Genetik (ikke-medicinsk)

From one of the world's great science writers and biologists: a book that reflects on the vast arc of evolutionary history and what it tells us about life on earth.How much do we really know about our past?For centuries, we have yearned to learn more about our ancestors and piece together the story of how we came to be. But language can only record so much. And fossils can be even harder to decipher. We are left groping in the dark, forced to speculate and reconstruct ways of life based on fragments of information.But what if there was a better way?In The Genetic Book of the Dead, Richard Dawkins explores the untapped potential of DNA to transform and transcend our understanding of evolution. In the future, a zoologist presented with a hitherto unknown animal will be able to read its body and its genes as detailed descriptions of the world its ancestors inhabited. This 'book of the dead' would uncover the remarkable ways in which animals have overcome obstacles, adapted to their environments and, again and again, developed remarkably similar ways of finding solutions to life's problems. What biologists call ?convergent evolution', the way in which species separated by vast stretches of time have evolved surprisingly recognisable forms and functions, is one of the most powerful and least understood forces driving life on earth.From the bestselling author of The Selfish Gene comes a revolutionary book that unlocks the door to a past more vivid, nuanced and fascinating than anything we have ever seen.

In this acclaimed bestseller, an explorer and Neanderthal hunter takes us on a riveting journey of discovery'With the style of a poet and imagination of a philosopher, Ludovic Slimak probes the minds of Neanderthals. . . This fun and provocative book is a reminder that we still have a lot to learn about biological intelligence' Steve BrusatteWhat if we have completely misunderstood who the Neanderthals truly were?For over a century we saw them as inferior to Homo Sapiens. Today, Neanderthals are seen as fully human, different from us only because of their distant cultural traditions. But does the truth lie somewhere else entirely?Neanderthal hunter and paleoanthropologist Ludovic Slimak understands these enigmatic creatures like no one else after studying them for three decades. Taking us on a fascinating archaeological investigation from the Arctic Circle to the deep Mediterranean forests, he traces their steps, deciphering their stories through every single detail they left behind.In this stunning, bold book, he argues that Neanderthals should be understood on their own terms. They had their own history, their own rituals, their own customs. Their own intelligence. A remarkable intelligence, for sure, but an intelligence that may have been very different from ours - although it can still teach us much about ourselves.A thought-provoking detective story, written with wit and verve, The Naked Neanderthal shifts our understanding of deep history - and in the process reveals just how much we have yet to learn.

Life is definitively purposive and creative. Organisms use genes in controlling their destiny. This book presents a new understanding of how living systems function, showing how organisms generate purposive behaviour. For general readers interested in evolutionary biology, systems biology, genetics, and history and philosophy of science.

En smuk og barsk beretning om sorg og tab samt lys og kærlighed. Da Alberte er 7 år gammel, får hun diagnosen Metakromatisk Leukodystrofi (MLD), en nervesygdom, der langsomt nedbryder hendes motoriske og kognitive færdigheder. Albertes mor beskriver ærligt og personligt, hvordan Albertes diagnose og sygdomsforløb rammer familien med et hårdt slag og kaster mor, far og storesøster ud i en følelsesmæssig nedtur, hvor de magtesløse lever med visheden om, at Alberte skal dø. Alligevel får dødens tilstedeværelse dem ikke til at opgive at finde en retning og mening med livet og lader lyset og kærligheden dominere i Albertes korte liv.

Sorte mennesker er ikke bedre til at løbe langt eller hurtigt end hvide mennesker. Hvide mennesker er ikke mere intelligente end sorte. Østasiatiske studerende er ikke naturligt bedre til matematik, jøder har ikke et medfødt talent for penge, og din hudfarve fortæller ikke noget om, hvilken race du tilhører.Disse og mange andre stereotyper og myter om race er netop de fundamenter, strukturel racisme hviler på.Bogen her giver et videnskabeligt blik på, hvad moderne genetik kan og ikke kan fortælle os om menneskelig forskellighed. Videnskaben er historisk set blevet brugt som et værktøj til at institutionalisere racismen, men i denne bog forsøger Rutherford at vise, hvordan videnskaben kan og bør bruges som et antiracistisk værktøj.Videnskabelige argumenter mod racisme er et våben til at afmontere pseudovidenskabelige ideer om, at de forskelle, der er mellem os mennesker som individer, kan sige noget om os mennesker som større grupper. Et våben mod racisme.Hvad vores gener siger (og ikke siger)om forskelle mellem mennesker

