Analytisk kemi

. The main aim of this book is to shine a spotlight on key experiments and their crucial importance for advancing our understanding of physics. Physics is an empirical science, and experiments have always been a driving force in the development of our understanding of nature. Facts matter. In that sense, the book attempts to be complementary to the many popularizations of theoretical physics, and to counterbalance the frequent emphasis there on more speculative ideas.Experimental physics is also an essential pillar in physics teaching, as well as helping broader audiences to better understand important concepts, particularly in challenging fields such as relativity or quantum physics, where our common sense intuition often fails.Readers are taken on an historical journey, starting with ¿Free Fall¿ and culminating in ¿Spooky Action at a Distance¿. En route they will encounter many important branches ofphysics, whose main ideas and theoretical description will be given a more empirical meaning. At the end, the reader is invited to reflect on what could be exciting and important directions for fundamental physics. All readers with an undergraduate degree in physical sciences or engineering will enjoy and learn much from this stimulating and original text.

Sample Handling and Trace Analysis of Pollutants: Innovations to Determine Organic Contaminants, Second Edition reviews the latest technologies and challenges in trace analysis of environmental pollutants, from selecting the right approach to tips for performing analytic procedures and measuring and reporting results. Written by internationally renowned experts in environmental analysis from 5 continents and edited by leaders in the field, this completely updated and revised volume presents the latest techniques developed over the past 10 years, such as high-resolution mass spectrometry, biosensors and imaging techniques. Important tools for problem-solving in the determination of environmental pollutants are also discussed.Chapters cover emerging pollutants in the environment, such as nanomaterials, microplastics, metabolites and/or transformation products and antimicrobial resistances. Specific sections describe field sampling techniques and sample preparation in environmental matrices: air, water, soil, sediment and biota, focus on passive samplers, cover the determination of these environmental contaminants based on analytical techniques, such as the use of gas chromatography and liquid chromatography coupled to mass spectrometry, immunoassays, and biosensors as well as advanced analytical methods such as imaging techniques.

This book introduces the background of scattering theory and discusses its latest applications to imaging ultrafast structural dynamics in gas-phase molecules and condensed matter.

This book provides an overview of the contemporary integrated biology approaches for solving structures and understanding mechanisms of complex biological systems.

This book offers historical and state-of-the-art molecular spectroscopy methods and applications in dynamic compression science, aimed at the upcoming generation in physical sciences involved in studies of materials at extremes. It begins with addressing the motivation for probing shock compressed molecular materials with spectroscopy and then reviews historical developments and the basics of the various spectroscopic methods that have been utilized. Introductory chapters are devoted to fundamentals of molecular spectroscopy, overviews of dynamic compression technologies, and diagnostics used to quantify the shock compression state during spectroscopy experiments. Subsequent chapters describe all the molecular spectroscopic methods used in shock compression research to date, including theory, experimental details for application to shocked materials, and difficulties that can be encountered. Each of these chapters also includes a section comparing static compression results. The last chapter offers an outlook for the future, which leads the next-generation readers to tackling persistent problems.

This volume details protocols on mass spectrometry and associated techniques. Chapters guide readers through micro- and macronutrients analysis, mass spectrometry-related methodologies, direct insertion, matrix-assisted laser desorption ionization (MALDI), gas chromatography (uni- and bi-dimensional), liquid chromatography, plasma mass spectrometry (ICP-MS), and analyses in food samples.  Authoritative and cutting-edge, Mass Spectrometry for Food Analysis aims to provide comprehensive and updated state-of-art methodologies and models for food analysis.

Focusing on green pathways this book covers the synthesis of carbon dots and their applications in the fields of bioanalytical, catalytic, biomedical, and environmental sciences.

This book describes a simple yet innovative method for performing Raman spectroscopy of samples submerged under liquid nitrogen. While Raman spectroscopy has proven to be a powerful tool for the characterization of the structure of matter in the gaseous, liquid, and solid phases, one major difficulty in its application has been laser damage to the material under investigation, especially for biological samples. This book demonstrates how immersion of the sample in liquid nitrogen protects the sample from thermal degradation and oxidation at high incident laser power and allows improvements in sensitivity and spectral resolution over room-temperature Raman spectroscopy, leading to the so-called RUN (Raman Spectroscopy Under liquid Nitrogen) technique. Cooling to liquid nitrogen temperature also allows the selection of the lowest energy molecular conformation for molecules which may have many low energy conformers. In addition, the presence of liquid nitrogen over a roughened surface improves the sensitivity of Surface Enhanced Raman Spectroscopy (SERS), enabling the closely related SERSUN (Surface-Enhanced Raman Spectroscopy Under liquid Nitrogen) technique. This book starts with the theoretical and experimental basics of Raman and polarized Raman spectroscopy, before moving on to detailed descriptions of RUN and SERSUN. Room temperature and RUN spectra are provided for over fifty molecules.

