Teknisk anvendelse af biomaterialer

This book highlights the latest clinical research and advancements in 3D (bio)printing and 4D printing using stimulus-responsive hydrogels as well as the concept of self-healing and its amalgamation with 3D printed injectable cell-laden tissue constructs. It also explores the use of metal-free ¿click¿ chemistry and enzymes such as horseradish peroxidase, hematin, tyrosinase, and transglutaminase to obtain chemically crosslinked hydrogels and the in vitro and in vivo responses. Lastly, the book briefly examines the future of drug delivery and the potentials offered by microrobotics and self-powered devices based on triboelectric nanogenerators. This book caters to biomedical researchers and clinical practitioners working in tissue reconstruction and drug/therapeutic delivery.

This book discusses recent trends and concepts in the field of biorefinery. It discusses optimal and economic strategies for converting biomass to value-added products to maximize profits with minimal environmental impact with a sustainability approach. The chapters of the book are focused on the current technologies, techno-economical aspects, life cycle assessment, and case studies. The book is divided into three sections; the first section presents strategies for the production of biofuels like bioethanol, biomethane, biohydrogen, bio-oil, gasification, etc., from the biomass in a sustainable way. The second sections review the extraction of bioactive chemicals, phenolic antioxidants, enzymes, and carboxylic acid from the biomass residue. The last section examines the utilization of biomass for the production of bioactive materials, including biofertilizers, bioadsorbents, activated carbon, nano-materials, and pigments. This book explores the relation between biofuels and the sustainable development goals (SDGs) 7.

This book introduces a fundamental understanding of orthopedic design for both engineers and medical staff. It addresses the gap and mystery that often exists between these two fields and provides a common ground for understanding. The book covers various aspects of orthopedic design, including the anatomy and biomechanics of bones and joints, the materials used in orthopedic devices, and the testing and evaluation of orthopedic devices. It also introduces computer-aided design with additive manufacturing in a practical sense, including the principles of non-parametric optimization (topology and shape optimization) in a scientific and practical way. The author provides dedicated examples and research studies to further clarify the concepts presented in the book and includes some of their own peer-reviewed papers to support the material. Additionally, it covers the practical applications of computer-aided design and additivemanufacturing in orthopedic design, including the use of virtual prototyping, computer simulation, and 3D printing techniques. The book aims to provide a comprehensive guide to orthopedic design and the latest advancements in the field.

This book presents the recent developments in immunomodulatory biomaterials for cell-based therapies in various diseases, including diabetes, cancer, cardiovascular disease, and bone regeneration. The authors first cover the fundamentals of conventional immunology and immunomodulation, before focusing on the history, advantages, and challenges of cell therapies. Biological cell therapy has gained immense attention for various diseases due to unique advantages it has over chemical drugs regarding cost, ease of production, toxicity, and therapeutic efficacy. However, these cell-based therapies need an inert delivery system that can locally deliver cells and minimally elicit foreign body response. The book discusses the foreign body response to the immunomodulatory biomaterials as well as the current and future strategies for potential mitigation of considerable immune responses toward immunomodulatory biomaterials and devices.

This book highlights the comprehensive overview of the current status and future potential of biopolymers in the textile industry, including the properties and performance of different types of biopolymers, the applications of biopolymers in various textile products, the challenges and limitations associated with their use, and the environmental impact and economic benefits of biopolymers in the textile industry. The textile industry is one of the largest and most important industries in the world, but it also has a significant environmental impact due to the use of non-renewable and non-biodegradable materials. Biopolymers, which are derived from renewable biological sources such as plants and microorganisms, have the potential to be a sustainable alternative to traditional textile materials. However, the use of biopolymers in the textile industry is still a relatively new and rapidly evolving field, and there is a need for more information and understanding about the opportunitiesand limitations associated with their use.

