Bioteknologi

Research in recent years has increasingly shifted away from purely academic research, and into applied aspects of the discipline, including climate change research, conservation, and sustainable development. It has by now widely been recognized that ¿traditional¿ knowledge is always in flux and adapting to a quickly changing environment. Trends of globalization, especially the globalization of plant markets, have greatly influenced how plant resources are managed nowadays. While ethnobotanical studies are now available from many regions of the world, no comprehensive encyclopedic series focusing on the worlds mountain regions is available in the market. Scholars in plant sciences worldwide will be interested in this website and its dynamic content. The field (and thus the market) of ethnobotany and ethnopharmacology has grown considerably in recent years. Student interest is on the rise, attendance at professional conferences has grown steadily, and the number of professionals calling themselves ethnobotanists has increased significantly (the various societies (Society for Economic Botany, International Society of Ethnopharmacology, Society of Ethnobiology, International Society for Ethnobiology, and many regional and national societies in the field currently have thousands of members). Growth has been most robust in BRIC countries.The objective of this new MRW on Ethnobotany of Mountain Regions is to take advantage of the increasing international interest and scholarship in the field of mountain research. We anticipate including the best and latest research on a full range of descriptive, methodological, theoretical, and applied research on the most important plants for each region. Each contribution will be scientifically rigorous and contribute to the overall field of study.

mRNA COVID-19 A¿¿lar¿, çok nadir vakalarda baz¿ ki¿ilerde sitomegalovirüsün (CMV) yeniden aktif hale gelmesine izin veren k¿sa ömürlü geçici bir immün bask¿lamaya neden olabilir. Sitomegalovirüsün bu yeniden aktivasyonu, nadir durumlarda miyokardite ve Guillain-Barré sendromuna ve bir dizi bäka rahats¿zl¿¿a neden olabilir. Sitomegalovirüs do¿ada her yerde bulunur ve her yätan insanda yayg¿nd¿r ve ergenlerde suçiçe¿i ve mononükleoza neden olan herpesvirüs ailesinin bir parças¿d¿r. Enfeksiyondan sonra CMV, ço¿u insan¿n vücudunda yäamlar¿ boyunca uykuda kal¿r, ancak bä¿¿¿kl¿k bask¿lanmas¿ s¿ras¿nda yeniden aktif hale gelebilir. 45 yä¿ndan büyük erkeklerde azalan CMV duyarl¿l¿¿¿, mRNA ä¿s¿ alm¿¿ genç insanlarda nadir görülen miyokardit vakalar¿n¿n olmas¿n¿n nedeni olabilir. CMV duyarl¿l¿¿¿ 16-45 yälar¿ aras¿nda artar. Tedaviler, ilaçlar ve hatta ä¿lar, bä¿¿¿kl¿k sistemini geçici olarak bask¿layabilir ve CMV'nin yeniden aktivasyonuna neden olabilir. Bununla birlikte, bu çok nadirdir, ancak COVID-19 mRNA ä¿s¿ alm¿¿ olanlarda nadir görülen miyokardit ve Guillain-Barré vakalar¿n¿n olas¿ bir nedeni olarak arät¿r¿lmal¿d¿r.

This book explores different aspects of entrepreneurship from both an academic and a commercial point of view. The first chapter the university culture is considered. The nature of the technology or service is important. Some technologies are adaptive, in that they are developing products that are already in the marketplace, and these fit easily in academic institutions. Other technologies are disruptive and new products must be developed. These fit less easily into university structures since a commercial entity is required. Chapter 4 considers the important requirements of conflict of interest (COI). Either the university culture or COI can hinder or aid entrepreneurial faculty.  The second chapter deals with the reasons why an individual faculty might wish to become entrepreneurial. In many cases, a faculty member wants to see their technology in practice and not just a publication in a scientific journal. If a technology is disruptive, then a commercial entity is probably essential. If so, then funding must be obtained. There are "e;valleys of death"e; (1) where scientific discoveries to useful products and (2) the development, production and marketing of a commercially viable product. Chapter 6 deals specifically with methods of funding start-up companies. Chapter 3 describes several innovative programs in biology. These include genetic approaches, plant management systems and the author's own program that deals with microbial approaches to sustainable agriculture. Chapter 5 describes the crucial areas of agreements, contracts, regulatory affairs and patents. These legal documents are critical components of entrepreneurial efforts and must be understood and pursued correctly.  Finally, this book could have been entitled "e;things I wish I had known when I first started commercial activities."e; It is my hope that it can make the path of fledgling entrepreneurial smoother and more successful.  

