Biovidenskab: generelle emner

How is a changing climate affecting hurricanes, and how are these changes intersecting with our changing exposure and vulnerability in ways that affect tropical cyclone risk? Crucially, how should this understanding be incorporated into risk management practice? This book takes a cross-sectoral look at how damaging tropical cyclone characteristics are changing and presents novel approaches to integrate science with risk assessment. In this new era of tropical cyclone impacts, understanding effective risk management practice in a changing climate is more important than ever.This book details the outcomes of new research focusing on climate risk related to hurricanes in a changing climate. Topics include characteristics of tropical cyclone risk, perspectives on hurricane risk management strategies in the built environment, and implications for commercial risk. Inspired by the Symposium on Hurricane Risk in a Changing Climate, this book brings together leading international academics and researchers, and provides a source reference for both risk managers and climate scientists for research on the interface between tropical cyclones, climate, and risk.8 chapters are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

The book reviews and reports the recent progress and knowledge on the specific impact of current and projected urban overheating as well as of the urban mitigation technologies on mortality and morbidity and urban vulnerability. It presents recent data and developments on the topic reported by some of the more distinguished researchers in this area. In parallel, it discusses new findings related to the characteristics and the magnitude of urban overheating and reports and analyzes the recent knowledge on the synergies between urban heat island and heatwaves. This book helps to advance our understanding on the interaction between Urban Heat Island (UHI) and overheating as well as their impact on energy demand and public health globally. Exploring the interaction between UHI and energy consumption requires the understanding on the dynamics of UHI intensity and air pollution index in different land use and how such interactions may vary in different cities in the world.  Moreover, this book focuses on different cities in Australia, Austria, Belgium, Brazil, Canada, Cyprus, Greece, Hong Kong, India, Asia, Spain, UK, and USA.

"Nuestras investigaciones han proporcionado informaciones fiables sobre el valor que cada raza y ecotipo local tiene para la selección, sobre la relación genética existente entre diferentes grupos de razas, sobre aspectos morfológicos y fisiológicos que las diferencias y sobre la medida de sus variabilidades. En relación a estos importantes detalles, antes teníamos un interés superficial o del todo inexistente.Pero solamente este preciso conocimiento puede ser la base para crear cruces o por una selección por combinaciones que sean fiables".

"This concise book for scientists and students interested in bioinformatics and data science covers all aspects of predictive modeling for biomarker discovery based on high-dimensional data, as well as modern data science methods for identification of parsimonious and robust multivariate biomarkers for medical diagnosis and personalized medicine"--

This volume covers the latest advancements and methods used to study DNA barcoding. The chapters in this book are organized into six parts: theory, DNA manipulation, specialized barcoding methods, analysis of DNA barcodes, completing a successful DNA barcode project, and barcoding as citizen science. Part One looks at several theoretical issues in DNA barcoding concerned with DNA barcodes that can and should be used. Part Two discusses protocols for processing samples into DNA barcodes, including DNA isolation, sequencing and managing samples, and the resulting DNA barcodes. Part Three explores the next generation of DNA barcoding such as FRET-based detection, dual nanopore detection, skimming, and closed-tube methods. Part Four addresses programs and websites that handle DNA barcoding data, and includes character-based approaches, barcode gap methods, integrated approaches, and Barcode of Life Database. Part Five offers protocols for producing a successfulDNA barcoding project including plant and animal examples and protocols for generating a DNA Barcode Reference Library. Lastly, Part Six talks about several novel protocols for setting up an educational program using DNA barcodes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and thorough, DNA Barcoding: Methods and Protocols encompasses a wide range of techniques and will be a useful reference tool for both scientist and student.

This second edition volume expands on the previous edition with discussions of the latest advancements and methods used by scientists to study systems biology. The chapters in this book are organized into four parts. Part One looks at models in systems biology and parameters identification such as short peptide analysis, metastasis models, and metabolomics. Part Two covers computational methods in the study of organisms, and cancer non-linear dynamics. Part Three discusses critical transition states across Waddington¿s like landscapes such as understanding cell differentiation through single-cell approaches and modeling mammary organogenesis from biological first principles. Part Four talks about specific fields of investigation including inborn errors of metabolism, system biology approach in epithelial-mesenchymal transition, and an approach to understanding how COVID-19 spreads in the population. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and comprehensive, Systems Biology, Second Edition is a valuable tool for any researcher looking to learn more about this important and developing field.

Pioneers of Evolution from Thales to Huxley ; With an Intermediate Chapter on the Causes of Arrest of the Movement, a classical book, has been considered essential throughout the human history, and so that this work is never forgotten we at Alpha Editions have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and designed. These books are not made of scanned copies of their original work and hence the text is clear and readable.

Section-Cutting; A Practical Guide to the Preparation and Mounting of Sections for the Microscope, Special Prominence Being given to the Subject of Animal Sections, a classical book, has been considered essential throughout the human history, and so that this work is never forgotten we at Alpha Editions have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and designed. These books are not made of scanned copies of their original work and hence the text is clear and readable.

