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The Song of the Cell is the vivid, thrilling and suspenseful story of the fundamental unit of life. It describes how scientists discovered cells, began to understand them, and are now using that knowledge to create new humans. Both panoramic and intimate, it is Siddhartha Mukherjee's most spectacular book yet.In the late 1600s, a distinguished English polymath, Robert Hooke, and an eccentric Dutch cloth-merchant, Antonie van Leeuwenhoek, look down their hand-made microscopes. What they see introduces a radical concept that alters both biology and medicine forever. It is the fact that complex living organisms are assemblages of tiny, self-contained, self-regulating units. Our organs, our physiology, our selves, are built from these compartments. Hooke christens them 'cells'.The discovery of cells announced the birth of a new kind of medicine. A hip fracture, a cardiac arrest, Alzheimer's, AIDS, lung cancer - all could be re-conceived as the results of cells, or a cellular ecosystem, functioning abnormally. And all could be treated by therapeutic manipulations of cells.This revolution in cell biology is still in progress: it represents one of the most significant advances in science and medicine.Rich with stories of scientists, doctors, and the patients whose lives may be saved by their work, The Song of the Cell is the third book in this extraordinary writer's exploration of what it means to be human.
Peter er flyttet hjem for at støtte sin lokale ishockeyklub efter at have lykkedes med en karriere som professionel ishockeyspiller. Mira står over for valget mellem en advokatkarriere og et stille og roligt liv som hustru og mor. De bor i samme by. Bjørneby. Bjørneby er første roman ud af to om en lille by med store drømme. Det er en fortælling om femtenårige pigers ubrydelige venskaber og syttenårige drenge, der spiller ishockey med byens stolthed på skuldrene. Om sport, lidenskab, familiens bånd og holdånd, men også om hvor let et helt samfund kan vende det blinde øje til, når katastrofen slår ned, og hvor langt vi er villige til at gå for vores børn i kærlighedens navn. Bjørneby er den første roman ud af to om en lille by med store drømme. "Et totalt knockout. Fra halvvejs i bogen og frem til sidste side læste jeg med tårer i øjnene. Jeg på skift grinte, blev ramt og berørt, frustreret og vred. Det er fortalt så overbevisende." - Bloggen Just här - just nu Bind 2 udkommer oktober 2018.
Årets mest uregerlige roman er skrevet af forfatteren til En mand der hedder Ove. Folk med angst er en roman om et gidseldrama, der stikker af og når uden for rækkevidde af al sund fornuft. Gidseltagningen finder sted under et åbent hus-arrangement, hvor en mislykket bankrøver låser sig inde sammen med en overentusiastisk ejendomsmægler, to bitre IKEA-afhængige, en gravid, en selvmorderisk multimillionær og en irriterende kanin. Det ender med, at gidseltageren giver op og sætter alle fri, men da politiet stormer lejligheden, er den … tom. Alle vidnerne fortæller efterfølgende deres version af begivenhederne i en række af usammenhængende vidneforklaringer, der rejser mange spørgsmål, og en klassisk kriminalgåde tager form: Hvordan lykkedes det den mislykkede bankrøver at undslippe fra lejligheden? Hvorfor er alle så vrede? Og: Hvad er der GALT med folk nu til dags?
Selv om Danmark ikke er verdens største ishockeynation, leverer vi stadig stjerner til verdens bedste ishockeyliga, den amerikanske National Hockey League (NHL).Siden Frans Nielsen blev den første dansker i amerikansk ishockey i 2007, har 13 andre danskere spillet sig til en plads i verdenseliten. I DANSKERNE I NHL går ishockeyskribenten Michael Søvsø tæt på den danske succes i USA og fortæller spillernes egne historier om at udleve drømmen på ishockeyens øverste hylde.I bogen kan du bl.a. møde Lars Eller, Nikolaj Ehlers, Frans Nielsen, Frederik Andersen, Jannik Hansen, Mikkel Bødker, Peter Regin, Oliver Lauridsen og Oliver Bjorkstrand.
