Medicinsk forskning

This volume explores the dynamic topic of tight junctions. The book focuses on tight junctions' role in sealing adjacent epithelial cells in a narrow band just beneath their apical surface. The book explains how tight junctions consist of a network of claudins and other proteins, and delves into how they hold cells together and form functional and protective barriers, regulating the passage of molecules and ions through the space between cells.The book opens with a discussion of the evolution of research on tight junctions, discussing a range of primary areas of growth, including the current knowledge on the particular physiological function of different claudins due to the development of an array of knock out mice. The chapters also explore in-depth studies of tight junctions in specific tissues (gut, lung and endothelia). This book offers a comprehensive understanding on post-translational modifications of occludin and its impact on tight junction function, as well as the molecular composition and function of tricellular tight junctions. This volume is particularly relevant to students and scientists in neuroscience, cell biology, physiology, cell differentiation, and cancer research.

Was hat die ¿Tropenmedizin" im ¿Globalen Norden" zu suchen? Was kann eine Universität, ein ¿Tropeninstitut", im ¿Globalen Norden" zur Verbesserung der Gesundheitssituation im ¿Globalen Süden" beitragen? Die Antwort: ¿Tropenmedizin" muss sich zu ¿Globaler Medizin" hin entwickeln. Das heutige Heidelberg Institute of Global Health an der Universität Heidelberg ist diesen Weg von seinen Anfängen als Institut für Tropenhygiene 1962 bis heute konsequent gegangen. Hans Jochen Diesfeld hat diesen Weg aktiv gestaltet und begleitet. Er zeichnet ihn in diesem Band nach und zeigt dabei die verschiedenen Einflussfaktoren und Herausforderungen auf. Er erweist damit all denen Referenz, die über vier akademische Generationen hinweg dazu beigetragen haben.

Periodontitis is a disease that affects more than half the adult population in the world. Treatment is often based on ancient recommendations consisting in mechanically removing material from damaged zones. However, novel therapeutic management strategies exist, from prevention to efficient treatment, and regeneration. The need of integrative approaches to circumvent this worldwide pledge can be achieved through:A better understanding of this complex disease by promoting scientific research and a comprehensive multidisciplinary approach, including epidemiology, microbiology, immunology, physiology, therapeutics, psychology, etc. A better outreach by promoting vulgarization and recommendations for health professionals.A better information of the empowered patients, leading them to consider prevention and to take part in their therapeutic course.The book "e;Periodontitis: Advances in Experimental Research"e; includes a timely collection of chapters covering all the fields of research about periodontitis, consisting in concise reviews by the best specialists themselves and with clinical perspectives for periodontitis. Recent technological advances have allowed to explore shadowed areas of periodontology.The book "e;Periodontitis: Advances in Experimental Research"e; is a unique occasion to set a milestone for a more integrated field of periodontitis, with a broad scientific, medical, and public audience thanks to dedicated sections in each chapter:Abstract and main body (scientific audience and expert clinicians)Highlights (scientific audience and clinicians)Impact for Practice (clinicians and economical/political decision makers)Summary for Patients (patients and economical/political decision makers)

The book titled 'Prebiotics, Probiotics and Nutraceuticals' is expected to direct many emerging research pathwaysneed at local and global levels for nutrition and food supplements for developing immunity for healthy life. This volume incorporates sixteen seminal papers on issue based research and their practical applications covering latest information and progress on different area of nutritional supplement research fight against disease. The book highlights the frontier issues and applications in nutritional biotechnology with wide coverage of the themes like Potentiality of Probiotics in Inactivation of Tetrodotoxin, Therapeutic Strategy for the Deterrence of COVID-19 with Relevance to Probiotics and Prospectives of Prebiotics, Probiotics and Synbiotics for Sustainable Development in Aquaculture.Plant based Bioactive compounds in Cancer Therapeutics, Recent Trends in Natural Medicines and Nutraceuticals Research, Probiotics as efficacious therapeutic option for treating gut-related diseases: molecular and immune-biological perspectives, The progressive development of probiotics, prebiotics, synbiotics research, and its multipurpose use in the ornamental fishery, The commercial perspective of probiotics, and bioremediating components in aquaculture pond management: A Case Study andPrebiotics as promising therapeutics for treating gut-related disorders : Biochemical and Molecular Perspectives. Prebiotics and Probiotics as Functional Foods: Prospect and Promises in Metabolic Diseases, Implications of probiotics and prebiotics on immune functions. Recent Trends in Natural Medicines and Nutraceuticals Research, Nutraceuticals are alternative to modern medicines, Socio-Economic Study of Prospective of probiotic, prebiotic and synbiotic for sustainable development of aquaculture in Indian Sunderban. This book will be very useful for the scholars, biotechnologists, agricultural scientists, nutritionist, medical doctors, researchers, teachers and students in the emerging field of biotechnology.

Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions.This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of Springer Nature's longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the 15th volume of a continuing series.

This book considers the intellectual property protection of clinical test data that has been submitted to governments, in particular through test data exclusivity rights. It focuses on how these intellectual property rights first emerged in the early 1980s, how they have globalised over the past four decades, and what impact they have had upon access to medicine. This book makes a number of significant and original contributions to the literature around the protection of submitted test data. First, the book draws upon the theory of regulatory globalisation to provide an explanation of how intellectual property rights in submitted pharmaceutical test data have become nearly ubiquitous in the legal systems of most major economies. Second, through a comprehensive analysis and synthesis of provisions on the protection of submitted test data in free trade agreements, as well as a comparison of a range of national approaches to the protection of submitted test data, it reveals the broader global regulatory pattern that has given rise to these intellectual property rights. Third, by analysing data on drug approvals in the US, it provides an empirical insight into the impact of test data exclusivity in national pharmaceutical markets. Fourth, the book covers a number of developments regarding test data exclusivity that have occurred as a result of responses to the COVID-19 pandemic, both at the national level as well as at the World Trade Organisation (WTO). This book will appeal to academics researching the intersection of intellectual property and the life sciences, civil society activists working to promote access to medicines, and students (particularly those at the post-graduate level) studying the relationship between intellectual property and medicine.

Readers will discover the relatively new and rapidly growing field of regenerative surgery and fat grafting, valuable for numerous plastic surgery, reconstructive, and aesthetic/cosmetic essentials.Though many books have covered specific areas or topics in regenerative surgery, the market lacks a work that tackles the full spectrum of regenerative surgery and its clinical application. This book responds to that need and presents chapters written by the best: world-renowned surgeons in their field.After an introduction that reflects basic research, most of the book focuses on clinical experience as it relates to applied techniques of processing fat and on the different uses from head to toe. Readers will learn about the history of regenerative surgery, important definitions and background information, and the evidence supporting the use of regenerative surgery. Practitioners will also find valuable guidance regarding the application of stem cells, evaluation of patient needs, and operative techniques for fat transfer. Subsequent chapters address topics such as graft types, the skin, wound healing, scar treatment, osteoarthritis, burns, scleroderma, hair rejuvenation, facial enhancement combined with facelift, chin augmentation with fat, and breast argumentation or reconstruction with fat. Particular attention is paid to gluteal augmentation with fat, body contouring, genital male and female rejuvenation, and upper and lower extremity regenerative surgery. Surgical anatomy and complications treatment and prevention were emphasized when applied. This resulted is two volumes that encompass 114 chapters, with multiple figures, and video clips, written by 242 authors (including 72 female colleagues) from five continents.Highly informative and carefully structured, this book provides invaluable insight for beginners and experienced plastic surgeons alike, while benefitting advanced surgeons, specialists, and undergraduate and graduate students.

These books bring together a panel of expert arbovirologists who recall the history of arbovirology from very personal perspectives. In these timely volumes, the authors describe seminal moments in their experiences in the field and how they integrated these findings with lab studies to further clarify the ecology and epidemiology of diverse arboviruses. Authors identify the most pressing questions that remain to be answered, providing a basis for current research and a stimulus to engage those entering the field. Over the last 20 years a generational gap has developed between the giants of arbovirus research and discovery and the new generation. This gap developed due to an ebbing of training and investment in passing the scepter to the next generation, leading to a lack of continuity among the generations that threatens to derail the rich history of virus discovery, field epidemiology and understanding of the richness of diversity that surrounds us. This lack of continuity may have immediate and disastrous consequences for public health when yet to be discovered arboviruses emerge. The purpose of these books is to bridge this gap by providing a historical context for the work being done today and provide continuity between the generations. To this end, the books provide a narrative of the thrill of scientific discovery and excitement of field adventures and lab studies of that generation -- essential reading for every arbovirologist, and highly recommended for all virologists and public health officials, as well as those students considering future research options. Volume I consists of the personal reflections of arbovirologists who played a significant role in the advancement of arbovirology across the globe. Volume II transitions to descriptions of region-specific and virus family-specific perspectives of arbovirology, as well as recollections of the early events of molecular advances and pathogenesis studies.

