Billeddiagnostik

This contributed volume focuses on cardiovascular diseases (CVDs), and explores the ways in which signaling mechanisms at the biochemical, molecular, and cellular levels in the blood vessels (vascular) and heart contribute to the underlying causes of development and progression of the CVDs. This volume covers unique topics such as oxidant signaling in vascular and heart diseases and health, cytoskeletal signaling in vascular health and disease, phospholipase signaling in CVDs, lipid signaling in vascular and myocardial health and diseases, and drug discovery in cellular signaling for cardiovascular diseases.This book assembles the most important discoveries made by leaders on the cellular signaling mechanisms operating behind the development and progression of life-threatening CVDs. It is an extremely useful resource for the investigators in the field of CVDs, and opens the discussion for further discovery of efficient management and effective treatment of the CVDs.

Artificial Intelligence has revolutionised areas of medicine. This book focuses on the integral role of AI in radiology, shedding light on how this technology can enhance patient care and streamline professional workflows.

This book systematically covers diagnostic imaging of lung cancers, including epithelial tumors, mesenchymal tumors, and hematolymphoid tumors, with emphasis on relationship between classification, molecular pathology, clinical findings, imaging manifestations and pathological discussion. In each chapter, selective cases and wealthy of typical illustrations are presented for helping readers to have an in-depth understanding of key points in differential diagnosis of different types of lung cancers. It will be an ideal reference for physicians involved in the diagnosis and treatment of lung cancers.

This richly illustrated and superbly organized text/atlas is an excellent point-of-care resource for practitioners at all levels of experience and training. Written by global leaders in the field, Imaging Anatomy: Head and Neck, second edition, provides a thorough understanding of the detailed normal anatomy that underlies contemporary imaging. This must-have reference employs a templated, highly formatted design; concise, bulleted text; and state-of- the-art images throughout that identify the clinical entities in each anatomic area, offering a unique opportunity to master the fundamentals of normal anatomy and accurately and efficiently recognize pathologic conditions. Features hundreds of detailed, full-color illustrations and more than 900 high-resolution, cross-sectional radiologic images that together illustrate the fine points of imaging anatomy for new and experienced head and neck imaging specialists Contains new chapters on external nose anatomy, the facial nerve in temporal bone, minor fissures and sutures around the temporal bone, and temporal bone anatomy on photon-counting detector (PCD) CT Provides updated, enlarged images and captions in areas such as facial muscles and the superficial musculoaponeurotic system, and frontal recess and related air cells Includes extensive new content on PCD CT; new details on relatively unknown anatomical foramina, such as the vomerovaginal canal and canaliculus innominatus; new content based on the International Frontal Sinus Anatomy Classification; and minute details on the course of nerves in the head and neck Includes a series of successive imaging slices in each standard plane of imaging (coronal, sagittal, and axial) to provide multiple views that further support learning Depicts common anatomic variants and covers the common pathological processes that manifest with alterations of normal anatomic landmarks Reflects new understandings of anatomy due to ongoing anatomic research as well as new, advanced imaging techniques Presents essential text in an easy-to-digest, bulleted format, enabling imaging specialists to find quick answers to anatomy questions encountered in daily practice Includes an eBook version that enables you to access all text, figures, and references with the ability to search, customize your content, make notes and highlights, and have content read aloud. Any additional digital ancillary content may publish up to 6 weeks following the publication date

Fluorescence Molecular Tomography: Principles and Applications is the first book to cover the underlying principles and practical applications of fluorescence molecular tomography (FMT) in a systematic manner. Using a tutorial approach, the text begins with an overview of the fundamentals of FMT and goes on to detail image reconstruction approaches (including linear and nonlinear reconstruction algorithms), FMT instrumentations (including time-domain, frequency-domain, and continuous-wave domain systems), and implementation of image-enhancing schemes (including both software and hardware approaches). Further chapters examine multimodal approaches combining photoacoustic tomography (PAT), computed tomography (CT), single-photon emission tomography (SPECT), and magnetic resonance imaging (MRI) and discuss bioluminescence tomography and miniaturized FMT from hand-held to endoscopic FMT. A final chapter looks at clinical applications and animal studies. This authoritative and practical guide will serve as a valuable reference for researchers, scientists, clinicians, and industry professionals.The first book dedicated to fluorescence molecular tomography (FMT); Covers underlying principles and practical applications; Written by a leading FMT research pioneer and expert.

This book is a multidisciplinary guide to head and neck cancer.Head and neck cancer remains one of the most technically complex cancer subsites to manage. This field involves highly specialized, multidisciplinary management and collaboration amongst surgeons, radiation oncologists, medical oncologists, radiologists, pathologists, and other health disciplines. The clinical and research landscape for head and neck oncology continues to evolve at a rapid pace.This multidisciplinary book provides the latest updates in the contemporary understanding and management of these tumors. The text incorporates updates in surgical techniques (minimally invasive and robotic techniques, reconstructive approaches), radiation medicine (new data on dose and fields, oligometastatic/oligoprogressive disease, retreatment), medical oncology (targeted, immunotherapy and molecular agents), in addition to other overarching topics such as side effects, biomarkers/nanotechnology, and epidemiology. Written by experts in their respective fields, chapters include the most up to date scientific and clinical information with perspectives from each relevant subspeciality. These sections are concise and accessible, yet comprehensive. Palliative medicine, pathologic and imaging principles, and health systems/economics considerations are also described.This book is an ideal resource for clinicians, trainees, and researchers dealing with, and interested in, this challenging malignancy. 