“I alle hans romaner stråler en sikker evne til at fortælle sandheder om mennesket med ubeskrivelig elegance.” KIRKUS REVIEWS”Når Fredrik Backman tager afsæt i følelserne, får det sentimentale en kraft – der som en hockeypuck går direkte i hjertet.” LANDSKRONA POSTENDet er så nemt bare at hade hinanden, at det er ubegribeligt, vi evner at gøre det modsatte.Bjørneby. I en snedækket skov i det høje nord ligger byen, hvis indbyggere rejser væk med samme hastighed, som arbejdspladserne forsvinder. Dem, der bliver, drømmer om storhed og succes. I en sport, ishockey! Men de husker også, at der er sket noget forfærdeligt på den bekostning.Veninderne Maya og Ana tilbringer sommeren på en afsides ø og forsøger at glemme, det, der er sket. Det lykkes ikke. Rivaliseringen mellem Bjørneby og nabobyen Hed intensiveres, og en af byens unge hockeyspiller går rundt med en hemmelighed. Hvis den bliver afsløret, må beboerne i Bjørneby tage stilling til, hvad de er for en slags mennesker. Hvad Bjørneby egentlig står for.Det siges, at volden kom til byen det år, men det er løgn. Den var der allerede.Os mod jer er den anden roman i portrættet af en lille by med store drømme. En fortælling om dræbende menneskelige relationer, loyalitet, venskab og en kærlighed, der overvinder alt. Eller det meste.“Hvad angår svensk eksport, så er Backmans popularitet på niveau med Abba og Stig Larssons.” NEW YORK TIMES
Medrivende og voldsom afslutning på trilogien om Bjørneby.Dette er en lille historie om de store spørgsmål: Hvad er en familie? Hvad er en ishockeyklub? Hvad er et samfund? Og hvad er vi villige til at ofre for at beskytte dem? Der er gået to år siden alt det, som ingen har lyst til at tænke på, skete. Alle har prøvet at komme videre, men der er noget ved dette sted, som gør det umuligt. Denne gang starter det med en storm, men ender med et opgør. Nogen, som har været væk længe, er på vej hjem. Nogen bliver begravet. Nogen forelsker sig, nogen drømmer om NHL, og nogen drømmer om hævn. Nogen sover ryg mod ryg med deres bedste ven, nogen forsøger at redde deres ægteskab, og nogen forsøger at redde deres børn. Nogen hader, nogen slås, nogen tager et skydevåben og går ned moden ishockeyhal. Det er ikke alt, hvad byen har kæmpet for, der kommer til at overleve, det er ikke alle, som er elsket, der kommer til at blive gamle. Så hvad er en familie? En ishockeyklub? Et samfund? Det er summen af vores valg. Hvad er vi villige til at ofre for at beskytte dem? Alt. Simpelthen alt.
From bestselling author Johanna Basford, a stunning new colouring book that invites artists to explore the great indoorsThrough her bestselling colouring books and distinctive illustrations, Johanna Basford's beautiful forests, ocean depths, and hidden magical kingdoms have enchanted millions of people around the world. In this newest work, Basford takes her audience indoors, inviting them to explore the wonders of the worlds within. Hidden within every illustration in Rooms of Wonder is a secret key and a locked door. Find the key, unlock the door and continue to the next room. Discover a busy craft studio, a wizard's workshop, a mouth-watering ice cream parlour and an opulent banquet hall. With hidden treasures, curious spaces and a few enchanted interiors, all you need to do is unlock the first door and begin your magical journey.
';New Dark Ageis among the most unsettling and illuminating books I've read about the Internet, which is to say that it is among the most unsettling and illuminating books I've read about contemporary life.'New YorkerAs the world around us increases in technological complexity, our understanding of it diminishes. Underlying this trend is a single idea: the belief that our existence is understandable through computation, and more data is enough to help us build a better world. In reality, we are lost in a sea of information, increasingly divided by fundamentalism, simplistic narratives, conspiracy theories, and post-factual politics. Meanwhile, those in power use our lack of understanding to further their own interests. Despite the apparent accessibility of information, we're living in a new Dark Age. From rogue financial systems to shopping algorithms, from artificial intelligence to state secrecy, we no longer understand how our world is governed or presented to us. The media is filled with unverifiable speculation, much of it generated by anonymous software, while companies dominate their employees through surveillance and the threat of automation. In his brilliant new work, leading artist and writer James Bridle surveys the history of art, technology, and information systems, and reveals the dark clouds that gather over our dreams of the digital sublime.