Biotic stresses cause yield loss of 31-42% in crops in addition to 6-20% during post-harvest stage. Understanding interaction of crop plants to the biotic stresses caused by insects, bacteria, fungi, viruses, and oomycetes, etc. is important to develop resistant crop varieties. Knowledge on the advanced genetic and genomic crop improvement strategies including molecular breeding, transgenics, genomics-assisted breeding and the recently emerging genome editing for developing resistant varieties in vegetable crops is imperative for addressing FPNEE (food, health, nutrition. energy and environment) security. Whole genome sequencing of these crops followed by genotyping-by-sequencing have facilitated precise information about the genes conferring resistance useful for gene discovery, allele mining and shuttle breeding which in turn opened up the scope for 'designing' crop genomes with resistance to biotic stresses.The nine chapters each dedicated to a vegetable crop or crop-group in this volume will deliberate on different types of biotic stress agents and their effects on and interaction with crop plants; will enumerate on the available genetic diversity with regard to biotic stress resistance among available cultivars; illuminate on the potential gene pools for utilization in interspecific gene transfer; will brief on the classical genetics of stress resistance and traditional breeding for transferring them to their cultivated counterparts; will enunciate the success stories of genetic engineering for developing biotic stress resistant varieties; will discuss on molecular mapping of genes and QTLs underlying biotic stress resistance and their marker-assisted introgression into elite varieties; will enunciate on different emerging genomics-aided techniques including genomic selection, allele mining, gene discovery and gene pyramiding for developing resistant crop varieties with higher quantity and better quality; and will also elaborate some case studies on genome editing focusing on specific genes for generating disease and insect resistant crops.

This edited book discusses the latest advancements in the area of biofuel development. It covers extensive information regarding different aspects and types of biofuels. The book provides a road map of the various kinds of biofuels available for consideration. It focuses on microbial based power generation, applications of nanotechnology in biofuel development, advancements in molecular techniques, economic and life cycle assessments. The book also highlights the commercialization prospects and economics of the various processes and an overview of the life cycle assessment of the various different kinds of biofuels. The contributors are experienced professors, academicians and scientists associated with renowned laboratories and institutes in India and abroad. This book is of interest to teachers, researchers, biofuel scientists, capacity builders and policymakers. Also the book serves as additional reading material for undergraduate and graduate students. National and international scientists, policy makers will also find this to be a useful read.

This book provides a comprehensive overview of current biosurfactant research and applications. Public awareness of environmental issues has increased significantly over the last decade, a trend that has been accompanied by industry demands for climate-friendly and environmentally friendly renewable raw materials. In the context of household products, biosurfactants could potentially meet this demand in the future due to their low ecotoxicity, excellent biodegradability, and use of renewable raw materials. The diversity of this class of molecules, which has only been marginally tapped to date, offers only an inkling of their future application potential. However, there are two main obstacles to their widespread commercial use on the growing surfactant market: the lack of attractive and competitive production technologies, and the limited structural diversity of commercially available biosurfactants. Addressing both of these core issues, this book will provide readers with a deeper understanding of the role of biosurfactants, including future opportunities and challenges.Chapter "e;Environmental Impacts of Biosurfactants from a Life Cycle Perspective: A Systematic Literature Review"e; is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

This book presents novel techniques, current trends, and cutting-edge technologies in energy and biochemical processes. The authors explore recent advances that solve challenges related to the implications and commercialization of these processes by introducing new techniques or modifying existing technologies to meet future demands for food materials, bioproducts, fossil fuels, biofuels, and bioenergy. Divided into three parts, the first section of the book addresses issues related to the utilization and management of energy towards the efficient characterization and conversion of wastes or raw-/bio- materials to useful products. The second section focuses largely on studies on molecular detection of analytes, purification, and characterization of products recovered from biochemical, enzymatic, food, and phytochemicals, as well as biostimulation and bioaugmentation processes. The final section discusses areas related to heat and mass transfer, fuel processing technologies, nanofluids, and their applications. 