This volume provides a collection of protocols from researchers in the statistical genomics field. Chapters focus on integrating genomics with other ¿omics¿ data, such as transcriptomics, epigenomics, proteomics, metabolomics, and metagenomics. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and thorough, Statistical Genomics hopes that by covering these diverse and timely topics researchers are provided insights into future directions and priorities of pan-omics and the precision medicine era.

Genetics and Epigenetics of Genitourinary Diseases aims to provide a comprehensive collection of data on genetics and epigenetics in almost all genitourinary diseases for researchers, clinicians, and graduate students. This book discusses several genetic and epigenetic changes like DNA methylation, mutations, single nucleotide polymorphisms, DNA rearrangements, chromosomal remodeling, microsatellite instability, and chromosomal instability (CIN) in genitourinary cancers. This book is split into 18 chapters, beginning with the importance of genetics and epigenetics in genitourinary diseases. It then goes on to cover the genetics and epigenetics of various diseases and tumors. Certain chapters present novel techniques of next-generation sequencing (NGS). Furthermore, RNA-Seq is discussed as a sequencing technique that uses NGS to reveal the presence and quantity of RNA in a biological sample. This book is a valuable resource for researchers, practitioners, and students in genetics and epigenetics who want to broaden their understanding of the field.

This volume details technologies on recombinant DNA and nucleic acid manipulation that underpin much of the biological sciences and instructions on how to conduct them successfully. Chapters guide the reader through the basics of oligonucleotide synthesis and DNA sequencing; recombinant DNA plasmid work; cell-free experiments and the latest developments in CRISPR approaches to genome modification. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and methods, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols.   Authoritative and cutting-edge, DNA Manipulation and Analysis aims to be the comprehensive guide for life scientists moving into the field of recombinant DNA and nucleic acid manipulation.

In Marrow Memory: Essays of Discovery Margaret Nowaczyk explores different facets of her life, from listening to the radio dramas of her childhood in Communist Poland to her work now as a pediatric clinical geneticist. These are beautifully crafted essays, full of hard-won truths and insights, generously shared with the reader.

This volume compiles a comprehensive range of methods to study key aspects of mitochondrial DNA including nucleoid structure and packaging, replication, genome integrity, and disease. Chapters are organized into eight methodological sections that cover in vitro and in vivo methods, including for mtDNA isolation, visualization, deep sequencing, gene editing, and diagnostic aspects of mtDNA disease. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and methods, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols.Authoritative and cutting-edge, Mitochondrial DNA: Methods and Protocols aims to be useful and informative for researchers and clinicians with an interest in mitochondrial DNA.

This second edition provides new and updated chapters covering computational and mathematical techniques and concepts related to the field of comparative genomics. The topics covered in the chapters range from those that address general techniques and concepts that apply to all organisms to others that are specialized and apply to specific biological systems such as viruses, bacteria, nematodes, and insects. Well-known comparative genomics web-based platforms are also covered in specific chapters. Written in the highly successful Methods in Molecular Biology series format, many chapters include introductions to their respective topics and step-by-step comparison procedures, demonstrated on actual sets of genome sequences.Authoritative and cutting-edge, Comparative Genomics: Methods and Protocols, Second Edition aims to ensure successful results in the further study of this vital field.