A radical new history of a dangerous idea
Written by internationally renowned author Stella Cottrell, this is an essential resource for students looking to refine their thinking, reading and writing skills.
The gripping new novel from the &i>Sunday Times&/i> bestselling author of &i>The Mercies, The Dance Tree&/i> is a transporting story of lust, family secrets and women under the eye of the Church.
When it comes to the climate, we don't need more marketing or anxiety. We need established facts and a plan for collective action.The climate is the fundamental issue of our time, yet it seems we can barely agree on what is really going on, let alone what needs to be done. We urgently need facts, not opinions. Insights, not statistics.The Carbon Almanac is a once-in-a-lifetime collaboration between hundreds of writers, researchers, thinkers, and leaders that focuses on what we know, what has come before, and what might happen next. With thousands of data points, articles and charts explaining carbon's impact on everything in our society, from our the economy to extreme weather events, it is the definitive source for facts and the basis for a global movement to fight climate change. This book isn't what the oil companies, marketers, activists, or politicians want you to believe. This is what's really happening, right now. Our planet is in trouble, and no one concerned group, corporation, country, or hemisphere canaddress this on its own. We are in this together. And it's not too late for concerted, collective action for change.
In this exhilarating memoir, three-time World Champion and Olympic gold-medalist Nathan Chen tells the story of his remarkable journey to success, reflecting on his life as a Chinese American figure skater and the joys and challenges he has experienced?including the tremendous sacrifices he and his family made, and the physical and emotional pain he endured. When three-year-old Nathan Chen tried on his first pair of figure skates, magic happened. But the odds of this young boy?one of five children born to Chinese immigrants?competing and making it into the top echelons of figure skating were daunting. Chen's family didn't have the resources or access to pay for expensive coaches, rink time, and equipment. But Nathan's mother, Hetty Wang, refused to fail her child. Recognizing his tremendous talent and passion, she stepped up as his coach, making enormous sacrifices to give Nathan the opportunity to compete in this exclusive world.That dedication eventually paid off at the 2022 Olympic Games in Beijing, where Chen?reverently known as the ?Quad King??won gold, becoming the first Asian-American man to stand at the highest podium in figure skating. In this moving and inspiring memoir Chen opens up for the first time, chronicling everything it took to pursue his dreams. Bolstered by his unwavering passion and his family's unconditional support, Chen reveals the most difficult times he endured, and how he overcame each obstacle?from his disappointment at the 2018 Olympic Games, to competing during a global pandemic, to the extreme physical and mental toll the sport demands.Pulling back the curtain on the figure skating world and the Olympics, Chen reveals what it was really like at the Beijing Games and competing on the US team in the same city his parents had left?and his grandmother still lived. Poignant and unfiltered, told in his own words, One Jump at a Time is the story of one extraordinary young man?and a testament to the love of a family and the power of persistence, grit, and passion.This memoir includes 16 pages of color photographs.
The essential companion to the million-copy bestseller The Success Principles, providing readers a practical, step-by-step workbook to transform their lives.
Endlich, das erste Buch von Melanie Berg! Die international erfolgreiche Strickdesignerin, die vor allem unter dem Namen Mairlynd bekannt ist, hat ihre schönsten Tücher zu einem wundervoll gestalteten Buch zusammengestellt. Ihre Fans und alle Strickbegeisterten in Deutschland und weltweit finden die Anleitungen in dieser zweisprachigen Ausgabe in deutscher und englischer Sprache. Drei wunderschöne neue Tücher werden exklusiv in "Shawls. Tücher stricken mit Stil - Knit in Style" veröffentlicht.Finally, the first book by Melanie Berg! The internationally successful knitwear designer, who is known foremost by the name of Mairlynd, has compiled her most beautiful shawls in this superbly designed book. Her fans as well as knitters all over the world will find the instructions in this bilingual edition in both English and German. Three beautiful new shawls are published exclusively in "Shawls. Tücher stricken mit Stil - Knit in Style".
