Local drug delivery - Jyoti Gupta - Bog

The concept that local delivery of antibiotics into the periodontal pockets achieves a greater, more potent concentration of drug than available with systemic delivery is very appealing. The amount of drug delivered often creates sulcular medication concentration exceeding the equivalent of 1mg/ml (1000ug/ml). This level is considered bactericidal for the majority of bacteria that exhibit resistance to systemically delivered concentration.