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The Three Functional States of Proteins explores how structured proteins, intrinsically disordered proteins, and phase separated proteins contribute to the complexity of cellular life, and offers insights into their roles in both health and disease. It discusses the latest research findings and highlight groundbreaking discoveries and innovative methodologies used to study these protein states. Traditionally, the different states of proteins have been defined based on their structures and functions. However, it is becoming increasingly clear that these criteria alone may not be sufficient to capture the complex and multifaceted properties of these molecules. Definitions based on thermodynamics and kinetics are now recognized as potentially more appropriate for comprehensively understanding protein states. Emerging evidence indicates that under physiological conditions, a majority of proteins possess the capability to exist in and transition between the native, droplet, and amyloid states. These distinct states play crucial roles in various cellular functions, influenced significantly by their physicochemical and structural properties. The book also considers the interactions among these states and discusses how their internal organization as individual molecules, as well as their collective organization as molecular assemblies are stabilized. Furthermore, it examines the processes by which these states are formed and the cellular functions associated with each specific state.

This book focuses on nonextensive statistical mechanics, a current generalization of Boltzmann-Gibbs (BG) statistical mechanics.Conceived nearly 150 years ago by Maxwell, Boltzmann and Gibbs, the BG theory, one of the greatest monuments of contemporary physics, exhibits many impressive successes in physics, chemistry, mathematics, and computational sciences. Presently, several thousands of publications by scientists around the world have been dedicated to its nonextensive generalization. A variety of applications have emerged in complex systems and its mathematical grounding is by now well advanced.Since the first edition release thirteen years ago, there has been a vast amount of new results in the field, all of which have been incorporated in this comprehensive second edition. Heavily revised and updated with new sections and figures, the second edition remains the go-to text on the subject.A pedagogical introduction to the BG theory concepts and their generalizations ¿ nonlinear dynamics, extensivity of the nonadditive entropy, global correlations, generalization of the standard CLT¿s, complex networks, among others ¿ is presented in this book, as well as a selection of paradigmatic applications in various sciences together with diversified experimental verifications of some of its predictions. Introduction to Nonextensive Statistical Mechanics is suitable for students and researchers with an interest in complex systems and statistical physics.

Geophysics and the Energy Transition involves four sections: What is the Energy Transition and why storage so important; selecting sites for storage; advanced monitoring technology; and moving forward to integrating Carbon Capture and Storage (CCS) within the Energy Transition. Geophysics will also play a role in finding and developing alternatives to fossil fuels such as natural hydrogen and geothermal using much of the knowledge gained from the CO2 storage industry. To provide the public and others with the confidence to move forward with a structured and cost-effective energy transition, this book provides the necessary evidence that we can store CO2 safely and effectively and use this as a significant component of the energy transition.¿We can also find and store new energy sources. Geophysics and the Energy Transition is written by experts in the field who have practiced the science and engineering associated with the subsurface for years. CCS is an integral component of the new energy transition but the application of Geophysics in the future will extend well beyond CCS if we are going to transition successfully to a carbon neutral environment. Science, engineering, and technology applications are important for site selection, characterization and monitoring to assure safe storage in the subsurface and energy sustainability in the future.¿

Life as we know it has always been confined to our single blue planet called earth. But will it always be that way? Discover just how close we are to changing life as we know it forever, and what it will take to push humanity into a new era of exploration and discovery. Find out how the next steps for our future will be unlike anything civilization as we know it has experienced.The article explores the feasibility of colonizing mars in the near future, discussing the benefits, current state of exploration, technological breakthroughs needed, and social and political challenges associated with establishing a martian colony. It also highlights the economic opportunities in space exploration and colonization, particularly in the emerging industry of space tourism. The importance of life support systems for long-term space travel is also discussed. The article concludes by emphasizing the potential humanitarian benefits of living on mars, particularly for refugees fleeing an unstable earth.The book also highlights the importance of mars for humanity's future. It discusses the potential for mars to serve as a backup plan for the survival of humanity in case of a catastrophic event on earth and as a stepping stone for further exploration of the solar system and beyond. The book also covers the knowledge and technology developed through mars missions and how they can be applied to other extreme environments on earth.The book also presents the ongoing research and development required to overcome the obstacles presented by the transport of humans to mars. It details the available technology and techniques for getting to mars, along with the ongoing research and development to overcome the challenges of the journey, including launch vehicles, chemical propulsion systems, surface retrieval and landing of humans and spacecrafts, and critical life support systems.

This book outlines the unparalleled potential of NMR relaxation experiments to elucidate molecular dynamics for undergraduates to academics and those in industry.

