Teknisk anvendelse af biomaterialer

This book is intended to shed light on the computational modeling and experimental techniques that are used in the characterization of various polymer based composite materials. It covers mechanisms, salient features, formulations, important aspects, and case studies of polymer composite materials utilized for various applications. The latest research in this area as well as possible avenues of future research is also highlighted to encourage the researchers.

This book examines the progress in the biotechnology sector in India towards knowledge and innovation driven Bioeconomy. The chapters of the book review different genome editing techniques and the GM crops focusing on the emerging potential in agricultural biotechnology. Chapters on Vaccines and AI in healthcare unfold huge opportunities in medical biotechnology. The book covers the advances in biotechnology towards delivering important benefits of healthcare, particularly through the pharmaceutical industry focusing on new healthcare interventions and delivering innovations. Further, it explores the major opportunities in industrial biotechnology related to bio-pharma, biorefinery, fermentation biotechnology, and growing synergies between industry-academia. Toward the end, the book also reviews the genetic regulation and the critical role of HRD. In summary, the book emphasizes on India as a strong bio-manufacturing hub for innovative, affordable and accessible products for the society and also for global markets while describing the sector wise strategies required.

This book presents the recent developments in immunomodulatory biomaterials for cell-based therapies in various diseases, including diabetes, cancer, cardiovascular disease, and bone regeneration. The authors first cover the fundamentals of conventional immunology and immunomodulation, before focusing on the history, advantages, and challenges of cell therapies. Biological cell therapy has gained immense attention for various diseases due to unique advantages it has over chemical drugs regarding cost, ease of production, toxicity, and therapeutic efficacy. However, these cell-based therapies need an inert delivery system that can locally deliver cells and minimally elicit foreign body response. The book discusses the foreign body response to the immunomodulatory biomaterials as well as the current and future strategies for potential mitigation of considerable immune responses toward immunomodulatory biomaterials and devices.

Therapeutic macromolecules and biologics have gained increasing importance in the last decade. Pulmonary and intranasal delivery of these therapeutic modalities, which have poor oral bioavailability, could constitute an attractive, non-invasive alternative to parenteral delivery. They can be considered for either topical use for treating diseases affecting the airways or for systemic use for treating a variety of other diseases. Therefore, this book is a readable, thoughtful, and useful guide on the latest research developments and the best options that people involved with pulmonary and intranasal route of administration and biologically active agents can bring to their practices. Furthermore, it explores the underlying scientific rationale for the strategies applied to overcome drug delivery challenges and provides insights to inspire further research in this growing area.

In today's society researchers are more focused on cleaner materials production for environmental sustainability. This approach aims at reducing waste and the development of materials with enhanced properties and functionality. This book focuses on optimizing manufacturing processes for sustainable composite materials. It discusses optimum utilization of resources by using minimum effort to save cost and energy.

This book introduces biomass which is utilized all over the world based on geographical, cultural, and historical background. It covers 18 major biomass types and several specific plants categorized into 3 groups based on their usage. The present and historical background of representative materials from biomass, such as cellulose, lignin, chitin, sugar, molasses, amylose, and other interesting natural biopolymers, such as hyaluronan, gum Arabic, and others are introduced. Furthermore, characteristic features of representative and influential plants, such as rice, eucalyptus, and oil palm are described together with historical episodes. Although physicochemical characteristic properties of each material and plant have been published over many decades, scarcely a comprehensive introduction on biomass together with Asian, European, and Latin American cultural backgrounds. In this book, biomass familiar to everybody¿s life is introduced based on scientific and cultural viewpoints. It guides readers to gain background knowledge of targeting biomass to be developed as industrial resources. In addition to students, scientists, and lecturers, the book will be useful for industrial engineers, both specialists in polymer science and technology and materials experts.

This detailed volume presents a series of protocols dealing with different aspects of inclusion body (IB) processing, from cloning procedures to purification of refolded product. Commencing with chapters on upstream processing, looking into different expression strategies for IB production, the book continues with downstream applications, highlighting early protein purification and subsequent analytics, as well as success stories of IB-based processes. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Inclusion Bodies: Methods and Protocols serves as an ideal resource for facilitating diverse aspects of IB processing.

