuse. Exposure to industrial chemical products and environmental hazards encompass pesticides, heavy metals, household products, toxic gases, toxic alcohol, and other industrial and environmental agents such as radiation exposures. The diagnosis and management of snake, scorpion and spider envenomation, marine toxins, food-borne toxins, and ingestion of toxic plants are all included in medical toxicology. This book is a valuable compilation of topics, ranging from the basic to the most recent developments in field of medical toxicology. Also included herein is a detailed explanation of the various concepts and applications of this field. Scientists and students actively engaged in the field of medical toxicology will find this book full of crucial and unexplored concepts.

Hypoxia is referred to as the condition of low oxygen level and it occurs naturally in high altitudes. As the altitude rises, total atmospheric pressure falls down and causes a lower partial pressure of oxygen causing hypobaric hypoxia. The humans have adjusted themselves to hypoxia that occurs at high altitude in various locations, which is possible due to genetic basis. The genetic signatures of certain populations are recognized in the hypoxia-inducible factor (HIF) pathway, responsible for the organization of transcriptional response to hypoxia. These genetic signatures are found in the HIF2A gene in Tibetans, which encodes for the prolyl hydroxylase domain protein 2 and HIF-2α gene. Adaptation to high altitude is the result of various genes that act in coordination with each other. Novel therapeutic approaches can be identified by unraveling the mechanisms of these genes. This book provides comprehensive insights on hypoxia. It will help the readers in keeping pace with the rapid developments in the study of human adaptation to hypoxia.

The book provides an overview of different nanoparticles, their classification, and their applications in healthcare, food sciences, environmental sciences, and agricultural sciences. The introductory chapters discuss different types of nanoparticles, their types, and their structural properties. The subsequent chapter examines factors that influence the biocompatibility and toxicity of NPs for the safe and sustainable development of emerging nanoparticles. The chapter systematically reviews the nanoparticle-based contrast agents employed in most common biomedical imaging modalities. The book further examines the applications of advanced nanoparticle design that are utilized for both non-personalized and precision applications for improving precision therapies. The book provides a comprehensive update on nanoparticles¿ toxic effects, the factors underlying their toxicity, and the mechanisms by which toxicity is induced. This book is an ideal guide for researchers and students interested in understanding the applications of nanoparticles in biomedical sciences and the healthcare sector.

Microplastics and nanoplastics have been recently found in most environmental media and in living organisms, thus representing a serious health concern of yet poorly known adverse consequences. This book summarizes recent findings on the sources, behavior, transformation, toxicity and remediation of microplastics, with focus on soils, water, wastewater, air, soils, plants and corals. Advanced methods for sampling, characterization, removal and degradation of microplastics.

"Veterinary Toxicology, in recent years, has acquired greater importance than ever before because of increasing and indiscriminate use of farm chemicals and drugs accompanied by rapid degrading impact of environmental pollution on health of animals. The indiscriminate feeding habits of domestic animals especially in developing countries make them more prone to the impact of natural toxicants especially Phytotoxins and Mycotoxins. Toxicology has been recognized as a separate discipline in veterinary sciences both at undergraduate and post graduate levels for the last four decades and a lot of emphasis has been given on its teaching, research and practical utility from clinical point of view. The book has been prepared in a most comprehensive manner with up-to date reference which offers invaluable, clinically oriented guidance on numerous potentially toxic substances. In addition, to covering traditional and non-traditional areas of toxicology it provides a wealth of quick reference charts and tables that put vital information at your finger tips in seconds

Public Health and Toxicology Issues in Drug Research: Toxicity and Toxicodynamics, Volume Two examines implications on public health and the impact of pharmaceuticals, chemical and food toxicants, dietary phytochemicals, and medical treatments. The book cover topics on pharmacokinetics and toxicokinetics, such as population pharmacokinetics/toxicokinetics, the design of toxicokinetic studies, and the use of toxicokinetic data in preclinical safety assessments. In addition, it investigates the health effect caused by the bioaccumulation of pharmaceutical and personal care products and the impact of drug-induced toxicity on different systems of the body. Final sections discuss the mechanistic pathways of food toxicants and illustrate the molecular mechanisms of the chemopreventive role of dietary phytochemicals. Ethical, legal, societal, and professional issues in toxicology round off coverage, making this a valuable resource for anyone interested in learning more about the health impact and public health issues related to the toxicity of pharmaceuticals, dietary supplements, personal care products, and medical treatments.