This book is about the technology of using fluid production or injection and pressure measurement signals from wellbores and relating those signals to the subsurface geology and subterranean reservoir properties. It is aimed at students of well-testing and practicing petroleum engineers or geoscience professionals for subsurface characterization and modeling.The topics include the art and science of well-test analysis, pattern recognition of rate and pressure signals, and a quantitative approach for estimating important subsurface geological parameters for subsurface aquifers and reservoirs containing oil, gas, and geothermal resources. The book is also particularly of value as a guide to asset managers actively developing unconventional reservoirs and CCUS.

Lanthanides in Enzymology and Microbiology, a new volume in the Foundations and Frontiers in Enzymology Series, offers a detailed discussion of lanthanides and lanthanide-dependent enzyme biology. In this book, more than a dozen global experts consider lanthanide enzymology fundamentals, organismal utilization of lanthanides, distribution and diversity of lanthanide-dependent enzymes, regulation of intracellular levels of lanthanides, gene expression regulation via lanthanides, as well as likely applications of lanthanide binding proteins. Lanthanide-dependent methanol and alcohol dehydrogenase metabolism are considered in both methylotrophs and non-methylotrophs, alongside various application areas, from recovery of rare earth elements to developing lanthanide ion binding peptides and biosynthesis of terpolymers through reverse-oxidation pathways. In providing this deep context and pathways for future research, this book acts as an invaluable resource in this emerging field for researchers and students of biochemistry, biotechnology, and environmental microbiology alike.

The current theory for the early universe centers around the Standard Model's vision of fields, forces, and particles inexplicably popping into existence within the first second of the Big Bang. That conjecture has worked for many years and has inspired an edifice of theoretical support, but it stretches credulity and leaves too many unanswered questions.What if the initial nugget of energy did not instantaneously turn into particles but was left to expand and lose density? As it thinned, isolated density fluctuations would swirl and grow by accretion, eventually creating thick-density supermassive blackholes, light-density particles, and a thin-density medium of dark energy. The support for this seemingly wild hypothesis is in the observational evidence demonstrating that everything we know of in the universe, including fields, forces, matter, and time, naturally evolves from relationships between those three energy densities. This is the story of those relationships.That profound realization comes through in the Second Edition of A New Vision of the Early Universe. It's the culmina­tion of forty years of research and study by the author, Robert J. Conover. The depth of his research, attention to detail, clear prose, and philosophical approach to analyzing difficult issues conspire to make this a well-respected treatise. The work is supported by numerous citations, quotes, and observations from many leading physicists, cosmologists, and mathemati­cians.

The main theme of the book is the presentation of techniques used to identify chaotic behavior in the evolution of conservative mechanical systems and their application to astronomical systems. It results from graduate courses given by the author over the years both at university and at several international summer schools.Along the book surfaces of section, Lyapunov characteristic exponents, frequency maps, MEGNO, dense grid maps, etc., are presented and discussed in connection with the applications. The initial chapter is devoted to the presentation of the main ideas of the chaotic dynamics of conservative systems in plain language so that they can be accessible to a wide range of professionals and students of physical sciences. The applications are mainly related to the motions in the solar system and extrasolar planetary systems.Another chapter is devoted to the applications to asteroids showing how the asteroidal belt is sculpted by chaos and resonances. The contrasting existence of gaps in the distribution of the asteroids and groups of asteroids in resonances is thoroughly discussed. The interest in applications to planetary systems is growing since the discovery of systems of resonant planets around some stars of the solar neighborhood. Exoplanets added a lot of cases to a problem that was before restricted to the planets of our solar system. The book includes an account of results already existing about compact systems.

This book showcases recent trends in brain-computer interface development. It highlights fascinating results in areas such as language decoding, spinal cord stimulation to enable gait and to restore hand functions. The contributions are based on the 12 nominated brain-computer interface projects of the BCI Award 2022. Every year an international jury selects the most innovate BCI projects and nominates 12 projects before selecting the 1st, 2nd and 3rd place winners. In the book, each project is described in detail by the team of scientists behind it, and the editors provide a concluding discussion of the highlights and overall progress in the field.

These Transactions provide a record of the organisational and administrative activities of the IAU XXX General Assembly, which took place in Vienna, Austria, in August 2018. They report and record all of the essential decisions taken by the governing body of the IAU. These include the approval of the financial accounts and of the proposed budget for the next three years, the admission of new national and individual members, the Divisions, Commissions, and Working Groups, the new Officers and Executive Committee, and the approval of Resolutions, as well as opening and closing ceremonies and other events. Focus Meetings are published in the 'Astronomy in Focus' series, and each of the six Symposia that took place has its own Proceedings. The world was forever changed by the COVID-19 pandemic shortly after this General Assembly, contributing to the delay in this volume's publication.

