Name: THE IMPACT OF HYPOXIA ON THE IN VITRO EXPANSION OF T AND NK CELLS
Price: 458.95 DKK
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Author: Maria Aparecida Lima da Silva
ISBN: 9786206944973

THE IMPACT OF HYPOXIA ON THE IN VITRO EXPANSION OF T AND NK CELLSaf Maria Aparecida Lima da Silva

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Infusions of T cells and NK cells (Natural Killer) from peripheral blood are being carried out to treat malignancies. Lymphocytes propagated ex vivo, in normoxia (20% O2), are infused intravenously and must survive the hypoxia associated with venous circulation, bone marrow (5% O2) and the tumor microenvironment (1% O2). The main objective of this study was to determine the proliferative capacity of human T and NK cells in normoxia (20% O2) versus hypoxia (1% O2), for 28 days, using an artificial antigen-presenting cell (aAPC) for clinical grade propagation.

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Sprog:
Engelsk

ISBN:
9786206944973

Forlag:
Our Knowledge Publishing

Indbinding:
Paperback

Sideantal:
52

Udgivet:
21. januar 2024

Størrelse:
150x4x220 mm.

Vægt:
96 g.

Leveringstid: 2-15 hverdage.
Forventet levering: 16. december 2024

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Forlænget returret til d. 31. januar 2025

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Beskrivelse af THE IMPACT OF HYPOXIA ON THE IN VITRO EXPANSION OF T AND NK CELLS

Infusions of T cells and NK cells (Natural Killer) from peripheral blood are being carried out to treat malignancies. Lymphocytes propagated ex vivo, in normoxia (20% O2), are infused intravenously and must survive the hypoxia associated with venous circulation, bone marrow (5% O2) and the tumor microenvironment (1% O2). The main objective of this study was to determine the proliferative capacity of human T and NK cells in normoxia (20% O2) versus hypoxia (1% O2), for 28 days, using an artificial antigen-presenting cell (aAPC) for clinical grade propagation.

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