The purpose of this atlas is to illustrate how to achieve reliable diagnoses when confronted by the different abnormalities, or ¿disease patterns¿, that may be visualized on CT scans of the chest. The task of pattern recognition has been greatly facilitated by the advent of high-technology CT such as helical and multidetector CT (MDCT) and dual-energy CT (DECT), and the focus of the book is very much on the role of state-of-the-art MDCT. A wide range of disease patterns and distributions are covered, with emphasis on the typical imaging characteristics of the various focal and diffuse lung diseases. In addition, clinical information relevant to differential diagnosis is provided and the underlying gross and microscopic pathology is depicted, permitting CT¿pathology correlation. The entire information relevant to each disease pattern is also tabulated for ease of reference. This book will be an invaluable handy tool that will enable the reader to quickly and easily reach a diagnosis appropriate to the pattern of lung abnormality identified on CT scans. And in this second edition, some more signs and several new diseases and their pattern have been developed and updated. They will be provided with imaging, clinical relevance and CT-pathology correlation. Moreover, the chapters and disease patterns in their order of presentation shall be somewhat changed for readers¿ easy legibility and understanding.

This book provides a detailed description of typical imaging features of bone tumors and tumor-like lesions in the wrist, hand, ankle and foot. Each chapter deals with one major bone tumor or tumor-like lesions, for example, chondroma, enchondroma, gout, giant cell tumors, lymphoma, osteosarcoma, bone metastases, etc. Typical cases are carefully selected from thousands of clinical cases accompanying with comprehensive imaging information of X-ray, CT and MRI. In-depth analysis and differential diagnostic tips from experienced bone tumour specialists is presented at the end of each chapter. This book will be useful and worthy to musculoskeletal radiologists, orthopaedic surgeons, general radiologists, and oncologists.

Computational and Network Modeling of Neuroimaging Data provides an authoritative and comprehensive overview of the many diverse modeling approaches that have been fruitfully applied to neuroimaging data. As neuroimaging is witnessing a massive increase in the quality and quantity of data being acquired, this book gives an accessible foundation to the field of computational neuroimaging, suitable for graduate students, academic researchers, and industry practitioners who are interested in adopting or applying model-based approaches in neuroimaging. It is widely recognized that effective interpretation and extraction of information from complex data requires quantitative modeling. However, modeling the brain comes in many diverse forms, with different research communities tackling different brain systems, different spatial and temporal scales, and different aspects of brain structure and function. This book takes a critical step towards synthesizing and integrating across different modeling approaches.

The aim of this book is to present new computational techniques and methodologies for the analysis of the clinical, epidemiological and public health aspects of SARS-CoV-2 and COVID-19 pandemic. The book presents the use of soft computing techniques such as machine learning algorithms for analysis of the epidemiological aspects of the SARS-CoV-2. This book clearly explains novel computational image processing algorithms for the detection of COVID-19 lesions in lung CT and X-ray images. It explores various computational methods for computerized analysis of the SARS-CoV-2 infection including severity assessment. The book provides a detailed description of the algorithms which can potentially aid in mass screening of SARS-CoV-2 infected cases. Finally the book also explains the conventional epidemiological models and machine learning techniques for the prediction of the course of the COVID-19 epidemic. It also provides real life examples through case studies. The book is intended for biomedical engineers, mathematicians, postgraduate students; researchers; medical scientists working on identifying and tracking infectious diseases.

This book, written by internationally renowned experts, is a comprehensive text covering all aspects and recommendations regarding the use of POCUS for critically ill neonates and children. Point of Care Ultrasound (POCUS) for the Neonatal and Pediatric Intensivist is structured to address and expand upon recently published international evidence-based POCUS guidelines endorsed by the European Society of Paediatric and Neonatal Intensive Care (ESPNIC).The book is richly illustrated and includes a robust collection of individual POCUS images and cases. The Electronic Supplementary Materials offer high quality and interesting video clips complementing reader learning, particularly for neonatology, pediatric critical care, and general pediatric providers. Chapter authors provide a practical, experience-based approach to clinical integration of POCUS applications and highlight relevant supportive literature as well as important limitations to POCUS use in the management of critically ill children. The information within the book is also intended to support further clinical and educational research in the practice of pediatric POCUS.