This detailed volume presents a series of protocols that are representative of recent developments and improvements in induced pluripotent stem cells (iPS cells) and corresponding human disease models. Reflecting the latest technology for generating induced pluripotent stem cells (iPS cells) and their initial characterization, the book explores techniques invaluable both for studies of disease-specific cell types and for their potential applications in regenerative medicine. Written for the highly successful Methods in Molecular Biology series, chapters include introduction to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Induced Pluripotent Stem Cells and Human Disease: Methods and Protocols serves as a vital guide that is valuable for not only experts but also novices in the stem cell field.

This second edition volume expands on the previous edition with new and updated chapters on the latest developments in the study of yeast within the biotechnology field. The chapters in this book cover topics such as transformation protocols for genetic engineering of Saccaromyces cerevisiae and Komagataella spp.; an overview of selection markers, promoters, and strains used for metabolic engineering of S. cerevisiae, P. pastoris, and Z. bailii; the use of yeast in CRISPR/Cas9 technology; tools to study metabolic pathway in Yarrowia lypolitica; and a discussion on the "e;universal expression system"e; that is applied in a broad spectrum of fungal species. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and authoritative, Yeast Metabolic Engineering: Methods and Protocols, Second Edition is a valuable resource for researchers and scientists interested in learning more about this important and developing field.

Metaverse Technologies in Healthcare focuses on data analysis, utilizing the possibilities of data to increase the effectiveness of healthcare organizations. As healthcare services aim to maintain the physical, mental, social and emotional well-being of human lives while the Metaverse is a blend of technological trends- Artificial Intelligence (AI), Augmented Reality (AR) and Virtual Reality (VR), collectively, they can deliver treatments and medicines, lower costs, and substantially enhance patient outcomes. The book redefines the digital health experience and describes the advantages of the Metaverse-based NFT technology in the healthcare sector, facilitating NFT avatars to interact with targeted audiences, and more.

Nanostructured Drug Delivery Systems in Infectious Disease Treatment explores a broad range of promising approaches for the treatment of infectious diseases using the latest advancements in nanomedical technologies. The book opens with an introduction about infectious diseases and global burdens. There is also specific discussion and assessment of the global impact of viruses with an emphasis on COVID-19, Zika, and Ebola. Subsequent chapters provide detailed information about various novel nanotherapeutic strategies used for delivering drugs for the treatment of various types of viral, bacterial, and fungal disorders. This will be a valuable resource for graduates, researchers, industry professionals, and anyone working to tackle the challenges of delivering drugs in a more targeted and efficient manner for the treatment of infectious diseases.

While technological advancement leads to societal benefits in terms of economic growth, it also brings with it challenges in its impact on the environment or human health. Sustainable development seeks a uniform means of comparing the economic benefits with the environmental and health costs associated with the implementation of a new technology. This revised encyclopedia investigates sustainability initiatives across a range of industries, providing insight into future opportunities for technological development. A broad spectrum of human challenges have only become more intense since publication of the first edition. For example, climate change is now observed across the globe as a contributor to large scale weather events, including extreme drought in Australia, intense wildfires in California, and flooding along the great rivers of Africa, North and South America. Land in the Amazon rain forest is destroyed to provide increased cropland, contributing to climate change. Expansion of the use of biomass as a raw material in chemical processing leads to food shortages. In many cases, these challenges have the greatest impact on the poorest nations, and the most polluting manufacturing facilities are located in the poorest communities, demonstrating social justice challenges. Encyclopedia of Sustainable Technologies, Four Volume Set provides a comprehensive analysis of the challenges of modern technology, and the innovations that are leading to better use of limited resources and improved resiliency as we learn to adapt to a changing world. Each chapter examines in depth a technological solution to support a specific human need, evaluates it relative to its impacts on the environment and human health, and considers the social justice issues underlying its development. The new edition provides a stronger link between manufacturing and climate change, updates on new technologies for the generation, distribution and storage of energy, new concepts in resiliency and modularity that have changed manufacturing and chemical processes, and emphasizes the trade-offs required to obtain desired products while minimizing environmental impact.

