Biomedicinsk teknik

This volume ¿Cell Engineerring 11 - Biopharmaceutical Manufacturing: Progress, Trends and Challenges¿ is a source of the latest innovative research and technical development in biomanufacturing systems. It is organised into 2 parts: 1) Manufacturing of recombinant therapeutic proteins (e.g. therapeutic antibodies, biosimilars/biogenerics) and 2) Manufacturing aspects of cell and gene therapy. Each with selected chapters on the following topics for both up- and downstream, such as: Advanced process strategies, especially continuous manufacturing, Advanced culture techniques, especially single-use systems, Process transfer, scale-up/scale-down models, Processing advances/Manufacturing productivity/efficiency, Model-assisted process understanding and development/Digital Twins, Process controls and analytics, Quality control, Quality by design, Facility design and full-scale commercial systems, manufacturing technology innovation.The book comprises contributions of experts from academia and industry active in the field of cell culture development for the production of recombinant proteins, cell therapy and gene therapy, with consideration of Digital Twin¿s and facility design. The knowledge and expertise of the authors cover disciplines like cell biology, engineering, biotechnology and biomedical sciences. Inevitably, some omissions will occur in the test, but the authors have sought to avoid duplications by extensive cross-referencing to chapters in other volumes of this series and elsewhere. We hope the volume provides a useful compendium of techniques for scientists in industrial and research laboratories active in this field.

This book presents the major therapeutic applications of modified rice bran arabinoxylan compound (RBAC) in cancer as well as other chronic inflammatory diseases. Written by active researchers and clinicians in the field of RBAC, the chapters cover the basic science that defines the unique function of RBAC as well as the clinical evidence derived through human studies. Particular focus is on recent findings from research over the past decades. This book is both practical and evidence based. It will be a core resource for researchers, students, and practitioners of nutrition and natural medicine, as well as be of value to all healthcare professionals with interest in integrative medicine.

This book gathers the proceedings of the 8th International Conference on Advancements of Medicine and Health Care through Technology, MEDITECH 2022, held virtually on 20¿22 October 2022, from Cluj-Napoca, Romania. It reports on both theoretical and practical developments in biomedical imaging and image processing, health technology, technologies for education, and biomedical signal processing and medical devices, measurements and instrumentation. Both the conference and the realization of this book were supported by the Romanian National Society for Medical Engineering and Biological Technology (SNIMTB).

This book gives insight into several aspects of the microbiology, biotechnology, and ecosystem sustainability of special and under-explored regions, that captivate human beings by their natural richness, their extensive biodiversity, the extraordinary forms of adaptation of the living beings that they inhabit, and even that keep living secrets as is the very origin of life. The chapters emphasize all aspects of biological diversity-its description, analysis, and conservation, and its controlled rational use by humankind. Also, the book is elaborated from a wide and multidisciplinary point of view. It presents reviews, research papers, comments, and research notes on biodiversity, ethnobiology, geoscience, chemistry, biological conservation, biotechnology, and ecosystem sustainability Two hotspots are the reference for this enriching book that describes details of extraordinary areas of the planet, from Cuatrociénegas, Coahuila (Mexico) to the Southern Western Ghats (India). The book will contribute to dealing with the practicalities of conservation management, economic, social, and political issues. It provides a forum for examining conflicts between sustainable development and human dependence on biodiversity in agriculture, environmental management, and biotechnology, and encourages contributions from developing countries to promote broad global perspectives on matters of biodiversity and conservation.

This book showcases recent trends in brain-computer interface development. It highlights fascinating results in areas such as language decoding, spinal cord stimulation to enable gait and to restore hand functions. The contributions are based on the 12 nominated brain-computer interface projects of the BCI Award 2022. Every year an international jury selects the most innovate BCI projects and nominates 12 projects before selecting the 1st, 2nd and 3rd place winners. In the book, each project is described in detail by the team of scientists behind it, and the editors provide a concluding discussion of the highlights and overall progress in the field.

Human history is filled with inventions and other innovations that resulted in a significant and lasting change in our civilization¿s course of development. From gasoline-powered vehicles to transistor-based electronics or jet airplanes, things we now take for granted often appeared suddenly and unexpectedly. Yet after their introduction, our world changed forever. Over the past two decades, artificial intelligence (AI) and machine learning (ML) have been stealthily increasing their presence in our everyday lives. This ¿randomly systematic¿ adoption process is exposing humanity to something we never previously directly faced: an intelligence that may (and likely will) exceed our own. Despite this, most people are not fully aware of current (and future) benefits, limitations, and threats related to AI/ML. Within health care, there is little awareness of what AI/ML is capable of and how these new capabilities are being implemented or utilized. It is this current state that serves as our ¿starting point¿ in the emerging debate on AI/ML in medicine and surgery, including its integration, projected influence, and many other considerations that are not that different from other past technology adoption paradigms. This book discusses both current trends and future developments in AI and ML across health care.