The nonlinear optical spectrum signal technology is a new type of optical characterization technology owing to its non-invasiveness and good biocompatibility. This book highlights a comprehensive introduction to the Stimulated Raman scattering (SRS), Anti-Stokes Raman Spectroscopy (CARS), Two-photon Excited Fluorescence (TPEF) and Second Harmonic Generation signals (SHG) technologies. The four types of nonlinear optical signals technologies, especially two-dimensional and three-dimensional imaging, have great application potential in physics, materials science, chemistry and biomedicine. The book covers principles, theoretical calculation methods, signal measurement methods and imaging specific methods. The theoretical part starts from the basics of nonlinear optics and the relationship with strong light, and gradually transitions to theoretical calculation methods for specific optical signals. it combines the classical theory and the quantum theory to help readers develop a thorough understanding of the technologies. The book is a good reference for graduate students majored in physics and chemistry and for researchers working on optics, photonics and materials science.

This work involves a basic and applied research on the two cores of the thiophene and pyrrole, the aim is to predict the chemical reactivity and biological activity and to establish a pharmacophore model for new bioactive molecules.The Computational Chemistry methods used in our work are: quantum methods, empirical methods. These methods were used to determine the structural parameters, electronics and energy associated with molecules studied. This study shows similar results between these various methods of calculation. The nature of such substituent (donor, acceptor) affects the electronic and energy parameters of thiophenes and pyrroles. A study of the structure-properties/activity has been carried out for a two series of bioactive derivatives of thiophene and pyrrole. The nature of the groups on heterocyclic ring of the studied molecules affects on their physico-chemical properties and by consequence on their pharmacological properties.

This book gives a comprehensive account of modern x-ray science, based on the use of synchrotron radiation and x-ray-free electron lasers (XFELs). It emphasizes the new capabilities of XFELs which extend the study of matter to the intrinsic timescales associated with the motion of atoms and chemical transformations and give birth to the new field of non-linear x-ray science. Starting with the historical understanding of the puzzling nature of light, it covers the modern description of the creation, properties, and detection of x-rays within quantum optics. It then presents the formulation of the interactions of x-rays with atomic matter, both, from semi-classical and first-principles quantum points of view. The fundamental x-ray processes and techniques, absorption, emission, Thomson, and resonant scattering (REXS and RIXS) are reviewed with emphasis on simple intuitive pictures that are illustrated by experimental results. Concepts of x-ray imaging and diffractive imaging of atomic and nano structures are discussed, and the quantum optics formulation of diffraction is presented that reveals the remarkable quantum substructure of light. The unique power of x-rays in providing atom and chemical-bond specific information and separating charge and spin phenomena through x-ray polarization (dichroism) effects are highlighted. The book concludes with the discussion of many-photon or non-linear x-ray phenomena encountered with XFELs, such as stimulated emission and x-ray transparency.

Bioconjugated Materials Part 2, Volume 103 in the Comprehensive Analytical Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters on bioconjugated materials. Each chapter is written by an international board of authors.

Annual Reports on NMR Spectroscopy, Volume 110, presents the latest release in a series that has established itself as a premier resource for both specialists and non-specialists interested in new techniques and applications pertaining to NMR spectroscopy.

Spectroscopic Measurement: An Introduction to the Fundamentals, Second Edition contains the foundational topics associated with optical spectroscopic techniques, covering the basic theory of applied spectroscopy and presenting alternative approaches to understand physical processes. Electromagnetism, quantum mechanics, statistical mechanics, molecular spectroscopy, optics, and radiation form the foundations of the field are all thoroughly covered. On top of these rest the techniques applying the fundamentals, including Emission Spectroscopy, Laser Induced Fluorescence, and Raman Spectroscopy. This comprehensive and fully updated second edition includes additional coaching and covers new material online broadening, nonlinear techniques such as coherent anti-Stokes Raman spectroscopy, and more.Researchers not formally trained in these topics, but who apply spectroscopy in their work, will appreciate the detail contained in this book to ensure accuracy of their technique and/or to develop more sophisticated measurements.