This volume ¿Cell Engineerring 11 - Biopharmaceutical Manufacturing: Progress, Trends and Challenges¿ is a source of the latest innovative research and technical development in biomanufacturing systems. It is organised into 2 parts: 1) Manufacturing of recombinant therapeutic proteins (e.g. therapeutic antibodies, biosimilars/biogenerics) and 2) Manufacturing aspects of cell and gene therapy. Each with selected chapters on the following topics for both up- and downstream, such as: Advanced process strategies, especially continuous manufacturing, Advanced culture techniques, especially single-use systems, Process transfer, scale-up/scale-down models, Processing advances/Manufacturing productivity/efficiency, Model-assisted process understanding and development/Digital Twins, Process controls and analytics, Quality control, Quality by design, Facility design and full-scale commercial systems, manufacturing technology innovation.The book comprises contributions of experts from academia and industry active in the field of cell culture development for the production of recombinant proteins, cell therapy and gene therapy, with consideration of Digital Twin¿s and facility design. The knowledge and expertise of the authors cover disciplines like cell biology, engineering, biotechnology and biomedical sciences. Inevitably, some omissions will occur in the test, but the authors have sought to avoid duplications by extensive cross-referencing to chapters in other volumes of this series and elsewhere. We hope the volume provides a useful compendium of techniques for scientists in industrial and research laboratories active in this field.

This volume presents the recent developments in synthetic biodegradable and biobased polymers. The syntheses of many polymer types such as polyesters and polyamides, and also their processing technologies are discussed herein, and new aspects from fundamental and from industrial research are covered. This combination of both perspectives within this volume will be of interest for many research scientists from academia and industry and also for lectures and teachers. Chapters ''BioPBSTM (Polybutylene succinate)'' and ''Polymer biodegradability 2.0: A holistic view on polymer biodegradation in natural and engineered environments'' are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com. For further details see license information in the chapter.

This book delves into optics and photonic materials, describing the development of an intelligent all-optical system capable of replicating the functional building blocks of the biological brain. Starting with an analysis of biological neuronal dynamics and traversing the state of the art of neuromorphic systems developed to date, the book arrives at a description of neural networks realized through spatial soliton technology.After a brief introduction to the biology of neural networks (Chapter 1), the book delves into the description of the neuromorphic problem emphasizing the peculiarities of optical hardware developed to date. (Chapter 2). Chapter 3 is dedicated to the description of psychomemories , which represent the modeling of human learning according to the theories of modern neuro-psychology. This chapter provides the prerequisites for understanding how solitonic neural networks (SNNs) are able to learn and how they approach biological models. Chapter 4 focuses on the experimentation of solitonic optic neurons in thin layers of lithium niobate. Optical techniques for supervised and unsupervised learning are discussed. The entire chapter is accompanied by theoretical, simulative and experimental results. This chapter explains how an X-junction neuron is able to establish synapses, modify them, or erase them. The erasure of solitonic structures represents an important innovation in the field of nonlinear optics. Finally, Chapter 5 reports on the implementation of a network of neurons capable of processing information and storing it exactly as a human episodic memory does. The chapter ends with a number of insights into the lines of research that are currently being pursued on the basis of the results obtained.The book is meant for graduate students and researchers in the fields of optics, photonic applications, and biology. However, the main beneficiaries of this book are senior researchers in the fieldof nonlinear optics and artificial intelligence. To fully understand the results, it is important to have a basic knowledge of optical physics and neuron biology.

With extensive research, real-world examples, and hands-on applications, this go-to guide offers a comprehensive look at the principles and practices of biochar--and all of its world-changing uses. Like many human discoveries, biochar has likely been invented, lost, and reinvented multiple times. It can be found in the rich terra preta soils of the Amazon and in the ancient "dark earths" dotting Africa, Asia, and Europe. However, biochar isn't just an archeological curiosity. In The Biochar Handbook, author Kelpie Wilson argues that the simple process of burning organic material in a low-oxygen, low-emission environment could be one of the most powerful tools we have to restore degraded soils and reduce our dependence on fossil fuels. In accessible and authoritative prose, Wilson demonstrates that biochar is a low-tech but effective means of reducing wildfire risks, restoring soil carbon, managing manure, weaning farms off of toxic inputs, and producing the best compost ever made. In this book, you'll also find: A pocket history of biochar Step-by-step instructions on making biochar for yourself Applications for soil water retention, pest deterrence, compost enhancement, and more Inspiring examples of ecosystem restoration and improved forest management Low-cost recipes, including Cultured Biochar and Sustainable Potting Soil Wilson makes a compelling case that biochar is both simple to make and a potent solution to a host of knotty problems, both global and close to home. Whether you're a gardener, homesteader, rancher, commercial farmer, permaculturalist, or forest manager, this book will show you how to put biochar to work, making you and your community more resilient as a result.