This book contains the papers selected by the Scientific Committee and represented at the XIII International Conference "Solar-Terrestrial Relations and Physics of Earthquake Precursors", which was hold at the Institute of Cosmophysical Research and Radio Wave Propagation, Far Eastern Branch of the Russian Academy of Sciences, Kamchatka. The papers describe the investigation results in the fields of atmosphere, ionosphere and magnetosphere physics. Mechanisms of transformation of solar wind energy into the energy of magnetospheric-ionospheric processes, effects of the processes in the Earth core on the lower and upper atmosphere, seismo-electromagnetic, seismo-electric and seismo-acoustic effects at different frequency ranges in the Earth crust, atmosphere and ionosphere are under consideration. Modern methods for geophysical data collection, processing, transfer and exchange as well as organisation issues of seismic activity monitoring are presented.The Conference "Solar-Terrestrial Relations and Physics of Earthquake Precursors" has 25 years of history. Scientists from Russia, Japan, Hungary, China, India, USA and other countries participate in it. In a traditional way, the Conference includes three sections: atmosphere physics, geophysical fields and their interaction, physics of earthquake precursors.

This book bridges the gap between physical foundations and medical applications of the NMR and MRI technologies, making them accessible to both physicists and biomedical scientists. The physical basis of these technologies is discussed in a manner that can be easily understood by scientists from different backgrounds, aiding them in gaining a clearer understanding of the subject.. For instance, the medical applications of NMR and MRI technologies are described in a way that is accessible to physicists. Moreover, geometrical descriptions and specific mathematical tools are used to facilitate the visualizations of many concepts. Furthermore, the book covers modern technologies such as hyperpolarization and several other state-of-the-art techniques, along with their foundations.

This volume gives a comprehensive, up-to-date review of cosmic masers as presented at IAU Symposium 380, the sixth international maser symposium. It describes time-domain and multiwavelength studies of maser sources via large observing facilities and networks, and discusses ongoing and future projects relevant to maser science.

Cosmology's journey to the present day has been a long one. This book outlines the latest research on modern cosmology and related topics from world-class experts. Through it, readers will learn how multi-disciplinary approaches and technologies are used to search the unknown and how we arrived at the knowledge used and assumptions made by cosmologists today. The book is organized into four parts, each exploring a theme that has troubled humankind for centuries. Since the dawn of time, looking at the sky, humans have tried to understand their origin, the laws governing it, and what influence it all has on human life. In most ancient civilizations, astronomers embodied the power of knowledge. This knowledge was not compartmentalized, and scientists often found philosophical implications within their quests, many of which destroyed the borders between the natural sciences. Even now, as observers and scientists continue to use conjecture to generate theoretical assumptions and laws that then have to be confirmed experimentally, said theoretical and experimental searches are being linked to philosophical thinking and artistic representation, as they were up until the 18th century. This multi-disciplinary book will appeal to anyone with an interest in the fields of Astronomy, Cosmology or Physics.

This symposium honors the contributions of Charlotte Moore Sitterly as a pioneer of spectroscopy, and astronomical spectroscopy in particular. The need for precise and accurate laboratory data in astrophysics has not diminished. Every time better spectrographs are built or new wavelength domains explored, we find critical information missing that is needed for analyses to derive abundances or to compare models of stars and planets to observations, in order to more fully understand the universe that we observe. IAU Symposium 371 encompassed nearly all the science themes that the IAU covers, from near to far in the universe, and at all wavelengths. But it concerned more than lab work in and of itself and brought together laboratory astrophysicists with the people who use that information, to learn about current advances and limitations, and future needs. A broad spectrum of the IAU's membership can benefit from these proceedings.

This textbook presents the principles and methods for the measurement of radioactivity in the environment. In this regard, specific low-level radiation counting and spectrometry or mass spectrometry techniques are discussed, including sources, distribution, levels and dynamics of radioactivity in nature. The author gives an accurate description of the fundamental concepts and laws of radioactivity as well as the different types of detectors and mass spectrometers needed for detection. Special attention is paid to scintillators, semiconductor detectors, and gas ionization detectors. In order to explain radiochemistry, some concepts about chemical separations are introduced as well. The book is meant for graduate and advanced undergraduate students in physics, chemistry or engineering oriented to environmental sciences, and to other disciplines where monitoring of the environment and its management is of great interest.