Farmaceutisk kemi og teknologi

Plant-based medicines and aromatics are increasingly in demand in the healthcare sector all over the globe, where they are used, not only for the treatment of various diseases, but also for maintaining good human health. Plants as Medicine and Aromatics: Uses of Botanicals reviews modern uses of ancient botanicals as medicine and aromatics, including chapters on both traditional usage to modern drug discovery development, as well as clinical research and development in ancient medicinal herbs.FeaturesAssesses the status of aromatics and medicinal plants as well as their modern uses.Elucidates the uses of plants within traditional culture practices for the prevention and treatment of diseases.Examines contemporary approaches being used to explore medicinal botany.A volume in the Exploring Medicinal Plants series, Plants as Medicine and Aromatics: Uses of Botanicals presents a comprehensive understanding in terms of modern uses of botanicals of medicinal and aromatic plants. It is useful to researchers, teachers, cultivators, students, and for those interested in herbal medicine.

This book discusses the utilization of nano-based formulations for control of viral agents. Antiviral potential of green synthesized silver, chitosan nanoparticles encapsulating curcumin, photoinduced antiviral carbon nanohorns, and role of carbon-based materials like fullerenes &carbon nanotubes in repression of viral antigens are explained.

This book is a valuable reference that discusses green technologies, like enzyme technologies, to meet the ever-growing demand of nutraceuticals and functional foods. Microorganisms like bacteria (lactic acid bacteria, Bacillus species), yeasts, and filamentous fungi have been exploited for food preparations globally. Microbial Enzymes in Production of Functional Foods and Nutraceuticals discusses how to use them commercially. Chapters include enzyme sources, processing, and the health benefits of microbial enzymes. Other interesting Chapters include the application of metagenomics and the molecular engineering of enzymes. This book is useful for students, academicians, and industry experts in food science and applied microbiology.

Poisonous plants are used in traditional medicine systems in various healing therapies. They are a rich resource of ingredients used in herbal drug formulations that are also used in the development of synthetic drugs. They are recognized for their antioxidant, anti-inflammation, anti-cancer, and anti-diabetic activities and for many other health benefits. Exploring Poisonous Plants: Medicinal Values, Toxicity Responses, and Therapeutic Uses provides an analysis of the most important poisonous herbs, shrubs, and trees, detailing poisonous plants while demonstrating endorsements for their potential therapeutic values.Features:Presents therapeutic potentials on various poisonous herbs, shrubs, and trees.Provides descriptions of notable toxic compounds and discusses their adverse effects when consumed by animals or people.Gives practical guidance for botanical description, distribution, phytochemical constituents, pharmacological studies, and traditional and other potential uses of selected poisonous plants.This volume in the Exploring Medicinal Plants series is appropriate for scientists, researchers, and students working with poisonous plants, as well as in areas of economic botany, plant biochemistry, biotechnology, pharmacognosy, pharmaceuticals, industrial chemistry, and nanomedicine.

This reference book provides advanced knowledge on sustainable biogenic waste management. It covers innovative waste processing technologies to produce biofuels, energy products, and biochemicals. To create a circular bioeconomy, it is imperative to develop processes where the waste generated through one process acts as a feedstock for the other. This book discusses the latest developments in biochemical and thermochemical methods of conversion and covers the potential of different kinds of biomass in more decentralized biorefineries. It describes sustainable solutions for a greener supplement to fossil resources. The book is meant for microbiologists, chemists, and biotechnologists.

An in-depth look at the pharmacological applications of 11 antidiabetic plants, examining antihyperglycemic, hypoglycemic, anti-lipidemic properties, and current genome editing research perspectives. Each chapter reviews a particular plant, explaining the therapeutic aspects and genome editing technology.

This book concerns use of real world data (RWD) and real world evidence (RWE) to aid drug development across product cycle. RWD are healthcare data that are collected outside the constraints of conventual controlled randomized trials (CRTs); whereas RWE is the knowledge derived from aggregation and analysis of RWD.