Performing any diagnostic test in medicine is always a matter of trying to get the condition of the patient diagnosed properly with the least effort, exposure, discomfort and at the same time with the lowest possible error probability.Pre-test probability is helpful but often imprecise, effectively overestimating the patient's risk profile. In a broader prevention objective, the phases of a disease, its onset, progression, and complications must be taken into account. The negative predictive value, which is so important, has in turn its main limitation in identifying the healthy patient, that is, the one who does not belong to any cluster of patients in which we would act in terms of prevention. In coronary syndromes, the goal is instead to evaluate coronary heart disease, from mild to more extensive and significant forms. For this purpose, it is necessary to use parameters that investigate different and complementary aspects: stenosis, ischemia, the morphology of the atherosclerotic plaque, metabolic processes, in particular vitality and apoptosis, the presence of inflammatory processes. The possibility, already present thanks to Hybrid Imaging, of 'joining' exams that study different aspects, will allow the patient to be increasingly characterized not only from a diagnostic point of view but also from a prognostic and personalized therapeutic choice.

The book examines recent developments in regenerative medicine and the use of musculoskeletal ultrasound. Musculoskeletal regeneration has become a prominent research topic, no doubt due to the sociological and economic pressures imposed by the current ageing population. The ever expanding role of regenerative medicine and the identification as well as characterization of stem cells have introduced a major paradigm shift in the field of musculoskeletal and sports medicine as well as orthopaedic surgery. Whereas in the past, diseased tissue was replaced with allograft material, current trends in research revolve around regenerating damaged tissue.Specifically, regenerative medicine stands in contrast to the standard treatment modalities which impair the body's natural abilities to facilitate endogenous repair mechanisms such as anti-inflammatory drugs; or destructive modalities (e.g., radiotherapy, nerve ablation, injections of botulinum toxin) and surgical interventions that permanently alter the functioning of a joint, bone or spine. When compared to other allopathic options (including knee and hip arthroplasty with a 90-day mortality rate of 0.7%), regenerative medicine treatment modalities have a lower incidence of adverse events with a growing body of statistically significant medical literature illustrating both their safety and efficacy. Focusing on the major values of regenerative medicine, this book with its 21 chapters is expected to fill an important void in the current literature. It will take that extra step to guide you in your day to day clinical practice. Featuring contributions from a large international group of leaders in regenerative medicine and musculoskeletal ultrasonography, this book is an authoritative reference for rheumatologists, physiatrists, sonographers, radiologists, physiotherapists and orthopaedic specialists.

Our understanding of human neuro-anatomy, and ability to safely access lesions in complex locations, are in continuous evolution.  The subcortical white matter space is among the most intricate, yet least understood, regions of the brain, with regards to its billions of connections and the subtle clinical and clinical functions it subserves. Neurosurgical procedures in the subcortical space and intraventricular system have been traditionally very difficult due to their depth, the need for brain retraction, and limited understanding and imaging capability of this region.  Common lesions encountered in the subcortical space include brain metastases, gliomas, and intracerebral hemorrhage.  Surgical access to this region has classically been hindered, and is highly limited by evolving technological applications to medicine and surgery.  Traditionally, the technology (optics, imaging, resection devices, illumination) needed to perform safe subcortical surgery was not commensurate with the surgeon's needs. Over the past decade, major strides in our ability to image, navigate, and safely access subcortical tumors and other lesions have been made.  These include parafascicular, trans-sulcal approaches that may be channel-based to provide safe retraction of the cortical and subcortical matter.  A confluence of optical, computational and mechanical technology have greatly enabled our ability to treat such lesions, and include advanced MR imaging such as diffusion tractography, neuronavigation, channel-based access ports, exoscopic visualization, fiber-optic illumination, and novel resection devices.Parafascicular, channel-based subcortical surgery is a relatively new field with evolving indications and approaches that promises to evolve considerably over the next several decades.  We aim to develop the first comprehensive reference text compiling the known evidence and experience from expert practitioners in the field of subcortical parafascicular surgery.  This book will provide a major foundation for future development of the field, and be a first and definitive reference for decades to come.Subcortical Neurosurgery: Open and Parafascicular Channel-Based Approaches for Subcortical and Intraventricular Lesions will be the definitive reference on surgery of the subcortical region.  It will comprehensively discuss all aspects of treatment of subcortical and intraventricular lesions, including neuroanatomy and neuroimaging of the subcortical space, principles of parafascicular subcortical channel-based surgery, common indications and approaches, and focused chapters for common subcortical lesions.  The first section of the reference focuses on the intricate anatomy and neuro-imaging of the subcortical space and ventricular system, with special emphasis on intricate white matter tracts and diffusion tractography imaging.  The next section of the book discusses principles of both open and parafascicular, channel-based approaches to subcortical and intraventricular lesions, in addition to workhorse approaches to common subcortical compartments.  Finally, specific pathological subcortical lesions that can be commonly addressed via parafascicular channel-based approaches, including brain metastases, gliomas, and intracerebral hemorrhage will be addressed. Authored by experts in the field of subcortical neurosurgery, this book was developed to provide a unique, comprehensive text for neurosurgeons, neuro-radiologists, and trainees from a variety of specialties interested in evolving minimally disruptive access and treatment of the subcortical space.

This text provides comprehensive atlas of open arterial reconstructions - primary and reoperations. This book describes in detail the 1) indications of the operation, 2) surgical anatomy 3) operative steps in a sequential order with easy to understand illustrations, 4) recognizing a potential complication 5) and if a complication occurs, the steps involved in managing the complication.