This book focuses on the recent innovations and therapeutic potentials of regenerative medicine and discusses the applications of stem cells, biomaterials, and tissue engineering in regenerative medicine. The book covers essential aspects of regenerative medicine, including tissue microenvironment, immunological perspectives, stem, and non-stem cell-mediated approaches, imaging techniques, biomarkers, and 3D printing technology. It also reviews the applications of biosensing technologies in regenerative medicine, including biomanufacturing, organ-on-a-chip technologies, and as indicators of therapeutic efficacy. Further, it focuses on the regenerative medicine approaches for diseases of the central nervous system. It also provides the therapeutic potential of regenerative medicine to improve soft tissue and wound healing, cardiovascular, neural, bone, and orofacial regeneration.¿

This book focuses on recent trends of research on alginate-based biomaterials in Drug Delivery strategies and biomedical engineering. It contains the widely used alginate-based biomaterials as micro to nano-controlled drug delivery (oral, ocular delivery, topical delivery, etc.) and its fabrication technology, characterization, and biomedical aspects (such as cancer therapy, tissue engineering, gene delivery, vaccine delivery, enzyme immobilization, wound healing, dental applications, etc.) in a single book. The chapters cover updated information, current research trends, informatics, and all aspects of applications. Alginate is a U.S. Food and Drug Administration (FDA)-approved natural biomaterial and has diverse biomedical applications. In recent years, researchers and scientists are working on the alginate-based drug delivery systems that have been designed and characterized as a matrix, micro to nanocarriers, fibers, composite/scaffolds, etc. Alginate has versatile properties such as biodegradable, biocompatible, nontoxic, and easily available. This book especially highlights both the drug delivery strategies and biomedical engineering aspects such as controlled drug delivery, drug targeting to the site of action, cancer therapy, gene and vaccine delivery, enzyme immobilization, tissue engineering, and regenerative medicine.

Therapeutic macromolecules and biologics have gained increasing importance in the last decade. Pulmonary and intranasal delivery of these therapeutic modalities, which have poor oral bioavailability, could constitute an attractive, non-invasive alternative to parenteral delivery. They can be considered for either topical use for treating diseases affecting the airways or for systemic use for treating a variety of other diseases. Therefore, this book is a readable, thoughtful, and useful guide on the latest research developments and the best options that people involved with pulmonary and intranasal route of administration and biologically active agents can bring to their practices. Furthermore, it explores the underlying scientific rationale for the strategies applied to overcome drug delivery challenges and provides insights to inspire further research in this growing area.

In today's society researchers are more focused on cleaner materials production for environmental sustainability. This approach aims at reducing waste and the development of materials with enhanced properties and functionality. This book focuses on optimizing manufacturing processes for sustainable composite materials. It discusses optimum utilization of resources by using minimum effort to save cost and energy.

This detailed volume presents a series of protocols dealing with different aspects of inclusion body (IB) processing, from cloning procedures to purification of refolded product. Commencing with chapters on upstream processing, looking into different expression strategies for IB production, the book continues with downstream applications, highlighting early protein purification and subsequent analytics, as well as success stories of IB-based processes. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Inclusion Bodies: Methods and Protocols serves as an ideal resource for facilitating diverse aspects of IB processing.

This book accumulates the most recent advancements in the field of bioengineering regarding hybrid science named nanobiotechnology and enriches the readers with vast and comprehensive knowledge about different biomedical applications of nanomaterials. It includes drug and gene delivery, tissue engineering, antimicrobial properties, hyperthermia, cancer therapy, bioimaging, biosensing, photoablation therapy, etc., utilizing the potential of different nanomaterials that are helpful for the well-being of diseased individuals. Furthermore, the concerns about multidrug-resistant microorganisms are increasing daily in the healthcare system. Since conventional therapies fail to combat various infectious diseases, novel nanotechnology techniques provide an alternative approach to developing innovative biomaterials. The novel features of nanomaterials need to be exploited for use in the biomedical engineering domain. They should be fabricated so that the novel multifunctional nanomaterials not only improve drug efficacy but also reduce their side effects. Moreover, a detailed understanding of the nanotoxicological effects of promising biomedical nanomaterials should necessarily be explored using the cell culture approach. Corona of nanomaterials should be investigated in detail to determine its fate in the biological system regarding safety concerns. This is the most important feature that is novel and explored in this book and would be very helpful for customers like clinicians, scientists, engineers, and technicians who will gain extensive knowledge from this book and work together to get the desired results in the healthcare sector.