The ¿Integrated Science of Global Epidemics¿ is the new proposed volume of Integrated Science Book series, aiming to publish the results of the most updated ideas and reviews on Global Epidemics. The whole world is suffering from complex problems, border less problems and global solution should be developed. The Integrated Science of Global Epidemics aims to highlight the combination of different disciplines, including formal sciences, physical-chemical sciences and engineering, biological sciences, medical sciences, and social sciences, to deal with complex problems such as global epidemics. This contributed volume could be used as guidelines for the entire scientific community and policy makers to successfully face these global threats.Chapter 27 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

This third and final volume in the "e;Ion Transport in Tumor Biology"e; collection presents novel diagnostic and therapeutic approaches in cancer based on the exploitation of ion transport proteins. The authors critically examine several transportome members, particularly Na+, K+, Ca2+, and Cl- channels, as well as organic solute carriers regarding their suitability as therapeutic targets. Synergistic effects resulting from the combined use of classical cytostatics with ion transport-inhibiting drugs are pointed out, and the capability of bispecific antibodies to function as anticancer drugs is discussed. As readers will also learn, the use of ion channel inhibitors could improve the outcome of radiotherapy because the development of radio-resistance during radiotherapeutic treatment often correlates with increases in the expression levels and conductance of ion channels. The translational topics of this volume form a bridge between biochemical research and therapeutic application.As part of a three-volume collection, this book will fascinate members of the active research community, as well as clinicians in the cancer field.

Many significant achievements in new ultrasound technologies to measure bone and models to elucidate the interaction and the propagation of ultrasonic waves in complex bone structures have been reported over the past ten years. Impaired bone remodeling affects not only the trabecular compartment but also the cortical one. Despite the crucial contribution of the cortical structure to the whole bone mechanical competence, cortical bone was understudied for a long time. A paradigm shift occurred around 2010, with a special focus placed on the importance of cortical bone. This has sparkled a great deal of interest in new ultrasound techniques to assess cortical bone. While our book 'Bone Quantitative Ultrasound' published in 2011 emphasized techniques to measure trabecular bone, this new book is devoted for a large part to the technologies introduced recently to measure cortical bone. These include resonant ultrasound spectroscopy, guided waves, scattering, and pulse-echo and tomography imaging techniques. Instrumentation, signal processing techniques and models used are detailed. Importantly, the data accumulated in recent years  such as anisotropic stiffness, elastic engineering moduli, compression and shear wave speeds of cortical bones from various skeletal sites are presented comprehensively. A few chapters deal with the recent developments achieved in quantitative ultrasound of trabecular bone. These include (i) scattering-based approaches and their application to measure skeletal sites such as the spine and proximal femur and (ii) approaches exploiting the poro-elastic nature of bone. While bone fragility and osteoporosis are still the main motivation for developing bone QUS, this Book also includes chapters reporting ultrasound techniques developed for other applications of high interest such as 3-D imaging of the spine, assessment of implant stability and transcranial brain imaging.This book, together with the book 'Bone Quantitative Ultrasound' published in 2011 will provide a comprehensive overview of the methods and principles used in bone quantitative ultrasound and will be a benchmark for all novice or experienced researchers in the field.The book will offer recent experimental results and theoretical concepts developed so far and would be intended for researchers, graduate or undergraduate students, engineers, and clinicians who are involved in the field.The book should be considered as a complement to the first book publisher in 2011, rather than a second edition, in the sense that basic notions already presented in the first book are not repeated.

This book serves as a practical guide and a manual on the application of isotopic tracers in understanding the cellular processes (e.g. molecular interactions, protein synthesis) in growth, development, and disease conditions. The techniques described in the book have been carefully chosen to underscore the role and relevance of isotopic tracers in the identification of molecular targets and mechanisms, and preclinical validation of potential therapeutics. This book is intended to be a valuable resource to non-experts that may include students, researchers, educators/teachers, and others who have an interest to understand the application of isotopic tracers in research. Each chapter includes a background, an outline of the method and underlying principles, and a detailed step-wise protocol. To augment the clarity and intellectual grasp, the chapters also include relevant illustrations and study questions. More importantly, the book covers techniques involving radioactive as well as non-radioactive tracers to expand the scope of isotopes in preclinical research including basic and applied science.