With contributions from world-leading scientists in each field, this book descries state-of-the-art, emerging issues and recent analytical approaches to hair analysis which will serve as an essential tool to clinical and forensic toxicology laboratories across the globe.

This book highlights the application of microfluidics in cell biology research, chemical biology, and drug discovery. It covers the recent breakthroughs and prospects of organ-on-a-chip, human-on-a-chip, multi-organ-on-a-chip for personalized medicine. The book presents the preclinical studies of organs-on-a-chip, concepts of multiple vascularized organ-on-chips, application of organ-on-a-chip in blood-brain barrier model, culture and co-culture of cells on multi-organ-on-chip and parameter measurements in microfluidic devices.  It underscores the advantage of microfluidic devices for developing efficient drug carrier particles, cell-free protein synthesis systems, and rapid techniques for direct drug screening.  Further, it entails human-on-a-chip for measuring the systemic response as well as immediate effects of an organ reaction on other organs. In summary, this book reviews the development of a microfluidic-based organ-on-a-chip device for the preclinical evaluation, ADME studies of drugs, chemicals, and medical devices. This book is a valuable source for pharma companies, product developers, students, researchers, academicians, and practitioners.

This detailed volume examines the complex study of the assessment of in situ bioavailability and toxicity of organic chemicals in aquatic systems with a toolbox of reliable techniques. Beginning with a section on approaches for chemical analytical and bioanalytical techniques in bioavailability research, the book continues with methods to monitor effects in situ and conduct bioassays to assess the effects of complex environmental samples. It concludes with descriptions of various computational models. Written for the Methods in Pharmacology and Toxicology series, chapters feature the kind of expert implementation advice that leads to greater success in the field. Authoritative and versatile, In Situ Bioavailability and Toxicity of Organic Chemicals in Aquatic Systems serves as an ideal guide to aid in tackling the challenge of analyzing and understanding chemical pollution in aquatic systems.

Effective drug delivery systems are essential in maximizing the therapeutic effects of the drugs in question. This book thoroughly analyses recent technological advances in new, nanomaterial-based drug delivery systems for the diagnosis and treatment of various diseases. These systems also have diverse applications in pharmaceutical, biomedical, biomaterial, and biotechnological fields. This book explains the different types of nanocarriers currently in development and covers both therapeutic and theranostic applications of drug-loaded nanocarriers and nanomedicine.Clinical research professionals, industrial pharmaceutical scientists, and veteran drug delivery developers benefit from the unique structure of this book, making it essential for the drug delivery researcher. Students, research scholars, and industrial professionals alike benefit from the current technological advancements, regulatory aspects, and the history of discovery and development in the field of nanomedicine presented in this book.

This book discusses a wide range of health-related mining issues, with particular reference to occupational diseases, metal toxicity, postural injuries in miners, modern fire safety controls, noise-induced hearing loss prevention, and noise mapping. Mining plays a central role in the development of modern civilization. By providing the essential raw materials, mining ensures progress, safety, and comfort of people. However, this necessary activity comes with several woes, the most important of which are occupational health hazards. Mines act as sources of constant danger and risk to the miners irrespective of the scale of mining, such as large-scale industrial mining or small-scale artisanal mining. Not only are there accidents, but continuous exposure to dust, metal toxicity, hazardous gases and fumes, and loud noises, giving rise to a variety of diseases to mine workers. The comprehensive coverage of issues and the case studies will make this book an essential reference and critical reading. Medical geology is a necessary discipline in earth sciences. Unfortunately, not much literature is available on this subject. Therefore, this book is essential for practicing engineers and supervisors in mines, health and safety professionals, researchers, and mining industry students.