This book brings together the latest information on almond genomics and transcriptomics, with a particular focus on cutting-edge findings, tools, and strategies employed in genome sequencing and analysis with regard to the most important agronomic traits. Cultivated almond [(Prunus dulcis (Miller) D. A. Webb, syn. Prunus amygdalus Batsch., Amygdalus communis L., Amygdalus dulcis Mill.)] is a tree crop producing seeds of great economic interest, and adapted to hot and dry climates. Domesticated in Southeast Asia, its small diploid genome and phenotypic diversity make it an ideal model to complement genomics studies on peach, generally considered to be the reference Prunus species. Both represent consanguineous species that evolved in two distinct environments: warmer and more humid in the case of peach, and colder and xerophytic for almond. The advent of affordable whole-genome sequencing, in combination with existing Prunus functional genomics data, has now made it possible to leverage the novel diversity found in almond, providing an unmatched resource for the genetic improvement of this species.

Dieses Buch befasst sich mit evidenzbasierten Praktiken, die einen effektiven Unterricht ermöglichen, um einen optimalen Bildungserfolg für Schüler zu gewährleisten. Es identifiziert Schlüsselstrategien, die auf umfangreichen Forschungsergebnissen basieren, welche ihre Wirksamkeit bei der Verbesserung der Schülerergebnisse bestätigen. Das Buch bietet Lehrkräften einen Leitfaden zur Unterscheidung zwischen Strategien, die evidenzbasiert sind, und solchen, für die es nur wenige oder gar keine Belege gibt. Es beschreibt gängige Unterrichtsstrategien, die häufig in Schulen eingesetzt werden, obwohl ihre Wirksamkeit kaum belegt ist. Darüber hinaus werden in dem Buch acht wichtige evidenzbasierte Unterrichtspraktiken genannt, die von den Lehrkräften direkt umgesetzt werden können, die theoretischen und forschungsbasierten Grundlagen für jede dieser Strategien erläutert, und es werden Leitlinien für Sonder- und allgemeinbildende Lehrkräfte gegeben, wie sie diese Strategien am effektivstenanwenden können, mit Links zu Videobeispielen für ihre Anwendung im Unterricht. Der Text untersucht auch häufige Hindernisse für den Einsatz evidenzbasierter Praktiken in Schulen. Es werden die Auswirkungen auf die Lehrerausbildung untersucht, wobei der Schwerpunkt auf der Ausbildung von Pädagogen liegt, damit sie evidenzbasierte Strategien erkennen und effektiv umsetzen können, wobei diejenigen vermieden werden, die nicht evidenzbasiert sind, selbst wenn sie in den Schulen beliebt sind. ¿Evidenzbasierte Lehrstrategien¿ ist ein unverzichtbares Nachschlagewerk für Forscher, Fachleute und Studenten der pädagogischen Psychologie, der Kinder- und Schulpsychologie und der Sozialarbeit, die daran interessiert sind, wirksame Lehrmethoden kennenzulernen und umzusetzen, die das Engagement der Schüler und ihre schulischen Leistungen verbessern, das sozial-emotionale Lernen stärken und die Schulabbrecherquote senken.

This book addresses the structural and biological properties of the extracellular matrix component and glycosaminoglycan polymer hyaluronan (or hyaluronic acid, HA).The book discusses various aspects of HA biology, e.g., HA synthesis and degradation, as well as the role of HA in embryogenesis, development, and cell maintenance. The reader will learn about the role of HA in different tissues as well as its biological activities triggered by the interaction with different HA receptors. A closer look is had at the involvement of HA in human pathologies such as cancer, kidney fibrosis and wound healing. Biotechnological and biomedical applications for HA such as scaffold generation and drug delivery, including the novel synthetic sulphated HA are explored.This work will appeal to a wide readership within the extracellular matrix and hyaluronan field. It can serve as an introduction to the field for junior scientists but can also help senior scientists to gain a broader view of the field beyond their area of specialization.The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.