NEW YORK TIMES BESTSELLER • Lauded Star Wars author James Luceno returns to pen an intense tale of ambition and betrayal that sets the stage for Rogue One: A Star Wars Story. War is tearing the galaxy apart. For years the Republic and the Separatists have battled across the stars, each building more and more deadly technology in an attempt to win the war. As a member of Chancellor Palpatine's top secret Death Star project, Orson Krennic is determined to develop a superweapon before the Republic's enemies can. And an old friend of Krennic's, the brilliant scientist Galen Erso, could be the key. Galen's energy-focused research has captured the attention of both Krennic and his foes, making the scientist a crucial pawn in the galactic conflict. But after Krennic rescues Galen, his wife, Lyra, and their young daughter, Jyn, from Separatist kidnappers, the Erso family is deeply in Krennic's debt. Krennic then offers Galen an extraordinary opportunity: to continue his scientific studies with every resource put utterly at his disposal. While Galen and Lyra believe that his energy research will be used purely in altruistic ways, Krennic has other plans that will finally make the Death Star a reality. Trapped in their benefactor's tightening grasp, the Ersos must untangle Krennic's web of deception to save themselves and the galaxy itself.
A searing critique of participatory art by an iconoclastic historian.
This comprehensive volume is the first to specifically target developing, adult and diseased neural stem cells. It explores recent advances in the understanding of neural stem cell biology along with strategies that use these cells to tackle neurological diseases and brain aging. Ten inclusive chapters discuss a wide range of topics including neurogenesis, neurodegeneration, demyelinating disease, mood regulation, and spinal cord regeneration, among others.Written by world-renowned scientists in the field, Neural Stem Cells in Development, Adulthood and Disease presents cutting-edge studies of interest to both established neurogenesis researchers and readers with general interests in nervous system science. It is an authoritative addition to the Stem Cell Biology and Regenerative Medicine series.
¿¿Non-parametric methods are widely used for studying populations that take on a ranked order (such as movie reviews receiving one to four stars). The use of non-parametric methods may be necessary when data have a ranking but no clear numerical interpretation, such as when assessing preferences. In terms of levels of measurement, non-parametric methods result in "ordinal" data. As non-parametric methods make fewer assumptions, their applicability is much wider than the corresponding parametric methods. In particular, they may be applied in situations where less is known about the application in question. Also, due to the reliance on fewer assumptions, non-parametric methods are more robust. Non-parametric methods have many popular applications, and are widely used in research in the fields of the behavioral sciences and biomedicine. This is a textbook on non-parametric statistics for applied research. The authors propose to use a realistic yet mostly fictional situation and series of dialogues to illustrate in detail the statistical processes required to complete data analysis. This book draws on a readers existing elementary knowledge of statistical analyses to broaden his/her research capabilities. The material within the book is covered in such a way that someone with a very limited knowledge of statistics would be able to read and understand the concepts detailed in the text.The ¿real world¿ scenario to be presented involves a multidisciplinary team of behavioral, medical, crime analysis, and policy analysis professionals work together to answer specific empirical questions regarding real-world applied problems. The reader is introduced to the team and the data set, and through the course of the text follows the team as they progress through the decision making process of narrowing the data and the research questions to answer the applied problem. In this way, abstract statistical concepts are translated into concrete and specific language.This text uses one data set from which all examples are taken. This is radically different from other statistics books which provide a varied array of examples and data sets. Using only one data set facilitates reader-directed teaching and learning by providing multiple research questions which are integrated rather than using disparate examples and completely unrelated research questions and data.
After having a nationally televised panic attack, Dan Harris knew he had to make some changes. A lifelong nonbeliever, he found himself on a bizarre adventure involving a disgraced pastor, a mysterious self-help guru, and a gaggle of brain scientists. Eventually, Harris realized that the source of his problems was the very thing he always thought was his greatest asset: the incessant, insatiable voice in his head, which had propelled him through the ranks of a hypercompetitive business, but had also led him to make the profoundly stupid decisions that provoked his on-air freak-out.Eventually Harris stumbled upon an effective way to rein in that voice, something he always assumed to be either impossible or useless: meditation, a tool that research suggests can do everything from lower your blood pressure to essentially rewire your brain. 10% Happier takes readers on a ride from the outer reaches of neuroscience to the inner sanctum of network news to the bizarre fringes of America's spiritual scene, and leaves them with a takeaway that could actually change their lives.This fifth anniversary edition features a new preface by Harris and new guided meditations from his favorite teachers, including Joseph Goldstein and Sharon Salzberg.