This two-volume book provides an enriching insight into the laser, covering different types of lasers, the basic science behind the technology, their role at the cutting-edge of current scientific research, and their wide-ranging applications. With just high school physics as a prerequisite and favoring qualitative yet scientifically sound explanations over high-level mathematics, this book is aimed at a broad spectrum of readers in physics, chemistry, engineering, medicine, and biology. Its engaging and lucid presentation is enhanced with plenty of illustrations, making the world of the laser accessible to undergraduate students in the sciences and any other inquisitive readers with high school physics under their belts. Furthermore, the text is often laced with anecdotes, picked from history, that are bound to pique the minds of the readers. It is ideal for self-study or as a complement to courses on optics and optoelectronics. This volume, Part 1 of 2, explains the fundamentals of optics, what a laser is, how it works, and what is unique about the light it emits, from fundamental quantum theory through population inversion and cavity to common laser types. It is followed by Part 2 which depicts the many advances in science enabled by the laser, including spectroscopy, nonlinear optics, optical cooling and trapping, and optical tweezers, among many others, and provides a glimpse into the ways that the laser affects our lives via its uses in medicine, manufacturing, the nuclear industry, energy, defence, communication, ranging, pollution monitoring, art conservation, fashion, beauty, and entertainment.

This book discusses chemometric methods for spectroscopy analysis including NIR, MIR, Raman, NMR, and LIBS, from the perspective of practical applied spectroscopy. It covers all aspects of chemometrics associated with analytical spectroscopy, including representative sample selection algorithm, outlier detection algorithm, model updating and maintenance algorithm and strategy and calibration performance evaluation methods.To provide a systematic and comprehensive overview the latest progress of chemometric methods including recent scientific research and practical applications are presented. In addition the book also highlights the improvement of classical algorithms and the extension of common strategies. It is therefore useful as a reference book for researchers engaged in analytical spectroscopy technology, chemometrics, analytical instruments and other related fields.

Environmental Analytical Chemistry investigates how to use modern scientific theory and advanced experimental techniques to identify and determine the types, components, amounts, and chemical forms of substances in the environment, including both naturally occurring chemicals and anthropogenic contaminants. The book covers the newest developments of environmental analytical chemistry, including discussions of pretreatment techniques of environmental samples, chemical species and speciation analysis, atmospheric pollutants analysis, water pollutants analysis, soil pollutants analysis, sensing techniques for environmental pollutants and on-site rapid emergency analytical technology for environmental emergencies.The book will be of use to researchers and technical personnel in the fields of environmental science, environmental chemistry, environmental monitoring, and analytical chemistry.

Armorial porcelains comprised the output of most European ceramics factories in the 18th and 19th Centuries in response to the large quantity of armorial porcelain services that were being imported from China bearing the coats of arms and crests of aristocratic families. Whereas these armorial services have been identified and covered for most porcelain manufactories the information relevant to their production by the two relatively short-lived Nantgarw and Swansea China Works has not been addressed as a theme until now. As an integral  component  of  the holistic forensic appraisal of porcelain, a functional and decorative artwork manifestly part of our cultural heritage and its ongoing preservation ,  the recording and identification of such artefacts is material for the future establishment of a database of factory production . The Nantgarw and Swansea factories only operated for a limited period in the second decade of the 19th Century and their porcelains were much appreciated  for their high quality and desirability by Georgian households. Today, examples are to be found in many museums and  ceramics collections and continue to excite the interest of specialists and the general public . This text provides the first comprehensive assessment of armorial porcelains from these two factories and the methodology and procedure for the identification of unknown armorial bearings and crests is illustrated; individual bearings are discussed  in detail and existing incorrect assignments in the literature are re-appraised. The difficulties in attribution of armorial heraldic achievements that are only minimally depicted are considered and directions for further studies using historical documentation are invoked. This book therefore fills a currently existing gap in the ceramics literature of the 19th Century. 

This book reports a study of a class of Dion-Jacobson-type layered perovskite oxides in which high oxide-ion conductivities in phases were discovered for the first time in the world. The oxide-ion conductors are important in various energy conversion devices and environmental protection applications such as solid-oxide fuel cells, oxygen gas sensors, oxygen separation membranes, and oxygen-based catalysts. The discoveries are based on a new screening method, called the bond valence method, combined with an original design concept. The present finding of high oxide-ion conductivity reported in the thesis suggested the potential of Dion-Jacobson phases as a platform to identify superior oxide-ion conductors.To understand what causes such high oxide-ion conductivities in these layered perovskite oxides, the author analyzed their crystal structures at high temperature and described the relationship between oxide-ion conductivities and their crystal structures. A deep understanding of the mechanisms of oxide-ion diffusivity at an atomic level in the Dion-Jacobson phases is clarified.The discovery of these materials, the new screening method, and the original design concept make possible the realization of many environment-friendly technologies. The findings in this thesis facilitate the possibilities for many novel applications that will help lead to a sustainable future.

This book summarizes the recent developments of mass spectrometry techniques in microbial analysis for researchers in the field and for those who are about to enter the field.

This book provides an overview on the properties and novel applications of graphene-based nanocomposites as chemical and biosensors.