This detailed volume provides a comprehensive resource covering the existing and state-of-the-art tools in the field of profiling chromatin accessibility and its dynamics. Beginning with a section on bulk-cell methods for profiling chromatin accessibility and nucleosome positioning that rely on enzymatic cleavage of accessible DNA and produce information about relative accessibility, the book continues with methods that use single-molecule and enzymatic approaches to solving the problem of mapping absolute occupancy/accessibility, emerging tools for mapping DNA accessibility and nucleosome positioning in single cells, imaging-based methods for visualizing accessible chromatin in its nuclear context, as well as computational methods for the processing and analysis of chromatin accessibility datasets. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Chromatin Accessibility: Methods and Protocols serves as an extensive and useful reference for researchers studying different facets of chromatin accessibility in a wide variety of biological contexts. Chapter 6 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

This book explains the advancements of plant biotechnology and advanced molecular biology and explores the details of influential tools that complement conventional breeding and accelerate the development of plants resilient to adverse agroclimatic conditions and biofortified plants. Plant biotechnology from the basic sciences to current applications, such as pathway engineering, precursor feeding, transformation, elicitation with biotic and abiotic elicitors, and scaling up in bioreactors, have been included in these chapters to improve the production of secondary metabolites from different medicinal plants. It also highlights important factors often overlooked by methodologies used to develop plants' tolerance against biotic and abiotic stresses and in developing special foods, bio-chemicals, and pharmaceuticals. This book is valuable for researchers or students working on biosciences. It is also an updated and advanced reference material for the agriculture and pharmaceutical industries.

This book reviews key advances and new fundamentals in genetics. The increasing importance of genetic approaches in diverse areas of biology and medical sciences constantly requires in-depth information on genetic discoveries and research strategies for advanced graduate-level students as well as current researchers. This book focuses on genetic studies of various animal model systems and their major contributions to establishing modern genetics. Information covered in this book is mostly based on original research papers that extend from classical to modern genetics and applications. The contents are organized into four parts. Part I introduces fundamental concepts and experimental strategies in classical genetics. Part II discusses molecular genetics with transposons, transgenesis, clonal analysis, and gene editing technologies. Part III emphasizes epigenetic regulation of genome organization and gene expression. Part IV integrates earlier parts with landmark genetic studies on non-coding RNAs in dosage compensation, programmed cell death, growth control related to cancer, and behavioral neurobiology.

This thorough volume presents a wide range of existing methods, from the very popular to the more exotic, in the area of plant genotyping. Many methods of plant genotyping were initially developed for medical research, but all genotyping methods, if they are to be successful, should be suitable for application across the full range of studies within plant biology, as seen in this collection. Plant genotyping methods herein are based on a variety of assessments, including DNA microarray, with its hundreds of thousands of simultaneous reactions, or separate individual studies of DNA sequencing and fragment analysis, PCR and qPCR, allele-specific molecular probes and primers, digestion with restriction endonucleases, microscopy and many others. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Plant Genotyping: Methods and Protocols offers researchers the opportunity to update their knowledge and choose the most suitable method of plant genotyping for their chosen application.

This second edition provides new and updated protocols that can be used for generation of knockout animals. Chapters guide the reader through basic protocols for three genome editing technologies, target design tools, and specific protocols for each animal. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Genome Editing in Animals: Methods and Protocols, Second Edition aims to be a useful practical guide to researches to help further their study in this field.

Nongenetic Information and Evolution investigates the origin and nature of nongenetic information and its role in the mechanisms of evolutionary change. This book opens with an introduction to the theoretical background and forms of nongenetic information, alongside its relationship with genetic information. It then explores nongenetic information across the biological kingdoms, including animals, nonneural organisms, plants, and unicellulars. It also covers epigenetics as a form of nongenetic information, exploring DNA methylation, histone modifications, chromatin remodeling, and miRNA expression in this context. This book closes with a discussion of nongenetic information in evolution, considering evidence demonstrating its inheritance and hereditary impact. This book provides a detailed overview of the origin and evolutionary impact of nongenetic inheritance, delivering a basis for further understanding the occurrence of hereditary phenomena and transgenerational phenotypic changes that do not involve genes. This is a useful reference for researchers in the field of epigenetics, evolutionary biology, developmental biology, and cellular and molecular biology.