This book presents the selected papers presented at the 2nd World Conference on Byproducts of Palms and their Applications (ByPalma 2021), held as a virtual conference on September 28-30, 2021. The conference focused on the byproducts of palm plantations around the globe and their current and potential applications. It provided an interdisciplinary platform for leading academic scientists, researchers, artisans, entrepreneurs and industry professionals as well as palm growers to exchange recent developments, technologies, innovations, trends, concerns, challenges, and opportunities, related to palm by-products R&D, manufacturing, and crafts. As a reference, it will be of interest to students, scientists, engineers, government officials, and industrial practitioners.

This book provides a comprehensive overview of recent developments to valorize fish waste as a source of useful products. In the first few chapters, an introductory section unearths global fish waste production, its detrimental effects and its role in the circular economy. The next section of the book discusses recent applications of fish waste and by-products utilization for the production of useful products such as fertilizers, biogas, biodiesel, fish sauce, enzymes and many more. This book will serve as an important source of recent research developments and applications of fish waste generated at different stages of fish processing. This book will also act as an important reference to the research group conducting research on fish and fish by-product utilization and valorization.

This volume presents select proceedings of ISAMPE National Conference on Composites (INCCOM-17). The volume focuses on recent developments in the composite industry for manufacturing including aerospace, defense, civilian and automobile industries. The content include chapters on research topics such as design, analysis and simulation, processing and composite tooling, high temperature composites, carbon-carbon composites, ultra high temperature composites, nano and smart composites, structural health monitoring, material characterization, non-destructive evaluation of composite structures, damage tolerance in composites, composite process modelling and simulation, composite repair technology, AI in composites, additive manufacturing of composites, start-up ideas in composite technology and applications of composites. This volume will be of interest to researchers and professionals in the fields of materials and mechanical engineering.

Challenges in Mechanics of Time-Dependent Materials & Mechanics of Biological Systems and Materials, Volume 2 of the Proceedings of the 2022 SEM Annual Conference & Exposition on Experimental and Applied Mechanics, the second volume of six from the Conference, brings together contributions to this important area of research and engineering.  The collection presents early findings and case studies on fundamental and applied aspects of Experimental Mechanics, including papers in the following general technical research areas: Characterization Across Length ScalesExtreme Conditions & Environmental EffectsDamage, Fatigue and FractureStructure, Function and PerformanceRate Effects in ElastomersViscoelasticity & ViscoplasticityResearch in ProgressCellular Biomechanics and MechanobiologyBiofilms and Microbe MechanicsTraumatic Brain InjuryCardiac and Vascular BiomechanicsOrthopedic and Disease BiomechanicsTime Dependence of BiomaterialsExperimental Techniques in Biological and Biomimetic Systems

This book presents an in-depth exploration of complex metal oxides, focusing on their applications in photocatalysis and biomedical materials. It highlights the practical importance of complex metal oxides, which have gained significant attention in recent years due to their diverse range of properties. The book specifically delves into the most representative series of compounds based on stable structural types of minerals, such as perovskite, fluorite, pyrochlore, corundum, and rutile. It also emphasizes the scientific interest in the pyrochlore mineral structure, which has been shown to exhibit photocatalytic activity.Recent studies have revealed that some compounds with the pyrochlore structure can act as promising candidates for photocatalysis. Additionally, the book highlights the use of photocatalysis in producing biomedical materials based on natural polymers. These materials possess a unique combination of components assembled in a specific structure, which makes them highly attractive for regenerative medicine associated with cell/tissue regeneration stimulation. Overall, this book offers a comprehensive analysis of the potential of complex metal oxides, particularly those with the pyrochlore structure, and is particularly useful for those researchers working in the fields of green chemistry and biomedical materials science.

Natural fiber composites are a preferred alternative to conventional composites due to their environment-friendly nature. However, their market share is limited due to: a) limited number and quantities of natural fibers available for composites, b) diversity in fibers structure, c) poor mechanical properties of fibers as well as composites, d) susceptibility to microbial attacks, and e) cellulose degradation temperature around 200 deg C, which hinders the development of natural fiber reinforced thermoplastic composites using thermoforming at high temperatures. A number of researchers have contributed to the solution of the problem of poor mechanical properties and issues related to fabrication during the last decade. This book covers these different solutions. The book is divided into two principal themes: a) structure-property relationship: fibers to composites-it includes the discussion on fibers, their surface modifications, variation in the structure of reinforcement, and approaches for the enhancement of properties. b) Fabrication process of composites-it includes the novel approaches used for the development of natural fiber composites using the commingling technique for thermoplastic composites.