Project managers in drug development are the driving force behind the coordination of efforts. This book provides a practical reference for project managers in the pharmaceutical and biotech drug development industry, with the goal of assisting in creating an efficient and effective team structure and environment. The text details the role of project managers at each stage of drug development, the key interfaces that the PM will need to work closely with, and essential tools of the trade including frequently used techniques and methodologies. This book is useful for both entry-level and advanced-level PMs, as well as non-project managers from other functions.FeaturesIncludes authors' recent experience with improved tactics and technologies/software at various stages of drug development.Provides the most up-to-date and best practices, techniques, and methodologies in project management.Details the role of the PM at each stage of drug development, including working with the key interfaces throughout the process.Diverse audience including nonproject managers in clinical development, clinical operations, regulatory affairs, medical affairs, clinical pharmacology, and biostatistics.Provides templates and timelines for critical paths from development to commercialization and has potential as a textbook on relevant courses.

Plant-based drugs play an important role in all cultures and have been crucial in maintaining health and fighting diseases, and by using contemporary methods of biotechnology, plants with explicit chemical compositions are propagated and genetically upgraded for the mining of pharmaceuticals. Phytopharmaceuticals and Biotechnology of Herbal Plants presents the latest advances in the development of transgenic plants, covering phototherapeutics, secondary metabolite production, metabolomics, metabolic engineering, bioinformatics, quality control of herbal plant products, crop improvement using various breeding techniques, tissue culture techniques, and the future of phytopharmaceuticals.Features:Describes developments and applications of phytopharmaceuticals of herbal plants.Highlights the importance of phytopharmaceutical of plants and potential applications in the food and pharma industries.Provides an overview of research on key anticancer drugs to elucidate the biotechnological approaches for their production in cell cultures.Places special emphasis on the biosynthetic pathway mapping and metabolic engineering.Phytopharmaceuticals and Biotechnology of Herbal Plants will be an invaluable resource to academics and researchers associated with plant science, herbal drug manufacturers, and phytochemists.

Organized by two leaders in the field, this text establishes a sound fundamental basis for the principles of the two-dimensional liquid chromatography technique, followed by a discussion of important practical considerations.

This book highlights application of nanomaterials for drug delivery, therapy, and engineering. It covers stimuli-sensitive drug delivery systems including an overview of the physical, chemical, biological, and nano systems. It also presents clinical status for different types of nanoplatforms and assesses novel applications of nanomaterials.

A disease is defined as rare if the prevalence is fewer than 200,000 in the United States. It is estimated that there are more than 7,000 rare diseases, which collectively affect 30 million Americans. This diverse and complex disease area poses challenges for patients, caregivers, regulators, drug developers and other stakeholders.

For more than five decades, scientists and researchers have relied on the Advances in Chromatography series. For Volume 54, the series editors have invited established chemists to offer cutting-edge reviews of chromatographic methods applied in the life sciences that emphasize the underlying principle of separation science.

A new generation of technological vaccines protect against many infectious diseases. This book describes synthetic peptide-based vaccine prototypes - the future of vaccination. Production of peptides becomes simple using automatic synthesizers. Peptides are weak immunogen and need adjuvants to provide an effective autoimmune response, which is why peptide antigens are conjugated with biopolymers and loaded with nanoparticles. The book illustrates the use of peptides vaccine systems and makes predictions of future development not only for infectious diseases, but also for cancers and brain diseases such as Alzheimer, Parkinson and psychiatric diseases. Key Features Summarizes current studies on technological vaccines Describes the uses of vaccines for the prevention of brain diseases Reviews the ways different polymers are used to enhance vaccine efficacy

This book explores the development of novel marine biosurfactants. The book also covers the utilization of marine surfactants for biological and biomedical, and environmental applications. Marine Surfactants: Preparations and Applications aims to examine every aspect of marine derived surfactants.The first part of the book discusses the isolation of marine surfactants from various organisms include marine bacteria, algae, cyanobacteria and so on. The editors also examine the cultivation of marine microorganisms and the harvesting of other natural biological resources from the sea. The next part of the book discusses the application marine surfactants, including oil spill removal in the sea, bioremediation of polluted water and soil, treatments for breast cancer, restoration of marine environments, nanoparticles synthesis, and development of different kinds of emulsifiers. With contributions from world-renowned experts in the field, this book will be an essential resource in understanding and developing various marine-derived surfactants. This book is intended for researchers and marine biotechnologists as well as medical practitioners working on a vast range of industrial and medical applications using marine materials. It would also be useful for students looking to understand the utilization of marine derived surfactants.