This book provides an overview of Data Monitoring Committees(DMC) - what was done in the past, what is currently being done, and thoughts on improvements for the future. Previous works focused primarily on large cardiovascular studies (where DMCs originated more than 30 years ago) but updated references are needed that discuss smaller, more flexible studies in areas such as oncology. The authors have attended ~800 DMC meetings from ~200 distinct studies across all areas of clinical studies (oncology, rheumatology, rare diseases, cardiology, immunology, etc.) This wide range of expertise will be used, as well as the expertise that comes from working with virtually every large biotechnology and pharmaceutical company and CRO for DMC work. The reader of the book will know when DMCs are needed or helpful, how to form the DMC, how to work with external CROs and with sponsor teams and the DMC to create needed DMC outputs, how the DMC meetings are conducted, and - especially for DMC members - what are considerations within the Closed Session to review safety/efficacy outputs to assess risk/benefit to make appropriate recommendations that protect the patient safety and trial integrity.This is a practical hands-on book on how to decide if a DMC is necessary, how to form the DMC, how to expertly create the necessary materials for the DMC and have smooth running DMC meetings. There is no specialized training in school about how DMCs work - frequently people may have been in industry for many years without ever needing to work with a DMC. This book is the helpful reference for those new to these DMCs. The DMC work is critical to be correctly implemented as the impact of DMC activity on safeguarding the trial is so important.This book provides the following:Provides thorough instructions on the steps needed to form and implement a Data Monitoring Committee for clinical trial evaluation;Includes practical and hands-on information on DMC implementation;Discusses a wide range of clinical trial ¿ by phase and therapeutic area.

This book provides an authoritative overview of botulinum neurotoxin (BoNT) treatment menus for 16 pain categories with an evidence-based literature review on each pain disorder, illustrative figures showing anatomy and techniquesIntroductory chapters cover basic information about the mechanism, function and the analgesic effects of the BoNTs based on the data derived from animal studies. Clinical chapters define pain in conditions such as post-herpetic and post-traumatic neuralgias, plantar fasciitis, low back pain, post-surgical pain syndromes and migraine in detail, provide discussion of current modes of treatment and updated information on BoNT therapy. Each chapter also includes illustrative case histories. The new edition is updated with all the new findings since the explosion in research and literature since 2015. New chapters on the history and pain in dentistry round out the update.Botulinum Toxin Treatment of Pain Disorders provides an invaluable resource for clinicians and researchers involved in the treatment of pain disorders including neurologists, pain medicine specialists, anesthesiologists, internists, those conducting research in pharmacology and toxicology as well as students in these areas.

A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Third Edition is a valuable reference providing a complete understanding of all aspects of nonclinical toxicology in pharmaceutical research. This updated edition has been expanded and re-developed covering a wide-range of toxicological issues in small molecules and biologics. Topics include ADME in drug discovery, pharmacokinetics, toxicokinetics, formulations, and genetic toxicology testing. The book has been thoroughly updated throughout to reflect the latest scientific advances and includes new information on antiviral drugs, anti-diabetic drugs, immunotherapy, and a discussion on post-pandemic drug development challenges and opportunities. This is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings.

This book focuses on the topic of ecotoxicology of aquatic macrophytes and is wide ranging, including the use of macrophytes for remediation of contaminated sites. Many human activities are threats to the equilibrium of natural ecosystems. Pollution from point and non-point sources can be assessed using a variety of techniques, such as biomonitoring, biomarkers and biosensors. In aquatic ecosystems, biomonitoring of pollutants is mostly conducted by analysis of the tissues of invertebrates and fishes, and biomarker studies are also more widely applied to animals rather than in plants. Aquatic macrophytes occupy a key niche in aquatic ecosystems and provide a range of ecosystem services. In addition to their role in primary production, vegetation plays a key role in the cycling and retention of nutrients and generally acts as a sink for pollutants. Therefore, because of their importance to aquatic ecosystems, more attention should be paid to understanding the fate of pollutants and to developing methods to evaluate the health status of macrophytic plants in freshwater, marine and estuarine environments.

"e;Doubt is our product,"e; a cigarette executive once observed, "e;since it is the best means of competing with the 'body of fact' that exists in the minds of the general public. It is also the means of establishing a controversy."e;In this eye-opening expose, David Michaels reveals how the tobacco industry's duplicitous tactics spawned a multimillion dollar industry that is dismantling public health safeguards. Product defense consultants, he argues, have increasingly skewed the scientific literature, manufactured and magnified scientific uncertainty, and influenced policy decisions to the advantage of polluters and the manufacturers of dangerous products. To keep the public confused about the hazards posed by global warming, second-hand smoke, asbestos, lead, plastics, and many other toxic materials, industry executives have hired unscrupulous scientists and lobbyists to dispute scientific evidence about health risks. In doing so, they have not only delayed action on specific hazards, but they have constructed barriers to make it harder for lawmakers, government agencies, and courts to respond to future threats. The Orwellian strategy of dismissing research conducted by the scientific community as "e;junk science"e; and elevating science conducted by product defense specialists to "e;sound science"e; status also creates confusion about the very nature of scientific inquiry and undermines the public's confidence in science's ability to address public health and environmental concerns Such reckless practices have long existed, but Michaels argues that the Bush administration deepened the dysfunction by virtually handing over regulatory agencies to the very corporate powers whose products and behavior they are charged with overseeing. In Doubt Is Their Product Michaels proves, beyond a doubt, that our regulatory system has been broken. He offers concrete, workable suggestions for how it can be restored by taking the politics out of science and ensuring that concern for public safety, rather than private profits, guides our regulatory policy. Named one of the best Sci-Tech books of 2008 by Library Journal!