This book is the first comprehensive compilation of deliberations on domestication, genetic and genomic resources, breeding, genetic diversity, molecular maps & mapping of important biotic stress as well as nutritional quality traits, genome sequencing, comparative genomics, functional genomics and genetic transformation. The economic, nutritional and health benefits especially antioxidants mediated antiaging effects of finger millet are also discussed. It also presents the input use efficiency, wide adaptation, post-harvest processing and value addition of the crop. Altogether, the book contains about 300 pages over 16 chapters authored by globally reputed experts on the relevant field in this crop. This book is useful to the students, teachers and scientists in the academia and relevant private companies interested in genetics, pathology, molecular genetics and breeding, genetic engineering, structural and functional genomics and nutritional quality aspects of the crop. This bookis also useful to seed and pharmaceutical industries.

This book provides an exhaustive, critical analysis of the challenges and opportunities associated with social enterprises and social innovation.  More specifically, it addresses questions such as: What is a social innovation? Which are the best theories that explain how social innovations are generated and propagated in the global society? What is a social enterprise? Which are the theoretical perspectives that best describe the functioning of Social Enterprises , the threats and opportunities? How do social enterprises deal with the profit and non profit worlds and how these interactions affect their capability to be social innovators?The most recent literature has focused on strategies integrating conflicting logic, organizational practices or processes. In all these cases, the hybrid nature of the organization is implemented and sustained through original business models, new organizational arrangements and governance and novel strategies.  We believe that the hybrid and institutional perspectives are just one of the many theoretical lenses that can be used to frame social innovation and social enterprises. Along this line, some have highlighted the inherent ethical nature of these phenomena, the critical role played by ethical values whose advancement go well beyond what expected by the corporate social responsibility, business ethics and institutional theorizing.This book follows these perspectives exploring the link between social innovation and social enterprises, presenting them as a new  a new possible field of research that support new ways to understand and theorize individual, organizational and community behaviors.

This book is the first comprehensive compilation of current knowledge on mulberry (Morus L.) covering botany, cytogenetics, biodiversity, genetics and breeding, tissue culture and genetic transformation, biotic and abiotic stresses, molecular mapping, QTL identification, whole genome sequencing and elucidation on functional genomics. As mulberry is one of the most economically important trees in Asian countries, it has attracted the attention of both academicians as well as industrialists. Being highly heterozygous due to long juvenile life coupled cross pollination among species, the genetics of this important crop species is yet to be unravelled. Nonetheless, the recent success of sequencing the genomes of haploid and diploid domesticated species has ushered in an era of intense molecular and genetic research to understand this crop well for its better utilization for mankind.In this book, efforts have been made to bring together key information on origin and distribution, taxonomy, morphological features, economic importance, abiotic stress responses, disease and pest resilience, current breeding strategies and their constraints, progress and prospects of gene mapping, elucidation of genes controlling metabolic and physiological pathways, and their utilization in crop improvement which are elaborated in about 250 pages over 13 chapters authored by globally leading experts on the species presented.This book is useful to the sericulture community in the world in general and students, teachers, and scientists in the academia for forage and fruit production, genetics, breeding, pathology, entomology, physiology, molecular genetics, in vitro culture and genetic engineering, and structural and functional genomics. This book is also useful to seed and biofuel industries.

This book is designed with the objective of studying microalgae and its application in the widest sense. Microalgae offer various inherent advantages as they are capable of accumulating lipids (20¿70%), and able to aid with the production of pigments, carbohydrates, and proteins. The book comprehensively covers microalgae isolation techniques, their cultivation, and wastewater treatment by microalgae as well as the impact on biomass, lipid extraction, biofuel, and utilization of residual biomass focusing on biorefinery approach. The volume discusses the conversion of defatted oiled microalgae biomass for different applications. Acknowledging these challenges, this book discusses the limitations, outcomes, and economic aspects

Currently, there are no textbooks on drug product manufacturing technology transfer that incorporate the latest regulatory expectations. Recent guidance from regulatory bodies such as the US FDA, EMEA, WHO, and PIC/S has adopted the ICH Lifecycle approach harmonizing concepts across regulatory guidance. This allows organizations to align their technology transfer activities for all regulated markets. However, there is a need for consensus and direction in approaching technology transfer, particularly in understanding how to manage the scale-up effects to ensure regulatory compliance.This textbook offers technology transfer solutions and guidance to the pharmaceutical industry. The chapters provide a systematic understanding of applying the technology transfer concepts in pharmaceutical manufacturing, promoting standardization within the industry. Since Stage 1b is not specified in detail within the regulations, pharmaceutical organizations are left to determine the requirementsof the stage. The need to justify the methodologies and utilization of sound science makes it more demanding. The textbook¿s authors provide innovative solutions for technology transfer challenges, making it a comprehensive reference document. The approaches can be applied to both small-molecule and large-molecule drug product manufacturing segments, addressing the unmet needs of the industry.

