Current Progress in Protein Kinase Research - Bailey Graham - Bog

Kinase refers to an enzyme that catalyzes the transfer of phosphate groups from high-energy, phosphate-donating molecules to specified molecules or substrates. Kinases may modify lipids, carbohydrates, proteins, or other molecules. Protein modifying kinases are called protein kinases. Kinase signaling is essential for regulating various metabolic events. AMP-activated protein kinase or AMPK is an enzyme, which is activated when the intracellular ATP levels are lower. It is one of the major regulators of cellular and organismal metabolism in eukaryotes, which is necessary for all cells to maintain a balance between ATP consumption and ATP generation. It is also known to play an essential role in regulating growth. AMPK can regulate lipid and glucose metabolism, therefore it is studied extensively as a suitable therapeutic target for treating obesity. This book unfolds the innovative aspects of protein kinase and kinase signaling. With state-of-the-art inputs by acclaimed experts of this field, this book targets students and professionals.