Biodegradable Microspheres - Basavaraj Nanjwade - Bog

The goal of any drug delivery system is to administer a therapeutic amount of a drug to the appropriate site in the body and achieve as well as maintain the desired plasma concentration for a specific duration. However, challenges such as incomplete drug release, shorter residence times of dosage forms in the upper gastrointestinal tract, and significant first-pass metabolism contribute to lower oral bioavailability. Parenteral drug delivery offers rapid attainment of therapeutically effective drug levels, but it comes with the drawback of a rapid decline in systemic drug levels or potential hazards associated with intravenous infusion, requiring close medical supervision, especially during hospitalization.These limitations inherent in conventional dosage forms have paved the way for an era of controlled and novel drug delivery systems. Specifically designed to release drugs at predetermined rates over predefined periods, controlled drug delivery systems aim to address the shortcomings of traditional drug formulations.Within the realm of microparticulate systems, microspheres hold special importance due to their ability to target drugs and provide controlled release.