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This book acts as a primer for radiographers upon performing computed tomography (CT) examinations. The focus resides in radiation physics, radiobiology, anatomy, imaging protocols and image evaluation. It seeks to provide readers insight into the practical and innovative approaches within CT, backed up with key literature and examples in practice. Recent innovations and the importance of new technology to acquire enhanced quality remain a focal point. These are essential in understanding the importance of dose optimization, patient anatomy and common pathology observed. Patient care will remain central in this book, supported with a dedicated chapter discussing effective communication, patient education, informed consent, coupled with the assessment of laboratory results and vital signs. The editors draw from recent publications and clinical expertise, supported with the growing trend of technological advances utilized within the CT environment. Critically, this volume focuses on the role of CT for an array of audiences but, more specifically, undergraduate and postgraduate radiographers worldwide.
The aim of the book is to introduce the state-of-the-art technologies in the field of brain and cognitive intelligence used in robotics control, particularly on studying how the brain learns and controls complex motor skills and how to replicate these in robots. This will be the first book that systematically and thoroughly deals with the above topics. Advances made in the past decades are described. Interesting topics such as human-robot interactions, neurorobotics, biomechanics in robotic control, robot vision, force control, and control and coordination of humanoid robots are covered.
This book focuses on cell culture-produced viral vaccines to meet the needs of the rapidly expanding research and development in academia and industry in the field. This book introduces the basic principles of vaccination and the manufacturing of viral vaccines. Bioprocessing of Viral Vaccines, will provide an overview of the advanced strategies needed to respond to the challenges of new and established viral infection diseases. The first few chapters cover the basics of virology and immunology as essential concepts to understand the function and design of viral vaccines. The core of the content is dedicated to process development, including upstream processing and cell culture of viral vaccines, downstream processing, and extensive analytical technologies specific to viral vaccines. Advanced process analytical technologies (PAT) and Quality by Design (QbD) concepts are also introduced in the context of vaccine manufacturing. The case studies included cover inactivated, attenuated vaccines exemplified by influenza vaccines, sub-unit vaccines exemplified by Virus Like Particles (VLPs: HPV vaccines) and sub-unit vaccines (Flublock), vectored vaccines: adenoviruses and Vesicular stomatitis Virus (VSV) vectored vaccines, genomic vaccines (DNA and mRNA) vaccines as developed for COVID-19 response in particular and a review of COVID-19 vaccines approved or in advanced clinical trials. This book is aimed at graduate engineers and professionals in the fields of vaccinology, bioprocessing, and biomanufacturing of viral vaccines.
This volume on applied pharmaceutical science and microbiology looks at the latest research on the applications of natural products for drug uses. It focuses on understanding how to apply the principles of novel green chemistry methods in the vital area of pharmaceuticals.
This text is an introduction to electrophysiology, following a quantitative approach. The first chapter summarizes much of the mathematics required in the following chapters. The second chapter presents a very concise overview of the general principles of electrical fields and current flow, mostly es- tablished in physical science and engineering, but also applicable to biolog- ical environments. The following five chapters are the core material of this text. They include descriptions of how voltages come to exist across membranes and how these are described using the Nernst and Goldman equations (Chapter 3), an examination of the time course of changes in membrane voltages that produce action potentials (Chapter 4), propagation of action potentials down fibers (Chapter 5), the response of fibers to artificial stimuli such as those used in pacemakers (Chapter 6), and the voltages and currents produced by these active processes in the surrounding extracellular space (Chapter 7). The subsequent chapters present more detailed material about the application of these principles to the study of cardiac and neural electrophysiology, and include a chapter on recent developments in mem- brane biophysics. The study of electrophysiology has progressed rapidly because of the precise, delicate, and ingenious experimental studies of many investigators. The field has also made great strides by unifying the numerous experimental observations through the development of increasingly accurate theoretical concepts and mathematical descriptions. The application of these funda- mental principles has in turn formed a basis for the solution of many different electrophysiological problems.
A number of food engineering operations, in which heat is not used as a preserving factor, have been employed and are applied for preparation (cleaning, sorting, etc.), conversion (milling, agglomeration, etc.) or preservation (irradiation, high pressure processing, pulsed electric fields, etc.) purposes in the food industry. This book presents a comprehensive treatise of all normally used food engineering operations that are carried out at room (or ambient) conditions, whether they are aimed at producing microbiologically safe foods with minimum alteration to sensory and nutritive properties, or they constitute routine preparative or transformation operations. The book is written for both undergraduate and graduate students, as well as for educators and practicing food process engineers. It reviews theoretical concepts, analyzes their use in operating variables of equipment, and discusses in detail different applications in diverse food processes.
Biomedical Engineering Program between Rutgers University and the University of Medicine and Dentistry of New Jersey entitled "e;Biopolymers"e; and "e;Patho- biology"e; during the past 15 years. It is our hope that this book will provide the reader with all the infor- mation necessary to understand the complexity of the biological reactions that are set into motion by implantation of a material or a device. We hope that this book will provide a framework for thinking about implant interactions with bio- logical systems. Although the field of studying pathobiological responses to im- plants is still in its infancy, we are now more aware of acute and chronic con- ditions that generate inflammatory responses as a result of wear debris, activation of complement, and acute hypersensitivity. As we learn more concerning these responses, it is hoped that our ability to design implants will also improve. We encourage readers to send to us any suggestions of additional topics that they would like to see covered in our book. Frederick H. Silver David L.