Red light therapy is a natural and 100% safe treatment that works by emitting special wavelengths that stimulate the mitochondria in cells to produce ATP, which is essential to build collagen. Once the light is absorbed by the skin, it produces light energy which is then converted to cell energy that is responsible for growing fiber cells, tissue & collagen. It increases skin elasticity and helps to naturally rejuvenate. This natural treatment is backed by several scientific studies and has been proven to be effective to treat certain skin conditions and improve overall health. Here are just a few things you will get out of this book: What is Red Light Therapy and whether or not you should use itAll possible benefits of Red Light TherapyInstructions on how to use red light therapy at YOUR OWN HOME10 reasons why you should use Red Light TherapyMost common mistakes while using Red Light TherapyKey Preparation before and during the therapy you need to know aboutMany Many more...In the same way that many people are shifting towards non-invasive, holistic treatments for illness, animal owners are increasingly open to alternative therapies for their beloved pets.Red light therapy works on animals in much the same way that it works on humans. Nearly all forms of life benefit from red and near-infrared light exposure when it is administered in a sustained manner over time.

Når forskning og innovation både er udfordringen og løsningenDet danske sundhedsvæsen er ramt af udfordringer. Med den demografiske udvikling forventes flere ældre og multisygdomsramte patienter, og hertil føjer sig et stigende problem med at sikre et godt arbejdsmiljø med kvalificeret personale.I denne antologi tager en række eksperter afsæt i sundhedsvæsenets udfordringer, når de undersøger, hvordan vi kan afhjælpe problemerne og skabe fremtidens sundhedsvæsen. Potentialet ved strategisk at inkorporere forskning og innovation i forskellige udviklingstendenser udfoldes, og flere vinkler på, hvordan man kan sammentænke drift, forskning, innovation og uddannelse i praksis, præsenteres:- Missionsorienteret forskning og innovation- Udvikling af forskningskultur på tværs af en stor organisation- Det offentlig-private samarbejde- Det digitaliserede sundhedsvæsen- Forsknings- og innovationsbroen- Klinisk kvalitet som outcome- Brugerinddragelse.Det danske sundhedsvæsen har behov for ledere, der kan lede i en kompleks organisatorisk virkelighed og forstår at lede udvikling og innovation ind i driften, så det får reel impact for både personale og patienter. Bogen kan læses som inspiration og debatoplæg af alle i sundhedssektoren med lederambitioner og -ansvar.

The first volume of the book-Emerging Human Viral diseases presents pathogenesis, diagnostics, and therapeutic strategies against viral respiratory and hemorrhagic fever diseases. The initial chapter discusses the underlying factors contributing to the emergence of these viral diseases. The subsequent chapters introduce structure, composition, and organization of viral genomes, and provide insight into function of important viral proteins. It also discusses the host factors that influence the outcome of viral infection and host immune response to the infections caused by these viruses. The book also discusses clinical manifestation and strategies for the prevention of virus diseases and highlights the recent technical advances in the diagnosis of virus diseases, prevention, and control strategies for viral infections.This timely book offers valuable resource for the scientists working in the field of emerging viral infections and those involved in preventing, controlling, and managing viral diseases.

This book introduces how to enhance the context capture ability of the model, improve the position information perception ability of the pretrained models, and identify and denoise the unlabeled entities. The Chinese medical named entity recognition is an important branch of the intelligent medicine, which is beneficial to mine the information hidden in medical texts and provide the medical entity information for clinical medical decision-making and medical classification. Researchers, engineers and post-graduate students in the fields of medicine management and software engineering.

This book presents the latest findings in the field of cardiac mechanobiology in health and disease.Cardiac mechanobiology provides knowledge of all aspects of mechanobiology of the heart. Cardiomyogenesis is discussed as well as the mechanobiology of cardiac remodeling and regeneration. The molecular mechanisms of mechanoperception and mechanotransduction in cardiomyocytes are explained, as well as stretch induced differentiation of cardiomyocytes derived from induced pluripotent stem cells. This volume of the series Cardiac and Vascular Biology complements the volume Vascular Mechanobiology in Physiology and Disease (volume 8) published in this series. The book is aimed at clinicians as well as researchers in cardiovascular biology, bioengineering and biophysics, and also represents an educational resource for young researchers and students in these fields.