Digital Technology in Public Health and Rehabilitation Care: COVID Era provides an in-depth examination on how digital technology has impacted public health and rehabilitation during the COVID-19 pandemic. The book showcases the range of digital technology applications utilized in healthcare, including the use of mobile phones, computers, wearable and non-wearable technologies, sensors, 3D printers, robotics, Artificial Intelligence (AI), internet technologies, websites and apps, virtual and augmented realities, and computer games. With a wealth of case studies and insights, this book is an essential resource on the impact of digital technology on public health and rehabilitation services in the COVID-19 era. The COVID-19 pandemic had a major impact on the rehabilitation services available to those in need, particularly for older adults, people with physical and cognitive impairments, children with autism and ADHD, and individuals with physical and mental health disorders. In response to these challenges, the book focuses on the potential for advanced digital technologies to revolutionize public health and rehabilitation services, highlighting the need for researchers and healthcare professionals to work together to promote digital-based interventions.

Carbon-Based Nanomaterials in Biosystems: Biophysical interface at Lower Dimensions provides a thoroughly comprehensive overview of all major aspects of carbon-based nanomaterials, their biophysical response, and biotechnological applications. The book articulates the underlying physics, chemistry, and the basic phenomenon of the broad-range carbon-based nanomaterials (CNMs) with biological systems, particularly the interface analysis. Organized in six sections, it discusses state-of art technological interventions of carbon-based nanomaterials and their application in biomedical sectors in healthcare, food sciences, and technology. The book also highlights the carrying capacity of different CNMs in payload efficiency mechanisms in various biomedical fields. The theranostic efficiency and the safety of various forms of CNMs is assessed. This book will be a helpful resource to those specializing in the areas of nanomedicine, bionanomaterials, and nanotechnology applications.

Nanofertilizer Synthesis: Methods and Types discusses the production of a variety of nano-fertilizers, including biological, chemical, and mechanical types. The book presents the latest information, highlights the benefits and impacts of each, and provides a single-volume resource to help effectively and efficiently identify options based on use-case. Exploring the topic from the various mechanistic types to the relevant regulatory, safety, and economic aspects, this volume will be appropriate for those working with and researching new nano-fertilizers which aid in nutrition control by increasing nutrient consumption efficiency as nutrients are bonded to nano-dimensional adsorbents, which in turn release nutrients considerably more slowly than traditional fertilizers. As the nano-fertilizer sector advances, one approach is to concentrate on macro elements (N, P, K), as switching to nano-fertilizers may result in significant environmental benefits by replacing the majority of these nutrients. Furthermore, the biosynthesis of nanomaterials employing bacteria, algae, yeast, fungus, actinomycetes, and plants has opened up a new field of study for the creation of inorganic nanoparticles as environmentally benign fertilizers. Because of the several-fold increase in the surface-to-volume ratio of nano-forms of nutrients, and their appropriateness for foliar application, where environmental losses are further decreased, nano-fertilizers may achieve higher efficiency.

Nanofertilizer Delivery, Effects and Application Methods explores the science of nutrient nanoformulation, a potential tool toward sustainable and climate-sensitive crops. The book discusses the potential agricultural benefits of nanofertilizers, from coverage of their formulation and delivery, to application, plant uptake, translocation, and destiny, and their overall effect on plant physiology and metabolism. As the widespread use of chemical fertilizers has been shown to causes significant damage to soil structure, mineral cycles, soil microbial flora, plants, and create human health risk, both immediately and for future generations, this book elucidates on the latest findings. According to recent studies, through environmental cues and biological demands, nano-fertilizers can respond to specifical challenges and boost agricultural yield by increasing the rate of seed germination, seedling growth, photosynthetic activity, nitrogen metabolism, and carbohydrate and protein synthesis. This book is ideal for researchers in industry and academia.

