HIV: Immunodeficiency syndrome - Leilane Ribeiro de Sousa - Bog

The recommendation to start using antiretrovirals early has shown great benefits, leading to an increase in morbidity and mortality and a reduction in the transmission of infection. The general aim of this study was therefore to report on antiretroviral treatment and resistance through a systematic review. All publications with data on antiretroviral treatment and resistance, scientific publications, between a certain date (2017-2021) were used. The viral mutations were named according to the consensus of the Los Alamos National Laboratory, using the sequencing of subtype B as a parameter, thus using the letter of the amino acid followed by the codon (gene locus) adding the letter of the new amino acid. In Brazil, the main mutagenic patterns identified with the highest prevalence are K70R, M184V, and T215F/Y, and sporadically L210W, Q151M, Y115F, G333D/E, F116Y, L74I.