Since its advent, nanotechnologies are considered key enabling technologies that take advantage of a wide array of nanomaterials (NMs) for biomedical and industrial applications generating significant societal and economic benefits. However, such innovation increases human exposure to these substances through inhalation, ingestion or dermal contact raising public health concerns. Furthermore, the NMs' specific physicochemical properties, that confer them unique beneficial characteristics, can also elicit nano-bio interactions leading to toxicity and concerns for public health. In addition, such properties can be affected by the surrounding matrix, particularly when incorporated in complex matrices such as food products, leading to secondary features potentially more relevant than primary characteristics for determining their toxicological outcome. These nano specific issues raise the question of whether the NMs may produce adverse outcomes that are not accounted for when using conventional toxicological approaches to assess their safety.Such uncertainties about the safety of NMs for human health and the environment may hamper a faster and more widespread exploration of their potentials. In response, the NMs definition has evolved, and nanotoxicology has developed towards new and more integrative approach methods to support regulatory and policy actions.This book provides a perspective on recent developments in the synthesis, application, and characterization of NMs and the related nanotechnologies, focusing on nanotoxicology for their accurate safety assessment early in the product development stage. The use of complex in vitro models, including multicellular systems and organoids, and "e;omics-based"e; approaches, such as transcriptomics or epigenomics, have greatly contributed to an in-depth understanding of the cellular and molecular mechanisms behind some NMs toxicity. Such mechanistic knowledge is equally addressed in this book and has set the basis for a predictive nanotoxicology approach building on adverse outcome pathways. In addition, considering the knowledge provided by the above-mentioned approaches, insights into risk assessment, standardization, and regulation of NMs are also included.Incorporating adequate nanosafety assessment early in the life-cycle of NMs will allow the implementation of the safe and sustainable-by-design paradigm enabling safety to keep pace with innovation.Chapters 10 and 15 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

This book presents a comprehensive view on mycotoxins of agricultural as well as non-agricultural environments and their health effects in humans and animals. Mycotoxins have immunosuppressive effects; but some of them can cause cancers, mutagenicity, neurotoxicity, liver and kidney damage, birth defects, DNA damage and respiratory disorders. The problem of mycotoxins is long-lasting and their direct or indirect exposures to humans and animals must be further discussed. The first chapter will cover the historical perspective of mycotoxins along with timeline while the second one will provide overview including classification of mycotoxins and mycotoxicoses. The comprehensive information/ literature on traditional, emerging and mushroom mycotoxins will be given in chapters 3, 4 and 5 respectively. Chapter 6 will deal with mycotoxins co-occurrence poisoning whereas new and masked mycotoxins will be described in chapter 7. The important aspects of mycotoxin studies like extraction, characterization and analysis and management strategies will be summarized in 8 and 9 chapters. The last chapter of the book will cover the recent developments in toxicokinetic studies of mycotoxins. The book will have the most up-to-date information and recent discoveries to deliver accurate data and to illustrate essential points to a wide range of readers including mycologists, clinicians, agricultural scientists, chemists, veterinarians, environmentalists and food scientists.

Efforts are being made by research organizations and cosmetic industries worldwide to develop more precise and targeted 3D models that mimic humans for testing cosmetic and personal health care product ingredients, following a complete ban on animal testing. This book includes several subtopics dedicated to the progress made, challenges faced, roadblocks encountered, and future prospects in the development and validation of 3D models for testing these products. The book consist of an editorial and 14 themed chapters that will showcase the significant progress made so far, challenges encountered, and future prospects in the development of 3D reconstruct models.

This book intends to report the new results of the study of bacteriocins, from basic research to application fields. It mainly introduces the biological characteristics of bacteriocins, the relationship between their structure and function, the antibacterial mode of action, and their application as antibacterial agents in food industry, medical care, and other areas, especially their application potential in human health. This book can be used as a reference book for researchers, undergraduates, and graduated students in the professional fields of food science and engineering, bioengineering, medicine, and agriculture.