This book demonstrates the extremely fascinating and interdisciplinary microbial domain. It helps in discovering the latest advances in microbiology and learns how they can help shape a more sustainable future for our planet. This comprehensive guide covers the latest breakthroughs in microbiology research and their practical applications in fields such as ecology, agriculture, biotechnology, and environmental science. Furthermore, the readers explore the cutting-edge technologies and methodologies that are driving the next generation of microbiology research. With expert insights from the leading microbiologists, this book is an essential resource for anyone interested in understanding the role of microbes in our world and harnessing their power for a better tomorrow.

Biomechatronics is rapidly becoming one of the most influential and innovative research directions defining the 21st century. The second edition Biomechatronics provides a complete and up-to-date account of this advanced subject at the university textbook level. This new edition introduces two new chapters - Animals Biomechatronics and Plants Biomechatronics - highlighting the importance of the rapidly growing world population and associated challenges with food production. Each chapter is co-authored by top experts led by Professor Marko B. Popovic, researcher and educator at the forefront of advancements in this fascinating field. Starting with an introduction to the historical background of Biomechatronics, this book covers recent breakthroughs in artificial organs and tissues, prosthetic limbs, neural interfaces, orthotic systems, wearable systems for physical augmentation, physical therapy and rehabilitation, robotic surgery, natural and synthetic actuators, sensors, and control systems. A number of practice prompts and solutions are provided at the end of the book. The second edition of Biomechatronics is a result of dedicated work of a team of more than 30 contributors from all across the globe including top researchers and educators in the United States (Popovic, Lamkin-Kennard, Herr, Sinyukov, Troy, Goodworth, Johnson, Kaipa, Onal, Bowers, Djuric, Fischer, Ji, Jovanovic, Luo, Padir, Tetreault), Japan (Tashiro, Iraminda, Ohta, Terasawa), Sweden (Boyraz), Turkey (Arslan, Karabulut, Ortes), Germany (Beckerle and Wiliwacher), New Zealand (Liarokapis), Switzerland (Dobrev), and Serbia (Lazarevic).

Joint Replacement in the Human Body provides a comprehensive exploration of artificial joint designs. The book's primary focus is to introduce readers to the diverse landscape of artificial joint technologies while offering insights into their historical development. This book is divided into three sections, each addressing specific aspects of joint replacements. The first section delves into artificial joints of the lower limb, including the hip, knee, and ankle. In the subsequent section, the book explores upper limb replacements, covering joints such as the shoulder, elbow, wrist, finger, and thumb.The third section tackles broader themes like biotribology, regulatory aspects of joint replacements, examines noteworthy case studies like metal-on-metal hips, and addresses joint replacements not easily categorized in the previous sections, such as spinal total disc replacements. This book offers a critical assessment of the diverse and evolving design concepts currently in use, ranging from established metal-on-polymer joints to innovative biomimetic solutions. This book is designed to swiftly equip readers with a deep understanding of contemporary joint replacements and the immediate and long-term challenges they present.

Nanozymes: Approachable Bio-applications provides an in-depth overview of nanozymes, with a special focus on nanozymes synthesis and their various applications in biological sciences. The book starts with introductory chapters exploring the enzymatic mechanism of nanozymes and providing the concept of engineering to surface modification to achieve enhanced nanozymatic properties. Subsequent chapters focus on the application of nanozymes in many different fields, including biomedical science, agriculture, environmental science and more.This work is an important reference source for worldwide materials scientists and researchers interested on the resent developments, challenges, and future directions of nanozymes research.

This book covers virtually all aspects of image formation in medical imaging, including systems based on ionizing radiation (x-rays, gamma rays) and non-ionizing techniques (ultrasound, optical, thermal, magnetic resonance, and magnetic particle imaging) alike. In addition, it discusses the development and application of computer-aided detection and diagnosis (CAD) systems in medical imaging.  Given its coverage, the book provides both a forum and valuable resource for researchers involved in image formation, experimental methods, image performance, segmentation, pattern recognition, feature extraction, classifier design, machine learning / deep learning, radiomics, CAD workstation design, human¿computer interaction, databases, and performance evaluation.