This book discusses electromagnetic waves and antennas used as diagnostic tools and therapeutic techniques for applications in cancer detection, stroke event detection, GI diagnostics, and cardiovascular risk predictions. It discusses electromagnetic devices, wireless implants, and in vitro and in vivo testing.
This book provides an interdisciplinary look at emerging trends in signal processing and biomedicine found at the intersection of healthcare, engineering, and computer science. It examines the vital role signal processing plays in enabling a new generation of technology based on big data, and looks at applications ranging from medical electronics to data mining of electronic medical records. Topics covered include analysis of medical images, machine learning, biomedical nanosensors, wireless technologies, and instrumentation and electrical stimulation. Biomedical Signal Processing: Innovation and Applications presents tutorials and examples of successful applications, and will appeal to a wide range of professionals, researchers, and students interested in applications of signal processing, medicine, and biology.
This open access volume compiles student reports from the 2021 Simula Summer School in Computational Physiology. Interested readers will find herein a number of modern approaches to modeling excitable tissue. This should provide a framework for tools available to model subcellular and tissue-level physiology across scales and scientific questions. In June through August of 2021, Simula held the seventh annual Summer School in Computational Physiology in collaboration with the University of Oslo (UiO) and the University of California, San Diego (UCSD). The course focuses on modeling excitable tissues, with a special interest in cardiac physiology and neuroscience. The majority of the school consists of group research projects conducted by Masters and PhD students from around the world, and advised by scientists at Simula, UiO and UCSD. Each group then produced a report that addreses a specific problem of importance in physiology and presents a succinct summary of the findings. Reports may not necessarily represent new scientific results; rather, they can reproduce or supplement earlier computational studies or experimental findings.Reports from eight of the summer projects are included as separate chapters. The fields represented include cardiac geometry definition (Chapter 1), electrophysiology and pharmacology (Chapters 2¿5), fluid mechanics in blood vessels (Chapter 6), cardiac calcium handling and mechanics (Chapter 7), and machine learning in cardiac electrophysiology (Chapter 8).
This book provides a comprehensive analysis of microbial polysaccharides, their current uses, and highlights biomedical opportunities. The topics comprise principally a) their extraction, isolation, purification and advanced production processes; b) characterization of their structural, physicochemical, and biological properties, among others, by several techniques; c) description of the advanced functionalization and modification methods for the polysaccharide based-material; and d) their applications and uses in medical and pharmaceutical fields. Each chapter is written by world-renowned academics and practitioners on their field.This is an essential reference for students in biomedical, chemical, material, and microbiology engineering as well as researchers and professionals in the medical field.
¿Sensors and measurement systems is an introduction to microsensors for engineering students in the final undergraduate or early graduate level, technicians who wants to know more about the systems they are using, and anybody curious enough to know what microsystems and microsensors can do. The book discusses five families of sensors: - Thermal sensors - Force and pressure sensors- Inertial sensors - Magnetic field sensors- Flow sensorsFor each sensor, theoretical, technology and application aspects are examined. The sensor function is modelled to understand sensitivity, resolution and noise. We ask ourselves: What do we want to measure? What are possible applications? How are the sensor chips made in the cleanroom? How are they mounted and integrated in a system?After reading this book, you should be able to:- Understand important thermal, mechanical, inertial and magnetic sensors- Work with characterization parameters for sensors- Choose sensors for a given application and apply them- Understand micromachining technologies for sensors
Biomaterials for Neural Tissue Engineering covers a range of materials and technologies used for regenerating or repairing neural tissue. With a strong focus on biomaterials and scaffolds, the book examines the testing and evaluation pathway for in-vitro and in-vivo testing trials. This book introduces the reader to the fundamentals of the nervous system from a tissue engineering perspective and goes on to describe contemporary technologies used in the development of neural repair materials, as well as currently available biomaterials suitable for neural tissue repair and regeneration. This detailed reference is ideal for those who are new to using biomaterials in tissue engineering, particularly those interested in the nervous system, including academics and early career researchers in the fields of materials science, regenerative medicine, biomedical engineering and clinical sciences.
Digital Twins for Healthcare: Design, Challenges and Solutions establishes the state-of-art in the specification, design, creation, deployment and exploitation of digital twins' technologies for healthcare and wellbeing. A digital twin is a digital replication of a living or non-living physical entity. When data is transmitted seamlessly, it bridges the physical and virtual worlds, thus allowing the virtual entity to exist simultaneously with the physical entity. A digital twin facilitates the means to understand, monitor, and optimize the functions of the physical entity and provide continuous feedback. It can be used to improve citizens' quality of life and wellbeing in smart cities and the virtualization of industrial processes.
This research and reference text will present the latest research on carbon dots and their applications in the biomedical field, including therapeutics, bio-imaging and diagnosis. It will be the first book dedicated to the biomedical applications of carbon dots.The key topics covered will include the use of carbon dots in therapeutic applications, applications in drug and gene delivery, uses in bio-imaging and uses in the fabrication of biosensors and nanobiosensors. The coverage of therapeutics will include the varied role of carbon dots in anti-inflammation, delivery of drugs and genes, anti-pathogenicity, tissue engineering and cancer therapies.
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