This all-encompassing volume addresses every critical aspect of Good Laboratory Practice (GLP) regulations and demonstrates effective strategies for implementation in a variety of laboratory settings

Continuous manufacturing of pharmaceuticals, including aspects of modern process development is highlighted in this book with both the 'why' and the 'how', emphasizing process modeling and process analytical technologies. Presenting specific case studies and drawing upon extensive experience from industry and academic opinion leaders, this book focuses on the practical aspects of continuous manufacturing. It gives the readers the strategic perspective and technical depth needed to adopt and implement these technologies, where appropriate, in order to gain the competitive edge in speed, agility, and reliability.Features:Discusses scientific solutions and process analytical technology to enable continuous manufacturing in the development of new drugsIncludes short stories about how some companies have adopted CM and what their drivers were and what benefits were realizedAddresses economic and practical considerations, unlike many other technical booksEmphasizes the practical aspects to give the reader the strategic imperative and technological depth to adopt and implement these technologiesHighlights the "why" and the "how", focusing on the need analysis and process modeling and process analytical technologies

Building on the success of the previous editions, the Textbook of Drug Design and Discovery, Fifth Edition, has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The information is presented in an up-to-date review form with an underlying and fundamental focus on the educational aspects.Beginning with an introduction to drug design and discovery, the first eight chapters cover molecular recognition, ligand-based drug design, and biostructure-based drug design. The authors also discuss drug-like properties and decision making in medicinal chemistry, chemical biology, natural products in drug discovery, and in vivo imaging in drug discovery.The middle six chapters provide an overview of peptide and protein drug design, prodrugs in drug design and development, and enzyme inhibitors. The authors also go through receptors (structure, function, and pharmacology), ion channels (structure and function), and neurotransmitter transporters (structure, function, and drug binding).The following chapters address important neurotransmitter systems, GABA and glutamic acid receptors and transporter ligands, acetylcholine, histamine, dopamine and serotonin, and opioid and cannabinoid receptors. The book concludes with an examination of neglected diseases, anticancer agents, tyrosine kinase receptors, and antibiotics.

From Current to Future Trends in Pharmaceutical Technology explores the current trends of this field and creates a multi-aspect framework for the reader. The book covers topics on pharmaceutics, pharmaceutical engineering, pre-formulation protocols, techniques, innovative excipients, bio-printing techniques, scale-up based on formulas on-a-chip, and regulatory aspects based on new scientific achievements. Modified dosage forms, new aspects on the compatibility of drug excipients interactions, and drug release by various dosage forms are included. Physical pharmacy (physical and biological stability of dosage forms), innovative excipients, patents on innovative formulations and regulatory issues related to the approval process of medicines are also discussed. The book is a valuable resource for a wide audience of academics, industrial researchers and professionals working in this field as the development of efficient and safe medicines is critical to future needs.

This book is the most comprehensive and complete treatise on nucleic acid therapeuticproducts, including mRNA vaccines, their manufacturing, formulations, andtesting for safety and efficacy. Details include cGMP-compliant manufacturing andregulatory filing steps. A new concept of "biosimilar" mRNA vaccine is presentedto secure fast approval of copies of mRNA vaccines. Projections of financial plansto establish RNA manufacturing facilities are provided, along with details of supplychain management. Finally, the future of nucleic acid products in gene therapy andother newer applications is presented, along with a perspective that all new vaccineswill be the nucleic acid type that will further provide first-time prevention of autoimmunedisorders. It is projected that both big pharma and start-ups will enter this field,and we can expect significant additions to our drug armamentarium soon.

This book deals with various clinical trials of nutraceuticals and dietary supplements covering various diseases such as maternal and fetal diseases, cancer, hepatic, gastric, hormonal, bone and renal diseases inclusive of case studies, so that the reader get current updates on the potency of nutraceuticals as well as dietary supplements.

Antimicrobial resistance has existed in nature long before the discovery of antibiotics. The mechanisms of resistance are prevalent among the bacterial population. Over a period of time and facilitated by indiscriminate usage of antibiotics, these mechanisms are transferred from one type of bacteria to another, including the pathogenic ones. In addition, the rate of discovery of novel antimicrobials is much slower than the rate of evolution of antimicrobial resistance. Therefore, there is a need for alternative strategies to control antimicrobial resistance to save lives. In this book, the novel strategies to combat antimicrobial resistance are described, emphasizing collaborative measures of control. We describe the concerted efforts undertaken by global communities to combat antimicrobial resistance in detail. The most efficient strategy could be a behavioral change towards indiscriminate consumption, usage, and prescription of antibiotics.