Generative Artificial Intelligence is rapidly advancing with many state-of-the-art performances on computer vision, speech processing, and natural language processing tasks. Generative adversarial networks and neural diffusion models can generate high-quality synthetic images of human faces, artworks, and coherent essays on different topics. Generative models are also transforming Medical Artificial Intelligence, given their potential to learn complex features from medical imaging and healthcare data. Hence, computer-aided diagnosis and healthcare are benefiting from Medical Artificial Intelligence and Generative Artificial Intelligence. This book presents the recent advances in generative models for Medical Artificial Intelligence. It covers many applications of generative models for medical image data, including volumetric medical image segmentation, data augmentation, MRI reconstruction, and modeling of spatiotemporal medical data. This book highlights the recent advancements in Generative Artificial Intelligence for medical and healthcare applications, using medical imaging and clinical and electronic health records data. Furthermore, the book comprehensively presents the concepts and applications of deep learning-based artificial intelligence methods, such as generative adversarial networks, convolutional neural networks, and vision transformers. It also presents a quantitative and qualitative analysis of data augmentation and synthesis performances of Generative Artificial Intelligence models. This book is the result of the collaborative efforts and hard work of many minds who contributed to it and illuminated the vast landscape of Medical Artificial Intelligence. The book is suitable for reading by computer science researchers, medical professionals, healthcare informatics, and medical imaging researchers interested in understanding the potential of artificial intelligence in healthcare. It serves as a compass for navigating the artificial intelligence-driven healthcare landscape.

This book provides an introduction to next-generation applications and technologies for improving diagnostic accuracy and prediction of treatment outcomes in dentistry through the use of artificial intelligence (AI) and machine learning (ML). The authors attempt to bridge the gap between dental research and global health outcomes, as well as provide a comprehensive guide to general and clinical aspects of dental and oral health issues and the etiology, prevalence, assessment, and management of these conditions. This book combines engineering applications and medical healthcare and will be an important reference for researchers, biomedical engineers, dental students, and dental practitioners. 

The hospital buildings are one of the most complex buildings/projects to plan, design, build, and operate. Hospital project planning involves site selection, Detailed Project Report (DPR) preparation, feasibility studies, room planning, hospital building zoning, and construction.This book provides in-depth knowledge and synchronization of the operational policies, licensing, services, equipment procurement, workforce recruitment, and establishing the set of Standard Operating Procedures (SOPs) before the start of hospital operations.This book helps enlighten site engineers and various in-charges to plan their hospital projects efficiently, completing all the jobs and activities well in time. This book narrates all the relevant issues and details about the hospital planning and construction activities in a tabular form and explains each activity extensively. Moreover, the tables provided in the book will also help the planners and executors assess the activity's progress and the person responsible for it.The key feature of the book is a very easily understandable English language that provides the best understanding to the students of Hospital Management, Para Medical Sciences, Architecture, Site Engineers, Site Supervisors, Hospital Promoters, Planners, and Designers.

This book reviews the potential of next-generation point-of-care diagnosis in healthcare. It also discusses the printed chip-based assay (Lab-on-a-Chip, Lab-on-a-PCB) for rapid, inexpensive biomarkers detection. The book presents the development of sensory systems based on the use of nanomaterials. It examines different biosensors for medical diagnosis using surface modification strategies of transducers. It presents electrochemical concepts based on different nanobiomaterials and nanocomposites for cancer theranostics. Notably, the book examines the recent advances in wearable, cost-effective hemodynamic sensors to detect diseases at an early stage. It further explores the combination of redox cycling and electrochemical detection to develop ultrasensitive and reproducible biosensors for point-of-care testing. Finally, the book summarizes the significant challenges in the point of care diagnostics and its future opportunities in healthcare. 

Biomaterials and Stem Cell Therapies for Biomedical Applications discusses the current research concepts and emerging technologies in the fields of biomaterials and tissue engineering. Divided into four distinct sections, the book explores these state-of-the art technologies, opening with a description of stem cell technologies for biomedical applications before exploring biomaterials for biomedical applications, combinational approaches using stem cells and biomaterials, and finally, nanomedicine approaches for tissue regeneration. Topics include wound healing, tissue engineering, regenerative biomaterials, and stem cell treatments for wound healing and tissue regeneration. This concise and informative volume presents the latest developments in a highly informative and easy-to-read style.

This book explores in depth the latest enabling technologies for regenerative medicine. The opening section examines advances in 3D bioprinting and the fabrication of electrospun and electrosprayed scaffolds. The potential applications of intelligent nanocomposites are then considered, covering, for example, graphene-based nanocomposites, intrinsically conductive polymer nanocomposites, and smart diagnostic contact lens systems. The third section is devoted to various drug delivery systems and strategies for regenerative medicine. Finally, a wide range of future enabling technologies are discussed. Examples include temperature-responsive cell culture surfaces, nanopatterned scaffolds for neural tissue engineering, and process system engineering methodologies for application in tissue development. This is one of two books to be based on contributions from leading experts that were delivered at the 2018 Asia University Symposium on Biomedical Engineering in Seoul, Korea - the companion book examines in depth novel biomaterials for regenerative medicine.