Section Cutting and Staining; A practical introduction to histological methods for students and practitioners, a classical book, has been considered essential throughout the human history, and so that this work is never forgotten we at Alpha Editions have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and designed. These books are not made of scanned copies of their original work and hence the text is clear and readable.

Darwin decía que las especies cambian para sobrevivir: viene un terremoto, se produce una inundación y sólo viven los que pueden correr más rápido o los que saben nadar. De acuerdo, pero ¿qué nos dice esta teoría sobre los cambios que no conducen a una mayor probabilidad de supervivencia o reproducción? Muy poco. ¿Por qué los dientes molares del hombre han disminuido de tamaño a lo largo de los siglos, al igual que los dedos de los pies? Desde luego, no para sobrevivir y reproducirse mejor. Veremos a lo largo de esta obra varios ejemplos que la teoría de Darwin no puede explicar y posibles razonamientos alternativos, respaldadas por experimentos científicos validados y aceptados por la comunidad científica. ¿Se equivocó Darwin? ¡Desde luego que no! Pero, como todas las obras de la ciencia, requiere revisiones y mejoras

Your interest in bees may be inspired by the humble honey bee and how they live together as individuals and yet act as one organism. Or you may want to help native bees thrive and multiply. Or you may want to harvest honey and beeswax for your own consumption or as part of a side hustle. Whatever the reason or reasons, this workbook is designed to help give you some basic information to help you decide how you might engage with native bees or keep honey bees.This primer is intended to introduce you to the most essential information you need to help you decide if you want to pursue the path of gardening for native bees and/or adopting your own bee hive.

"This book is published under the aegis of the Science and Engineering editorial board of ANU Press."

William Shakespeare has undergone psychological analyses ever since Freud diagnosed Hamlet with an Oedipus complex. But now, two psychologists propose to turn the tables by telling how Shakespeare himself understood human behavior and the innermost workings of the human mind.

This volume looks at classic and novel methods currently used by researchers to understand mood and anxiety disorders and foster precision medicine. Chapters in this book cover topics such as how the sucrose preference succeeds or fails as a measurement of anhedonia; fear conditioning in laboratory rodents; animal models for mania; rodent models for studying the impact of variation in early life mother-infant interactions on mood and anxiety; and prediction of susceptibility/resilience toward animal models of PTSD. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.   Comprehensive and cutting-edge, accommodating the novel views on how the neurobiology of psychiatric disorders should be reconceptualized, Psychiatric Vulnerability, Mood, and Anxiety Disorders: Tests and Models in Mice and Rats is a valuable resource for all researchers interested in learning more about this important and developing field. 

This second edition details new and updated methods used for studying prokaryotic non-coding RNAs and their protein accomplices. Chapters detail discovery of ncRNAs, characterization of their structure, functions, and their interactomes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Bacterial Regulatory RNA: Methods and Protocols, Second Edition aims to ensure successful results in the further study of this vital field.

This detailed volume provides a comprehensive collection of protocols for epigenomic research, powering our ability to analyze epigenetic modifications across the entire genome. Beginning with methods used to investigate epigenomic modifications such as DNA methylation, histone modifications, and chromatin structure, the book continues with methods for manipulating the epigenome, including platforms for epigenome editing, inducible systems for epigenome editing, and epigenetically modified animals. Written for the highly successful Methods in Molecular Biology series, chapters feature introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Epigenomics: Methods and Protocols serves as an ideal resource for researchers looking to further expand the utility and scope of epigenomics research.

This detailed book examines the main methods to study mammalian monoamine oxidases (MAOs), ranging from cell biology to computational chemistry. Beginning with techniques on how to obtain pure samples of MAO A and MAO B, the volume continues by covering assays and techniques used to measure MAO enzymatic activity and perform inhibition studies, methods to address cellular localization and function of MAOs, either in cell lines or in animal models, as well as computational methods applied to rational drug design approaches that are used to develop new MAO inhibitors. Written for the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Monoamine Oxidase: Methods and Protocols serves as a vital resource for scientists who are interested in studying MAOs and other similar amine oxidase enzymes.

This volume covers the latest techniques that study the synthesis of melatonin, its receptor function, and its effects at the cellular and systemic level. The chapters are organized into three parts. Part One describes methods for the detection of melatonin and its biological derivatives in various biological samples, the manipulation of melatonin synthesis by the pineal gland in animals, and the principal source of melatonin in mammals. Part Two explores methods to measure the biological effects and consequences of melatonin binding to high-affinity G protein-coupled receptors. Part Three describes methods to measure the physiological effects that are regulated by melatonin in animals, particularly in rodent models. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and thorough, Melatonin: Methods and Protocols is a valuable resource for any researcher interested in investigating melatonin, from its production to its mechanisms of action and systemic effects.  