This edited volume provides insights about the molecular virology, pathoenesis of infection and host responses to varicella-zoster virus, which is a medically important human herpesvirus.  The chapters not only discuss genetics and molecular evolution of the virus, but also new structure-based knowledge on the functions of viral glycoproteins. Further, the authors illustrate how mechanisms from the virus are used to take over and remodel host cells during pathogeneis. These mechanisms also enable viral modulation of host cells and evasion of the host immune response. Part of these evasion and survival strategies, is the reaction to triggered host cell responses like autophagy, the stress response, modulation of apoptosis and other cell death pathways. This hands-on knowledge is crucial for students and clinicians in Virology, Immunology, and Infectious Diseases.Chapter "e;Common features between stroke following varicella in children and stroke following herpes zoster in adults"e; is available open access under a Creative Commons Attribution 4.0 International License via Springerlink.com.

This book presents the state of the art on the topic of recycling of plastic building materials, comprising a synthetic market analysis, and presenting the latest developments in plastic recycling technologies. The book also makes recommendations to optimize the success of recycling and encourage the circular economy, while acknowledging the environmental and sustainability implications of plastic recycling for building construction. The distinctive features of this book are the variety of topics covered on sustainable plastic recycling, the discussion of advances in plastic recycling technology, detailed illustrations, and summarized descriptions of separation processes. This book is a guide for both technical and non-technical readers, and for anyone involved in plastic waste or recycling, including researchers and students in plastics engineering, polymer science, polymer chemistry, environmental science, and sustainable materials.

This book provides a comprehensive presentation of the most frequently used high resolution manufacturing techniques available, as well as the polymeric materials used for each of the techniques. Divided into two parts covering the technologies and materials used and the impact on different research fields and case studies, High Resolution Manufacturing from 2D to 3D/4D Printing: Applications in Engineering and Medicine addresses issues like throughput improvement by volumetric 3D printing and presenting novel applications and case studies. In addition, this book also covers the latest breakthrough developments and innovations to help readers understand the future applications of this technology across various disciplines, including biomedicine, electronics, energy, and photonics.

This book discusses the extraction, purification, modification, and processing of biobased materials and their various industrial applications, across biomedical, pharmaceutical, construction, and other industries. It includes contributions from experts on hybrid biopolymers and bio-composites, bioactive and biodegradable materials, bio-inert polymers, natural polymers and composites, and metallic natural materials. Therefore, this encyclopedia is a useful reference for scientists, academicians, research scholars, and technologists. Major challenges of biobased materials are their efficient development, cost-effective, and green & environment friendly production/applications. This encyclopedia answers these challenges to professionals and scientists for proper utilization of biobased materials. It presents the recent practices of biobased materials technology in different scientific and engineering domains. It helps the bounded industrial outcomes to reach the general readership of different domains. This encyclopedia bridges the technological gaps between the industrial and academic professionals and the novice young students/scholars. The interdisciplinarity of this encyclopedia makes it unique for a wide readership.  The topic of biobased materials is currently popular in the scientific community, working in such following areas as Recycled materials, Renewable materials, Materials for efficiency, Materials for waste treatment, Materials for reduction of environmental load, Materials for easy disposal or recycle, Hazardous free materials, Materials for reducing human health impact, Materials for energy efficiency, Materials for green energy, etc. This is a relatively hot topic in materials science and has strong demands for energy, material and money savings, as well as heavy contamination problems, despite that the area of biobased materials belongs to most important fields of modern science & technology, no important encyclopedias have been published in the area of "e;biobased materials"e;

This book provides a selection of recent developments in scanning ion conductance microscopy (SICM) technology and applications. In recent years, SICM has been applied in an ever-increasing number of areas in the bioanalytical sciences. SICM is based on an electrolyte-filled nanopipette with a nanometer-scale opening, over which an electric potential is applied. The induced ion current is measured, which allows to directly or indirectly quantify various physical quantities such as pipette-sample distance, ion concentration, sample elastic modulus among many others. This makes SICM well suited for applications in electrolytes - most prominently for the study of live cells.This book starts with a historic overview starting from the days of the invention of SICM by Paul Hansma at the University of California at Santa Barbara in 1989. SICM is a member of the family of scanning probe microscopies. It is related to another prominent member of the family, atomic force microscopy (AFM), which has found application in almost any field of nanoscale science. The advantages and disadvantages of SICM over AFM are also outlined. One of the most effective and break-through applications of SICM nanopipettes is in electrochemistry. The different routes and applications for doing electrochemistry using nanopipettes are also discussed. In addition the book highlights the ability of SICM for surface positioning with nanometer precision to open up new vistas in patch clamp measurements subcellular structures. Finally the book presents one research area where SICM has been making a lot of contributions, cardiac research and the endeavors to combine SICM with super-resolution optical microscopy for highest-resolution joint topography and functional imaging.