This book describes a new strategy for rehabilitation from injury and/or disease using Crucial Event Therapy. Recent studies have shown that individuals can recuperate more rapidly from surgery and other invasive procedures intended to correct the negative effects of disease or injury through the use of life support systems that operate at the body's natural biofrequencies. The same observation has been clinically shown to reverse the degenerative effects of neurodegenerative diseases such as Parkinson¿s and Alzheimer's Disease.Crucial Event Therapy describes medicine as the operational control of the functions of the human body treated as a network-of-networks, with 1/f-variable crucial events coding the dynamic states of health and disease through information flow within a network and information exchange between biomedical networks. A new way of thinking based on the statistics of Cortical Events is presented and the relevant literature is suitably referenced. This is anideal book for biophysicists and data scientists seeking to understand the connection of complexity measures for the study of consciousness with the clinical aspects of designing a rehabilitation strategy.

This book aims to highlight the latest achievements in the use of AI and multimodal artificial intelligence in biomedicine and healthcare. Multimodal AI is a relatively new concept in AI, in which different types of data (e.g. text, image, video, audio, and numerical data) are collected, integrated, and processed through a series of intelligence processing algorithms to improve performance. The edited volume contains selected papers presented at the 2022 Health Intelligence workshop and the associated Data Hackathon/Challenge, co-located with the Thirty-Sixth Association for the Advancement of Artificial Intelligence (AAAI) conference, and presents an overview of the issues, challenges, and potentials in the field, along with new research results. This book provides information for researchers, students, industry professionals, clinicians, and public health agencies interested in the applications of AI and Multimodal AI in public health and medicine.

This book covers a variety of advanced communications technologies that can be used to analyze medical data and can be used to diagnose diseases in clinic centers. The book is a primer of methods for medicine, providing an overview of explainable artificial intelligence (AI) techniques that can be applied in different medical challenges. The authors discuss how to select and apply the proper technology depending on the provided data and the analysis desired. Because a variety of data can be used in the medical field, the book explains how to deal with challenges connected with each type. A number of scenarios are introduced that can happen in real-time environments, with each pared with a type of machine learning that can be used to solve it.

Clinical trials are research studies performed in people that are aimed at evaluating a medical device, drug, or surgical or behavioral intervention. They are the primary way that researchers find out if a new treatment, like a new drug or medical device (e. g., a neuroendovascular device) is safe and effective for patients. A clinical trial is used to confirm if a new treatment is more effective and/or has less harmful side effects than the standard treatment. Other clinical trials test methods of early disease detection, sometimes before there are any symptoms. Still, others test methods to prevent health problems. A clinical trial may also look at how to improve the quality of life in those individuals with a life-threatening disease or chronic health problem. Clinical trials sometimes even study the role of caregivers or support groups. Therefore, clinical trials are very important in the development of medicine. A good clinical trial can influence therapeutic modality and even transform our healthcare work. This book provides a comprehensive review of clinical trials.

Biomaterials play a crucial role in the field of biomedical engineering, offering innovative solutions for a wide range of medical applications. From artificial organs to drug delivery systems, biomaterials have revolutionized healthcare and continue to shape the future of medicine. In this subchapter, we will delve into the fundamental aspects of biomaterials, providing students of biomedical engineering with a comprehensive understanding of this exciting field.Firstly, it is important to define what biomaterials are. Simply put, biomaterials are materials that interact with biological systems, either as a whole or at the molecular level. These materials can be natural, such as collagen or silk, or synthetic, such as polymers or ceramics. Understanding the properties and characteristics of different biomaterials is crucial for designing and developing successful biomedical devices and implants.We will explore the various types of biomaterials commonly used in biomedical engineering, including metals, ceramics, polymers, and composites. Each material has unique properties and advantages, which make them suitable for specific applications. For example, metals like titanium are commonly used for orthopedic implants due to their excellent mechanical properties, biocompatibility, and corrosion resistance.Furthermore, we will discuss the interactions between biomaterials and the human body. When a biomaterial is implanted or used in a medical device, it interacts with the surrounding biological environment, which can elicit various responses. These interactions can be classified into four categories: mechanical, chemical, physical, and biological. Understanding these interactions is crucial for predicting the behavior of biomaterials inside the body and ensuring their safe and effective use.Additionally, we will examine the biocompatibility of biomaterials, which refers to their ability to perform their desired function without causing any adverse reactions in the body. Biocompatibility is a complex concept that involves multiple factors such as cytotoxicity, immunogenicity, and hemocompatibility. We will explore the various tests and standards used to evaluate the biocompatibility of biomaterials, ensuring that students have a comprehensive understanding of this critical aspect.Finally, we will discuss the future trends and advancements in biomaterials. From tissue engineering to smart biomaterials, the field is rapidly evolving, opening up new possibilities for biomedical engineering. Understanding these trends will not only enhance students' knowledge but also inspire them to contribute to the future of biomaterials and healthcare.