This volume explores the latest techniques used to study neurodevelopmental diseases (NDD) that range from molecular aspects to integrated research approaches and brain imaging in living rodents. Chapters in this book cover topics such as protocols to deliver shRNA in vitro and in vivo using lentiviral particles to knock-down specific protein expression; experimental procedures to use recombinant fluorescent probes to visualize endogenous proteins at the mammalian synapse; CRISPR/Cas9 toolkit to assess either gain- or loss-of-gene function in brain organoids; detailed protocols to use in vivo manipulations to correct the behavioral phenotypes in cognitive disorder mouse lines; and experimental approaches to genetically engineer macaque models of NDDs and investigate how genetic predisposition may cause neural and functional alterations. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and practical, Translational Research Methods in Neurodevelopmental Disorders is a valuable resource for all researchers who want to learn more about this important and developing field.  

"For decades the practice of manifestation has been widely dismissed as self-involved, materialistic pseudoscience. But as neuroscientist and recognized compassion leader Dr. James Doty reveals, manifestation introduces us to different possibilities, and it lays the groundwork for a kinder, better world. Doty grounds us in the practices that change our brain structures: attention, meditation, visualization, and compassion. This mind magic allows us to move through the world in ways that help us see clearly-reclaiming our agency, realizing our dreams, and reaching out to help others along the path. Where previous works about manifestation have focused narrowly on outward success and individual benefit, Mind Magic delivers an openhearted call to make manifestation part of a deeper contribution to healing the problems we face today"--

Complications of Hysteroscopy: Diagnosis and Management is a step-by-step reference to explain various problems that can be encountered during a hysteroscopy procedure. It is a complete guide on the diagnosis and management of different causes of hysteroscopy mishaps to master how to diagnose and select the most appropriate strategy of all aspects of what could go wrong and applying that knowledge in different clinical settings. It is an essential reference for anyone in the research and medical field.

This dissertation's primary goal is to trouble the ableism embedded in how written communication is taught and evaluated. Drawing on principles of disability justice, user experience (UX) design, and socially just writing assessment theory, I develop equity-oriented approaches to classroom grading, writing program directed self-placement, and theories ofvalidity. I argue that for writing assessment ecologies to continue moving toward the goals of justice and equity, including intersectional anti-ableism, there must be commitments to crip community building, flexibility as access, radical trust, and participatory localization

This book offers a comprehensive overview of the most important neurochemicals and approaches everything from the neurochemical's perspective. It attempts to integrate the biochemical pathways of synthesis and metabolism of these neurochemicals with the disease states and point out the avenues of diagnostic testing and therapeutic intervention. Each chapter focuses on a specific neurochemical and provides a brief history, the biochemical profile, metabolism, physiological functions, and the clinical aspects. The clinical part of each chapter includes a discussion on disease states with either increased or reduced activity of the neurochemical and either activation or inhibition of the relevant receptors. This book is targeted toward practitioners and students of neuroscience and is written to emphasize the importance of these neurochemicals in the brain. With this emphasis on background neurochemical processes, the readers will be pointed towards logical diagnostic studies, laboratory investigations, and therapies based on the neurochemical dysfunction that underlies various disease states.

The rapid demise of coral reefs worldwide has spurred efforts to develop innovative conservation and restoration methods. Many of these rely on omics approaches to produce genetic, genomic, transcriptomic, epigenomic or metabolomic data to inform conservation and restoration interventions. This book provides the state of play of this field. It discusses topics ranging from how genomic and environmental DNA (eDNA) data can be used to inform marine protected area design and cryopreservation strategies, the use of knowledge on adaptive genetic and epigenetic variation to maximise environmental stress tolerance of coral stock, harnessing transcriptome data to develop early warning markers, the use of microbial symbiont omics data in guiding restoration strategies, to applications of metabolomics and genetic engineering. How best to translate omics data to resource managers is also discussed.

This book offers the reader a journey through the counterintuitive nature of Brownian motion under confinement. Diffusion is a universal phenomenon that controls a wide range of physical, chemical, and biological processes. The transport of spatially-constrained molecules and small particles is ubiquitous in nature and technology and plays an essential role in different processes. Understanding the physics of diffusion under conditions of confinement is essential for a number of biological phenomena and potential technological applications in micro- and nanofluidics, among others. Studies on diffusion under confinement are typically difficult to understand for young scientists and students because of the extensive background on diffusion processes, physics, and mathematics that is required. All of this information is provided in this book, which is essentially self-contained as a result of the authors¿ efforts to make it accessible to an audience of students from avariety of different backgrounds. The book also provides the necessary mathematical details so students can follow the technical process required to solve each problem. Readers will also find detailed explanations of the main results based on the last 30 years of research devoted to studying diffusion under confinement. The authors approach the physical problem from various angles and discuss the role of geometries and boundary conditions in diffusion. This textbook serves as a comprehensive and modern overview of Brownian motion under confinement and is intended for young scientists, graduate students, and advanced undergraduates in physics, physical chemistry, biology, chemistry, chemical engineering, biochemistry, bioengineering, and polymer and material sciences.

This book constitutes the refereed proceedings of the 21st International Conference on Computational Methods in Systems Biology, CMSB 2023, held in Luxembourg City, Luxembourg, during September 13¿15, 2023.The 14 full papers and 3 tool papers presented in this book were carefully reviewed and selected from 28 submissions. CMSB focuses on modeling, simulation, analysis, design and control of biological systems and covers the broad field of computational methods and tools in systems and synthetic biology and their applications.