This book elucidates the sustainable production of commercially important biomolecules in medicines, food, and beverage processing, through biological systems, including microorganisms, animal cells, plant cells, tissues, enzymes, and in vitro. It discusses promising technologies for the manipulation of cells including, genetic engineering, synthetic biology, genome editing, and metabolic engineering. The initial chapters of the book introduce topics on biomanufacturing, circular economy, strain design and improvement, upstream and downstream processing. The subsequent chapters cover artificial intelligence-assisted production, designer cell factories, biosensors for monitoring biomolecules, different cells factories, biosynthetic pathways, and genome editing approaches for scale-up biomanufacturing. Lastly, the book discusses the opportunities and challenges of implementing biological systems for the production of biomolecules.¿This book is a valuable source for students, researchers, scientists, clinicians, stakeholders, policymakers, and practitioners to understand biomanufacturing for the sustainable production of biomolecules.

This updated volume reflects new and evolved techniques to study detection, profiling, and manipulation of microRNAs (miRNAs) in plants and animals. After overviews of how best to detect, identify, and validate microRNAs, the book continues by exploring state-of-the-art protocols for microRNA detection, approaches to profile the expression level of microRNAs, spatial expression analysis, describe in silico analysis of microRNAs and their targets, as well as protocols for functional analysis of microRNAs and their targets by CRISPR/Cas. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, MicroRNA Detection and Target Identification: Methods and Protocols, Second Edition aims to ensure successful results in the further study of this vital field.

This volume provides protocols on evidence for polyploidy and how it can be unveiled. Chapters guide readers through evolutionary experiments, measure effects of polyploidy, evidence for (remnants of) ancient WGDs, models of chromosome number evolution, population genomics approaches to study polyploidy, analysing genetic data from polyploid populations, Phylogenetic and phylogenomic methods, gene expression, gene regulation, unicellular alga (Chlamydomonas),  and a fast-growing duckweed (Spirodela). Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Polyploidy: Method and Protocols aims to be of interest to experimental and computational (evolutionary) biologists, molecular biologists, and biotechnologists.

This volume details state-of-the-art computational methods designed to manage, analyze, and generally leverage epigenomic and epitranscriptomic data. Chapters guide readers through fine-mapping and quantification of modifications, visual analytics, imputation methods, supervised analysis, and integrative approaches for single-cell data. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Computational Epigenomics and Epitranscriptomics aims to provide an overview of epiomic protocols, making it easier for researchers to extract impactful biological insight from their data.

MicroRNA Advances and Application in Plant Biology presents a broad range of tools and techniques used for microRNA identification and utilization for diversity analysis in plants, crop improvement, and gene regulation. With expert insights, this book addresses those concepts through curated chapters that are well-illustrated with informative data, tables, figures, and photographs. While biological microRNA database resources have been created for the better understanding of structural and functional properties of primary-microRNAs (pri-microRNAs) to mature microRNAs, there remains a need for foundation understanding of how microRNAs may play a very crucial role in a plant lifecycle as an regulatory and stress tolerance molecule. There are still many unanswered questions about the structural and functional properties of the microRNAs, like the role of microRNA in crop improvement, gene regulation, stress tolerance, disease resistance plant, plant communication, and environmental interaction.

With one volume each year, this series keeps scientists and advanced students informed of the latest developments and results in all areas of the plant sciences. This latest volume includes reviews on plant physiology, biochemistry, genetics and genomics, forests, and ecosystems.

This second edition volume expands on the previous edition with discussions of the latest technology and advancements in the development of RNA vaccines and proposed solutions on how to tackle currently unmet medical needs. The chapters in this book are organized into four parts and cover topics such as replication and non-replicating RNA vectors, formulation and delivery of RNA vaccines, and clinical and nonclinical development of RNA vaccines. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Practical and comprehensive, RNA Vaccines: Methods and Protocols, Second Edition is a valuable resource for any researcher interested in learning more about this important and developing field.