The fascinating area of molecular medicine provides a molecular and cellular description of health and disease. Starting with the understanding of gene regulation and epigenetics, i.e., the interplay of transcription factors and chromatin, this book will provide an fundamental basis of nearly all processes in physiology, both in health as well as in most common disorders, such as cancer, diabetes as well as in autoimmune diseases. Most non-communicable human diseases have a genetic (= inherited) as well as an epigenetic component. The later one is based on our lifestyle choices and environmental exposures. Many common diseases, such as type 2 diabetes, can be explained only to some 20% via a genetic predisposition. We cannot change the genes that we are born with but we can take care of the remaining 80% being primarily based on our epigenome. Therefore, there is a high level of individual responsibility for staying healthy. Thus, not only biologists and biochemists should be aware of this topic, but all students of biomedical disciplines will benefit from being introduced into the concepts of molecular medicine. This will provide them with a good basis for their specialized disciplines of modern life science research. The book is subdivided into 42 chapters that are linked to a series of lecture courses in ¿Molecular Medicine and Genetics¿, ¿Molecular Immunology¿, ¿Cancer Biology¿ and ¿Nutrigenomics¿ that is given by one of us (C. Carlberg) in different forms since 2002 at the University of Eastern Finland in Kuopio. This book represents an updated version and fusion of the books textbooks ¿Mechanisms of Gene Regulation: How Science Works¿ (ISBN 978-3-030-52321-3), ¿Human Epigenetics: How Science Works¿ (ISBN 978-3-030-22907-8). ¿Molecular Immunology: How Science Works¿ (ISBN 978-3-031-04024-5), ¿Cancer Biology: How Science Works¿ (ISBN 978-3-030-75699-4) and ¿Nutrigenomics: How Science Works¿ (ISBN 978-3-030-36948-4). By combining basic understanding of cellular mechanism with clinical examples, the authors hope to make this textbook a personal experience. A glossary in the appendix will explain the major specialist¿s terms.

This collection explores state-of-the-art methods and protocols for research on photodynamic therapy (PDT) and its use in a wide range of medical applications, from antiviral to anticancer. Beginning with an extensive section on in vitro and in vivo models, the volume continues with chapters on oxygen-independent photosensitizers, next-generation photosensitization strategies, contemporary insights into the immunomodulatory effects of PDT, antimicrobial effects of PDT, as well as a variety of general biochemical and molecular biological techniques. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detailed implementation advice that ensures successful results in the lab. Thorough and authoritative, Photodynamic Therapy: Methods and Protocols serves as an ideal source of inspiration for both new and established PDT scientists and a guide for designing innovative research programs in this continuously advancing and multidisciplinary field.

InhoudsopgaveWe zijn erDe hoogleraar doet helemaal meeWie is dan de tweede promotorIs de bieb open op zondagGaan we dan eerst alleen maar lezenHeb ik de hele vraagstelling alWie vraag ik om dit hoofdstuk te herzienWie bepaalt eigenlijkIk heb hoofdpijnJa dit is nieuwMijn partner weet het niet meerDe hoogleraar wil een conceptIk vraag bij HRM/P&O om wat supportDe hoogleraar is nu ongeduldigWat was de vraagstelling ook alweerDe tweede promotor heeft dit te zeggenDan is er die dagDe commissie is het oneensHoeveel tijd heb ik nogDe tweede promotor trekt de kar rechtDan is er een datum te plannenOp de dag van het publiek verdedigenJa dank u voor deze vraagIk verklaar nuDe auteur promoveerde in 2001

Die Ansicht ¿Es liegt alles in unseren Genen und wir können es nicht ändern¿ hat sich in den letzten 150 Jahren seit Gregor Mendels Experimenten mit blühenden Erbsenpflanzen entwickelt. Es gibt jedoch eine besondere Form der Genetik, die Epigenetik, bei der unsere Gene nicht verändert werden, sondern geregelt wird, wie und wann sie genutzt werden. Unsere Umwelt und Lebensstilentscheidungen beeinflussen die Epigenetik unserer Zellen und Organe, d. h. die Epigenetik verändert sich dynamisch während unseres gesamten Lebens. Wir haben also die Möglichkeit, unsere Epigenetik sowohl positiv als auch negativ zu verändern.In diesem Buch wird auf molekularer Ebene erklärt, wie unser Genom mit Umweltsignalen verbunden ist. Es zeigt auf, dass die epigenetische Programmierung ein Lernprozess ist, der zu einem epigenetischen Gedächtnis in jeder Zelle unseres Körpers führt. Die zentrale Bedeutung der Epigenetik während der Embryogenese und der zellulären Differenzierung sowie beim Alterungsprozess und dem Risiko für die Entstehung von Krebs werden erörtert. Darüber hinaus wird die Rolle des Epigenoms als molekularer Speicher für zelluläre Ereignisse nicht nur im Gehirn, sondern auch in Stoffwechselorganen und im Immunsystem beschrieben.Das Buch ist die Übersetzung des Lehrbuchs ¿Human Epigenetics: How Science Works¿ (ISBN 978-3-030-22907-8) der Autoren. In den ersten fünf Kapiteln werden die molekularen Grundlagen der Epigenetik erläutert, während die folgenden sieben Kapitel Beispiele für die Auswirkungen der Epigenetik auf die menschliche Gesundheit und Krankheit liefern.