This volume covers various aspects of affinity chromatography along with examples of its applications. Chapters guide readers through methodologies to purify a diverse array of molecular targets such as antibodies, extracellular vesicles, recombinant proteins, biomarkers, metabolites, plant organelles, nucleic acids, ligand identification and protocols on building affinity matrix. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Affinity Chromatography: Methods and Protocols aims to be an invaluable resource to anyone employing affinity chromatography-based methodologies.

This book provides the reader with an updated comprehensive view of the rapidly developing and fascinating field of fluorescence spectroscopy and microscopy. In recent years, fluorescence spectroscopy and microscopy have experienced rapid technological development, which has enabled the detection and monitoring of single molecules with high spatial and temporal resolution. Thanks to these developments, fluorescence has become an even more popular method in physical, biological and related fields. This book guides the reader through both basic and advanced fluorescence spectroscopy and microscopy approaches with a focus on their applications in membrane and protein biophysics. Each of the four parts: A - Fluorescence Spectroscopy, B - Fluorescence Microscopy, C - Applications of Fluorescence Spectroscopy and Microscopy to biological membranes and D - Applications of Fluorescence Spectroscopy to protein studies are written by experts within the field. The book isintended for both complete beginners who want to quickly orient themselves in the large number of existing fluorescent methods, as well as for advanced readers who are interested in particular methods and their proper use.Chapter ¿Dynamics and Hydration of Proteins Viewed by Fluorescence Methods: Investigations for Protein Engineering and Synthetic Biology¿ is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Describing the importance of surfactants in electrochemical investigations related to biologically and environmentally vital chemicals, this book charts the progression of highly responsive electrochemical sensors using surfactants as a modifying agent in the sensor field.

This third edition is a comprehensive and extended study about the best known approaches for preparing the main types of glycosides, covering the classic and more recent glycosylation reactions used for preparing simple and challenging glycosides currently used as potent antiviral and antineoplastic drugs, or fluorogenic substrates used for enzymatic detection in cell biology.  Besides, this new edition provides more examples of the glycosidic methodologies followed for preparing complex glycoconjugates such as glycoproteins and glycosphingolipids and gangliosides used as adjuvants or as synthetic vaccines candidates.Also, additional mechanistic evidence is presented for better understanding of the glycosylation reaction, trying to identify the variables mainly depending on protecting and leaving groups, as well as catalyst and reaction condition which altogether directs the anomeric stereo control.A chapter on the glycoside hydrolysis is included in view of the increasing interest in the use of biomass as a natural and renewable source for obtaining important intermediates or products used in food or valuable materials.The author includes information in the characterization of glycosides section with the aim of giving additional tools for the structural assignment through NMR, X-Ray and mass spectra techniques.

This volume focuses on the potential use of probiotics in treating metabolic disorders such as diabetes mellitus, metabolic acidosis, and gut dysbiosis. Chapters draw an association between gut microbiota and its diversity with metabolic diseases like diabetes, obesity, related liver and gut disorders; gut-brain axis; increased inflammation, and a compromised immune system resulting from these manifestations and scope of intervention with probiotics. Special attention is laid on describing the mechanisms of action of such beneficial effects of probiotic administration. The ability of probiotics to decrease metabolic endotoxemia by restoring the disrupted intestinal mucosal barrier is also included.The volume is a comprehensive compilation describing the scope and application of probiotic and prebiotic therapy in treating metabolic disorders. Readers will discover how probiotics are not just confined to the microbiology industry but are showing promising results in the medical and pharmaceutical sectors.

Examining the unique contribution of ILs towards current environmental challenges, this book addresses the importance of their role in the detection of micropollutants and decontamination processes in air and water compartments.

Infrared Spectroscopy - Perspectives and Applications is a compendium of contributions from experts in the field of infrared (IR) spectroscopy. This assembly of investigations and reviews provides a comprehensive overview of the fundamentals as well as the groundbreaking applications in the field. Chapters discuss IR spectroscopy applications in the food and biomedicine sectors and for measuring transport through polymer membranes, characterizing lignocellulosic biomasses, detecting adulterants, and characterizing enamel surface advancements. This book is an invaluable resource and reference for students, researchers, and other interested readers.

This second edition details new and updated chapters on key methodologies and breakthroughs in the mass spectrometry imaging (MSI) field. Chapters guide readers through nano-Desorption Electrospray Ionisation (nDESI), Matrix Assisted Laser Desorption Ionisation-2 (MALDI-2), Laser Ablation - Inductively Coupled Plasma-Mass Spectrometry (LA-ICP-MS) ,Imaging Mass Cytometry (IMC) with a variety of diverse samples including eye tissue, crop analysis, 3D cell culture models, and counterfeit goods analysis. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Imaging Mass Spectrometry: Methods and Protocols, Second Edition aims to be a useful and practical guide to new researchersand experts looking to expand their knowledge.