Each year for the past three years, there have been about 50 new molecular medicines approved by the United States Food & Drug Administration (FDA), of which approximately 25% were new biopharmaceuticals. Over 200 recombinant proteins, monoclonal antibodies, antibody drug conjugates, fusion proteins, and Fab fragments are now in the marketplace in both the United States of America (USA) and European Union (EU). There are also now over 60 biosimilars available for all major classes of recombinant proteins and monoclonal antibodies. In addition, gene therapies using genetically engineered viruses and genetically engineered cells are now in the marketplace, and continually growing. This degree of change is reflected in the over 400 CMC regulatory compliance references listed in this book that were either issued or updated since the release of the third edition. Deficiencies in biopharmaceutical CMC regulatory compliance rarely result in termination of a product, but incan readily cause months if not years of delay in initiating clinical trials, or advancing clinical development stages, or even market approval. In summary, this book:Updates real-world CMC deficiency examples with current examples;Addresses current FDA and EMA requirements and expectations for CMC regulatory compliance;Now includes CMC regulatory compliance for the new gene-based biopharmaceuticals.

Practical Pharmaceutics contains essential knowledge on the preparation, quality control, logistics, dispensing and use of medicines. It features chapters written by experienced pharmacists and scientists working in hospitals, academia and industry throughout Europe, including practical examples as well as information on current GMP and GMP-based guidelines and EU-legislation. In this second edition all chapters have been updated with numerous new as well as didactically revised illustrations and tables. A completely new chapter about therapeutic proteins and Advanced Therapy Medicinal Products was added.From prescription to production, from usage instructions to procurement and the impact of medicines on the environment, the book provides step-by-step coverage that will help a wide range of readers, students as well as professionals. It offers product knowledge for all pharmacists working directly with patients and it will enable them to make the required medicine available, to store medicines properly, to adapt medicines if necessary and to dispense medicines with the appropriate information for patients as well as caregivers about product care and how to maintain the quality of the product. The basic knowledge presented in the book will also be valuable for industrial pharmacists to remind and focus them on the application of the medicines manufactured.The basic and practical knowledge on the design, preparation and quality management of medicines can directly be applied by the pharmacists whose main duty is production in community and hospital pharmacies and in industry. Undergraduate as well as graduate pharmacy students will find knowledge presented in a coherent way and fully supported with relevant examples.Practical Pharmaceutics has become a reliable and recognised source for the acquisition of pharmaceutical-technological knowledge. The book is used in the curriculum of a number of international universities and schools of Pharmacy.

This volume focuses on the biomedical aspects of inorganic polyphosphates, a family of unique bio-inorganic polymers.In recent years, great advances have been made in understanding the development, metabolism, and physiological role of inorganic polyphosphates. These energy-rich polymers, which consist of long chains of phosphate units, are evolutionary old molecules. The acidocalcisomes, conserved organelles from bacteria to humans, as well as the mitochondria play a central role in polyphosphate production and storage. Polyphosphates have been assigned multiple functions, some of which are closely related to medically important processes, such as blood coagulation and fibrinolysis, energy metabolism, cell cycle regulation, apoptosis, chaperon function, microvascularization, stress response, neurodegeneration and aging. The development of bioinspired polyphosphate particles, in combination with suitable hydrogel-forming polymers enabled the development of new strategies in regenerative medicine, in particular for hard and soft tissue repair, but also in drug delivery and antimicrobial defense. This book not only highlights the basic research in this area, but also discusses possible applications. Therefore, it appeals to scientists working in cell biology, biochemistry, and biomedicine and practicioners alike.

This book offers a comprehensive and timely overview of the latest developments in the field of biomechanics and extensive knowledge of tissue structure, function, and modeling. Gathering chapters written by authoritative scientists, it reports on a range of continuum and computational models of solids, and related experimental works, for biomechanical applications. It discusses cutting-edge advances such as constitutive modeling and computational simulation of biological tissues and organs under physiological and pathological conditions, and their mechanical characterization. It covers  innovative studies on arteries, heart, valvular tissue, and thrombus, brain tumor, muscle, liver, kidney, and stomach, among others. Written in honor of Professor Gerhard A. Holzapfel,  the book provides specialized readers with a thorough and timely overview of different types of modeling in biomechanics, and current knowledge about biological structures and function.