This book provides a methodical compilation of deriving composites from the hidden treasure of the aquatic world.Continuous and rapid progress in the composite industries have increased the demand for resilient, economically viable, and sustainable composite materials having enhanced mechanical , thermal and electrical properties which better suits there respective applications.If the materials/organisms used for the production or conversion of composites are renewable, degradable and easily and abundantly available then it gives great opportunity to the researchers to work on different options or processes to make them a viable technology. This work describes the organisms and materials present in the aquatic environment for the production of composite materials. Elaborating the versatile green expedients and their potential applications in the field of composites.  Since, growing ecological and environmental consciousness has driven efforts for development of new innovative materials for various end-use applications.Therefore the LCA an circular bio-economy will be discussed to be efficient and sustainable. This book is ideal for the students, academicians, researchers and industry players. It also cover the present scenario, applications and future perspectives of composites derived from aquatic organisms. This compiled book features chapters that discuss the conversion of different materials  and organisms present in aquatic environment to composite materials like micro-algae, seaweeds, chitosan, collagen, agar cyanobacteria etc.in a viable manner.

This book gives insight into several aspects of the microbiology, biotechnology, and ecosystem sustainability of special and under-explored regions, that captivate human beings by their natural richness, their extensive biodiversity, the extraordinary forms of adaptation of the living beings that they inhabit, and even that keep living secrets as is the very origin of life. The chapters emphasize all aspects of biological diversity-its description, analysis, and conservation, and its controlled rational use by humankind. Also, the book is elaborated from a wide and multidisciplinary point of view. It presents reviews, research papers, comments, and research notes on biodiversity, ethnobiology, geoscience, chemistry, biological conservation, biotechnology, and ecosystem sustainability Two hotspots are the reference for this enriching book that describes details of extraordinary areas of the planet, from Cuatrociénegas, Coahuila (Mexico) to the Southern Western Ghats (India). The book will contribute to dealing with the practicalities of conservation management, economic, social, and political issues. It provides a forum for examining conflicts between sustainable development and human dependence on biodiversity in agriculture, environmental management, and biotechnology, and encourages contributions from developing countries to promote broad global perspectives on matters of biodiversity and conservation.

Environmental pollution is a worldwide concern now. A major section of the world population is struggling for drinking water. Polluted soil is resulting into low agricultural productivity and thus creating challenges in the way of sustainable livelihood of a large section of human population. Biological treatment can offer both green solutions for wastewater treatment and resource recovery as well. Like algal-based systems can be utilized for wastewater treatment and production of biofuels from the biomass grown on the wastewater. Bio-based nanomaterials have been extensively studied for their employability in the health care, process optimization, water resource management, dealing with environmental pollutants, biosensors, and many others. Bioprospecting of novel biological agents, bio-based products, and bioresource recovery are paving the way for sustainable development as they are providing local solutions for a number of problems.In this proposed book, we start with the introduction to bio-nanotechnological principles and later on discuss bio-based nanomaterials employability for a diverse range of applications from environment to energy to health care. This book provides with current trends in bio-nanotechnology for anthropogonic purposes, prospects, challenges, and way forward.

This book provides the latest developments in functional and engineering materials for defence applications. It contains a total of 20 book chapters in 2 proposed volumes: Vol. 1. Defence Functional Materials and Vol. 2. Defence Engineering Materials. All the book chapters are authored by leading scientists from the premier institutes, such as DRDO laboratory, DMSRDE, Kanpur, India, and edited by Drs. N Eswara Prasad, RJH Wanhill, and DK Setua. Both the authors and the editors are well known internationally for their seminal works in the Functional and Engineering Materials R&D and S&T. The principal purpose of this two-volume book is to provide the salient features of materials selection, synthesis, development and qualification for many a classical applications encompassing aero, naval and ground-based defence systems. They would surely act as valuable vade mecums for both active researchers, defence experts, post-graduate students, and faculty members who like to work and contributeto defence forces through research in areas such as defence materials, products, prototypes, sub-systems and systems that need cutting edge technologies and the latest and best materials and materials solutions.

This book presents the latest developments in the field of vegetable oil -based composites. It focuses on different vegetable oils such as castor, linseed, corn, soybean, olive, palm, and canola oils;, and fillers from inorganic materials and agricultural residues used in the preparation of vegetable oil -based composites. There are several advantages to vegetable oil-based polymer composites, due to their universal availability, inherent biodegradability, low price, and superb environmental credentials (i.e., low eco-toxicity and low toxicity towards humans). This book will be of is of interest to researchers working in the field of bio-based composite materials for the development of green and sustainable materials.

This book provides the latest developments in functional and engineering materials for defence applications. It contains a total of 20 book chapters in 2 proposed volumes: Vol. 1. Defence Functional Materials and Vol. 2. Defence Engineering Materials. All the book chapters are authored by leading scientists from the premier institutes, such as DRDO laboratory, DMSRDE, Kanpur, India, and edited by Drs. N Eswara Prasad, RJH Wanhill, and DK Setua. Both the authors and the editors are well known internationally for their seminal works in the Functional and Engineering Materials R&D and S&T. The principal purpose of this two-volume book is to provide the salient features of materials selection, synthesis, development and qualification for many a classical applications encompassing aero, naval and ground-based defence systems. They would surely act as valuable vade mecums for both active researchers, defence experts, post-graduate students, and faculty members who like to work and contribute to defence forces through research in areas such as defence materials, products, prototypes, sub-systems and systems that need cutting edge technologies and the latest and best materials and materials solutions.

This volume presents the recent developments in synthetic biodegradable and biobased polymers. The syntheses of many polymer types such as polyesters and polyamides, and also their processing technologies are discussed herein, and new aspects from fundamental and from industrial research are covered. This combination of both perspectives within this volume will be of interest for many research scientists from academia and industry and also for lectures and teachers. Chapters ''BioPBSTM (Polybutylene succinate)'' and ''Polymer biodegradability 2.0: A holistic view on polymer biodegradation in natural and engineered environments'' are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com. For further details see license information in the chapter.

This book reviews state of the art of polymeric biomaterials for regenerative medicine and highlights advances in both fundamental science and clinical practice. It summarizes the latest techniques in polymeric scaffold fabrication, delivery carriers, physiochemical property modulation, as well as their influence on the adhesion and performance of biomolecules, cells, and tissues. It also describes methods for creating biofunctional surfaces/interfaces and subsequently modulating the host response to implantable materials. Lastly, it discusses the applications of biomaterials and constructs in soft-tissue regenerative medicine. It is a valuable resource for materials scientists and engineers wishing to identify research priorities to fulfill clinical needs and provides physicians with insights into emerging novel biomaterials. This integrated approach also offers engineering students a sense of the relevance of materials science in the development of novel therapeutic strategies.In the second edition, most of the chapters are updated according to the latest progress of this research field. A new chapter on nerve regeneration is also included.

This book delves into optics and photonic materials, describing the development of an intelligent all-optical system capable of replicating the functional building blocks of the biological brain. Starting with an analysis of biological neuronal dynamics and traversing the state of the art of neuromorphic systems developed to date, the book arrives at a description of neural networks realized through spatial soliton technology.After a brief introduction to the biology of neural networks (Chapter 1), the book delves into the description of the neuromorphic problem emphasizing the peculiarities of optical hardware developed to date. (Chapter 2). Chapter 3 is dedicated to the description of psychomemories , which represent the modeling of human learning according to the theories of modern neuro-psychology. This chapter provides the prerequisites for understanding how solitonic neural networks (SNNs) are able to learn and how they approach biological models. Chapter 4 focuses on the experimentation of solitonic optic neurons in thin layers of lithium niobate. Optical techniques for supervised and unsupervised learning are discussed. The entire chapter is accompanied by theoretical, simulative and experimental results. This chapter explains how an X-junction neuron is able to establish synapses, modify them, or erase them. The erasure of solitonic structures represents an important innovation in the field of nonlinear optics. Finally, Chapter 5 reports on the implementation of a network of neurons capable of processing information and storing it exactly as a human episodic memory does. The chapter ends with a number of insights into the lines of research that are currently being pursued on the basis of the results obtained.The book is meant for graduate students and researchers in the fields of optics, photonic applications, and biology. However, the main beneficiaries of this book are senior researchers in the fieldof nonlinear optics and artificial intelligence. To fully understand the results, it is important to have a basic knowledge of optical physics and neuron biology.

This book outlines the latest research on the design and fabrication of the biomaterials used in mimicked scaffolds for tissue engineering for maxillofacial and orthopedic applications. The book is written based on integration and optimized concepts of 3 main parts 1) principle of tissue engineering; 2) mimicking of structure and function of scaffolds which is similar to extracellular matrix (ECM); and 3) mimicked scaffolds for tissue engineering in maxillofacial and orthopedic surgery. The content of this book which is interdisciplinary in nature caters to medical product designers, materials scientists and engineers, biologists, and surgeons who have interest in the field of bone tissue engineering.